| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Nitta, Y Katono, A Itoh, T Hasegawa, T Nabeshim. Nicotine reverses scopolamine-induced impairment of performance in passive avoidance task in rats through its action on the dopaminergic neuronal system. Pharmacology, biochemistry, and behavior. vol 49. issue 4. 1995-04-12. PMID:7886091. |
the effects of nicotine were inhibited by the preadministration of mecamylamine, sch 23390, and (-)sulpiride, which are nicotinic acetylcholine, d1, and d2 receptor antagonists, respectively. |
1995-04-12 |
2023-08-12 |
rat |
| H Wan. [Modulatory effects of nicotine on muscarinic acetylcholine receptors and its molecular mechanisms]. Sheng li ke xue jin zhan [Progress in physiology]. vol 25. issue 3. 1995-03-31. PMID:7878439. |
[modulatory effects of nicotine on muscarinic acetylcholine receptors and its molecular mechanisms]. |
1995-03-31 |
2023-08-12 |
Not clear |
| M R Picciotto, M Zoli, C Léna, A Bessis, Y Lallemand, N Le Novère, P Vincent, E M Pich, P Brûlet, J P Changeu. Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature. vol 374. issue 6517. 1995-03-30. PMID:7870173. |
nicotine affects many aspects of behaviour including learning and memory through its interaction with neuronal nicotinic acetylcholine receptors (nachr). |
1995-03-30 |
2023-08-12 |
mouse |
| K Meguro, S Yamaguchi, H Arai, T Nakagawa, C Doi, M Yamada, Y Ikarashi, Y Maruyama, H Sasak. Nicotine improves cognitive disturbance in senescence-accelerated mice. Pharmacology, biochemistry, and behavior. vol 49. issue 3. 1995-03-22. PMID:7862736. |
senescence-accelerated mice (sam), a murine model of age-related deterioration in learning ability, were studied as to the acetylcholine (ach) contents in the brain tissues and the effect of nicotine administration. |
1995-03-22 |
2023-08-12 |
mouse |
| M Sorimachi, Y Abe, K Furukawa, N Akaik. Mechanism underlying the ATP-induced increase in the cytosolic Ca2+ concentration in chick ciliary ganglion neurons. Journal of neurochemistry. vol 64. issue 3. 1995-03-17. PMID:7861148. |
atp was effective in increasing [ca]in in the presence of a desensitizing concentration of nicotine (100 microm), and simultaneous addition of maximal doses of atp and nicotine caused an additive increase in [ca]in, suggesting that atp acts on a site distinct from nicotinic acetylcholine receptors. |
1995-03-17 |
2023-08-12 |
chicken |
| J R James, H F Villanueva, J H Johnson, S Arezo, J A Rosecran. Evidence that nicotine can acutely desensitize central nicotinic acetylcholinergic receptors. Psychopharmacology. vol 114. issue 3. 1995-03-16. PMID:7855204. |
current concepts concerning nicotine's cns mechanism(s) of action suggest that this drug produces its effects via an interaction at nicotinic-cholinergic receptors (nachrs) sensitive to acetylcholine. |
1995-03-16 |
2023-08-12 |
rat |
| R Maneckjee, J D Minn. Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 5. issue 10. 1995-03-14. PMID:7848904. |
previously, we have shown that opioids acting via specific receptors inhibit the growth of human lung cancer cells while nicotine, acting through nicotinic acetylcholine receptors, reverses this inhibition. |
1995-03-14 |
2023-08-12 |
human |
| R N Kalaria, P Homayoun, P J Whitehous. Nicotinic cholinergic receptors associated with mammalian cerebral vessels. Journal of the autonomic nervous system. vol 49 Suppl. 1995-03-02. PMID:7836682. |
we found carbachol-displaceable [3h]acetylcholine (ach) and [3h]nicotine (nic) binding sites in preparations of intraparenchymal cerebral microvessels (cmv) and larger pial vessels from human and pig brains. |
1995-03-02 |
2023-08-12 |
human |
| C M de Fiebre, E M Meyer, J C Henry, S I Muraskin, W R Kem, R L Papk. Characterization of a series of anabaseine-derived compounds reveals that the 3-(4)-dimethylaminocinnamylidine derivative is a selective agonist at neuronal nicotinic alpha 7/125I-alpha-bungarotoxin receptor subtypes. Molecular pharmacology. vol 47. issue 1. 1995-02-28. PMID:7838125. |
the derivative 3-(4)-dimethylaminocinnamylidine anabaseine (dmac) was found to be a selective alpha 7 receptor agonist; it was more potent than nicotine, acetylcholine, anabaseine, and other derivatives at activating the alpha 7 receptor subtype, while displaying little agonist activity at alpha 4 beta 2 and other receptor subtypes. |
1995-02-28 |
2023-08-12 |
xenopus_laevis |
| C M de Fiebre, E M Meyer, J C Henry, S I Muraskin, W R Kem, R L Papk. Characterization of a series of anabaseine-derived compounds reveals that the 3-(4)-dimethylaminocinnamylidine derivative is a selective agonist at neuronal nicotinic alpha 7/125I-alpha-bungarotoxin receptor subtypes. Molecular pharmacology. vol 47. issue 1. 1995-02-28. PMID:7838125. |
anabaseine and nicotine prolonged the time course of activation of alpha 4 beta 2 receptors, compared with acetylcholine, suggesting sequential channel-blocking activity. |
1995-02-28 |
2023-08-12 |
xenopus_laevis |
| K Lee, A Ito, K Koshimura, T Ohue, Y Takagi, S Miw. Differential effects of hypoxia on ligand binding properties of nicotinic and muscarinic acetylcholine receptors on cultured bovine adrenal chromaffin cells. Journal of neurochemistry. vol 64. issue 2. 1995-02-21. PMID:7830082. |
to clarify the postsynaptic effects, we used cultured bovine adrenal chromaffin cells as a model of postsynaptic neurons and examined specific binding of l-[3h]nicotine (an agonist for nicotinic acetylcholine receptors: nachrs) and 22na+ flux under control and hypoxic conditions. |
1995-02-21 |
2023-08-12 |
cattle |
| M Tsutsui, N Yanagihara, E Miyamoto, A Kuroiwa, F Izum. Correlation of activation of Ca2+/calmodulin-dependent protein kinase II with catecholamine secretion and tyrosine hydroxylase activation in cultured bovine adrenal medullary cells. Molecular pharmacology. vol 46. issue 6. 1995-02-02. PMID:7808423. |
nicotine but not muscarine increased the ca(2+)-independent activity as potently as did acetylcholine, and hexamethonium but not atropine completely blocked the acetylcholine-induced increase. |
1995-02-02 |
2023-08-12 |
cattle |
| A B Cachelin, G Rus. Unusual pharmacology of (+)-tubocurarine with rat neuronal nicotinic acetylcholine receptors containing beta 4 subunits. Molecular pharmacology. vol 46. issue 6. 1995-02-02. PMID:7808438. |
current responses evoked by rapid application of cholinergic agonists (acetylcholine, nicotine, or 1,1-dimethyl-4-phenylpiperazinium) were recorded from voltage-clamped oocytes. |
1995-02-02 |
2023-08-12 |
rat |
| G H Zhang, J E Melvi. Nicotine increases [Ca2+]i in rat sublingual mucous acini by stimulating neurotransmitter release from presynaptic terminals. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 207. issue 3. 1995-01-25. PMID:7800685. |
taken together, these results suggest that nicotine first triggers the release of acetylcholine from presynaptic nerve terminals associated with the dispersed sublingual acini which then activates muscarinic receptors. |
1995-01-25 |
2023-08-12 |
rat |
| R Zwart, D Abraham, M Oortgiesen, H P Vijverber. alpha 4 beta 2 subunit combination specific pharmacology of neuronal nicotinic acetylcholine receptors in N1E-115 neuroblastoma cells. Brain research. vol 654. issue 2. 1995-01-09. PMID:7527290. |
pharmacological characteristics of native neuronal nicotinic acetylcholine receptor-mediated ion currents in mouse n1e-115 neuroblastoma cells have been investigated by superfusion of voltage clamped cells with known concentrations of the agonists acetylcholine, nicotine and cytisine, and the antagonists alpha-bungarotoxin and neuronal bungarotoxin. |
1995-01-09 |
2023-08-12 |
mouse |
| R Zwart, D Abraham, M Oortgiesen, H P Vijverber. alpha 4 beta 2 subunit combination specific pharmacology of neuronal nicotinic acetylcholine receptors in N1E-115 neuroblastoma cells. Brain research. vol 654. issue 2. 1995-01-09. PMID:7527290. |
the sensitivity of the nicotinic acetylcholine receptor for agonists followed the agonist potency rank-order: nicotine approximately acetylcholine >> cytisine. |
1995-01-09 |
2023-08-12 |
mouse |
| R Zwart, D Abraham, M Oortgiesen, H P Vijverber. alpha 4 beta 2 subunit combination specific pharmacology of neuronal nicotinic acetylcholine receptors in N1E-115 neuroblastoma cells. Brain research. vol 654. issue 2. 1995-01-09. PMID:7527290. |
the ec50 values of acetylcholine and nicotine are 78 microm and 76 microm, respectively. |
1995-01-09 |
2023-08-12 |
mouse |
| R Zwart, D Abraham, M Oortgiesen, H P Vijverber. alpha 4 beta 2 subunit combination specific pharmacology of neuronal nicotinic acetylcholine receptors in N1E-115 neuroblastoma cells. Brain research. vol 654. issue 2. 1995-01-09. PMID:7527290. |
equal concentrations of acetylcholine and nicotine induce inward currents with approximately the same peak amplitude whereas cytisine induces much smaller inward currents. |
1995-01-09 |
2023-08-12 |
mouse |
| X Yang, J J Buccafusc. Effect of chronic central treatment with the acetylcholine analog methylcarbamylcholine on cortical nicotinic receptors: correlation between receptor changes and behavioral function. The Journal of pharmacology and experimental therapeutics. vol 271. issue 2. 1994-12-29. PMID:7965780. |
chronic administration of nicotine results in increased numbers of specific nicotinic acetylcholine receptors (nachrs) within the central nervous system. |
1994-12-29 |
2023-08-12 |
rat |
| S Alaranta, E Klinge, E Kostiainen, U M Parkkisenniem. Relaxation of the bovine retractor penis muscle by a small K+ excess and the role of K+ in its neurogenic relaxation. European journal of pharmacology. vol 259. issue 2. 1994-12-08. PMID:7957614. |
the mechanism of the relaxation of the bovine retractor penis muscle induced by 6.7 mm k+ as well as the role of k+ in the neurogenic relaxation of this muscle induced by nicotine, acetylcholine or electrical field stimulation, was studied. |
1994-12-08 |
2023-08-12 |
cattle |