| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Miyata, T Yanagit. [Mechanism of nicotine dependence]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 33. issue 5. 1999-02-16. PMID:9844376. |
these effects are considered to be induced by the ability of nicotine to promote the release of catecholamines, acetylcholine, beta-endorphine, glucocorticoid, and other kinds of hormones. |
1999-02-16 |
2023-08-12 |
Not clear |
| D A Smith, A F Hoffman, D J David, C E Adams, G A Gerhard. Nicotine-evoked nitric oxide release in the rat hippocampal slice. Neuroscience letters. vol 255. issue 3. 1999-02-10. PMID:9832189. |
acetylcholine (ach) with neostigmine, or nicotine was delivered by pressure ejection from pipettes placed within 300 microm of the no sensors. |
1999-02-10 |
2023-08-12 |
rat |
| K Sabey, K Paradiso, J Zhang, J H Steinbac. Ligand binding and activation of rat nicotinic alpha4beta2 receptors stably expressed in HEK293 cells. Molecular pharmacology. vol 55. issue 1. 1999-02-04. PMID:9882698. |
activation of nicotinic receptors was studied using whole-cell patch clamp methods, and acetylcholine, nicotine, dimethylphenylpiperazinium, and cytisine all produced a conductance increase. |
1999-02-04 |
2023-08-12 |
rat |
| K Sabey, K Paradiso, J Zhang, J H Steinbac. Ligand binding and activation of rat nicotinic alpha4beta2 receptors stably expressed in HEK293 cells. Molecular pharmacology. vol 55. issue 1. 1999-02-04. PMID:9882698. |
di-hydro-beta-erythroidine blocked physiological responses to acetylcholine and nicotine (ic50, 2.5 nm), and reduced cytisine binding in a competitive manner (ki 20 nm). |
1999-02-04 |
2023-08-12 |
rat |
| K Sabey, K Paradiso, J Zhang, J H Steinbac. Ligand binding and activation of rat nicotinic alpha4beta2 receptors stably expressed in HEK293 cells. Molecular pharmacology. vol 55. issue 1. 1999-02-04. PMID:9882698. |
physostigmine enhanced the response to low concentrations of acetylcholine or nicotine. |
1999-02-04 |
2023-08-12 |
rat |
| J M Vernier, H Holsenback, N D Cosford, J P Whitten, F Menzaghi, R Reid, T S Rao, A I Sacaan, G K Lloyd, C M Suto, L E Chavez-Noriega, M S Washburn, A Urrutia, I A McDonal. Conformationally restricted analogues of nicotine and anabasine. Bioorganic & medicinal chemistry letters. vol 8. issue 16. 1999-01-28. PMID:9873508. |
a series of conformationally restricted analogues of nicotine has been synthesized and evaluated as agonists of neuronal acetylcholine receptors. |
1999-01-28 |
2023-08-12 |
human |
| L Liu, G Q Chang, Y Q Jiao, S A Simo. Neuronal nicotinic acetylcholine receptors in rat trigeminal ganglia. Brain research. vol 809. issue 2. 1999-01-20. PMID:9853116. |
the application of nicotine to the various epithelia served by the trigeminal nerve produces irritation and/or pain by activating neuronal nicotinic acetylcholine receptors (nnachrs) in sensory neurons. |
1999-01-20 |
2023-08-12 |
rat |
| M J Parker, A Beck, C W Luetj. Neuronal nicotinic receptor beta2 and beta4 subunits confer large differences in agonist binding affinity. Molecular pharmacology. vol 54. issue 6. 1999-01-12. PMID:9855644. |
the rank order of kiapp values of additional nicotinic ligands, determined in competition assays, was cytisine < nicotine < acetylcholine < carbachol < curare. |
1999-01-12 |
2023-08-12 |
rat |
| M J Parker, A Beck, C W Luetj. Neuronal nicotinic receptor beta2 and beta4 subunits confer large differences in agonist binding affinity. Molecular pharmacology. vol 54. issue 6. 1999-01-12. PMID:9855644. |
affinities for six additional agonists (acetylcholine, anabasine, cytisine, 1, 1-dimethyl-4-phenylpiperazinium, lobeline, and nicotine) were determined in competition assays. |
1999-01-12 |
2023-08-12 |
rat |
| M J Parker, A Beck, C W Luetj. Neuronal nicotinic receptor beta2 and beta4 subunits confer large differences in agonist binding affinity. Molecular pharmacology. vol 54. issue 6. 1999-01-12. PMID:9855644. |
particularly striking examples are the affinities displayed by alpha2beta2 and alpha2beta4, which differ in 1,1-dimethyl-4-phenylpiperazinium, nicotine, lobeline, and acetylcholine affinity by 120-, 86-, 85-, and 61-fold, respectively. |
1999-01-12 |
2023-08-12 |
rat |
| A Schrattenholz, S Pfeiffer, V Pejovic, R Rudolph, J Godovac-Zimmermann, A Maelick. Expression and renaturation of the N-terminal extracellular domain of torpedo nicotinic acetylcholine receptor alpha-subunit. The Journal of biological chemistry. vol 273. issue 49. 1999-01-08. PMID:9829968. |
binding of small ligands was demonstrated by competition with alpha-[3h]bungarotoxin yielding the following ki values: acetylcholine, 69 microm; nicotine, 0.42 microm; anatoxin-a, 3 mirom; tubocurarine, 400 microm; and methyllycaconitine, 0.12 microm. |
1999-01-08 |
2023-08-12 |
Not clear |
| M Katsura, S Ohkuma, J Xu, Y Hibino, A Tsujimura, K Kuriyam. Continuous treatment with nicotine increases diazepam binding inhibitor (DBI) and its mRNA in the mouse brain. Brain research. Molecular brain research. vol 55. issue 2. 1999-01-05. PMID:9582452. |
these results indicate that chronic functional interaction between nicotine and nicotinic acetylcholine receptors has a critical role in increases in dbi content and its mrna expression. |
1999-01-05 |
2023-08-12 |
mouse |
| O Yilmaz, L Kanit, B E Okur, S Pöğü. Effects of nicotine on active avoidance learning in rats: sex differences. Behavioural pharmacology. vol 8. issue 2-3. 1998-12-29. PMID:9833020. |
nicotine, a cognition enhancer and a drug of abuse, exerts its central actions through neuronal nicotinic acetylcholine receptors which show sexual dimorphism. |
1998-12-29 |
2023-08-12 |
rat |
| D E Dar, O Zinde. Catecholamine secretion from bovine adrenal chromaffin cells induced by the dextrorotatory isomer of anatoxin-a. General pharmacology. vol 31. issue 5. 1998-12-23. PMID:9809471. |
mecamylamine (1 microm) and atropine (100 microm) inhibited the secretion induced by (+)anatoxin-a (1 microm), as well as that induced by nicotine (10 microm), acetylcholine (10 microm and 100 microm) and oxotremorine-m (100 microm). |
1998-12-23 |
2023-08-12 |
cattle |
| A D Maus, E F Pereira, P I Karachunski, R M Horton, D Navaneetham, K Macklin, W S Cortes, E X Albuquerque, B M Conti-Fin. Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors. Molecular pharmacology. vol 54. issue 5. 1998-12-16. PMID:9804613. |
we demonstrated previously that human skin keratinocytes express acetylcholine receptors (achrs) sensitive to acetylcholine and nicotine, which regulate cell adhesion and motility. |
1998-12-16 |
2023-08-12 |
human |
| A D Maus, E F Pereira, P I Karachunski, R M Horton, D Navaneetham, K Macklin, W S Cortes, E X Albuquerque, B M Conti-Fin. Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors. Molecular pharmacology. vol 54. issue 5. 1998-12-16. PMID:9804613. |
patch-clamp experiments demonstrated that the bec achrs are functional, and they are activated by acetylcholine and nicotine. |
1998-12-16 |
2023-08-12 |
human |
| F Wang, M E Nelson, A Kuryatov, F Olale, J Cooper, K Keyser, J Lindstro. Chronic nicotine treatment up-regulates human alpha3 beta2 but not alpha3 beta4 acetylcholine receptors stably transfected in human embryonic kidney cells. The Journal of biological chemistry. vol 273. issue 44. 1998-12-01. PMID:9786868. |
chronic nicotine treatment up-regulates human alpha3 beta2 but not alpha3 beta4 acetylcholine receptors stably transfected in human embryonic kidney cells. |
1998-12-01 |
2023-08-12 |
human |
| F Wang, M E Nelson, A Kuryatov, F Olale, J Cooper, K Keyser, J Lindstro. Chronic nicotine treatment up-regulates human alpha3 beta2 but not alpha3 beta4 acetylcholine receptors stably transfected in human embryonic kidney cells. The Journal of biological chemistry. vol 273. issue 44. 1998-12-01. PMID:9786868. |
the functional properties of the alpha3 achrs in tsa201 cells were characterized by whole cell patch clamp using both acetylcholine and nicotine as agonists. |
1998-12-01 |
2023-08-12 |
human |
| Y J Cao, Y Y Pen. Activation of nicotinic receptor-induced postsynaptic responses to luteinizing hormone-releasing hormone in bullfrog sympathetic ganglia via a Na+-dependent mechanism. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 21. 1998-11-12. PMID:9770547. |
thus, nicotine activated nicotinic acetylcholine receptors and produced lhrh release via a mechanism that is different from the mechanism for evoked release. |
1998-11-12 |
2023-08-12 |
Not clear |
| D V Priola, X Cao, C Anagnostelis, E Basseng. Intrinsic neural regulation of the heart in the chronic, conscious dog. The American journal of physiology. vol 274. issue 6. 1998-11-05. PMID:9841534. |
acetylcholine (ach) and nicotine (nic) were administered via an indwelling coronary artery catheter. |
1998-11-05 |
2023-08-12 |
dog |