| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J A Stivers, M T Kaltwasser, P S Hill, V J Hruby, J N Crawle. Ventral tegmental oxytocin induces grooming. Peptides. vol 9 Suppl 1. 1993-06-21. PMID:2856647. |
systemic pretreatment with haloperidol and sch 23390 effectively blocked grooming induced by oxy in the vta, suggesting that oxy is directly stimulating oxy receptors on vta neurons to release dopamine at postsynaptic sites regulating grooming behaviors. |
1993-06-21 |
2023-08-11 |
rat |
| T Akai, M Yamaguchi, E Mizuta, S Kun. Effects of terguride, a partial D2 agonist, on MPTP-lesioned parkinsonian cynomolgus monkeys. Annals of neurology. vol 33. issue 5. 1993-06-21. PMID:8098931. |
behavioral effects of terguride, a partial dopamine d2 agonist, on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-lesioned parkinsonian cynomolgus monkeys were compared with those of the dopamine agonist apomorphine and the dopamine antagonist haloperidol. |
1993-06-21 |
2023-08-12 |
monkey |
| A C McCreary, C A Marsde. Cocaine-induced behaviour: dopamine D1 receptor antagonism by SCH 23390 prevents expression of conditioned sensitisation following repeated administration of cocaine. Neuropharmacology. vol 32. issue 4. 1993-06-21. PMID:8497339. |
the potentiation of the effects of cocaine by a small dose of haloperidol may indicate increased release of dopamine due to blockade of pre-synaptic d2 autoreceptors. |
1993-06-21 |
2023-08-12 |
Not clear |
| E Tanaka, M Mishima, K Kawakami, N Sakai, N Sugiura, T Taniguchi, K Kun. N-isopropyl-p-iodoamphetamine receptors in normal and cancerous tissue of the human lung. European journal of nuclear medicine. vol 20. issue 4. 1993-06-11. PMID:8387920. |
the ic50 values of various amines were as follows: imp, 9 x 10(-5) m; propranolol, 5 x 10(-4) m; haloperidol, 6 x 10(-4) m; ketamine, 9 x 10(-3) m; dopamine, 1 x 10(-2) m. the imp receptors of cancerous tissue obtained from human lung also had two binding sites with kd values of 54 +/- 2 and 5277 +/- 652 nm and bmax values of 7 +/- 1 and 103 +/- 21 pmol/mg protein (n = 3) respectively. |
1993-06-11 |
2023-08-12 |
human |
| G Chouinard, B Jones, G Remington, D Bloom, D Addington, G W MacEwan, A Labelle, L Beauclair, W Arnot. A Canadian multicenter placebo-controlled study of fixed doses of risperidone and haloperidol in the treatment of chronic schizophrenic patients. Journal of clinical psychopharmacology. vol 13. issue 1. 1993-06-10. PMID:7683702. |
in a double-blind study, 135 inpatients with a diagnosis of chronic schizophrenia were randomly assigned to 8 weeks of treatment with one of six parallel treatments: risperidone (a new central 5-hydroxytryptamine2 and dopamine d2 antagonist), 2, 6, 10, 16 mg/day; haloperidol, 20 mg/day; or placebo, after a single-blind placebo washout period. |
1993-06-10 |
2023-08-12 |
Not clear |
| P J Brent, L A Chah. Enhancement of the opiate withdrawal response by antipsychotic drugs in guinea-pigs is not mediated by sigma binding sites. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 3. issue 1. 1993-05-20. PMID:8097127. |
haloperidol, a 'typical' neuroleptic, with affinity for both dopamine (da) receptors and sigma binding sites, exacerbates morphine withdrawal in guinea-pigs. |
1993-05-20 |
2023-08-12 |
Not clear |
| S J Chrapusta, F Karoum, M F Egan, R J Wyat. Haloperidol and clozapine increase intraneuronal dopamine metabolism, but not gamma-butyrolactone-resistant dopamine release. European journal of pharmacology. vol 233. issue 1. 1993-05-19. PMID:8472742. |
haloperidol and clozapine increase intraneuronal dopamine metabolism, but not gamma-butyrolactone-resistant dopamine release. |
1993-05-19 |
2023-08-12 |
rat |
| S J Chrapusta, F Karoum, M F Egan, R J Wyat. Haloperidol and clozapine increase intraneuronal dopamine metabolism, but not gamma-butyrolactone-resistant dopamine release. European journal of pharmacology. vol 233. issue 1. 1993-05-19. PMID:8472742. |
following acute and chronic haloperidol or clozapine treatment, gamma-butyrolactone was given to block dopamine neuronal impulse flow. |
1993-05-19 |
2023-08-12 |
rat |
| B S Neal-Beliveau, J N Joyce, I Luck. Serotonergic involvement in haloperidol-induced catalepsy. The Journal of pharmacology and experimental therapeutics. vol 265. issue 1. 1993-05-18. PMID:8386235. |
the ability of serotonin (5-ht)-selective compounds to reverse catalepsy due to blockade of dopamine (da) receptors was examined in rats treated with the antipsychotic haloperidol (hal). |
1993-05-18 |
2023-08-12 |
rat |
| P Blier, A Lista, C De Montign. Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: I. Effect of spiperone. The Journal of pharmacology and experimental therapeutics. vol 265. issue 1. 1993-05-18. PMID:8474032. |
haloperidol and ketanserin (5 mg/kg, i.p., 24 h before the experiment) were ineffective in blocking the responsiveness of ca3 pyramidal neurons to 5-ht, thereby demonstrating that the dopamine d2 and 5-ht2 properties of spiperone could not account for the attenuated responsiveness of the hippocampus neurons to 5-ht. |
1993-05-18 |
2023-08-12 |
rat |
| M Ukai, E Mori, T Kameyam. Discriminative stimulus properties of cocaine in the rat using a two-choice discrete-trial avoidance paradigm. Pharmacology, biochemistry, and behavior. vol 44. issue 4. 1993-05-11. PMID:8097045. |
haloperidol (0.1 and 0.3 mg/kg), the d1 dopamine antagonist 7-chloro-2,3,4,5-tetrahydro-3-methyl-phenyl-1-h-benzazepine-7-ol maleate (sch23390) (0.01-0.3 mg/kg), and the d2 dopamine antagonist s(-)-sulpiride (20.0 and 40.0 mg/kg) only partially blocked the stimulus effects of cocaine. |
1993-05-11 |
2023-08-12 |
rat |
| T Yamamoto, M Ohno, K Sugimachi, S Uek. Discriminative stimulus properties of NIK-247 and tetrahydroaminoacridine, centrally active cholinesterase inhibitors, in rats. Pharmacology, biochemistry, and behavior. vol 44. issue 4. 1993-05-11. PMID:8469688. |
however, neither the nik-247 nor the tha stimulus was antagonized by the dopamine antagonists haloperidol, sch 23390, and sulpiride. |
1993-05-11 |
2023-08-12 |
rat |
| F I Tarazi, O Shirakawa, C A Tamming. Low dose raclopride spares the extrapyramidal system in rat brain from metabolic effects. European journal of pharmacology. vol 232. issue 1. 1993-04-29. PMID:8096189. |
the effect of a highly selective dopamine d2 receptor antagonist, raclopride ((-)-(s)-3,5-dichloro-n-(1-ethyl-2-pyrrolidinyl) methyl-6-methoxysalicylamide tartrate), on regional cerebral glucose metabolism in rat brain was determined using [14c]2-deoxyglucose autoradiography, and compared to a typical neuroleptic, haloperidol. |
1993-04-29 |
2023-08-12 |
rat |
| S Yamada, H Yokoo, S Nish. Chronic treatment with haloperidol modifies the sensitivity of autoreceptors that modulate dopamine release in rat striatum. European journal of pharmacology. vol 232. issue 1. 1993-04-29. PMID:8458389. |
chronic treatment with haloperidol modifies the sensitivity of autoreceptors that modulate dopamine release in rat striatum. |
1993-04-29 |
2023-08-12 |
rat |
| S Yamada, H Yokoo, S Nish. Chronic treatment with haloperidol modifies the sensitivity of autoreceptors that modulate dopamine release in rat striatum. European journal of pharmacology. vol 232. issue 1. 1993-04-29. PMID:8458389. |
the effects of apomorphine or sulpiride on electrically evoked dopamine release from striatal slices of rats pretreated with haloperidol were investigated. |
1993-04-29 |
2023-08-12 |
rat |
| S Yamada, H Yokoo, S Nish. Chronic treatment with haloperidol modifies the sensitivity of autoreceptors that modulate dopamine release in rat striatum. European journal of pharmacology. vol 232. issue 1. 1993-04-29. PMID:8458389. |
chronic haloperidol treatment (1 mg/kg per day for 21 days) significantly reduced electrically evoked dopamine release from striatal slices until 72 h after the last injection. |
1993-04-29 |
2023-08-12 |
rat |
| S Yamada, H Yokoo, S Nish. Chronic treatment with haloperidol modifies the sensitivity of autoreceptors that modulate dopamine release in rat striatum. European journal of pharmacology. vol 232. issue 1. 1993-04-29. PMID:8458389. |
the apomorphine-induced reduction and the sulpiride-induced increase in evoked dopamine release were significantly enhanced by the chronic treatment with haloperidol at 72 h after the last injection. |
1993-04-29 |
2023-08-12 |
rat |
| S Yamada, H Yokoo, S Nish. Chronic treatment with haloperidol modifies the sensitivity of autoreceptors that modulate dopamine release in rat striatum. European journal of pharmacology. vol 232. issue 1. 1993-04-29. PMID:8458389. |
these results suggest that an increase in the sensitivity of dopamine autoreceptors due to chronic treatment with haloperidol could partially account for the reduction in dopamine release from striatal slices of rats. |
1993-04-29 |
2023-08-12 |
rat |
| C Evinger, M A Basso, K A Manning, P A Sibony, J J Pellegrini, A K Hor. A role for the basal ganglia in nicotinic modulation of the blink reflex. Experimental brain research. vol 92. issue 3. 1993-04-21. PMID:8454014. |
second, haloperidol, a dopamine (d2) receptor antagonist, blocked the effect of nicotine on the blink reflex. |
1993-04-21 |
2023-08-12 |
rat |
| C Marin, T N Chas. Dopamine D1 receptor stimulation but not dopamine D2 receptor stimulation attenuates haloperidol-induced behavioral supersensitivity and receptor up-regulation. European journal of pharmacology. vol 231. issue 2. 1993-04-20. PMID:8095897. |
the administration of the selective dopamine d1 receptor agonist skf38393 alone or in combination with the selective dopamine d2 receptor agonist quinpirole attenuated the effect of haloperidol. |
1993-04-20 |
2023-08-12 |
rat |