| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Konradi, L A Kobierski, T V Nguyen, S Heckers, S E Hyma. The cAMP-response-element-binding protein interacts, but Fos protein does not interact, with the proenkephalin enhancer in rat striatum. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 15. 1993-09-07. PMID:8346209. |
however, we observe a dissociation in the time course of activation of c-fos and proenkephalin mrna in rat striatum after administration of the dopamine d2 receptor antagonist haloperidol. |
1993-09-07 |
2023-08-12 |
rat |
| S M Meiergerd, T A Patterson, J O Schen. D2 receptors may modulate the function of the striatal transporter for dopamine: kinetic evidence from studies in vitro and in vivo. Journal of neurochemistry. vol 61. issue 2. 1993-08-24. PMID:8336153. |
in separate studies it was shown that acute and chronic treatments with haloperidol at 0.5 mg/kg, i.p., reduced the reuptake transport of dopamine in vivo following intrastriatal stimulation of its release by k+. |
1993-08-24 |
2023-08-12 |
Not clear |
| R Hitzemann, Y Qian, B Hitzeman. Dopamine and acetylcholine cell density in the neuroleptic responsive (NR) and neuroleptic nonresponsive (NNR) lines of mice. The Journal of pharmacology and experimental therapeutics. vol 266. issue 1. 1993-08-19. PMID:8101223. |
the neuroleptic responsive (nr) and neuroleptic nonresponsive (nnr) selected lines of mice differ more than 10-fold in the ed50 for catalepsy induced by a wide variety of neuroleptics with a high dopamine d2/d1 receptor activity ratio, e.g., haloperidol. |
1993-08-19 |
2023-08-12 |
mouse |
| M Dragunow, D Young, P Hughes, G MacGibbon, P Lawlor, K Singleton, E Sirimanne, E Beilharz, P Gluckma. Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain injury? Brain research. Molecular brain research. vol 18. issue 4. 1993-08-12. PMID:8326831. |
activation of central muscarinic receptors with pilocarpine, or block of d2 dopamine receptors with haloperidol, treatments which do not cause neuronal damage, strongly induced fos and jun b in hippocampal and striatal neurons, but only induced c-jun very weakly. |
1993-08-12 |
2023-08-12 |
Not clear |
| T Kubot. Neuroleptic malignant syndrome induced by nemonapride. Acta neurologica. vol 15. issue 2. 1993-08-10. PMID:8328325. |
nemonapride is a highly selective dopamine d-2 antagonist, equivalent to haloperidol. |
1993-08-10 |
2023-08-12 |
Not clear |
| O Kikumoto, Y Okamoto, H Hayakawa, N Yokota, K Kawai, N Motohashi, S Yamawak. [Effects of risperidone on catalepsy and cerebral dopamine, serotonin and GABA metabolism in the rat: comparison with haloperidol]. Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology. vol 13. issue 1. 1993-07-23. PMID:7686319. |
[effects of risperidone on catalepsy and cerebral dopamine, serotonin and gaba metabolism in the rat: comparison with haloperidol]. |
1993-07-23 |
2023-08-12 |
rat |
| J Caboche, P Vernier, M Rogard, M J Besso. Haloperidol increases PPE mRNA levels in the caudal part of the nucleus accumbens in the rat. Neuroreport. vol 4. issue 5. 1993-07-22. PMID:8513136. |
in this study, the effects of an interruption of dopamine transmission by haloperidol (a dopaminergic receptor antagonist) were examined in the rat nucleus accumbens. |
1993-07-22 |
2023-08-12 |
rat |
| B V Kumar, P S Sastr. Dopamine receptors in human foetal brains: characterization, regulation and ontogeny of [3H]spiperone binding sites in striatum. Neurochemistry international. vol 20. issue 4. 1993-07-15. PMID:1304871. |
spiperone binding sites were characterized in a 40-week-old foetal brain to be dopamine receptors by the following criteria: (1) it was localized in a crude mitochondrial pellet that included synaptosomes; (2) binding was saturable at 0.8 nm concentration; (3) dopaminergic antagonists spiperone, haloperidol, pimozide, trifluperazine and chlorpromazine competed for the binding with ic50 values in the range of 0.3-14 nm while agonists--apomorphine and dopamine gave ic50 values of 2.5 and 10 microm, respectively suggesting a d2 type receptor. |
1993-07-15 |
2023-08-11 |
human |
| B Levant, E B DeSouz. Differential pharmacological profile of striatal and cerebellar dopamine receptors labeled by [3H]quinpirole: identification of a discrete population of putative D3 receptors. Synapse (New York, N.Y.). vol 14. issue 1. 1993-07-15. PMID:8099762. |
spiperone, haloperidol, (+)butaclamol, and clozapine were more potent in competing for [3h]quinpirole binding at striatal dopamine receptors than cerebellar receptors by 83-, 59-, 11-, and 6-fold, respectively. |
1993-07-15 |
2023-08-12 |
Not clear |
| G Pelletie. Regulation of proopiomelanocortin gene expression in rat brain and pituitary as studied by in situ hybridization. Annals of the New York Academy of Sciences. vol 680. 1993-07-15. PMID:8512219. |
the role of dopamine was investigated following the administration of the dopaminergic antagonist haloperidol and the d2 dopaminergic receptor agonist bromocriptine. |
1993-07-15 |
2023-08-12 |
rat |
| T I Lidsky, S P Banerje. Acute administration of haloperidol enhances dopaminergic transmission. The Journal of pharmacology and experimental therapeutics. vol 265. issue 3. 1993-07-14. PMID:8389855. |
it has been demonstrated that haloperidol, by blocking presynaptic d2 receptors, enhances dopamine release. |
1993-07-14 |
2023-08-12 |
rat |
| T I Lidsky, S P Banerje. Acute administration of haloperidol enhances dopaminergic transmission. The Journal of pharmacology and experimental therapeutics. vol 265. issue 3. 1993-07-14. PMID:8389855. |
substantia nigra lesions that depleted striatal dopamine blocked the suppressive effects of haloperidol. |
1993-07-14 |
2023-08-12 |
rat |
| B R Shivakumar, V Ravindranat. Oxidative stress and thiol modification induced by chronic administration of haloperidol. The Journal of pharmacology and experimental therapeutics. vol 265. issue 3. 1993-07-14. PMID:8509999. |
haloperidol, a widely used neuroleptic, acts through blockade of dopamine receptors leading to increased turnover of dopamine. |
1993-07-14 |
2023-08-12 |
rat |
| B R Shivakumar, V Ravindranat. Oxidative stress and thiol modification induced by chronic administration of haloperidol. The Journal of pharmacology and experimental therapeutics. vol 265. issue 3. 1993-07-14. PMID:8509999. |
administration of haloperidol leads to development of tolerance (supersensitivity of the dopamine autoreceptors) to neuroleptics, which is associated with decreased turnover of dopamine; this may result in overcoming the oxidative stress generated initially due to increased dopamine turnover. |
1993-07-14 |
2023-08-12 |
rat |
| I Sora, Y Fujiwara, H Tomita, H Ishizu, K Akiyama, S Otsuki, H I Yamamur. Lack of effect of haloperidol or methamphetamine treatment on the mRNA levels of two dopamine D2 receptor isoforms in rat brain. The Japanese journal of psychiatry and neurology. vol 46. issue 4. 1993-07-07. PMID:1304623. |
lack of effect of haloperidol or methamphetamine treatment on the mrna levels of two dopamine d2 receptor isoforms in rat brain. |
1993-07-07 |
2023-08-11 |
rat |
| A K Ball, W H Baldridge, T C Fernbac. Neuromodulation of pigment movement in the RPE of normal and 6-OHDA-lesioned goldfish retinas. Visual neuroscience. vol 10. issue 3. 1993-06-24. PMID:8494804. |
the effect of light, dopamine, or serotonin on dark-adapted retinas was blocked by the dopamine receptor antagonists haloperidol and sulpiride. |
1993-06-24 |
2023-08-12 |
Not clear |
| A K Ball, W H Baldridge, T C Fernbac. Neuromodulation of pigment movement in the RPE of normal and 6-OHDA-lesioned goldfish retinas. Visual neuroscience. vol 10. issue 3. 1993-06-24. PMID:8494804. |
dopamine and serotonin mimicked the effect of light when injected into lesioned dark-adapted eyes, but their effects were also not blocked by haloperidol or sulpiride. |
1993-06-24 |
2023-08-12 |
Not clear |
| I Panocka, P Pompei, M Mass. Suppression of alcohol preference in rats induced by risperidone, a serotonin 5-HT2 and dopamine D2 receptor antagonist. Brain research bulletin. vol 31. issue 5. 1993-06-22. PMID:7684315. |
risperidone (10 mg/kg) evoked an inhibitory effect on alcohol preference similar (rapid onset, but short duration) to that observed after treatment with the dopamine d2 receptor antagonist haloperidol, 0.0625 mg/kg, sc. |
1993-06-22 |
2023-08-12 |
rat |
| E W Karbon, M E Abreu, R H Erickson, C Kaiser, K J Natalie, D B Clissold, S Borosky, M Bailey, L A Martin, M J Pontecorv. NPC 16377, a potent and selective sigma-ligand. I. Receptor binding, neurochemical and neuroendocrine profile. The Journal of pharmacology and experimental therapeutics. vol 265. issue 2. 1993-06-22. PMID:8388461. |
unlike haloperidol, bmy 14802, ifenprodil and clozapine, behaviorally effective doses of npc 16377 did not increase dopamine turnover in the frontal cortex, nucleus accumbens or corpus striatum of rats. |
1993-06-22 |
2023-08-12 |
rat |
| J A Stivers, M T Kaltwasser, P S Hill, V J Hruby, J N Crawle. Ventral tegmental oxytocin induces grooming. Peptides. vol 9 Suppl 1. 1993-06-21. PMID:2856647. |
the dopamine d-2 receptor antagonist, haloperidol, and the d-1 receptor antagonist, sch 23390, when microinjected into the vta five minutes before microinjection of oxy into the vta, did not block oxy-induced grooming, suggesting that oxy is not working through a dopamine autoreceptor on the vta neurons. |
1993-06-21 |
2023-08-11 |
rat |