| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Janowsky, K A Neve, J M Kinzie, B Taylor, T de Paulis, J K Belkna. Extrastriatal dopamine D2 receptors: distribution, pharmacological characterization and region-specific regulation by clozapine. The Journal of pharmacology and experimental therapeutics. vol 261. issue 3. 1992-07-14. PMID:1534844. |
chronic (14 day) administration of two dopamine d2 receptor antagonists, either the typical neuroleptic haloperidol (1.5 mg/kg i.p.) |
1992-07-14 |
2023-08-11 |
rat |
| D J Schlyer, N D Volkow, J S Fowler, A P Wolf, C Y Shiue, S L Dewey, B Bendriem, J Logan, R Raulli, R Hitzeman. Regional distribution and kinetics of haloperidol binding in human brain: a PET study with [18F]haloperidol. Synapse (New York, N.Y.). vol 11. issue 1. 1992-07-14. PMID:1604422. |
the uptake of [18f]haloperidol in the whole brain in normals was high (6.6% of the injected dose at 2 hr), and regional distribution was much more extensive than could be accounted for by the distribution of dopamine d2 receptors. |
1992-07-14 |
2023-08-11 |
human |
| D J Schlyer, N D Volkow, J S Fowler, A P Wolf, C Y Shiue, S L Dewey, B Bendriem, J Logan, R Raulli, R Hitzeman. Regional distribution and kinetics of haloperidol binding in human brain: a PET study with [18F]haloperidol. Synapse (New York, N.Y.). vol 11. issue 1. 1992-07-14. PMID:1604422. |
these results are discussed in terms of the pharmacokinetics of haloperidol in the human brain and its binding to dopamine d2 receptors and to sigma receptors. |
1992-07-14 |
2023-08-11 |
human |
| A D Dmitriev, E A Kizim, M B Smirnova, I D Shcheglova, A M Ugole. [The endorphins of the epithelial and subepithelial structures of the rat small intestine and the evolutionary hypotheses of the formation of the mechanisms of the negative regulation of their synthesis]. Zhurnal evoliutsionnoi biokhimii i fiziologii. vol 27. issue 6. 1992-07-08. PMID:1817415. |
the effects of the agonist of the glucocorticoid hormones dexamethasone and dopamine antagonist--haloperidol on the concentration of immunoreactive alpha-, beta- and gamma-endorphins in duodenum, ileum, and jejunum of rats were studied. |
1992-07-08 |
2023-08-11 |
rat |
| R E Mistlberger, D G Mumb. The limbic system and food-anticipatory circadian rhythms in the rat: ablation and dopamine blocking studies. Behavioural brain research. vol 47. issue 2. 1992-07-01. PMID:1590946. |
additional groups of intact rats were treated with the dopamine antagonist haloperidol (0.3 mg/kg or 2.0 mg/kg) 30 min prior to daily feeding, but this also did not prevent the emergence of food-entrained rhythms. |
1992-07-01 |
2023-08-11 |
rat |
| P Kehoe, C B Boyla. Cocaine-induced effects on isolation stress in neonatal rats. Behavioral neuroscience. vol 106. issue 2. 1992-07-01. PMID:1590955. |
in addition, intraperitoneal administration of the dopamine antagonist haloperidol (0.5 & 1.0 mg/kg) before 1.25 and 2.5 mg/kg cocaine produced a significant elevation in vocalizations compared with saline pretreatment, which indicates a blocking of cocaine's effect on calling behavior. |
1992-07-01 |
2023-08-11 |
rat |
| A Y Deutch, D S Camero. Pharmacological characterization of dopamine systems in the nucleus accumbens core and shell. Neuroscience. vol 46. issue 1. 1992-06-30. PMID:1350665. |
administration of haloperidol increased dopamine utilization in both nucleus accumbens sectors, but augmented utilization to a significantly greater degree in the nucleus accumbens core. |
1992-06-30 |
2023-08-11 |
rat |
| N Mitra, K P Mohanakumar, D K Gangul. Dissociation of serotoninergic and dopaminergic components in acute effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Brain research bulletin. vol 28. issue 3. 1992-06-29. PMID:1350496. |
interestingly, treatment with haloperidol, the dopamine (d1/d2) antagonist, before and after mptp administration caused an early onset and prolongation of the inhibitory phase without affecting the initial hyperexcitement. |
1992-06-29 |
2023-08-11 |
mouse |
| A K Srivastava, Y P Srivastava, P P Gupta, R B Verm. Characterization of dopamine receptors involved in central thermoregulation in rabbits. Indian journal of experimental biology. vol 29. issue 11. 1992-06-26. PMID:1816089. |
haloperidol, a d1 receptor blocker produced consistent hypothermia, whereas d2 receptor blocker metoclopramide produced hyperthermia, pretreatment with haloperidol competitively blocked the hyperthermic response of dopamine. |
1992-06-26 |
2023-08-11 |
Not clear |
| D E Case. Dopamine D1 (SCH 23390) and D2 (haloperidol) antagonists in drug-naive monkeys. Psychopharmacology. vol 107. issue 1. 1992-06-24. PMID:1534177. |
dopamine d1 (sch 23390) and d2 (haloperidol) antagonists in drug-naive monkeys. |
1992-06-24 |
2023-08-11 |
monkey |
| J W Holada. Neuroendocrine-immune interactions and their relevance to the pharmacology of critical care medicine. Klinische Wochenschrift. vol 69 Suppl 26. 1992-06-18. PMID:1813709. |
drugs commonly used in the icu have previously unrecognized effects on the immune system; these drugs (including steroid hormones, dopamine agonists, metoclopramide, haloperidol, morphine, mucolytics, cyclosporine and other pharmacologic agents) affect the release of hormones that, in turn, modulate immune function. |
1992-06-18 |
2023-08-11 |
Not clear |
| T V Nguyen, B E Kosofsky, R Birnbaum, B M Cohen, S E Hyma. Differential expression of c-fos and zif268 in rat striatum after haloperidol, clozapine, and amphetamine. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 10. 1992-06-16. PMID:1374894. |
antipsychotic drugs with potent dopamine d2 receptor antagonist properties, such as haloperidol, induced both c-fos and zif268 mrna in the caudate-putamen; however, the atypical antipsychotic drug clozapine induced zif268 but not c-fos mrna in that region. |
1992-06-16 |
2023-08-11 |
rat |
| J R Hollerman, E D Abercrombie, A A Grac. Electrophysiological, biochemical, and behavioral studies of acute haloperidol-induced depolarization block of nigral dopamine neurons. Neuroscience. vol 47. issue 3. 1992-06-16. PMID:1584410. |
in both control rats and rates tested four to 10 days postlesion, the electrophysiological response of nigral dopamine neurons to increasing doses of haloperidol consisted of either: (1) an increase in firing rate which reached a plateau at six to 10 spikes per second, or (2) no response (i.e., less than 20% change in firing rate). |
1992-06-16 |
2023-08-11 |
rat |
| J R Hollerman, E D Abercrombie, A A Grac. Electrophysiological, biochemical, and behavioral studies of acute haloperidol-induced depolarization block of nigral dopamine neurons. Neuroscience. vol 47. issue 3. 1992-06-16. PMID:1584410. |
administration of additional doses of haloperidol up to lethal levels did not elicit further changes in dopamine cell firing in these rats. |
1992-06-16 |
2023-08-11 |
rat |
| J R Hollerman, E D Abercrombie, A A Grac. Electrophysiological, biochemical, and behavioral studies of acute haloperidol-induced depolarization block of nigral dopamine neurons. Neuroscience. vol 47. issue 3. 1992-06-16. PMID:1584410. |
in contrast, in 6-hydroxydopamine-treated rats tested four to six weeks postlesion, acute administration of haloperidol was not only more consistent in producing increases in dopamine cell firing rate, but also caused six out of seven dopamine neurons tested to cease firing upon entering a state of depolarization block. |
1992-06-16 |
2023-08-11 |
rat |
| J R Hollerman, E D Abercrombie, A A Grac. Electrophysiological, biochemical, and behavioral studies of acute haloperidol-induced depolarization block of nigral dopamine neurons. Neuroscience. vol 47. issue 3. 1992-06-16. PMID:1584410. |
in parallel studies, haloperidol caused an increase in the extracellular dopamine levels measured by microdialysis in the striatum of control rats, whereas administration of the same dose of haloperidol to 6-hydroxydopamine-treated rats four to six weeks postlesion did not elicit any change in extracellular dopamine levels. |
1992-06-16 |
2023-08-11 |
rat |
| J R Hollerman, E D Abercrombie, A A Grac. Electrophysiological, biochemical, and behavioral studies of acute haloperidol-induced depolarization block of nigral dopamine neurons. Neuroscience. vol 47. issue 3. 1992-06-16. PMID:1584410. |
these results show that 6-hydroxydopamine-induced dopamine depletions produce a time-dependent change in the responsivity of the nigrostriatal dopamine system to acute haloperidol administration. |
1992-06-16 |
2023-08-11 |
rat |
| J R Hollerman, E D Abercrombie, A A Grac. Electrophysiological, biochemical, and behavioral studies of acute haloperidol-induced depolarization block of nigral dopamine neurons. Neuroscience. vol 47. issue 3. 1992-06-16. PMID:1584410. |
in this altered system, the induction of depolarization block of spike activity in nigral dopamine neurons by haloperidol was not associated with a corresponding decrease in extracellular dopamine levels measured in the striatum. |
1992-06-16 |
2023-08-11 |
rat |
| P Hansell, M Sjöquis. Dopamine receptor blockade and synthesis inhibition during exaggerated natriuresis in spontaneously hypertensive rats. Acta physiologica Scandinavica. vol 144. issue 3. 1992-06-12. PMID:1585811. |
when spontaneously hypertensive rats were pretreated with the dopamine receptor blockers haloperidol (n = 14, 1 mg kg-1), sch23390 (n = 8, 30 micrograms h-1 kg-1) or the dopamine synthesis inhibitor benserazide (n = 8, 50 mg kg-1; n = 5, 100 mg kg-1), the natriuretic response to volume expansion was only 16, 35, 59 and 42%, respectively, of that in untreated shr. |
1992-06-12 |
2023-08-11 |
rat |
| M Johnson, K Mitros, D M Stone, R Zobrist, G R Hanson, J W Gib. Effect of flunarizine and nimodipine on the decrease in tryptophan hydroxylase activity induced by methamphetamine and 3,4-methylenedioxymethamphetamine. The Journal of pharmacology and experimental therapeutics. vol 261. issue 2. 1992-06-05. PMID:1374469. |
because haloperidol failed to mimic the protective action of flunarizine, it is unlikely that flunarizine exerts its action by blocking the dopamine d-2 receptors. |
1992-06-05 |
2023-08-11 |
rat |