| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| U Warpman, A Nordber. Epibatidine and ABT 418 reveal selective losses of alpha 4 beta 2 nicotinic receptors in Alzheimer brains. Neuroreport. vol 6. issue 17. 1996-09-24. PMID:8747166. |
subtypes of nicotinic acetylcholine receptors (nachrs) were characterized in human temporal cortex and in a alpha 4 beta 2 nachr-transfected m10 cell line using the nicotinic agonists epibatidine, abt 418 and (-)nicotine in competition studies with [3h]nicotine and [3h]cytisine. |
1996-09-24 |
2023-08-12 |
human |
| F Wang, V Gerzanich, G B Wells, R Anand, X Peng, K Keyser, J Lindstro. Assembly of human neuronal nicotinic receptor alpha5 subunits with alpha3, beta2, and beta4 subunits. The Journal of biological chemistry. vol 271. issue 30. 1996-09-03. PMID:8663494. |
in the case of receptors containing alpha3 and beta4 subunits, the addition of alpha5 subunits had little effect on the responses to acetylcholine or nicotine. |
1996-09-03 |
2023-08-12 |
human |
| F Wang, V Gerzanich, G B Wells, R Anand, X Peng, K Keyser, J Lindstro. Assembly of human neuronal nicotinic receptor alpha5 subunits with alpha3, beta2, and beta4 subunits. The Journal of biological chemistry. vol 271. issue 30. 1996-09-03. PMID:8663494. |
however, in the case of receptors containing alpha3 and beta2 subunits, the addition of alpha5 subunits reduced the ec50 for acetylcholine from 28 to 0.5 microm and the ec50 for nicotine from 6.8 to 1.9 microm, while increasing the efficacy of nicotine from 50% on alpha3beta2 receptors to 100% on alpha3beta2alpha5 receptors. |
1996-09-03 |
2023-08-12 |
human |
| b' G Brunn, I Wessler, K Rack\\xc3\\xa. Mucosa-dependent muscarinic liberation of prostaglandins from rat isolated trachea. British journal of pharmacology. vol 116. issue 3. 1996-07-18. PMID:8640337.' |
acetylcholine and the muscarinic agonist, carbachol but not nicotine, increased the rate of tritium outflow maximally by about 30%. |
1996-07-18 |
2023-08-12 |
rat |
| F Lebargy, K Benhammou, D Morin, R Zini, S Urien, F Brée, J Bignon, A Branellec, G Lagru. Tobacco smoking induces expression of very-high-affinity nicotine binding sites on blood polymorphonuclear cells. American journal of respiratory and critical care medicine. vol 153. issue 3. 1996-07-01. PMID:8630545. |
the targets of nicotine in the central nervous system (cns) have been identified as nicotinic acetylcholine (ach) receptors. |
1996-07-01 |
2023-08-12 |
Not clear |
| M A Abreo, N H Lin, D S Garvey, D E Gunn, A M Hettinger, J T Wasicak, P A Pavlik, Y C Martin, D L Donnelly-roberts, D J Anderson, J P Sullivan, M Williams, S P Arneric, M W Hollada. Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. Journal of medicinal chemistry. vol 39. issue 4. 1996-06-28. PMID:8632405. |
recent evidence indicating the therapeutic potential of cholinergic channel modulators for the treatment of central nervous system (cns) disorders as well as the diversity of brain neuronal nicotine acetylcholine receptors (nachrs) have suggested an opportunity to develop subtype-selective nachr ligands for the treatment of specific cns disorders with reduced side effect liabilities. |
1996-06-28 |
2023-08-12 |
human |
| M Ballivet, C Alliod, S Bertrand, D Bertran. Nicotinic acetylcholine receptors in the nematode Caenorhabditis elegans. Journal of molecular biology. vol 258. issue 2. 1996-06-24. PMID:8627624. |
both receptors desensitise quickly upon agonist application, are more sensitive to nicotine than to acetylcholine, and are efficiently blocked by dihydro-beta-erythroidine. |
1996-06-24 |
2023-08-12 |
chicken |
| M L Burleson, W K Milso. Cardio-ventilatory control in rainbow trout: II. Reflex effects of exogenous neurochemicals. Respiration physiology. vol 101. issue 3. 1996-05-21. PMID:8607001. |
acetylcholine and nicotine stimulated all cardio-ventilatory variables. |
1996-05-21 |
2023-08-12 |
Not clear |
| E Carstens, I Saxe, R Ralp. Brainstem neurons expressing c-Fos immunoreactivity following irritant chemical stimulation of the rat's tongue. Neuroscience. vol 69. issue 3. 1996-04-18. PMID:8596661. |
in barbiturate-anesthetized rats, one of the following was applied to the dorsal surface of the tongue: nicotine (0.5%), capsaicin (0.1%), histamine (2 or 20%), piperine (0.2%), acetylcholine (10%) or vehicle control (0.9% saline, dh2o, 70% ethanol). |
1996-04-18 |
2023-08-12 |
rat |
| C R Vibat, J A Lasalde, M G McNamee, E L Ocho. Differential desensitization properties of rat neuronal nicotinic acetylcholine receptor subunit combinations expressed in Xenopus laevis oocytes. Cellular and molecular neurobiology. vol 15. issue 4. 1996-03-07. PMID:8565045. |
chronic administration of nicotine up-regulates mammalian neuronal nicotinic acetylcholine receptors (nachrs). |
1996-03-07 |
2023-08-12 |
rat |
| C R Vibat, J A Lasalde, M G McNamee, E L Ocho. Differential desensitization properties of rat neuronal nicotinic acetylcholine receptor subunit combinations expressed in Xenopus laevis oocytes. Cellular and molecular neurobiology. vol 15. issue 4. 1996-03-07. PMID:8565045. |
the responses to various concentrations of acetylcholine (ach) or nicotine were analyzed by the two electrode voltage clamp technique. |
1996-03-07 |
2023-08-12 |
rat |
| P Riekkinen, J Kuitunen, M Riekkine. Effects of thalamic and nucleus basalis infusions of nicotine on cortical EEG. Neuroreport. vol 6. issue 12. 1996-01-26. PMID:8527728. |
the present study was designed to investigate the hypothesis that nicotine may act via thalamic and basal forebrain nicotinic acetylcholine receptors to suppress neocortical high voltage spindling and slow waves in awake rats. |
1996-01-26 |
2023-08-12 |
rat |
| S A Grando, R M Horton, E F Pereira, B M Diethelm-Okita, P M George, E X Albuquerque, B M Conti-Fin. A nicotinic acetylcholine receptor regulating cell adhesion and motility is expressed in human keratinocytes. The Journal of investigative dermatology. vol 105. issue 6. 1996-01-04. PMID:7490471. |
acetylcholine and the nicotinic agonist nicotine increased cell-substrate and cell-cell adherence of cultured keratinocytes and stimulated their lateral migration. |
1996-01-04 |
2023-08-12 |
human |
| D C Perry, K J Kella. [3H]epibatidine labels nicotinic receptors in rat brain: an autoradiographic study. The Journal of pharmacology and experimental therapeutics. vol 275. issue 2. 1995-12-19. PMID:7473129. |
in the present study, the distribution of binding was almost identical for both radioligands and closely resembled that of previously published autoradiographic studies with two other nicotinic ligands, [3h]acetylcholine and [3h]nicotine. |
1995-12-19 |
2023-08-12 |
rat |
| J A Rosecran. Nicotine as a discriminative stimulus: a neurobiobehavioral approach to studying central cholinergic mechanisms. Journal of substance abuse. vol 1. issue 3. 1995-12-05. PMID:7580220. |
whether acetylcholine is the mediator of nicotine's effects at these receptor sites, as was once thought, has yet to be clearly determined. |
1995-12-05 |
2023-08-12 |
mouse |
| M L Burleson, W K Milso. Cardio-ventilatory control in rainbow trout: I. Pharmacology of branchial, oxygen-sensitive chemoreceptors. Respiration physiology. vol 100. issue 3. 1995-11-30. PMID:7481112. |
acetylcholine and nicotine were potent neurochemical stimulants; muscarine had only a slight effect. |
1995-11-30 |
2023-08-12 |
Not clear |
| R A Lester, J A Dan. Acetylcholine receptor desensitization induced by nicotine in rat medial habenula neurons. Journal of neurophysiology. vol 74. issue 1. 1995-11-29. PMID:7472323. |
a 5-min continuous exposure to 1 microm nicotine reduced the amplitude of the acetylcholine (30 microm, 1 s) test response to < 30% of its control value. |
1995-11-29 |
2023-08-12 |
rat |
| V Gerzanich, X Peng, F Wang, G Wells, R Anand, S Fletcher, J Lindstro. Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors. Molecular pharmacology. vol 48. issue 4. 1995-11-29. PMID:7476906. |
pharmacological properties of the (+)- and (-)-isomers of synthetic epibatidine, exo-2-(6-chloro-3-pyridyl)-7-azabicyclo-[2.2.1]heptane, were compared with nicotine and acetylcholine on several subtypes of chicken and human nicotinic acetylcholine receptors (achrs). |
1995-11-29 |
2023-08-12 |
human |
| V Gerzanich, X Peng, F Wang, G Wells, R Anand, S Fletcher, J Lindstro. Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors. Molecular pharmacology. vol 48. issue 4. 1995-11-29. PMID:7476906. |
apparent affinity was 100 to 1000-fold higher for epibatidine than for nicotine or acetylcholine. |
1995-11-29 |
2023-08-12 |
human |
| D E Dar, O Zinde. Strychnine affects catecholamine secretion from bovine adrenal medulla chromaffin cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 352. issue 1. 1995-11-28. PMID:7477420. |
strychnine at > 1 microm inhibited catecholamine release stimulated by 10 microm acetylcholine, or 10 microm nicotine, but not by excess k+ (59 mm), the sodium ionophore veratridine (100 microm) or the calcium ionophore a-23187 (10 microm). |
1995-11-28 |
2023-08-12 |
cattle |