| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J C Jaen, B W Caprathe, T A Pugsley, L D Wise, H Akunn. Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and sigma receptors. Journal of medicinal chemistry. vol 36. issue 24. 1994-01-11. PMID:7902870. |
following parenteral administration of both enantiomers of 3a, dopamine synthesis and turnover in rat striatum, cortex, and mesolimbic areas were increased, in a manner similar to the effects produced by haloperidol itself. |
1994-01-11 |
2023-08-12 |
rat |
| R Day, M K Schäfer, M W Collard, E Weihe, H Aki. Prodynorphin gene expression in the rat intermediate pituitary lobe: gender differences and postpartum regulation. Endocrinology. vol 133. issue 6. 1994-01-06. PMID:8243288. |
intermediate lobe prodyn gene expression was not regulated by dopamine, in contrast to intermediate lobe pomc mrna levels, which were increased with haloperidol and decreased with bromocriptine treatment, as expected. |
1994-01-06 |
2023-08-12 |
rat |
| J Ułas, L Nguyen, C W Cotma. Chronic haloperidol treatment enhances binding to NMDA receptors in rat cortex. Neuroreport. vol 4. issue 8. 1993-12-27. PMID:7902135. |
our data suggest that haloperidol may exert its antipsychotic effects by enhancement of glutamatergic functions as well as by the blockade of dopamine receptors. |
1993-12-27 |
2023-08-12 |
rat |
| S O Ogren, J Lundström, L B Nilsson, M Widma. Dopamine D2 blocking activity and plasma concentrations of remoxipride and its main metabolites in the rat. Journal of neural transmission. General section. vol 93. issue 3. 1993-12-21. PMID:8217058. |
remoxipride and its active metabolites, the phenolic compounds fla797(-) and fla908(-) and the catecholic ncq436(-) and haloperidol, were examined for their ability to block hypothermia in the rat induced by dopamine (da) d2 receptor stimulation. |
1993-12-21 |
2023-08-12 |
rat |
| P G Osborne, N Mataga, H Onoe, Y Watanab. Behavioral activation by stimulation of a GABAergic mechanism in the preoptic area of rat. Neuroscience letters. vol 158. issue 2. 1993-12-14. PMID:8233095. |
the gaba agonist, muscimol (10, 20 and 100 microm) induced a dose-dependent increase in locomotor activity and grooming which was attenuated by co-perfusion with the gaba antagonist, bicuculline (10 microm), and was blocked by systemic injection of haloperidol, a preferential dopamine d2 receptor antagonist (0.25 mg/kg). |
1993-12-14 |
2023-08-12 |
rat |
| Y Maruoka, Y Ohno, T Kato, A Hirose, T Tatsuno, M Nakamur. Effects of SM-9018, a potential atypical neuroleptic, on the central monoaminergic system in rats. Japanese journal of pharmacology. vol 62. issue 4. 1993-12-10. PMID:7901446. |
the sm-9018-induced increase of dopamine (da) turnover, as indexed by hva/da and dopac/da ratios, was comparable in the cerebral cortex and striatum, whereas the typical neuroleptic haloperidol preferentially enhanced the striatal da turnover. |
1993-12-10 |
2023-08-12 |
rat |
| S A Wolfe, E B De Souz. Sigma and phencyclidine receptors in the brain-endocrine-immune axis. NIDA research monograph. vol 133. 1993-12-10. PMID:8232518. |
furthermore, the immunologic and endocrine effects of neuroleptics such as haloperidol, which have previously been attributed primarily to actions at d2 dopamine receptors, may also be mediated via sigma receptors in brain, lymphoid, and endocrine organs. |
1993-12-10 |
2023-08-12 |
rat |
| H Saji, Y Yonekura, K Tanahashi, Y Iida, Y Iwasaki, Y Magata, J Konishi, A Yokoyam. Myocardial accumulation of a dopamine D2 receptor-binding radioligand, 2'-iodospiperone. Annals of nuclear medicine. vol 7. issue 3. 1993-12-03. PMID:7692910. |
treatment with haloperidol and (+) butaclamol, which have a high affinity for dopamine d2 receptors, also tended to reduce the myocardial uptake of radioactivity, while (-)-butaclamol, which has no affinity for dopamine d2 receptors, caused no change in uptake. |
1993-12-03 |
2023-08-12 |
mouse |
| A A Larson, X Su. Regulation of sigma activity by the amino-terminus of substance P in the mouse spinal cord: involvement of phencyclidine (PCP) sites not linked to N-methyl-D-aspartate (NMDA) activity. Neuropharmacology. vol 32. issue 9. 1993-12-03. PMID:7694172. |
we compared the effect of a pcp ligand, dizocilpine (mk-801), to that of haloperidol, a sigma ligand and dopamine antagonist. |
1993-12-03 |
2023-08-12 |
mouse |
| A A Larson, X Su. Regulation of sigma activity by the amino-terminus of substance P in the mouse spinal cord: involvement of phencyclidine (PCP) sites not linked to N-methyl-D-aspartate (NMDA) activity. Neuropharmacology. vol 32. issue 9. 1993-12-03. PMID:7694172. |
like sp(1-7), 5 nmol of the sigma ligand 1,3-di(2-tolyl)guanidine (dtg) also enhanced behaviors elicited by ka, and this effect was also blocked by haloperidol or d-sp(1-7), but not spiperone (2.5 nmol), a dopamine antagonist. |
1993-12-03 |
2023-08-12 |
mouse |
| P R Buckland, M C O'Donovan, P McGuffi. Clozapine and sulpiride up-regulate dopamine D3 receptor mRNA levels. Neuropharmacology. vol 32. issue 9. 1993-12-03. PMID:7901792. |
we have previously shown that the typical antipsychotics haloperidol and loxapine also increased the mrna levels of the dopamine d3 receptor and these results suggest that up-regulation of dopamine d3 receptor mrna may be associated with the therapeutic action of antipsychotic drugs. |
1993-12-03 |
2023-08-12 |
rat |
| M H Teicher, N I Barber, H A Gelbard, A L Gallitano, A Campbell, E Marsh, R J Baldessarin. Developmental differences in acute nigrostriatal and mesocorticolimbic system response to haloperidol. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 9. issue 2. 1993-12-01. PMID:8216697. |
dose-dependent effects of haloperidol (2.66 nmol/kg to 79.8 mmol/kg, ip) on levels of dopamine, homovanillic acid (hva) and dihydroxyphenylacetic acid (dopac) were assessed in the corpus striatum, nucleus accumbens, and medial prefrontal cortex (pfctx) of 18-, 30-, and 110-day-old rats. |
1993-12-01 |
2023-08-12 |
rat |
| P Mailleux, J J Vanderhaeghe. Dopaminergic regulation of cannabinoid receptor mRNA levels in the rat caudate-putamen: an in situ hybridization study. Journal of neurochemistry. vol 61. issue 5. 1993-11-29. PMID:7901331. |
in a second set of experiments, treatments with the dopamine d1 receptor antagonist sch-23390, haloperidol, and the d2 receptor antagonist sulpiride induced significantly higher cannabinoid receptor mrna levels (respectively, 67, 34, and 27%) in the caudate-putamen. |
1993-11-29 |
2023-08-12 |
rat |
| S J Kanes, B A Hitzemann, R J Hitzeman. On the relationship between D2 receptor density and neuroleptic-induced catalepsy among eight inbred strains of mice. The Journal of pharmacology and experimental therapeutics. vol 267. issue 1. 1993-11-29. PMID:7901398. |
as measured by quantitative receptor autoradiography, the haloperidol ed50 shows a significant positive correlation with [3h]spiroperidol binding to somatodendritic autoreceptors in the midbrain dopamine cell groups (a8, a9 and a10), but not with binding in the striatum. |
1993-11-29 |
2023-08-12 |
mouse |
| H H Garza, S Mayo, W D Bowen, B R DeCosta, D J Car. Characterization of a (+)-azidophenazocine-sensitive sigma receptor on splenic lymphocytes. Journal of immunology (Baltimore, Md. : 1950). vol 151. issue 9. 1993-11-17. PMID:7691955. |
radioreceptor assays under reduced lighting show (+)-azidophenazocine can effectively block the binding of sigma ligands [3h]haloperidol (ic50 = 30 nm, ki = 19.0 nm) and [3h](+)-pentazocine (ic50 = 40 nm, ki = 350 nm), but not the dopamine (d2) ligand [3h]spiperone (ic50 > 5 microm) to splenic lymphocytes. |
1993-11-17 |
2023-08-12 |
Not clear |
| B Moghaddam, B S Bunne. Depolarization inactivation of dopamine neurons: terminal release characteristics. Synapse (New York, N.Y.). vol 14. issue 3. 1993-11-12. PMID:8105547. |
the functional consequences of chronic treatment with haloperidol (0.5 mg/kg s.c. for 21-23 days) on striatal extracellular levels of dopamine and excitatory amino acids, aspartate and glutamate, were examined using microdialysis techniques. |
1993-11-12 |
2023-08-12 |
Not clear |
| B Moghaddam, B S Bunne. Depolarization inactivation of dopamine neurons: terminal release characteristics. Synapse (New York, N.Y.). vol 14. issue 3. 1993-11-12. PMID:8105547. |
our studies indicate that, in both awake and anesthetized animals, chronic haloperidol treatment does not appear to change basal outflow of dopamine and its response to an exogenous antagonist (i.e., a challenge dose of haloperidol). |
1993-11-12 |
2023-08-12 |
Not clear |
| B Moghaddam, B S Bunne. Depolarization inactivation of dopamine neurons: terminal release characteristics. Synapse (New York, N.Y.). vol 14. issue 3. 1993-11-12. PMID:8105547. |
furthermore, in chronic haloperidol and vehicle-treated animals, extracellular dopamine levels were decreased below our limit of detection following perfusion of tetrodotoxin through the probe, or into the medial forebrain bundle, suggesting that in both groups of animals extracellular dopamine levels are neuronally derived and seemed to depend equally on impulse flow. |
1993-11-12 |
2023-08-12 |
Not clear |
| B Moghaddam, B S Bunne. Depolarization inactivation of dopamine neurons: terminal release characteristics. Synapse (New York, N.Y.). vol 14. issue 3. 1993-11-12. PMID:8105547. |
however, some differences were observed between the vehicle and haloperidol-treated animals: the excitatory action of 30 mm k+ on extracellular dopamine levels was decreased, and extracellular levels of glutamate were significantly increased, in animals treated chronically with haloperidol. |
1993-11-12 |
2023-08-12 |
Not clear |
| L S Leung, C Y Yi. Rhythmic delta-frequency activities in the nucleus accumbens of anesthetized and freely moving rats. Canadian journal of physiology and pharmacology. vol 71. issue 5-6. 1993-11-10. PMID:8104675. |
however, stimulation of the ventral tegmental area suppressed the accumbens delta membrane potential oscillations and eeg, and this effect was antagonized by haloperidol, suggesting that endogenous dopamine release may suppress the accumbens delta rhythm. |
1993-11-10 |
2023-08-12 |
rat |