| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C W Wuenschell, J Zhao, J D Tefft, D Warburto. Nicotine stimulates branching and expression of SP-A and SP-C mRNAs in embryonic mouse lung culture. The American journal of physiology. vol 274. issue 1. 1998-02-19. PMID:9458815. |
the effect of nicotine exposure on surfactant gene expression is apparently mediated by nicotinic acetylcholine receptors because it was blocked by d-tubocurarine. |
1998-02-19 |
2023-08-12 |
mouse |
| S Shioda, S Nakajo, T Hirabayashi, H Nakayama, K Nakaya, K Matsuda, Y Naka. Neuronal nicotinic acetylcholine receptor in the hypothalamus: morphological diversity and neuroendocrine regulations. Brain research. Molecular brain research. vol 49. issue 1-2. 1998-02-11. PMID:9387862. |
nicotine may up-regulate vasopressin gene expression in the supraoptic nucleus, acting through nicotinic acetylcholine receptors. |
1998-02-11 |
2023-08-12 |
rat |
| G B Wells, R Anand, F Wang, J Lindstro. Water-soluble nicotinic acetylcholine receptor formed by alpha7 subunit extracellular domains. The Journal of biological chemistry. vol 273. issue 2. 1998-02-09. PMID:9422757. |
for all three, their equilibrium binding affinities for alpha-bungarotoxin, nicotine, and acetylcholine, combined with their velocity sedimentation profiles, were consistent with the formation of native-like achrs. |
1998-02-09 |
2023-08-12 |
xenopus_laevis |
| P J Corringer, S Bertrand, S Bohler, S J Edelstein, J P Changeux, D Bertran. Critical elements determining diversity in agonist binding and desensitization of neuronal nicotinic acetylcholine receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 2. 1998-02-03. PMID:9425007. |
introduction of the alpha4 residues 183-191 into alpha7 subunit sequence (chimera c2) selectively increased the apparent affinities for equilibrium binding and for ion channel activation by acetylcholine, resulting in a receptor that no longer displays differences in the responses to acetylcholine and nicotine. |
1998-02-03 |
2023-08-12 |
Not clear |
| P J Corringer, S Bertrand, S Bohler, S J Edelstein, J P Changeux, D Bertran. Critical elements determining diversity in agonist binding and desensitization of neuronal nicotinic acetylcholine receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 2. 1998-02-03. PMID:9425007. |
introduction of the alpha4 residues 151-155 (chimera b) produced a approximately 100-fold increase in the apparent affinity for both acetylcholine and nicotine in equilibrium binding measurements. |
1998-02-03 |
2023-08-12 |
Not clear |
| E J Popke, Y Tizabi, M A Rahman, S M Nespor, N E Grunber. Prenatal exposure to nicotine: effects on prepulse inhibition and central nicotinic receptors. Pharmacology, biochemistry, and behavior. vol 58. issue 4. 1998-01-30. PMID:9408185. |
the present experiment examined effects of prenatal nicotine exposure (6 mg/kg/day via osmotic minipump) throughout gestation on prepulse inhibition of the acoustic startle response (ppi) and on the density of nicotinic acetylcholine receptors (nachrs) in the brains of 5-week-old sprague-dawley rats. |
1998-01-30 |
2023-08-12 |
rat |
| S Zia, A Ndoye, V T Nguyen, S A Grand. Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells. Research communications in molecular pathology and pharmacology. vol 97. issue 3. 1998-01-27. PMID:9387186. |
the purpose of this study was to investigate the possibility of direct toxic effects of nicotine (nic) on human bronchial epithelial cells (bec) suggested by our previous findings of functional nicotinic acetylcholine receptors (nachrs) in the epithelial cells lining mucocutaneous membranes. |
1998-01-27 |
2023-08-12 |
mouse |
| O Blomqvist, M Ericson, J A Engel, B Söderpal. Accumbal dopamine overflow after ethanol: localization of the antagonizing effect of mecamylamine. European journal of pharmacology. vol 334. issue 2-3. 1998-01-22. PMID:9369343. |
it has been suggested that ethanol exerts its mesolimbic dopamine activating effects and its reinforcing effects via interaction with central nicotinic acetylcholine receptors, thus providing a basis for the often observed covariation between ethanol and nicotine consumption. |
1998-01-22 |
2023-08-12 |
Not clear |
| M R Picciotto, M Zoli, R Rimondini, C Léna, L M Marubio, E M Pich, K Fuxe, J P Changeu. Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine. Nature. vol 391. issue 6663. 1998-01-22. PMID:9428762. |
acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine. |
1998-01-22 |
2023-08-12 |
mouse |
| W R Kem, V M Mahnir, R L Papke, C J Lingl. Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. The Journal of pharmacology and experimental therapeutics. vol 283. issue 3. 1998-01-15. PMID:9399967. |
although the maximum currents generated by anabaseine and anabasine at alpha7 receptors were equivalent to that of acetylcholine, the maximum response to nicotine was only about 65% of the acetylcholine response. |
1998-01-15 |
2023-08-12 |
mouse |
| C Gotti, D Fornasari, F Clement. Human neuronal nicotinic receptors. Progress in neurobiology. vol 53. issue 2. 1998-01-07. PMID:9364611. |
nicotine is a very widely used drug of abuse, which exerts a number of neurovegetative, behavioural and psychological effects by interacting with neuronal nicotinic acetylcholine receptors (nachrs). |
1998-01-07 |
2023-08-12 |
human |
| H Zhong, C A Nurs. Nicotinic acetylcholine sensitivity of rat petrosal sensory neurons in dissociated cell culture. Brain research. vol 766. issue 1-2. 1998-01-02. PMID:9359598. |
- 60 mv), ach induced a hexamethonium-sensitive, inward current (iach), mimicked by nicotine application, suggesting the presence of neuronal nicotinic acetylcholine receptors (nachr). |
1998-01-02 |
2023-08-12 |
rat |
| M R Picciotto, M Zoli, V Zachariou, J P Changeu. Contribution of nicotinic acetylcholine receptors containing the beta 2-subunit to the behavioural effects of nicotine. Biochemical Society transactions. vol 25. issue 3. 1998-01-02. PMID:9388554. |
contribution of nicotinic acetylcholine receptors containing the beta 2-subunit to the behavioural effects of nicotine. |
1998-01-02 |
2023-08-12 |
Not clear |
| F Olale, V Gerzanich, A Kuryatov, F Wang, J Lindstro. Chronic nicotine exposure differentially affects the function of human alpha3, alpha4, and alpha7 neuronal nicotinic receptor subtypes. The Journal of pharmacology and experimental therapeutics. vol 283. issue 2. 1997-12-08. PMID:9353385. |
because chronic exposure to nicotine and nicotinic drugs might both activate and desensitize nicotinic acetylcholine receptors (achrs), we sought to determine whether prolonged exposure to nicotine concentrations encountered in tobacco users differentially affects electrophysiological properties of major subtypes of human neuronal nicotinic achrs. |
1997-12-08 |
2023-08-12 |
human |
| C Léna, J P Changeu. Role of Ca2+ ions in nicotinic facilitation of GABA release in mouse thalamus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 2. 1997-11-28. PMID:8987780. |
presynaptic nicotinic acetylcholine receptors (nachrs) are present in many regions of the brain and potentially serve as targets for the pharmacological action of nicotine in vivo. |
1997-11-28 |
2023-08-12 |
mouse |
| K Poth, T J Nutter, J Cuevas, M J Parker, D J Adams, C W Luetj. Heterogeneity of nicotinic receptor class and subunit mRNA expression among individual parasympathetic neurons from rat intracardiac ganglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 2. 1997-11-28. PMID:8987781. |
analysis of the whole-cell pharmacology of these neurons showed a diversity of responses to the agonists acetylcholine, nicotine, cytisine, and 1,1-dimethyl-4-phenylpiperazinium, suggesting that a heterogeneous population of nicotinic receptor classes, or subtypes, is expressed by individual neurons. |
1997-11-28 |
2023-08-12 |
rat |
| B Hamon, J Glowinski, C Giaum. Nicotine inhibits slowly inactivating K+ currents in rat cultured striatal neurons. Pflugers Archiv : European journal of physiology. vol 434. issue 5. 1997-10-23. PMID:9242730. |
as shown on cultured striatal neurons recorded in whole-cell configuration, both acetylcholine (in the presence of atropine) and nicotine reduced voltage-dependent outward currents. |
1997-10-23 |
2023-08-12 |
rat |
| L Z Fuller, C Lu, D G McMahon, M D Lindemann, M S Jorgensen, S W Rau, J E Sisken, B A Jackso. Stimulus-secretion coupling in porcine adrenal chromaffin cells: effect of dexamethasone. Journal of neuroscience research. vol 49. issue 4. 1997-10-23. PMID:9285518. |
dex treatment also significantly potentiated the increase in cytosolic ca2+ in response to membrane depolarization with kcl (delta + 20%; n = 29; p < 0.05), but did not affect the amplitude of ca2+ transients elicited by nicotine or acetylcholine. |
1997-10-23 |
2023-08-12 |
rat |
| G H Zhang, R J Helmke, A C Mörk, J R Martine. Regulation of cytosolic free Ca2+ in cultured rat alveolar macrophages (NR8383). Journal of leukocyte biology. vol 62. issue 3. 1997-10-10. PMID:9307072. |
acetylcholine, nicotine, isoproterenol, substance p, and vasoactive intestinal polypeptide did not alter [ca2+]i. inositol 1,4,5-trisphosphate (ip3) formation was also activated by atp. |
1997-10-10 |
2023-08-12 |
rat |
| C P Fenster, M F Rains, B Noerager, M W Quick, R A Leste. Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 15. 1997-10-03. PMID:9221773. |
influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine. |
1997-10-03 |
2023-08-12 |
xenopus_laevis |