| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R DeLucia, C Scavone, M A Camill. Striatal dopamine receptor supersensitivity after long-term haloperidol treatment of hypophysectomized rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 22. issue 6. 1990-03-26. PMID:2620186. |
dopamine (da) receptor sensitivity was studied after long-term treatment with haloperidol (0.5 and 3.0 mg/kg, ip, single daily dose) or saline in hypophysectomized and intact rats. |
1990-03-26 |
2023-08-11 |
rat |
| G Debonnel, P Gaudreau, R Quirion, C de Montign. Effects of long-term haloperidol treatment on the responsiveness of accumbens neurons to cholecystokinin and dopamine: electrophysiological and radioligand binding studies in the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 10. issue 2. 1990-03-21. PMID:2137531. |
effects of long-term haloperidol treatment on the responsiveness of accumbens neurons to cholecystokinin and dopamine: electrophysiological and radioligand binding studies in the rat. |
1990-03-21 |
2023-08-11 |
rat |
| G Debonnel, P Gaudreau, R Quirion, C de Montign. Effects of long-term haloperidol treatment on the responsiveness of accumbens neurons to cholecystokinin and dopamine: electrophysiological and radioligand binding studies in the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 10. issue 2. 1990-03-21. PMID:2137531. |
since long-term haloperidol treatment results in a depolarization inactivation of a10 dopaminergic neurons, these results suggest that, despite the reduced firing activity of mesolimbic dopaminergic neurons induced by the long-term haloperidol treatment, dopamine is still released in an amount sufficient to maintain a normal neuronal responsiveness of postsynaptic accumbens neurons to da, whereas the release of cck is possibly decreased to a greater extent, resulting in an enhanced responsiveness of the neurons to this peptide. |
1990-03-21 |
2023-08-11 |
rat |
| I S Login, J J Pancrazio, Y I Ki. Dopamine enhances a voltage-dependent transient K+ current in the MMQ cell, a clonal pituitary line expressing functional D2 dopamine receptors. Brain research. vol 506. issue 2. 1990-03-19. PMID:2137361. |
dopamine at 1 microm increased by 50% (p less than 0.001) the peak of ik evoked by a test potential to +80 mv and the response was prevented by pretreatment with 100 nm haloperidol, a d2 receptor antagonist. |
1990-03-19 |
2023-08-11 |
Not clear |
| J Ichikawa, H Y Meltze. Apomorphine does not reverse reduced basal dopamine release in rat striatum and nucleus accumbens after chronic haloperidol treatment. Brain research. vol 507. issue 1. 1990-03-19. PMID:2302571. |
apomorphine does not reverse reduced basal dopamine release in rat striatum and nucleus accumbens after chronic haloperidol treatment. |
1990-03-19 |
2023-08-11 |
rat |
| J Ichikawa, H Y Meltze. Apomorphine does not reverse reduced basal dopamine release in rat striatum and nucleus accumbens after chronic haloperidol treatment. Brain research. vol 507. issue 1. 1990-03-19. PMID:2302571. |
chronic administration of haloperidol (2 mg/kg x 21 days) in drinking water decreased basal dopamine (da) release and metabolism in rat striatum and nucleus accumbens in awake, freely moving rats. |
1990-03-19 |
2023-08-11 |
rat |
| M B Djamgoz, M Kirsch, H J Wagne. Haloperidol suppresses light-induced spinule formation and biphasic responses of horizontal cells in fish (roach) retina. Neuroscience letters. vol 107. issue 1-3. 1990-03-14. PMID:2616031. |
haloperidol was used as a dopamine antagonist to suppress light-induced formation of spinules in retinae of the cyprinid fish, the roach. |
1990-03-14 |
2023-08-11 |
Not clear |
| P M Carvey, L R Ptak, L Kao, H L Klawan. Striatal homogenates from animals chronically treated with haloperidol stimulate dopamine and GABA uptake in cultures of rostral mesencephalic tegmentum. Clinical neuropharmacology. vol 12. issue 5. 1990-03-13. PMID:2611766. |
striatal homogenates from animals chronically treated with haloperidol stimulate dopamine and gaba uptake in cultures of rostral mesencephalic tegmentum. |
1990-03-13 |
2023-08-11 |
rat |
| H H Berendsen, F Jenck, C L Broekkam. Selective activation of 5HT1A receptors induces lower lip retraction in the rat. Pharmacology, biochemistry, and behavior. vol 33. issue 4. 1990-03-06. PMID:2533357. |
no significant antagonism was found with the dopamine antagonists haloperidol and spiperone, the alpha 2 agonist clonidine and the alpha 1 antagonist prazosin and the alpha 2 antagonist idazoxan. |
1990-03-06 |
2023-08-11 |
rat |
| D J Heal, M R Prow, W R Bucket. Clonidine produces mydriasis in conscious mice by activating central alpha 2-adrenoceptors. European journal of pharmacology. vol 170. issue 1-2. 1990-03-06. PMID:2575524. |
of the dopamine antagonists, haloperidol, sch 23390 and brl 34778. |
1990-03-06 |
2023-08-11 |
mouse |
| J Gerlach, D E Case. Remoxipride, a new selective D2 antagonist, and haloperidol in cebus monkeys. Progress in neuro-psychopharmacology & biological psychiatry. vol 14. issue 1. 1990-03-05. PMID:1967845. |
nine cebus monkeys, 6 with mild spontaneous oral dyskinesia (tongue protrusions), were tested with two dopamine d2 antagonists, remoxipride (a new substituted benzamide) and haloperidol, and with two dopamine agonists, methylphenidate and apomorphine. |
1990-03-05 |
2023-08-11 |
human |
| S A Zinn, K J Lookingland, L T Chapin, K E Moore, H A Tucke. Prolactin regulation of dopaminergic neurons in the infundibulum pituitary stalk of bull calves. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 193. issue 2. 1990-03-02. PMID:2300597. |
subcutaneous injections of the dopamine antagonist haloperidol every 6 hr for 1 day increased serum concentrations of prolactin and accumulation of dihydroxyphenylalanine in the infundibulum/stalk. |
1990-03-02 |
2023-08-11 |
rat |
| H A DeWald, T G Heffner, J C Jaen, D M Lustgarten, A T McPhail, L T Meltzer, T A Pugsley, L D Wis. Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. Journal of medicinal chemistry. vol 33. issue 1. 1990-02-22. PMID:1967318. |
racemic 16a exhibited moderate affinity for the dopamine (da) d2 receptor labeled with the da antagonist ligand [3h]haloperidol and moderate in vivo activity; it attenuated gamma-butyrolactone-stimulated da synthesis, decreased da neuronal firing of substantia nigra da neurons, and inhibited exploratory locomotor activity in rats, a profile consistent with a da autoreceptor agonist mechanism of action. |
1990-02-22 |
2023-08-11 |
rat |
| K M Merchant, L G Bush, J W Gibb, G R Hanso. Dopamine D2 receptors exert tonic regulation over discrete neurotensin systems of the rat brain. Brain research. vol 500. issue 1-2. 1990-02-20. PMID:2532557. |
blockade of dopamine d2 receptors with either the selective antagonist, sulpiride, or the non-selective antagonist, haloperidol, induces 2- to 3-fold increases in the content of neurotensin-like immunoreactivity in the striatum and the nucleus accumbens of the rat brain. |
1990-02-20 |
2023-08-11 |
rat |
| K M Merchant, L G Bush, J W Gibb, G R Hanso. Dopamine D2 receptors exert tonic regulation over discrete neurotensin systems of the rat brain. Brain research. vol 500. issue 1-2. 1990-02-20. PMID:2532557. |
interestingly, treatment of animals with sulpiride or haloperidol, following the depletion of dopamine by either 6-hydroxydopamine or reserpine plus alpha-methyl-p-tyrosine, did not add to the elevation in neurotensin content of either structure caused by the dopamine depletion alone. |
1990-02-20 |
2023-08-11 |
rat |
| P R Sanber. Neuroleptic-induced emotional defecation: effects of pimozide and apomorphine. Physiology & behavior. vol 46. issue 2. 1990-01-30. PMID:2602459. |
in addition, when apomorphine was combined with haloperidol, defecation levels were also increased suggesting that this phenomenon is not directly mediated by dopamine receptors. |
1990-01-30 |
2023-08-11 |
rat |
| M Clagett-Dame, R Schoenleber, C Chung, J F McKelv. Preparation of an affinity chromatography matrix for the selective purification of the dopamine D2 receptor from bovine striatal membranes. Biochimica et biophysica acta. vol 986. issue 2. 1990-01-24. PMID:2531613. |
dopamine d2 receptor was eluted from the affinity resin using a competing dopaminergic antagonist molecule, haloperidol. |
1990-01-24 |
2023-08-11 |
cattle |
| B Costall, A M Domeney, R J Naylo. Desenkephalin-gamma-endorphin is an antagonist of the hyperactivity response induced by infusion of dopamine into the nucleus accumbens of rat and ventral striatum of marmoset. Neuropharmacology. vol 28. issue 11. 1990-01-17. PMID:2574424. |
in contrast, in experiments performed in the rat, the level of spontaneous locomotor activity was increased 2- to 3-fold after cessation of a regimen of infusion of dopamine and haloperidol. |
1990-01-17 |
2023-08-11 |
rat |
| N Minamitani, K Chihara, H Kaji, H Kodama, T Kita, T Fujit. Alpha 2-adrenergic control of growth hormone (GH) secretion in conscious male rabbits: involvement of endogenous GH-releasing factor and somatostatin. Endocrinology. vol 125. issue 6. 1990-01-09. PMID:2479528. |
intravenous injection of yohimbine (yom; an alpha 2-antagonist), chlorpromazine (cpz), and haloperidol (hal; dopamine and alpha-adrenergic antagonists) completely suppressed this pulsatile gh secretion (mean 6-h gh levels, 2.98 +/- 0.24, 3.48 +/- 0.24, and 2.91 +/- 0.29 ng/ml, respectively; p less than 0.001), whereas prazosin (an alpha 1-antagonist), pimozide (a selective dopamine antagonist), sulpiride, and ym-09151-2 (ym; d2-specific antagonists) failed to affect the gh secretory pattern (mean 6-h gh levels, 6.61 +/- 0.73, 6.71 +/- 0.56, 5.44 +/- 0.44, and 6.87 +/- 1.44 ng/ml, respectively). |
1990-01-09 |
2023-08-11 |
human |
| O Magnusson, C J Fowle. Comparison of the effects of the novel antipsychotic agent remoxipride on dopamine and noradrenaline turnover in the rat brain. Pharmacology & toxicology. vol 65. issue 4. 1990-01-08. PMID:2573899. |
both remoxipride (5.6 mumol/kg intraperitoneally) and haloperidol (0.23 mumol/kg intraperitoneally) increased the rate of striatal dopamine disappearance following inhibition of tyrosine hydroxylase by h 44/68 without corresponding effect on hypothalamic and frontal cortical noradrenaline disappearance. |
1990-01-08 |
2023-08-11 |
rat |