| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P F VonVoigtlander, M A Burian, J S Althaus, L R William. Effects of chronic haloperidol on vitamin E levels and monoamine metabolism in rats fed normal and vitamin E deficient diets. Research communications in chemical pathology and pharmacology. vol 68. issue 3. 1990-09-17. PMID:2385757. |
neuroleptics such as haloperidol that acutely accelerate dopamine synthesis and metabolism may cause peroxidative stress as indicated by depletions of vitamin e. such depletions are capable of reducing dopamine levels and synthesis. |
1990-09-17 |
2023-08-11 |
rat |
| P F VonVoigtlander, M A Burian, J S Althaus, L R William. Effects of chronic haloperidol on vitamin E levels and monoamine metabolism in rats fed normal and vitamin E deficient diets. Research communications in chemical pathology and pharmacology. vol 68. issue 3. 1990-09-17. PMID:2385757. |
the possibility that this and the effect of chronic haloperidol are mediated by peroxidative damage to dopamine neurons must be considered. |
1990-09-17 |
2023-08-11 |
rat |
| T De Boer, J A Tonnaer, C J De Vos, A M Van Delf. Neurochemical studies with the potential antipsychotic compound trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H- dibenz[2,3:6,7]oxepino[4,5-c]pyrrolidine maleate. Arzneimittel-Forschung. vol 40. issue 5. 1990-09-13. PMID:1974433. |
trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz [2,3:6,7]oxepino[4,5-c]pyrrolidine maleate (org 5222) has dopamine d2 antagonistic and negligible anticholinergic properties of the classical neuroleptic haloperidol. |
1990-09-13 |
2023-08-11 |
Not clear |
| D Nouel, I Dubuc, P Kitabgi, J Costenti. Centrally administered [D-Trp11]neurotensin, as well as neurotensin protected from inactivation by thiorphan, modifies locomotion in rats in a biphasic manner. Peptides. vol 11. issue 3. 1990-09-13. PMID:2381875. |
it was antagonized by the dopamine antagonist haloperidol (50 micrograms/kg, ip). |
1990-09-13 |
2023-08-11 |
rat |
| M Le Dafniet, P Lefebvre, A Barret, C Mechain, M C Feinstein, A M Brandi, F Peillo. Normal and adenomatous human pituitaries secrete thyrotropin-releasing hormone in vitro: modulation by dopamine, haloperidol, and somatostatin. The Journal of clinical endocrinology and metabolism. vol 71. issue 2. 1990-09-12. PMID:1974264. |
normal and adenomatous human pituitaries secrete thyrotropin-releasing hormone in vitro: modulation by dopamine, haloperidol, and somatostatin. |
1990-09-12 |
2023-08-11 |
human |
| M Le Dafniet, P Lefebvre, A Barret, C Mechain, M C Feinstein, A M Brandi, F Peillo. Normal and adenomatous human pituitaries secrete thyrotropin-releasing hormone in vitro: modulation by dopamine, haloperidol, and somatostatin. The Journal of clinical endocrinology and metabolism. vol 71. issue 2. 1990-09-12. PMID:1974264. |
after 1 h of equilibration the perifusion medium was collected every 2 min (1 ml/fraction) for 3 h. trh, prl, and gh were measured by ria under basal conditions and in the presence of 10(-10) to 10(-6) mol/l dopamine (da), alone or concomitant with haloperidol, or in the presence of 10(-10) or 10(-6) mol/l somatostatin. |
1990-09-12 |
2023-08-11 |
human |
| G Flügge, A Jurdzinski, S Brandt, E Fuch. Alpha 2-adrenergic binding sites in the medulla oblongata of tree shrews demonstrated by in vitro autoradiography: species related differences in comparison to the rat. The Journal of comparative neurology. vol 297. issue 2. 1990-08-23. PMID:1973422. |
furthermore, in the area c1, 3h-rauw binding was inhibited by the dopamine antagonist haloperidol. |
1990-08-23 |
2023-08-11 |
human |
| J Duteil, F A Rambert, J Pessonnier, J F Hermant, R Gombert, E Assou. Central alpha 1-adrenergic stimulation in relation to the behaviour stimulating effect of modafinil; studies with experimental animals. European journal of pharmacology. vol 180. issue 1. 1990-08-13. PMID:1973114. |
the modafinil-induced increase in locomotor activity in mice was prevented by the centrally acting alpha 1-adrenoceptor antagonists, prazosin and phenoxybenzamine, and by reserpine but not by the mixed dopamine d-1/d-2 antagonist, haloperidol, the dopamine d-2 antagonist, sulpiride, the peripherally acting alpha 1-adrenoceptor antagonist, phentolamine, the alpha 2-adrenoceptor antagonist, yohimbine, the beta-adrenoceptor antagonist, propranolol, or by the catecholamine synthesis inhibitor, alpha-methyl-p-tyrosine. |
1990-08-13 |
2023-08-11 |
mouse |
| R Castro, B Brito, V Notari. Prenatal haloperidol alters the expression of DNA polymerases in brain regions of neonate rats. Cellular and molecular neurobiology. vol 10. issue 2. 1990-08-13. PMID:2364411. |
previous studies have reported a marked reduction in the [3h]thymidine incorporation in forebrain after administration of a dopamine antagonist such as haloperidol. |
1990-08-13 |
2023-08-11 |
rat |
| R Castro, B Brito, V Notari. Prenatal haloperidol alters the expression of DNA polymerases in brain regions of neonate rats. Cellular and molecular neurobiology. vol 10. issue 2. 1990-08-13. PMID:2364411. |
by northern blot analysis, we have studied the steady-state mrna levels for genes involved in dna metabolism, in neonate rat mesencephalon and forebrain, after chronic prenatal blockade of dopamine receptors with haloperidol. |
1990-08-13 |
2023-08-11 |
rat |
| D E Hernandez, L Jenne. Inhibition of neurotensin-induced miosis by blockade of ocular dopamine pathways. Journal of ocular pharmacology. vol 6. issue 1. 1990-08-08. PMID:1972961. |
of interest however was the observation that destruction of ocular dopamine (da) nerve endings with 6-hydroxydopamine (6-ohda) + desmethylimipramine (dmi), or blockade of d-2 da receptors with haloperidol significantly inhibited the miotic response to ic nt. |
1990-08-08 |
2023-08-11 |
Not clear |
| C Iñiguez, P Tamayo, E Romero, M J Gayoso, J De Jua. Alterations in prolactin secretion during the 1st postnatal month following perinatal dopaminergic blockade with haloperidol. Neuroendocrinology. vol 51. issue 6. 1990-08-08. PMID:2114005. |
this research was intended to study the effects of perinatal haloperidol administration on the postnatal secretion of prolactin (prl) with the aim of investigating the existence of a 'critical period' during which the lack of dopamine influence could cause long-term alterations in the secretion of this hormone. |
1990-08-08 |
2023-08-11 |
rat |
| M T Bardo, S L Bowling, R C Pierc. Changes in locomotion and dopamine neurotransmission following amphetamine, haloperidol, and exposure to novel environmental stimuli. Psychopharmacology. vol 101. issue 3. 1990-08-08. PMID:2163539. |
changes in locomotion and dopamine neurotransmission following amphetamine, haloperidol, and exposure to novel environmental stimuli. |
1990-08-08 |
2023-08-11 |
rat |
| M T Bardo, S L Bowling, R C Pierc. Changes in locomotion and dopamine neurotransmission following amphetamine, haloperidol, and exposure to novel environmental stimuli. Psychopharmacology. vol 101. issue 3. 1990-08-08. PMID:2163539. |
locomotor behavior and dopamine (da) neurotransmission were assessed in rats exposed to either a novel or familiar stimulus environment while under the influence of amphetamine, haloperidol or saline. |
1990-08-08 |
2023-08-11 |
rat |
| J W Commissiong, C Slimovitch, G Toffan. Regulation of the synthesis and metabolism of striatal dopamine after disruption of nerve conduction in the medial forebrain bundle. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:2361171. |
furthermore, haloperidol can act directly on the striatal, dopaminergic nerve terminal, to cause an increase in the synthesis and metabolism of striatal dopamine. |
1990-08-08 |
2023-08-11 |
rat |
| C Hindelang, J M Félix, F M Laurent, M J Klein, M E Stoecke. Ontogenesis of proopiomelanocortin gene expression and regulation in the rat pituitary intermediate lobe. Molecular and cellular endocrinology. vol 70. issue 3. 1990-08-08. PMID:2361568. |
the effects of acute or chronic postnatal treatment with a dopamine antagonist (haloperidol) or a dopamine agonist (bromocriptine) show that the physiological dopaminergic inhibitory control of pomc gene expression operates as early as postnatal day 5. |
1990-08-08 |
2023-08-11 |
rat |
| V La Grutta, M Sabatin. Substantia nigra-mediated anticonvulsant action: a possible role of a dopaminergic component. Brain research. vol 515. issue 1-2. 1990-08-01. PMID:2357581. |
the possibility of dopamine involvement was further tested by studying the effects of intraperitoneal injection of haloperidol, a dopamine receptor blocking agent on nigrohippocampal influences, while to verify the precise site of action, in other groups of cats, sulpiride and apomorphine (d-receptor antagonist and agonist, respectively) were locally administered in the dorsal hippocampus. |
1990-08-01 |
2023-08-11 |
cat |
| L H Jiang, R J Kasser, C A Altar, R Y Wan. One year of continuous treatment with haloperidol or clozapine fails to induce a hypersensitive response of caudate putamen neurons to dopamine D1 and D2 receptor agonists. The Journal of pharmacology and experimental therapeutics. vol 253. issue 3. 1990-07-31. PMID:1972751. |
one year of continuous treatment with haloperidol or clozapine fails to induce a hypersensitive response of caudate putamen neurons to dopamine d1 and d2 receptor agonists. |
1990-07-31 |
2023-08-11 |
rat |
| L H Jiang, R J Kasser, C A Altar, R Y Wan. One year of continuous treatment with haloperidol or clozapine fails to induce a hypersensitive response of caudate putamen neurons to dopamine D1 and D2 receptor agonists. The Journal of pharmacology and experimental therapeutics. vol 253. issue 3. 1990-07-31. PMID:1972751. |
in a "blind" experimental design, the sensitivity of caudate-putamen (cpu) cells to the selective dopamine (da) d1 receptor agonist skf-38393 and d2 receptor agonist ly171555 (quinpirole) in rats treated with either haloperidol (hal), clozapine or tap water for 1 year was compared using the techniques of single cell recording and microiontophoresis. |
1990-07-31 |
2023-08-11 |
rat |
| F G Williams, M P Murtaugh, A J Beit. The effect of acute haloperidol treatment on brain proneurotensin mRNA: in situ hybridization analyses using a novel fluorescence detection procedure. Brain research. Molecular brain research. vol 7. issue 4. 1990-07-31. PMID:2163009. |
these studies describe the normal anatomical distribution of neurons containing the mrna coding for neurotensin (proneurotensin/neuromedin n) in the rat forebrain and midbrain and examine how that distribution is altered by acute administration of the dopamine antagonist haloperidol. |
1990-07-31 |
2023-08-11 |
rat |