| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C D Blaha, A G Phillip. Pharmacological evidence for common mechanisms underlying the effects of neurotensin and neuroleptics on in vivo dopamine efflux in the rat nucleus accumbens. Neuroscience. vol 49. issue 4. 1992-12-14. PMID:1436486. |
the effects of the neuropeptide neurotensin and the typical neuroleptic haloperidol on dopamine efflux were compared in the posteromedial nucleus accumbens of the chloral hydrate-anesthetized rat using in vivo chronoamperometry. |
1992-12-14 |
2023-08-11 |
rat |
| C D Blaha, A G Phillip. Pharmacological evidence for common mechanisms underlying the effects of neurotensin and neuroleptics on in vivo dopamine efflux in the rat nucleus accumbens. Neuroscience. vol 49. issue 4. 1992-12-14. PMID:1436486. |
both neurotensin and haloperidol administration elicited an immediate increase in dopamine efflux in the nucleus accumbens. |
1992-12-14 |
2023-08-11 |
rat |
| C D Blaha, A G Phillip. Pharmacological evidence for common mechanisms underlying the effects of neurotensin and neuroleptics on in vivo dopamine efflux in the rat nucleus accumbens. Neuroscience. vol 49. issue 4. 1992-12-14. PMID:1436486. |
amphetamine, administered during the peak dopamine stimulatory effects induced by neurotensin or haloperidol, resulted in increases above baseline which were significantly greater than the effects of amphetamine alone. |
1992-12-14 |
2023-08-11 |
rat |
| C D Blaha, A G Phillip. Pharmacological evidence for common mechanisms underlying the effects of neurotensin and neuroleptics on in vivo dopamine efflux in the rat nucleus accumbens. Neuroscience. vol 49. issue 4. 1992-12-14. PMID:1436486. |
these combined drug treatment effects on baseline dopamine efflux were additive, indicating that the effects of amphetamine were not potentiated by neurotensin or haloperidol pretreatments. |
1992-12-14 |
2023-08-11 |
rat |
| C D Blaha, A G Phillip. Pharmacological evidence for common mechanisms underlying the effects of neurotensin and neuroleptics on in vivo dopamine efflux in the rat nucleus accumbens. Neuroscience. vol 49. issue 4. 1992-12-14. PMID:1436486. |
these in vivo results suggest that neurotensin and haloperidol may augment dopamine efflux in the nucleus accumbens via common mechanisms of action which may involve activation of mesotelencephalic dopamine neuronal firing. |
1992-12-14 |
2023-08-11 |
rat |
| J P Seibyl, S W Woods, S S Zoghbi, R M Baldwin, H M Dey, A W Goddard, Y Zea-Ponce, G Zubal, M Germine, E O Smit. Dynamic SPECT imaging of dopamine D2 receptors in human subjects with iodine-123-IBZM. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 33. issue 11. 1992-12-08. PMID:1432157. |
haloperidol caused a 2.6-fold increase in the rate of washout of specific striatal activity in comparison to that in the 10 control subjects and was consistent with drug-induced displacement of radioligand from the dopamine d2 receptor. |
1992-12-08 |
2023-08-11 |
human |
| G C Rigdon, J K Weatherspoo. 5-Hydroxytryptamine 1a receptor agonists block prepulse inhibition of acoustic startle reflex. The Journal of pharmacology and experimental therapeutics. vol 263. issue 2. 1992-12-08. PMID:1432685. |
reduction of prepulse inhibition by 8-ohdpat was antagonized by (-)propranolol, a 5-ht1a receptor antagonist, and partially by haloperidol, a dopamine d2 receptor antagonist, but not by ketanserin or methysergide, 5-ht2 receptor antagonists. |
1992-12-08 |
2023-08-11 |
human |
| D C Hoffma. Typical and atypical neuroleptics antagonize MK-801-induced locomotion and stereotypy in rats. Journal of neural transmission. General section. vol 89. issue 1-2. 1992-12-04. PMID:1358122. |
pretreatment with the typical neuroleptic haloperidol (0.01, 0.05, 0.1, 0.5 mg/kg sc) and the dopamine d2 receptor selective antagonist eticlopride (0.005, 0.01, 0.05 mg/kg sc) each resulted in significant and dose-dependent reductions of locomotor activity and sniffing. |
1992-12-04 |
2023-08-11 |
rat |
| A Albinsson, G Andersso. The effect of amperozide, a new antipsychotic drug, on plasma corticosterone concentration in the rat. Life sciences. vol 51. issue 19. 1992-12-04. PMID:1359366. |
nor was it inhibited by the dopamine d2 receptor antagonist haloperidol. |
1992-12-04 |
2023-08-11 |
rat |
| K F Martin, I Phillips, M Hearson, M R Prow, D J Hea. Characterization of 8-OH-DPAT-induced hypothermia in mice as a 5-HT1A autoreceptor response and its evaluation as a model to selectively identify antidepressants. British journal of pharmacology. vol 107. issue 1. 1992-12-04. PMID:1422568. |
the response was also antagonized by the dopamine d2 receptor antagonists, haloperidol and brl 34778. |
1992-12-04 |
2023-08-11 |
mouse |
| b' R R Ga\\xc4\\xadnetdinov, E A Budygin, G I Kovalev, V S Kudrin, K S Raevski\\xc4\\xa. [Different effects of typical and atypical neuroleptics on K+-stimulated dopamine release from isolated rat striatum]. Biulleten\' eksperimental\'noi biologii i meditsiny. vol 114. issue 7. 1992-12-01. PMID:1358258.' |
effects of haloperidol (10(-7)-alpha 10(-5) m), trifluoperazine, metoclopramide, tiapride, sulpiride, thioridazine, clozapine remoxipride, raclopride, cis- and trans-isomers of carbidine, sch 23390 (all at the 10(-6) m) on the k(+)-stimulated (28 mm) dopamine (da) release from isolated rat striatum were studied. |
1992-12-01 |
2023-08-11 |
rat |
| P Simon, B Guardiola, J Bizot-Espiard, P Schiavi, J Costenti. 5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists. Psychopharmacology. vol 108. issue 1-2. 1992-11-25. PMID:1357709. |
the hypothermic effect of the drug was reversed by haloperidol in mice, suggesting that it behaves as a direct dopamine agonist. |
1992-11-25 |
2023-08-11 |
mouse |
| S K Gupta, R K Mishr. Effects of chronic treatment of haloperidol and clozapine on levels of G-protein subunits in rat striatum. Journal of molecular neuroscience : MN. vol 3. issue 4. 1992-11-20. PMID:1390000. |
chronic administration of typical neuroleptic drugs, such as haloperidol, causes the supersensitivity of brain dopamine d2 receptor in striatum and limbic regions, while the atypical neuroleptic clozapine does not. |
1992-11-20 |
2023-08-11 |
rat |
| M Maeda, S Sasaki, T Fukumura, E Fukuzawa, K Watanabe, M Kojima, T Tahara, K Masuda, Y Ichiy. Positron-emitting N-[18F]fluoroalkyl and [18F]fluoropyrrolidinyl analogues of eticlopride as potential in vivo radioligands for dopamine D2 receptors. Chemical & pharmaceutical bulletin. vol 40. issue 7. 1992-11-20. PMID:1394695. |
the striatal accumulation was selectively inhibited by pre-injection of haloperidol, a dopamine d2 antagonist, without affecting accumulation in other tissues. |
1992-11-20 |
2023-08-11 |
rat |
| G Schettini, C Ventra, T Florio, M Grimaldi, O Meucci, A Marin. Modulation by GTP of basal and agonist-stimulated striatal adenylate cyclase activity following chronic blockade of D1 and D2 dopamine receptors: involvement of G proteins in the development of receptor supersensitivity. Journal of neurochemistry. vol 59. issue 5. 1992-11-20. PMID:1402912. |
rats receiving injections of specific antagonists of dopamine receptors (sch 23390 for d1, haloperidol for d2, and haloperidol+sch 23390) once daily for 21 days develop a selective supersensitivity of the blocked receptors. |
1992-11-20 |
2023-08-11 |
rat |
| K G Todd, C H Beck, M T Martin-Iverso. Effects of D1 and D2 dopamine antagonists on behavior of polydipsic rats. Pharmacology, biochemistry, and behavior. vol 42. issue 3. 1992-11-18. PMID:1409772. |
the behavioral and neurochemical effects of sch3390 (sch), a dopamine (da) d1 antagonist, and haloperidol (hal), a da d2 receptor antagonist, on schedule-induced polydipsia (sip) were examined. |
1992-11-18 |
2023-08-11 |
rat |
| J F Hyde, T P Jeruss. Bilateral neurochemical changes induced by unilateral cerebral haloperidol administration: evidence for cerebral asymmetry in the rat. Pharmacology, biochemistry, and behavior. vol 42. issue 3. 1992-11-18. PMID:1409779. |
dopamine, 3,4-dihydroxyphenylacetic acid (dopac), homovanillic acid (hva), norepinephrine, and 5-hydroxyindole-3-acetic acid (5-hiaa) were measured by high-performance liquid chromatography 15 min after right or left intracarotid infusion of haloperidol. |
1992-11-18 |
2023-08-11 |
rat |
| J F Hyde, T P Jeruss. Bilateral neurochemical changes induced by unilateral cerebral haloperidol administration: evidence for cerebral asymmetry in the rat. Pharmacology, biochemistry, and behavior. vol 42. issue 3. 1992-11-18. PMID:1409779. |
dopamine levels were significantly lower in the left striatum and right olfactory tubercle after intravenous haloperidol infusions. |
1992-11-18 |
2023-08-11 |
rat |
| J F Hyde, T P Jeruss. Bilateral neurochemical changes induced by unilateral cerebral haloperidol administration: evidence for cerebral asymmetry in the rat. Pharmacology, biochemistry, and behavior. vol 42. issue 3. 1992-11-18. PMID:1409779. |
these data indicate that unilateral cerebral administration of haloperidol induces asymmetric and side-dependent alterations in dopamine and serotonin metabolites. |
1992-11-18 |
2023-08-11 |
rat |
| R Williams, S F Ali, F M Scalzo, K Soliman, R R Holso. Prenatal haloperidol exposure: effects on brain weights and caudate neurotransmitter levels in rats. Brain research bulletin. vol 29. issue 3-4. 1992-11-16. PMID:1356601. |
to assess the role of dopamine in prenatal neurological development of the rat, haloperidol (hal) was given in daily 2.5 or 5 mg/kg sc doses to dams over gestational days 6 to 20. |
1992-11-16 |
2023-08-11 |
rat |