| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J C Cooper, O Gutbrod, V Witzemann, C Methfesse. Pharmacology of the nicotinic acetylcholine receptor from fetal rat muscle expressed in Xenopus oocytes. European journal of pharmacology. vol 309. issue 3. 1997-01-15. PMID:8874153. |
using the voltage-clamp technique, the response to a range of agonists was measured, listed in order of (decreasing) activity efficacy: anatoxin > or = epibatidine > acetylcholine > dmpp (1,1-dimethyl-4-phenylpiperazinium) > > cytisine > pyrantel > nicotine > coniine > tubocurare > lobeline. |
1997-01-15 |
2023-08-12 |
rat |
| J C Cooper, O Gutbrod, V Witzemann, C Methfesse. Pharmacology of the nicotinic acetylcholine receptor from fetal rat muscle expressed in Xenopus oocytes. European journal of pharmacology. vol 309. issue 3. 1997-01-15. PMID:8874153. |
single-channel current were measured in outside-out patches for acetylcholine, nicotine, cytisine, anatoxin and epibatidine. |
1997-01-15 |
2023-08-12 |
rat |
| E Stetzer, U Ebbinghaus, A Storch, L Poteur, A Schrattenholz, G Kramer, C Methfessel, A Maelick. Stable expression in HEK-293 cells of the rat alpha3/beta4 subtype of neuronal nicotinic acetylcholine receptor. FEBS letters. vol 397. issue 1. 1997-01-14. PMID:8941710. |
the order of potency of the nicotinic agonists tested was cytisine approximately = nicotine > acetylcholine. |
1997-01-14 |
2023-08-12 |
human |
| H Yamashita, S Nakamur. Nicotine rescues PC12 cells from death induced by nerve growth factor deprivation. Neuroscience letters. vol 213. issue 2. 1996-12-30. PMID:8858629. |
the protective effect of nicotine was abolished by hexamethonium or mecamylamine, inhibitors of nicotinic acetylcholine (nach) receptors. |
1996-12-30 |
2023-08-12 |
Not clear |
| P C Kearney, M W Nowak, W Zhong, S K Silverman, H A Lester, D A Doughert. Dose-response relations for unnatural amino acids at the agonist binding site of the nicotinic acetylcholine receptor: tests with novel side chains and with several agonists. Molecular pharmacology. vol 50. issue 5. 1996-12-26. PMID:8913372. |
interestingly, consideration of three different agonists (acetylcholine, nicotine, and tetramethylammonium) does not discriminate between these two best-characterized binding site residues. |
1996-12-26 |
2023-08-12 |
xenopus_laevis |
| G Bicke. Transmitter-induced calcium signalling in cultured neurons of the insect brain. Journal of neuroscience methods. vol 69. issue 1. 1996-12-20. PMID:8912933. |
application of acetylcholine (ach) or nicotine promoted a calcium influx into the cell body and neurites. |
1996-12-20 |
2023-08-12 |
Not clear |
| W R Weaver, V A Chiappinell. Single-channel recording in brain slices reveals heterogeneity of nicotinic receptors on individual neurons within the chick lateral spiriform nucleus. Brain research. vol 725. issue 1. 1996-12-06. PMID:8828591. |
single-channel openings were observed in 84% of patches (n = 118) when the nicotinic agonists acetylcholine (1-100 microm), carbamylcholine (3-100 microm), or nicotine (3-10 microm) were present in the patch pipette. |
1996-12-06 |
2023-08-12 |
chicken |
| G BROWNLEE, E S JOHNSO. THE SITE OF THE 5-HYDROXYTRYPTAMINE RECEPTOR ON THE INTRAMURAL NERVOUS PLEXUS OF THE GUINEA-PIG ISOLATED ILEUM. British journal of pharmacology and chemotherapy. vol 21. 1996-12-01. PMID:14081661. |
dose/response measurements were made on the guinea-pig isolated ileum with six agonists, acetylcholine, 5-hydroxytryptamine, nicotine, dimethylphenylpiperazinium, choline phenyl ether and histamine. |
1996-12-01 |
2023-08-12 |
Not clear |
| G BROWNLEE, E S JOHNSO. THE SITE OF THE 5-HYDROXYTRYPTAMINE RECEPTOR ON THE INTRAMURAL NERVOUS PLEXUS OF THE GUINEA-PIG ISOLATED ILEUM. British journal of pharmacology and chemotherapy. vol 21. 1996-12-01. PMID:14081661. |
acetylcholine and histamine were chosen because of their direct mode of action on smooth muscle, nicotine, dimethylphenylpiperazinium and choline phenyl ether were used as examples of drugs that act at the ganglionic acetylcholine receptor. |
1996-12-01 |
2023-08-12 |
Not clear |
| G BROWNLEE, E S JOHNSO. THE SITE OF THE 5-HYDROXYTRYPTAMINE RECEPTOR ON THE INTRAMURAL NERVOUS PLEXUS OF THE GUINEA-PIG ISOLATED ILEUM. British journal of pharmacology and chemotherapy. vol 21. 1996-12-01. PMID:14081661. |
the strength of potentiation decreased in the order 5-hydroxytryptamine, nicotine, dimethylphenylpiperazinium and choline phenyl ether, and acetylcholine. |
1996-12-01 |
2023-08-12 |
Not clear |
| G BROWNLEE, E S JOHNSO. THE SITE OF THE 5-HYDROXYTRYPTAMINE RECEPTOR ON THE INTRAMURAL NERVOUS PLEXUS OF THE GUINEA-PIG ISOLATED ILEUM. British journal of pharmacology and chemotherapy. vol 21. 1996-12-01. PMID:14081661. |
thus hexamethonium, pentolinium, and nicotine in its competitive phase, blocked contractions due to nicotine, dimethylphenylpiperazinium and choline phenyl ether and left those due to 5-hydroxytryptamine, acetylcholine and histamine unchanged. |
1996-12-01 |
2023-08-12 |
Not clear |
| G BROWNLEE, J HARR. SOME PHARMACOLOGICAL PROPERTIES OF THE CIRCULAR AND LONGITUDINAL MUSCLE STRIPS FROM THE GUINEA-PIG ISOLATED ILEUM. British journal of pharmacology and chemotherapy. vol 21. 1996-12-01. PMID:14110754. |
the longitudinal preparation was sensitive to acetylcholine, methacholine, carbachol, 5-hydroxytryptamine, histamine and nicotine, while the circular preparation was insensitive to 5-hydroxytryptamine, histamine and nicotine, and responded to the choline esters only in high concentrations. |
1996-12-01 |
2023-08-12 |
Not clear |
| W D PATON, J W THOMPSO. THE GANGLION BLOCKING ACTION OF PROCAINAMIDE. British journal of pharmacology and chemotherapy. vol 22. 1996-12-01. PMID:14126044. |
antagonized responses due to acetylcholine, histamine and, most effectively, to nicotine. |
1996-12-01 |
2023-08-12 |
Not clear |
| J H BURN, W R GIBBON. THE PART PLAYED BY CALCIUM IN DETERMINING THE RESPONSE TO STIMULATION OF SYMPATHETIC POSTGANGLIONIC FIBRES. British journal of pharmacology and chemotherapy. vol 22. 1996-12-01. PMID:14211684. |
these and other experiments show a close similarity between the release of catechol amines from the adrenal medulla by acetylcholine and the release of noradrenaline from the postganglionic fibre by stimulation or by nicotine. |
1996-12-01 |
2023-08-12 |
rabbit |
| H Wang, W Y Cui, C G Li. Regulatory effects of acutely repeated nicotine treatment towards central muscarinic receptors. Life sciences. vol 59. issue 17. 1996-11-27. PMID:8890920. |
sensitivity of brain muscarinic acetylcholine receptors to the agonists was examined in nicotine tolerant animals which were developed by acutely repeated injections of nicotine. |
1996-11-27 |
2023-08-12 |
mouse |
| I Kämpfer, D Sorger, R Schliebs, W Kärger, K Günther, K Schulze, W H Knap. Radioiodination of nicotine with specific activity high enough for mapping nicotinic acetylcholine receptors. European journal of nuclear medicine. vol 23. issue 2. 1996-11-05. PMID:8925850. |
radioiodination of nicotine with specific activity high enough for mapping nicotinic acetylcholine receptors. |
1996-11-05 |
2023-08-12 |
rat |
| V V Uteshev, D R Stevens, H L Haa. Alpha-bungarotoxin-sensitive nicotinic responses in rat tuberomammillary neurons. Pflugers Archiv : European journal of physiology. vol 432. issue 4. 1996-10-31. PMID:8764960. |
application of acetylcholine (ach), nicotine or 1, 1-dimethyl-4-phenylpiperazinium elicited an inward current in histaminergic neurons of the tuberomammillary nucleus. |
1996-10-31 |
2023-08-12 |
rat |
| S Efthimiopoulos, D Vassilacopoulou, J A Ripellino, N Tezapsidis, N K Robaki. Cholinergic agonists stimulate secretion of soluble full-length amyloid precursor protein in neuroendocrine cells. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 15. 1996-10-29. PMID:8755600. |
cholinergic receptor agonists, including acetylcholine, nicotine, or carbachol, stimulated the rapid secretion of solappcyt, a process that was inhibited by cholinergic antagonists. |
1996-10-29 |
2023-08-12 |
human |
| S L Yates, M Bencherif, E N Fluhler, P M Lippiell. Up-regulation of nicotinic acetylcholine receptors following chronic exposure of rats to mainstream cigarette smoke or alpha 4 beta 2 receptors to nicotine. Biochemical pharmacology. vol 50. issue 12. 1996-10-24. PMID:8849326. |
up-regulation of nicotinic acetylcholine receptors following chronic exposure of rats to mainstream cigarette smoke or alpha 4 beta 2 receptors to nicotine. |
1996-10-24 |
2023-08-12 |
mouse |
| L Liu, S A Simo. Capsaicin and nicotine both activate a subset of rat trigeminal ganglion neurons. The American journal of physiology. vol 270. issue 6 Pt 1. 1996-09-26. PMID:8764165. |
to determine whether neuronal nicotine acetylcholine receptors (nachr) are present on capsaicin-sensitive neurons, whole cell patch-clamp recordings were performed on rat trigeminal ganglion cells. |
1996-09-26 |
2023-08-12 |
rat |