| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Agnès L Auclair, Mark S Kleven, Catherine Barret-Grévoz, Martine Barreto, Adrian Newman-Tancredi, Ronan Depoortèr. Differences among conventional, atypical and novel putative D(2)/5-HT(1A) antipsychotics on catalepsy-associated behaviour in cynomolgus monkeys. Behavioural brain research. vol 203. issue 2. 2009-09-10. PMID:19464324. |
typical antipsychotics such as haloperidol exert their therapeutic effects via blockade of dopamine (da) d(2) receptors, leading to extrapyramidal symptoms (eps) in humans and catalepsy in rodents. |
2009-09-10 |
2023-08-12 |
rat |
| Allison M Mott, Eric J Nunes, Lyndsey E Collins, Russell G Port, Kelly S Sink, Jörg Hockemeyer, Christa E Müller, John D Salamon. The adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedure. Psychopharmacology. vol 204. issue 1. 2009-09-02. PMID:19132351. |
the adenosine a2a antagonist msx-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a t-maze cost/benefit procedure. |
2009-09-02 |
2023-08-12 |
rat |
| Adeline Etievant, Cécile Bétry, Jørn Arnt, Nasser Haddjer. Bifeprunox and aripiprazole suppress in vivo VTA dopaminergic neuronal activity via D2 and not D3 dopamine autoreceptor activation. Neuroscience letters. vol 460. issue 1. 2009-09-01. PMID:19450663. |
moreover, we have also shown that the d(2/3) receptor antagonist haloperidol prevents the inhibitory effects of these antipsychotics, confirming their partial d(2)-like agonistic activities [l. dahan, h. husum, o. mnie-filali, j. arnt, p. hertel, n. haddjeri, effects of bifeprunox and aripiprazole on rat serotonin and dopamine neuronal activity and anxiolytic behaviour, j. psychopharmacol. |
2009-09-01 |
2023-08-12 |
rat |
| C A Wilson, C L Dakin, J A Rico, A Golmohamad, Y Ahmad-Jauhari, D C Davie. The anti-dopaminergic agent, haloperidol, antagonises the feminising effect of neonatal serotonin on sexually dimorphic hypothalamic nuclei and tyrosine hydroxylase immunoreactive neurones. Journal of neuroendocrinology. vol 21. issue 7. 2009-08-31. PMID:19453825. |
to investigate whether the effect of 5-ht is mediated by dopamine and whether testosterone exerts its masculinising effect by reducing 5-ht and dopamine activity, male pups were treated with (-)doi alone or together with the dopamine antagonist, haloperidol, over days 8-16 post partum, whereas females were treated with testosterone propionate on day 2 post partum. |
2009-08-31 |
2023-08-12 |
rat |
| C A Wilson, C L Dakin, J A Rico, A Golmohamad, Y Ahmad-Jauhari, D C Davie. The anti-dopaminergic agent, haloperidol, antagonises the feminising effect of neonatal serotonin on sexually dimorphic hypothalamic nuclei and tyrosine hydroxylase immunoreactive neurones. Journal of neuroendocrinology. vol 21. issue 7. 2009-08-31. PMID:19453825. |
the findings that th-ir neurone number and dopamine activity are greater in the female avpv; the feminising effect of 5-ht is prevented by a haloperidol; and the masculinising effect of testosterone propionate is accompanied by a decrease in th-ir neurone number and dopamine concentration in the female avpv, suggest that dopamine is involved in hypothalamic sexual differentiation and may mediate the effect of 5-ht. |
2009-08-31 |
2023-08-12 |
rat |
| Shrinivas K Kulkarni, Mahendra Bishnoi, Kanwaljit Chopr. In vivo microdialysis studies of striatal level of neurotransmitters after haloperidol and chlorpromazine administration. Indian journal of experimental biology. vol 47. issue 2. 2009-08-27. PMID:19374163. |
this study was planned to investigate changes in striatal levels of norepinephrine, dopamine and serotonin after acute and chronic administration of classical neuroleptics (haloperidol and chlorpromazine). |
2009-08-27 |
2023-08-12 |
rat |
| D A De Steno, C Schmaus. A role for dopamine D2 receptors in reversal learning. Neuroscience. vol 162. issue 1. 2009-08-25. PMID:19401217. |
here we show that mice lacking dopamine d2 receptors exhibited significantly impaired performance in the reversal learning phase of an attention-set-shifting task (asst) and that wild type mice treated chronically with the d2-like receptor antagonist haloperidol exhibited the same cognitive deficit. |
2009-08-25 |
2023-08-12 |
mouse |
| Yong Liu, Changping Hu, Yamei Tang, Jindong Chen, Min Dong, Tao Song, Xianghui Zhang, Jingping Zha. Clozapine inhibits strychnine-sensitive glycine receptors in rat hippocampal neurons. Brain research. vol 1278. 2009-08-18. PMID:19409375. |
in addition, clo inhibition of i(gly) was not influenced by blocking d(1) and d(2) dopamine receptors with haloperidol (hal). |
2009-08-18 |
2023-08-12 |
rat |
| Mariana Bendlin Calzavara, Wladimir Agostini Medrano, Raquel Levin, Sonia Regina Kameda, Monica Levy Andersen, Sergio Tufik, Regina Helena Silva, Roberto Frussa-Filho, Vanessa Costhek Abíli. Neuroleptic drugs revert the contextual fear conditioning deficit presented by spontaneously hypertensive rats: a potential animal model of emotional context processing in schizophrenia? Schizophrenia bulletin. vol 35. issue 4. 2009-08-06. PMID:18281713. |
pharmacological characterization consisted in the evaluation of the effects of the following drugs administered previously to the acquisition of the cfc: pentylenetetrazole (anxiogenic) and chlordiazepoxide (anxiolytic); methylphenidate and amphetamine (used for adhd); lamotrigine, carbamazepine, and valproic acid (mood stabilizers); haloperidol, ziprasidone, risperidone, amisulpride, and clozapine (neuroleptic drugs); metoclopramide and sch 23390 (dopamine antagonists without antipsychotic properties); and ketamine (a psychotomimmetic). |
2009-08-06 |
2023-08-12 |
rat |
| Jennifer Trevitt, Christopher Vallance, Allison Harris, Tamara Good. Adenosine antagonists reverse the cataleptic effects of haloperidol: implications for the treatment of Parkinson's disease. Pharmacology, biochemistry, and behavior. vol 92. issue 3. 2009-08-05. PMID:19463269. |
in the first experiment the dopamine d2 antagonist, haloperidol, was used to induce catalepsy. |
2009-08-05 |
2023-08-12 |
Not clear |
| Jesus Bertran-Gonzalez, Kerstin Håkansson, Anders Borgkvist, Theano Irinopoulou, Karen Brami-Cherrier, Alessandro Usiello, Paul Greengard, Denis Hervé, Jean-Antoine Girault, Emmanuel Valjent, Gilberto Fison. Histone H3 phosphorylation is under the opposite tonic control of dopamine D2 and adenosine A2A receptors in striatopallidal neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 7. 2009-08-03. PMID:19158668. |
the antipsychotic agent haloperidol regulates gene transcription in striatal medium spiny neurons (msns) by blocking dopamine d2 receptors (d2rs). |
2009-08-03 |
2023-08-12 |
mouse |
| Jesus Bertran-Gonzalez, Kerstin Håkansson, Anders Borgkvist, Theano Irinopoulou, Karen Brami-Cherrier, Alessandro Usiello, Paul Greengard, Denis Hervé, Jean-Antoine Girault, Emmanuel Valjent, Gilberto Fison. Histone H3 phosphorylation is under the opposite tonic control of dopamine D2 and adenosine A2A receptors in striatopallidal neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 7. 2009-08-03. PMID:19158668. |
using bacterial artificial chromosome (bac)-transgenic mice that express egfp under the control of the promoter of the dopamine d1 receptor (d1r) or the d2r, we found that haloperidol induced a rapid and sustained increase in the phosphorylation of histone h3 in the striatopallidal msns of the dorsal striatum, with no change in its acetylation. |
2009-08-03 |
2023-08-12 |
mouse |
| Yoshihiro Tadori, Robert A Forbes, Robert D McQuade, Tetsuro Kikuch. Receptor reserve-dependent properties of antipsychotics at human dopamine D2 receptors. European journal of pharmacology. vol 607. issue 1-3. 2009-07-07. PMID:19217900. |
in an effort to elucidate aripiprazole's pharmacological activity in relation to clinically relevant fluctuation of dopamine d(2) receptor reserves, we compared the properties of aripiprazole to other antipsychotics, quetiapine, clozapine, olanzapine, ziprasidone, risperidone and haloperidol, a dopamine d(2) receptor partial agonist, bifeprunox, dopamine d(3) receptor modulators, bp897 (n-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]naphthalene-2-carboxamide) and gr103691 (4'-acetyl-n-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]biphenyl-4-carboxamide), and a 5-ht(1a) partial agonist, buspirone using forskolin-stimulated camp accumulation in clonal chinese hamster ovary cell lines expressing low and high densities of human dopamine d(2s) receptors (hd(2s)-low and hd(2s)-high, respectively). |
2009-07-07 |
2023-08-12 |
human |
| Fernando Germes Piñ. [Chorea gravidarum. A case report]. Ginecologia y obstetricia de Mexico. vol 77. issue 3. 2009-07-07. PMID:19400520. |
the dopamine antagonists as the haloperidol and the chlorpromazine are useful to control the symptoms and are safe at lower doses. |
2009-07-07 |
2023-08-12 |
Not clear |
| Xavier López-Gil, Francesc Artigas, Albert Adel. Role of different monoamine receptors controlling MK-801-induced release of serotonin and glutamate in the medial prefrontal cortex: relevance for antipsychotic action. The international journal of neuropsychopharmacology. vol 12. issue 4. 2009-06-26. PMID:18752722. |
to study the contribution of different monoaminergic receptors (for which clozapine and haloperidol exhibit distinct affinities) to these effects, here we used in-vivo microdialysis to examine the role of local blockade of dopamine d2, 5-ht2a and alpha1-adrenergic receptors as well as agonism at dopamine d1 and 5-ht1a receptors in the mpfc on the increased efflux of glutamate and 5-ht elicited by mk-801. |
2009-06-26 |
2023-08-12 |
Not clear |
| Angela C Scibelli, Tamara J Phillip. Combined scopolamine and ethanol treatment results in a locomotor stimulant response suggestive of synergism that is not blocked by dopamine receptor antagonists. Alcoholism, clinical and experimental research. vol 33. issue 3. 2009-06-19. PMID:19120057. |
we also investigated whether the dopamine d1-like receptor antagonist, sch-23390 or the dopamine d2-like receptor antagonist, haloperidol, could block the extreme stimulant response found following co-administration of scopolamine and ethanol. |
2009-06-19 |
2023-08-12 |
Not clear |
| Philip Seema. Schizophrenia model of elevated D2(High) receptors: haloperidol reverses the amphetamine-induced elevation in dopamine D2(High). Schizophrenia research. vol 109. issue 1-3. 2009-06-03. PMID:19171464. |
schizophrenia model of elevated d2(high) receptors: haloperidol reverses the amphetamine-induced elevation in dopamine d2(high). |
2009-06-03 |
2023-08-12 |
Not clear |
| Yanbo Zhang, Haiyun Xu, Jue He, Bin Yan, Wengao Jiang, Xiaokun Li, Xin-Min L. Quetiapine reverses altered locomotor activity and tyrosine hydroxylase immunoreactivity in rat caudate putamen following long-term haloperidol treatment. Neuroscience letters. vol 420. issue 1. 2009-06-02. PMID:17466452. |
haloperidol (hal) is a typical antipsychotic drug and known to cause extrapyramidal symptoms (eps) that may be associated with the blockade of dopamine d2-receptors in nigrostriatal pathway by the drug. |
2009-06-02 |
2023-08-12 |
rat |
| Chandra C Cardoso, Kelly R Lobato, Ricardo W Binfaré, Priscilla K Ferreira, Angelo O Rosa, Adair Roberto S Santos, Ana Lúcia S Rodrigue. Evidence for the involvement of the monoaminergic system in the antidepressant-like effect of magnesium. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 2. 2009-06-02. PMID:19059299. |
a 5-ht(1a) receptor antagonist), way100635 (0.1 mg/kg, s.c., a selective 5-ht(1a) receptor antagonist), ritanserin (4 mg/kg, i.p., a 5-ht(2a/2c) receptor antagonist), ketanserin (5 mg/kg, a preferential 5-ht(2a) receptor antagonist), prazosin (1 mg/kg, i.p., an alpha(1)-adrenoceptor antagonist), yohimbine (1 mg/kg, i.p., an alpha(2)-adrenoceptor antagonist), haloperidol (0.2 mg/kg, i.p., a non selective dopaminergic receptor antagonist), sch23390 (0.05 mg/kg, s.c., a dopamine d(1) receptor antagonist) or sulpiride (50 mg/kg, i.p., a dopamine d(2) receptor antagonist) 30 min before the administration of magnesium chloride (30 mg/kg, i.p.) |
2009-06-02 |
2023-08-12 |
mouse |
| Mark E Bardgett, Melissa Depenbrock, Nathan Downs, Megan Points, Leonard Gree. Dopamine modulates effort-based decision making in rats. Behavioral neuroscience. vol 123. issue 2. 2009-05-18. PMID:19331447. |
the dopamine agonist, d-amphetamine, biased the rats toward choosing the large-reward arm and blunted the effects of sch-23390 or haloperidol. |
2009-05-18 |
2023-08-12 |
rat |