| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Sawaguchi, M Matsumura, K Kubot. Effects of dopamine antagonists on neuronal activity related to a delayed response task in monkey prefrontal cortex. Journal of neurophysiology. vol 63. issue 6. 1990-07-31. PMID:2358883. |
using iontophoretic techniques, we investigated the influence of dopamine (da) antagonists [haloperidol (hal), a non-selective da antagonist; sulpiride (sul), a selective antagonist for d2 receptors; and fluphenazine (flu), a potent antagonist for d1 receptors] on neuronal activity related to a delayed response (dr) task in the monkey prefrontal cortex (pfc). |
1990-07-31 |
2023-08-11 |
monkey |
| Y Kamikawa, Y Shim. Inhibitory effects of catecholamines on cholinergically and non-cholinergically mediated contractions of guinea-pig isolated bronchial muscle. The Journal of pharmacy and pharmacology. vol 42. issue 2. 1990-07-20. PMID:1972400. |
the inhibitory effect of dopamine was unaffected either by propranolol (2 microm), yohimbine (2 microm) or haloperidol (10 microm). |
1990-07-20 |
2023-08-11 |
Not clear |
| K Yamaguchi, H Hama, C Adach. Inhibitory role of periventricular dopaminergic mechanisms in hemorrhage-induced vasopressin secretion in conscious rats. Brain research. vol 513. issue 2. 1990-07-16. PMID:2350705. |
the plasma avp response was markedly enhanced by intracerebroventricular injection (10 microliters) of a dopamine antagonist, haloperidol (0.15 mumol), which did not affect the responses of arterial pressure and hematocrit significantly. |
1990-07-16 |
2023-08-11 |
rat |
| E Vasar, L Allikmets, A Soosaar, A Lan. Similar behavioral and biochemical effects of long-term haloperidol and caerulein treatment in albino mice. Pharmacology, biochemistry, and behavior. vol 35. issue 4. 1990-07-02. PMID:2111914. |
in contrast, the motor excitation induced by amphetamine (an indirect dopamine agonist, 3 mg/kg ip) was increased after haloperidol or caerulein administration. |
1990-07-02 |
2023-08-11 |
mouse |
| E Vasar, L Allikmets, A Soosaar, A Lan. Similar behavioral and biochemical effects of long-term haloperidol and caerulein treatment in albino mice. Pharmacology, biochemistry, and behavior. vol 35. issue 4. 1990-07-02. PMID:2111914. |
cck-8 seems to modulate the action of haloperidol through altering the sensitivity of dopamine, opioid, gaba-a and benzodiazepine receptors. |
1990-07-02 |
2023-08-11 |
mouse |
| P W Kalivas, P Duffy, H Eberhard. Modulation of A10 dopamine neurons by gamma-aminobutyric acid agonists. The Journal of pharmacology and experimental therapeutics. vol 253. issue 2. 1990-06-21. PMID:2160011. |
this effect was antagonized by intra-a10 administration of the gamma-aminobutyric acida antagonist, bicuculline, and by peripheral administration of haloperidol, and was associated with an increase in extracellular levels of dopamine metabolites in the nucleus accumbens. |
1990-06-21 |
2023-08-11 |
rat |
| S L Cottingham, D Pickar, T K Shimotake, P Montpied, S M Paul, J N Crawle. Tyrosine hydroxylase and cholecystokinin mRNA levels in the substantia nigra, ventral tegmental area, and locus ceruleus are unaffected by acute and chronic haloperidol administration. Cellular and molecular neurobiology. vol 10. issue 1. 1990-06-14. PMID:1970757. |
these data suggest that haloperidol administration does not alter the level of tyrosine hydroxylase or cholecystokinin mrnas in midbrain dopamine neurons of the rat. |
1990-06-14 |
2023-08-11 |
rat |
| R B Page, M Gropper, E Woodard, J Townsend, S Davis, R M Brya. Role of catecholamines in regulating ovine median eminence blood flow. The American journal of physiology. vol 258. issue 5 Pt 2. 1990-06-13. PMID:1970927. |
blood flow was measured in the ovine median eminence and neural lobe before and after the intravenous infusion of dopamine (n = 7), the d1 agonist skf 38393 (n = 4), the d2 agonist bromocriptine (n = 4), and the dopamine antagonist haloperidol (n = 5). |
1990-06-13 |
2023-08-11 |
Not clear |
| J Ichikawa, H Y Meltze. The effect of chronic clozapine and haloperidol on basal dopamine release and metabolism in rat striatum and nucleus accumbens studied by in vivo microdialysis. European journal of pharmacology. vol 176. issue 3. 1990-05-31. PMID:2184042. |
the effect of chronic clozapine and haloperidol on basal dopamine release and metabolism in rat striatum and nucleus accumbens studied by in vivo microdialysis. |
1990-05-31 |
2023-08-11 |
rat |
| J Ichikawa, H Y Meltze. The effect of chronic clozapine and haloperidol on basal dopamine release and metabolism in rat striatum and nucleus accumbens studied by in vivo microdialysis. European journal of pharmacology. vol 176. issue 3. 1990-05-31. PMID:2184042. |
the effects of chronic treatment with clozapine and haloperidol on basal dopamine release and metabolism were studied in the striatum and the nucleus accumbens of awake, freely moving rats using in vivo microdialysis. |
1990-05-31 |
2023-08-11 |
rat |
| J Ichikawa, H Y Meltze. The effect of chronic clozapine and haloperidol on basal dopamine release and metabolism in rat striatum and nucleus accumbens studied by in vivo microdialysis. European journal of pharmacology. vol 176. issue 3. 1990-05-31. PMID:2184042. |
chronic haloperidol (2 mg/kg x 21 days) but not chronic clozapine (20 mg/kg x 21 days) decreased basal dopamine release and metabolism in both the striatum and the nucleus accumbens. |
1990-05-31 |
2023-08-11 |
rat |
| M Joëls, C M Pennartz, H Sijbesma, J Schippe. Eltoprazine suppresses hyperpolarizing responses to serotonin in rat hippocampus. The Journal of pharmacology and experimental therapeutics. vol 253. issue 1. 1990-05-30. PMID:2329512. |
the eltoprazine-induced effects persisted in the presence of tetrodotoxin and tetraethylammonium and also when haloperidol and phentolamine were added to the medium, indicating that the small agonistic effects of eltoprazine are not due to an indirect activation of dopamine or alpha adrenergic receptors. |
1990-05-30 |
2023-08-11 |
rat |
| B Moghaddam, B S Bunne. Acute effects of typical and atypical antipsychotic drugs on the release of dopamine from prefrontal cortex, nucleus accumbens, and striatum of the rat: an in vivo microdialysis study. Journal of neurochemistry. vol 54. issue 5. 1990-05-18. PMID:1969939. |
the effect of haloperidol was also attenuated in the medial prefrontal cortex; 0.1 mg/kg did not increase the outflow of dopamine and the effect of 0.5 mg/kg haloperidol was of shorter duration in the prefrontal cortex than that observed in striatum and nucleus accumbens. |
1990-05-18 |
2023-08-11 |
rat |
| S P Bagch. Antidopaminergic action of verapamil and several other drugs: inactivation of vesicular dopamine. Life sciences. vol 46. issue 12. 1990-05-08. PMID:1969603. |
haloperidol, a potent dopamine (da-2) antagonist, caused only a weak decrease of dopamine. |
1990-05-08 |
2023-08-11 |
Not clear |
| P M Carvey, L C Kao, T J Zhang, R L Amdur, D H Lin, R Singh, H L Klawan. Dopaminergic alterations in cotreatments attenuating haloperidol-induced hypersensitivity. Pharmacology, biochemistry, and behavior. vol 35. issue 2. 1990-05-03. PMID:2320636. |
chronic treatment of the laboratory rat with haloperidol results in an increased stereotypic behavioral response to subsequent dopamine agonist challenge. |
1990-05-03 |
2023-08-11 |
rat |
| W D Bowen, E L Moses, P J Tolentino, J M Walke. Metabolites of haloperidol display preferential activity at sigma receptors compared to dopamine D-2 receptors. European journal of pharmacology. vol 177. issue 3. 1990-04-26. PMID:2155804. |
metabolites of haloperidol display preferential activity at sigma receptors compared to dopamine d-2 receptors. |
1990-04-26 |
2023-08-11 |
rat |
| W D Bowen, E L Moses, P J Tolentino, J M Walke. Metabolites of haloperidol display preferential activity at sigma receptors compared to dopamine D-2 receptors. European journal of pharmacology. vol 177. issue 3. 1990-04-26. PMID:2155804. |
haloperidol bound with equal affinity to sigma and dopamine d-2 receptors (ki = 2.8 nm). |
1990-04-26 |
2023-08-11 |
rat |
| W D Bowen, E L Moses, P J Tolentino, J M Walke. Metabolites of haloperidol display preferential activity at sigma receptors compared to dopamine D-2 receptors. European journal of pharmacology. vol 177. issue 3. 1990-04-26. PMID:2155804. |
however, reduced haloperidol bound to dopamine receptors with 85-fold lower affinity compared to haloperidol (ki = 239 nm). |
1990-04-26 |
2023-08-11 |
rat |
| W D Bowen, E L Moses, P J Tolentino, J M Walke. Metabolites of haloperidol display preferential activity at sigma receptors compared to dopamine D-2 receptors. European journal of pharmacology. vol 177. issue 3. 1990-04-26. PMID:2155804. |
the chlorophenyl-hydroxy-piperidine metabolite of haloperidol lacked affinity for dopamine receptors, but bound with moderate affinity to sigma receptors (ki = 326 nm). |
1990-04-26 |
2023-08-11 |
rat |
| W D Bowen, E L Moses, P J Tolentino, J M Walke. Metabolites of haloperidol display preferential activity at sigma receptors compared to dopamine D-2 receptors. European journal of pharmacology. vol 177. issue 3. 1990-04-26. PMID:2155804. |
these findings suggest that administration of haloperidol results initially in effects mediated through both dopamine and sigma receptors, but as metabolism proceeds the sigma actions would be expected to decline at a significantly slower rate than the dopaminergic actions. |
1990-04-26 |
2023-08-11 |
rat |