| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sabine Kagerer, Catja Winter, Hans-Jürgen Möller, Michael Soyk. Effects of haloperidol and atypical neuroleptics on psychomotor performance and driving ability in schizophrenic patients. Results from an experimental study. Neuropsychobiology. vol 47. issue 4. 2003-08-08. PMID:12824745. |
the present study was designed to evaluate the effects of atypical neuroleptics in comparison with a conventional dopamine antagonist neuroleptic (haloperidol) on several dimensions of psychomotor performance (visual perception, attention, reaction time, and sensorimotor performance) considered to be of relevance in evaluating driving fitness. |
2003-08-08 |
2023-08-12 |
human |
| S E McCormick, A J Stoess. Central administration of the neurotensin receptor antagonist SR48692 attenuates vacuous chewing movements in a rodent model of tardive dyskinesia. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770567. |
chronic treatment with the typical antipsychotic haloperidol elicits neurotensin immunoreactivity in a large number of striatopallidal and a modest number of striatonigral projection neurons, whilst treatment with the potent dopamine releaser, methamphetamine, induces intense neurotensin immunoreactivity in striatonigral projection neurons. |
2003-07-30 |
2023-08-12 |
Not clear |
| Craig R Rush, William W Stoops, Lon R Hays, Paul E A Glaser, Lon S Hay. Risperidone attenuates the discriminative-stimulus effects of d-amphetamine in humans. The Journal of pharmacology and experimental therapeutics. vol 306. issue 1. 2003-07-24. PMID:12676890. |
future studies should compare the behavioral effects of d-amphetamine after pretreatment with a selective d2 dopamine (e.g., haloperidol) or 5-ht2 serotonin (e.g., ritanserin) antagonist to determine the relative contribution of dopamine and serotonin systems in mediating the behavioral effects of stimulants in humans. |
2003-07-24 |
2023-08-12 |
Not clear |
| S Kähkönen, J Ahvenine. Combination of magneto- and electroencephalography in studies of monoamine modulation on attention. Methods and findings in experimental and clinical pharmacology. vol 24 Suppl C. 2003-07-10. PMID:12575485. |
this component can be modulated with drugs affecting dopamine transmission in the brain, such as haloperidol and droperidol, whereas no effects seem to be caused by acute tryptophan depletion (atd), decreasing serotonin synthesis in the brain. |
2003-07-10 |
2023-08-12 |
human |
| Smita Patel, Kerry L Chapman, Deborah Marston, Peter H Hutson, C Ian Raga. Pharmacological and functional characterisation of dopamine D4 receptors in the rat retina. Neuropharmacology. vol 44. issue 8. 2003-07-08. PMID:12763097. |
quinpirole (0.03-3 micro ) produced a dose-related decrease of the light sensitive camp pool which was reversed by haloperidol, clozapine and the d4 selective antagonist, l-745870 with a rank order of potency suggesting that the quinpirole effect is due to activation of the dopamine d4 receptors. |
2003-07-08 |
2023-08-12 |
rat |
| A Klein, W J Schmid. Catalepsy intensifies context-dependently irrespective of whether it is induced by intermittent or chronic dopamine deficiency. Behavioural pharmacology. vol 14. issue 1. 2003-07-02. PMID:12576881. |
in both experiments we found a very stable intensification of catalepsy over 9 (haloperidol rats) and 11 (lesioned rats) days, showing that intensification is not due to intermittent dopamine depletion. |
2003-07-02 |
2023-08-12 |
rat |
| Hans O Kalkman, Erika Loetsche. alpha2C-Adrenoceptor blockade by clozapine and other antipsychotic drugs. European journal of pharmacology. vol 462. issue 1-3. 2003-07-02. PMID:12591093. |
therefore, the antagonistic potencies of the antipsychotics clozapine, chlorpromazine, risperidone, olanzapine, haloperidol, quetiapine, ziprasidone, iloperidone and aripiprazole were quantified using cell lines expressing the recombinant human alpha(2c)-adrenoceptor, alpha(2a)-adrenoceptor, or dopamine d(2l) receptor. |
2003-07-02 |
2023-08-12 |
human |
| Hans O Kalkman, Erika Loetsche. alpha2C-Adrenoceptor blockade by clozapine and other antipsychotic drugs. European journal of pharmacology. vol 462. issue 1-3. 2003-07-02. PMID:12591093. |
yohimbine and idazoxan were the most potent alpha(2a)-adrenoceptor antagonists, yohimbine and iloperidone were the most potent alpha(2c)-adrenoceptor antagonists, and haloperidol and olanzapine were the most potent dopamine d(2) receptor antagonists. |
2003-07-02 |
2023-08-12 |
human |
| Yushi U Adachi, Yoshihiko Aramaki, Maiko Satomoto, Hideyuki Higuchi, Kazuhiko Watanab. Halothane attenuated haloperidol and enhanced clozapine-induced dopamine release in the rat striatum. Neurochemistry international. vol 43. issue 2. 2003-06-13. PMID:12620279. |
halothane attenuated haloperidol and enhanced clozapine-induced dopamine release in the rat striatum. |
2003-06-13 |
2023-08-12 |
rat |
| Zhuo Yang, Mark Wheatley, John H Coot. Neuropeptides, amines and amino acids as mediators of the sympathetic effects of paraventricular nucleus activation in the rat. Experimental physiology. vol 87. issue 6. 2003-06-11. PMID:12530399. |
a low dose of dopamine increased renal sympathetic activity and this was selectively antagonised by haloperidol; however, the latter was without effect on pvn excitatory responses. |
2003-06-11 |
2023-08-12 |
rat |
| Roberto W Invernizzi, Claudio Garavaglia, Rosario Samani. The alpha 2-adrenoceptor antagonist idazoxan reverses catalepsy induced by haloperidol in rats independent of striatal dopamine release: role of serotonergic mechanisms. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 5. 2003-06-11. PMID:12644843. |
the alpha 2-adrenoceptor antagonist idazoxan reverses catalepsy induced by haloperidol in rats independent of striatal dopamine release: role of serotonergic mechanisms. |
2003-06-11 |
2023-08-12 |
rat |
| Gerhard Gründer, Ingo Vernaleken, Matthias J Müller, Eugen Davids, Nilufar Heydari, Hans-Georg Buchholz, Peter Bartenstein, Ole L Munk, Peter Stoeter, Dean F Wong, Albert Gjedde, Paul Cummin. Subchronic haloperidol downregulates dopamine synthesis capacity in the brain of schizophrenic patients in vivo. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 4. 2003-05-29. PMID:12655326. |
subchronic haloperidol downregulates dopamine synthesis capacity in the brain of schizophrenic patients in vivo. |
2003-05-29 |
2023-08-12 |
human |
| Junji Ichikawa, Zhu Li, Jin Dai, Herbert Y Meltze. Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism. Brain research. vol 956. issue 2. 2003-04-22. PMID:12445705. |
preferential increases in both cortical dopamine (da) and acetylcholine (ach) release have been proposed to distinguish the atypical antipsychotic drugs (apds) clozapine, olanzapine, risperidone and ziprasidone from typical apds such as haloperidol. |
2003-04-22 |
2023-08-12 |
rat |
| N Enginar, P Yamantürk, A Nurten, R Nurten, H Koyuncuoğl. Scopolamine-induced convulsions in fasted mice after food intake: determination of blood glucose levels, [3H]glutamate binding kinetics and antidopaminergic drug effects. Neuropharmacology. vol 44. issue 2. 2003-04-02. PMID:12623218. |
with saline or dopamine antagonists, 2 mg/kg chlorpromazine or 2 or 4 mg/kg haloperidol, were treated 10 min later with either saline or 3 mg/kg scopolamine. |
2003-04-02 |
2023-08-12 |
mouse |
| Izzettin Hatip-Al-Khatib, Funda Bolukbaşi-Hati. Modulation of the negative inotropic effect of haloperidol by drugs with positive inotropic effects in isolated rabbit heart. Pharmacology. vol 66. issue 1. 2003-03-26. PMID:12169761. |
haloperidol is a typical antipsychotic drug with inhibitory effects on dopamine and calcium homeostasis. |
2003-03-26 |
2023-08-12 |
rabbit |
| Izzettin Hatip-Al-Khatib, Funda Bolukbaşi-Hati. Modulation of the negative inotropic effect of haloperidol by drugs with positive inotropic effects in isolated rabbit heart. Pharmacology. vol 66. issue 1. 2003-03-26. PMID:12169761. |
the effect of haloperidol was also reduced by norepinephrine (e(max) = 37.16 +/- 1.84; ec(50) = 1.73 +/- 0.24 micromol/l, pd'(2) = 6.97 +/- 0.08) and dopamine (e(max) = 35.68 +/- 2.78; ec(50) = 0.69 +/- 0.01 micromol/l, pd'(2 )7.48 +/- 0.15). |
2003-03-26 |
2023-08-12 |
rabbit |
| Brian M Ross, Robert J Brooks, Margaret Lee, Kathryn S Kalasinsky, Shawn P Vorce, Mary Seeman, Paul J Fletcher, Sylvie D Turenn. Cyclooxygenase inhibitor modulation of dopamine-related behaviours. European journal of pharmacology. vol 450. issue 2. 2003-03-24. PMID:12206852. |
both drugs inhibited catalepsy induced by the dopamine d1-like receptor antagonist r(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine (sch23390), the dopamine d2-like receptor antagonist raclopride and by haloperidol, findings in agreement with a dopaminergic effect of cyclooxygenase inhibitors. |
2003-03-24 |
2023-08-12 |
rat |
| b' Iu A Andreeva, V S Kudrin, K S Raevski\\xc4\\xa. [Effect of 17beta-estradiol on haloperidol effects in Wistar rats]. Eksperimental\'naia i klinicheskaia farmakologiia. vol 65. issue 6. 2003-03-24. PMID:12596525.' |
decreased intensity of the haloperidol catalepsy, reduced the haloperidol-induced increase in the dopamine turnover, and decreased the level of dopamine metabolites in nucleus accumbens of both female and male test animals. |
2003-03-24 |
2023-08-12 |
rat |
| Darakshan J Haleem, Farhat Batool, Nadia H Khan, Noor Kamil, Obaid Ali, Zafar S Saify, Mohammad A Halee. Differences in the effects of haloperidol and clozapine on brain serotonin and dopamine metabolism and on tests related to extrapyramidal functions in rats. Medical science monitor : international medical journal of experimental and clinical research. vol 8. issue 9. 2003-03-20. PMID:12218936. |
differences in the effects of haloperidol and clozapine on brain serotonin and dopamine metabolism and on tests related to extrapyramidal functions in rats. |
2003-03-20 |
2023-08-12 |
rat |
| Tadashi Ishibashi, Junko Wakabayashi, Yukihiro Ohn. 7-Hydroxy-N,N'-di-n-propyl-2-aminotetraline, a preferential dopamine D3 agonist, induces c-fos mRNA expression in the rat cerebellum. Japanese journal of pharmacology. vol 89. issue 3. 2003-03-12. PMID:12184738. |
the effect of 7-oh-dpat was blocked by two dopamine d2-type-receptor antagonists, haloperidol and perospirone, but not the d1-type-receptor antagonist sch23390. |
2003-03-12 |
2023-08-12 |
rat |