| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P P Rowell, D S Dugga. Long-lasting inactivation of nicotinic receptor function in vitro by treatment with high concentrations of nicotine. Neuropharmacology. vol 37. issue 1. 1998-10-08. PMID:9680263. |
exposure of nicotinic acetylcholine receptors (nachrs) to brief pulses of nicotine results in the stimulation of dopamine release, whereas prolonged treatment with low concentrations of nicotine (approximately 10 nm) produces a reversible blockade of a subsequent nicotine challenge as a result of nachr desensitization. |
1998-10-08 |
2023-08-12 |
rat |
| S D Buckingham, C Adcock, M S Sansom, D B Sattelle, H A Bayli. Functional characterization of a mutated chicken alpha7 nicotinic acetylcholine receptor subunit with a leucine residue inserted in transmembrane domain 2. British journal of pharmacology. vol 124. issue 4. 1998-10-02. PMID:9690867. |
no significant difference in the apparent affinity of nicotine or acetylcholine between mutant and wild-type receptors was observed. |
1998-10-02 |
2023-08-12 |
chicken |
| F Berger, F H Gage, S Vijayaraghava. Nicotinic receptor-induced apoptotic cell death of hippocampal progenitor cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 17. 1998-09-09. PMID:9712657. |
nicotine has many effects on cns functions, presumably through its action on neuronal nicotinic acetylcholine receptors (achrs). |
1998-09-09 |
2023-08-12 |
Not clear |
| J M Griffith, J E O'Neill, F Petty, D Garver, D Young, R Freedma. Nicotinic receptor desensitization and sensory gating deficits in schizophrenia. Biological psychiatry. vol 44. issue 2. 1998-09-08. PMID:9646891. |
although nicotinic receptors normally desensitize after activation by acetylcholine or nicotine, pathologically increased desensitization might cause receptor dysfunction in schizophrenia. |
1998-09-08 |
2023-08-12 |
Not clear |
| L Ke, C M Eisenhour, M Bencherif, R J Luka. Effects of chronic nicotine treatment on expression of diverse nicotinic acetylcholine receptor subtypes. I. Dose- and time-dependent effects of nicotine treatment. The Journal of pharmacology and experimental therapeutics. vol 286. issue 2. 1998-09-02. PMID:9694939. |
nachrs also are targets of nicotine, which acts acutely like acetylcholine to stimulate nachr function. |
1998-09-02 |
2023-08-12 |
human |
| B F O'Hara, D M Edgar, V H Cao, S W Wiler, H C Heller, T S Kilduff, J D Mille. Nicotine and nicotinic receptors in the circadian system. Psychoneuroendocrinology. vol 23. issue 2. 1998-08-26. PMID:9621396. |
the extent to which these influences are mediated by nicotinic acetylcholine receptors (nachrs) has been controversial, as have the specific actions of nicotine and acetylcholine in the suprachiasmatic nucleus (scn) of the hypothalamus. |
1998-08-26 |
2023-08-12 |
rat |
| M Katsura, S Ohkuma, K Kuriyam. [Functional involvement of diazepam binding inhibitor (DBI) in the establishment of drug dependence]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 33. issue 2. 1998-08-04. PMID:9613098. |
these results suggest that the changes in the levels of cerebral dbi induced by continuous treatments with alcohol and nicotine may be involved in the establishment of dependence by alcohol and nicotine, and such changes may be regulated by the benzodiazepine and nicotinic acetylcholine receptors, respectively. |
1998-08-04 |
2023-08-12 |
mouse |
| H Klapproth, K Racké, I Wessle. Acetylcholine and nicotine stimulate the release of granulocyte-macrophage colony stimulating factor from cultured human bronchial epithelial cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 357. issue 4. 1998-07-24. PMID:9606035. |
acetylcholine and nicotine stimulate the release of granulocyte-macrophage colony stimulating factor from cultured human bronchial epithelial cells. |
1998-07-24 |
2023-08-12 |
human |
| H Klapproth, K Racké, I Wessle. Acetylcholine and nicotine stimulate the release of granulocyte-macrophage colony stimulating factor from cultured human bronchial epithelial cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 357. issue 4. 1998-07-24. PMID:9606035. |
the stimulatory effect was attenuated or even lost with high agonist concentrations (10 microm acetylcholine; 100 microm nicotine) suggesting receptor desensitization. |
1998-07-24 |
2023-08-12 |
human |
| J Bugajski, A Gadek-Michalska, J Borycz, R Głó. Effect of indomethacin on nicotine-induced ACTH and corticosterone response. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 49. issue 1. 1998-07-17. PMID:9594419. |
these results show that nicotine given systemically stimulates acth and corticosterone secretion by selective activation of central and peripheral acetylcholine nicotinic receptors. |
1998-07-17 |
2023-08-12 |
rat |
| H Yamada, A Ogura, S Koizumi, A Yamaguchi, Y Moriyam. Acetylcholine triggers L-glutamate exocytosis via nicotinic receptors and inhibits melatonin synthesis in rat pinealocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 13. 1998-07-02. PMID:9634560. |
moreover, acetylcholine or nicotine inhibited norepinephrine-dependent serotonin n-acetyltransferase activity, which results in decreased melatonin synthesis. |
1998-07-02 |
2023-08-12 |
rat |
| S Zevin, M E Schaner, K M Giacomin. Nicotine transport in a human choriocarcinoma cell line (JAR). Journal of pharmaceutical sciences. vol 87. issue 6. 1998-07-01. PMID:9607946. |
counterflux of [3h]nicotine uptake was produced by unlabeled nicotine and mecamylamine but not by cotinine or acetylcholine, consistent with a carrier-mediated transport process. |
1998-07-01 |
2023-08-12 |
human |
| P Whiteaker, C G Sharples, S Wonnacot. Agonist-induced up-regulation of alpha4beta2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition. Molecular pharmacology. vol 53. issue 5. 1998-06-18. PMID:9584223. |
chronic nicotine up-regulates the number of high affinity nicotinic acetylcholine receptors (nachrs) in mammalian brain. |
1998-06-18 |
2023-08-12 |
Not clear |
| M J Marks, K W Smith, A C Collin. Differential agonist inhibition identifies multiple epibatidine binding sites in mouse brain. The Journal of pharmacology and experimental therapeutics. vol 285. issue 1. 1998-05-12. PMID:9536034. |
however, inhibition of epibatidine binding by nicotine, acetylcholine, methylcarbachol and cytisine in olfactory bulbs revealed a biphasic pattern consistent with the presence of two sites differentially sensitive to inhibition by these nicotinic agonists. |
1998-05-12 |
2023-08-12 |
mouse |
| H W Korf, S Kroeber, C Schomeru. Regulation of the intracellular concentration of free calcium ions in pinealocytes of the rainbow trout and the rat. Biological signals. vol 6. issue 4-6. 1998-04-21. PMID:9500657. |
these channels, however, mediate the increase in calcium influx which is observed in virtually all rat pinealocytes upon stimulation with acetylcholine or nicotine. |
1998-04-21 |
2023-08-12 |
rat |
| B Schilström, G G Nomikos, M Nisell, P Hertel, T H Svensso. N-methyl-D-aspartate receptor antagonism in the ventral tegmental area diminishes the systemic nicotine-induced dopamine release in the nucleus accumbens. Neuroscience. vol 82. issue 3. 1998-04-09. PMID:9483535. |
systemic nicotine enhances burst firing of dopamine neurons in the ventral tegmental area and dopamine release in the nucleus accumbens, mainly via stimulation of nicotinic acetylcholine receptors in the ventral tegmental area. |
1998-04-09 |
2023-08-12 |
rat |
| J M Dessirier, M O'Mahony, J M Sieffermann, E Carsten. Mecamylamine inhibits nicotine but not capsaicin irritation on the tongue: psychophysical evidence that nicotine and capsaicin activate separate molecular receptors. Neuroscience letters. vol 240. issue 2. 1998-04-02. PMID:9486473. |
using a two-alternative forced-choice (2-afc) discrimination test coupled with category intensity ratings, we investigated the effect of mecamylamine, an antagonist of neuronal nicotinic acetylcholine receptors (nachrs), on oral irritation elicited by nicotine or capsaicin. |
1998-04-02 |
2023-08-12 |
human |
| A Jackson, C A Nurs. Role of acetylcholine receptors and dopamine transporter in regulation of extracellular dopamine in rat carotid body cultures grown in chronic hypoxia or nicotine. Journal of neurochemistry. vol 70. issue 2. 1998-02-24. PMID:9453559. |
role of acetylcholine receptors and dopamine transporter in regulation of extracellular dopamine in rat carotid body cultures grown in chronic hypoxia or nicotine. |
1998-02-24 |
2023-08-12 |
rat |
| A Jackson, C A Nurs. Role of acetylcholine receptors and dopamine transporter in regulation of extracellular dopamine in rat carotid body cultures grown in chronic hypoxia or nicotine. Journal of neurochemistry. vol 70. issue 2. 1998-02-24. PMID:9453559. |
using dissociated rat carotid body (cb) cultures, we compared levels of extracellular dopamine (da) around oxygen-sensitive glomus cells grown for approximately 12 days in normoxia (nox; 20% o2), chronic hypoxia (chox; 6% o2), or chronic nicotine (cnic; 10 microm nicotine, 20% o2), with or without acetylcholine (ach) receptor (achr) agonists/antagonists and blockers of da uptake. |
1998-02-24 |
2023-08-12 |
rat |
| H Miao, C Liu, K Bishop, Z H Gong, A Nordberg, X Zhan. Nicotine exposure during a critical period of development leads to persistent changes in nicotinic acetylcholine receptors of adult rat brain. Journal of neurochemistry. vol 70. issue 2. 1998-02-24. PMID:9453571. |
nicotine exposure during a critical period of development leads to persistent changes in nicotinic acetylcholine receptors of adult rat brain. |
1998-02-24 |
2023-08-12 |
mouse |