| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Sánchez-Wandelmer, A Dávalos, G de la Peña, S Cano, M Giera, A Canfrán-Duque, F Bracher, A Martín-Hidalgo, C Fernández-Hernando, M A Lasunción, R Bust. Haloperidol disrupts lipid rafts and impairs insulin signaling in SH-SY5Y cells. Neuroscience. vol 167. issue 1. 2010-06-17. PMID:20123000. |
haloperidol exerts its therapeutic effects basically by acting on dopamine receptors. |
2010-06-17 |
2023-08-12 |
human |
| Karuppiah Kanagarajadurai, Manoharan Malini, Aditi Bhattacharya, Mitradas M Panicker, Ramanathan Sowdhamin. Molecular modeling and docking studies of human 5-hydroxytryptamine 2A (5-HT2A) receptor for the identification of hotspots for ligand binding. Molecular bioSystems. vol 5. issue 12. 2010-05-12. PMID:19763327. |
further, starting from the model structure of human 5-ht(2a) receptor, docking studies were attempted to envisage how it might interact with eight of its ligands (such as serotonin, dopamine, doi, lsd, haloperidol, ketanserin, risperidone and clozapine). |
2010-05-12 |
2023-08-12 |
human |
| Minori Nishiguchi, Hiroshi Kinoshita, Shogo Kasuda, Montonori Takahashi, Takehiko Yamamura, Kiyoshi Matsui, Harumi Ouchi, Takako Minami, Shigeru Hishida, Hajime Nishi. Effects of dopamine antagonists on methamphetamine-induced dopamine release in high and low alcohol preference rats. Toxicology mechanisms and methods. vol 20. issue 3. 2010-04-30. PMID:20163290. |
with haloperidol treatment both strains of rats showed a significantly greater maximum increase on map-induced dopamine release compared with respective control rats. |
2010-04-30 |
2023-08-12 |
rat |
| Minori Nishiguchi, Hiroshi Kinoshita, Shogo Kasuda, Montonori Takahashi, Takehiko Yamamura, Kiyoshi Matsui, Harumi Ouchi, Takako Minami, Shigeru Hishida, Hajime Nishi. Effects of dopamine antagonists on methamphetamine-induced dopamine release in high and low alcohol preference rats. Toxicology mechanisms and methods. vol 20. issue 3. 2010-04-30. PMID:20163290. |
the map-induced increase in dopamine release following haloperidol pre-treatment was greater than sch23390 pre-treatment in both strains. |
2010-04-30 |
2023-08-12 |
rat |
| Andrea Gogos, Perrin Kwek, Carolina Chavez, Maarten van den Buus. Estrogen treatment blocks 8-hydroxy-2-dipropylaminotetralin- and apomorphine-induced disruptions of prepulse inhibition: involvement of dopamine D1 or D2 or serotonin 5-HT1A, 5-HT2A, or 5-HT7 receptors. The Journal of pharmacology and experimental therapeutics. vol 333. issue 1. 2010-04-22. PMID:20042529. |
8-oh-dpat-induced ppi disruption was reversed by pretreatment with the 5-ht(1a) receptor antagonist n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-2-pyridinylcyclohexanecarboxamide maleate salt (way 100,635; 1 mg/kg) and the typical antipsychotic and dopamine d(2) receptor antagonist haloperidol (0.25 mg/kg), but it was not reversed by pretreatment with the dopamine d(1) receptor antagonist r-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine hydrochloride (sch 23390; 0.1 mg/kg), the 5-ht(2a/2c) receptor antagonist ketanserin (2 mg/kg), or the 5-ht(7) receptor antagonist sb-269970 (10 mg/kg). |
2010-04-22 |
2023-08-12 |
rat |
| Hidemori Uchiyama, Akihisa Toda, Masumi Imoto, Satoko Nishimura, Hiroaki Kuroki, Shinji Soeda, Hiroshi Shimeno, Shigenori Watanabe, Reiko Eyanag. The stimulatory effects of caffeine with oseltamivir (Tamiflu) on light-dark behavior and open-field behavior in mice. Neuroscience letters. vol 469. issue 2. 2010-04-12. PMID:19963037. |
this enhancement was inhibited by a dopamine d(2) receptor antagonist, haloperidol (0.1mg/kg, s.c.). |
2010-04-12 |
2023-08-12 |
mouse |
| Isabel García-Tornadú, Ana M Ornstein, Astrid Chamson-Reig, Michael B Wheeler, David J Hill, Edith Arany, Marcelo Rubinstein, Damasia Becu-Villalobo. Disruption of the dopamine d2 receptor impairs insulin secretion and causes glucose intolerance. Endocrinology. vol 151. issue 4. 2010-04-09. PMID:20147524. |
on the other hand, short-term treatment with cabergoline, a dopamine agonist, resulted in glucose intolerance and decreased insulin response to glucose in wild-type but not in drd2(-/-) mice; this effect was partially prevented by haloperidol, a d2r antagonist. |
2010-04-09 |
2023-08-12 |
mouse |
| Tino Dyhring, Elsebet Ø Nielsen, Clas Sonesson, Fredrik Pettersson, Jonas Karlsson, Peder Svensson, Palle Christophersen, Nicholas Water. The dopaminergic stabilizers pridopidine (ACR16) and (-)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties. European journal of pharmacology. vol 628. issue 1-3. 2010-04-05. PMID:19919834. |
in contrast to the high-affinity typical antipsychotics haloperidol and raclopride, the dopaminergic stabilizers acr16 and (-)-osu6162 both displayed fast dopamine d(2) receptor dissociation properties, a feature that has previously been suggested as a contributing factor to antipsychotic atypicality and attributed mainly to low receptor affinity. |
2010-04-05 |
2023-08-12 |
Not clear |
| Andreea Oliviana Diaconescu, Mahesh Menon, Jimmy Jensen, Shitij Kapur, Anthony Randal McIntos. Dopamine-induced changes in neural network patterns supporting aversive conditioning. Brain research. vol 1313. 2010-04-05. PMID:19961836. |
blocking dopamine transmission via haloperidol was associated with significant functional connectivity across an alternate network of regions including the left amygdala seed and the right insula, the left acc (ba 24/32), bilateral ipl (ba 40), precuneus (ba 7), post-central gyrus, middle frontal gyrus (ba 46), and supplementary motor area (sma, ba 6) to the cs+ versus the cs-. |
2010-04-05 |
2023-08-12 |
human |
| Orit Holtzman-Assif, Vincent Laurent, R Frederick Westbroo. Blockade of dopamine activity in the nucleus accumbens impairs learning extinction of conditioned fear. Learning & memory (Cold Spring Harbor, N.Y.). vol 17. issue 2. 2010-03-22. PMID:20154351. |
in experiment 1, rats systemically injected with the d2 dopamine antagonist, haloperidol, froze more across multiple extinction sessions and on a drug-free retention test than control rats. |
2010-03-22 |
2023-08-12 |
rat |
| V S Shubina, M B Abramova, V P Lavrovskaia, L L Pavlik, E I Lezhnev, D A Moshko. [The influence of dopamine on the ultrastructure of BHK-21 cells]. Tsitologiia. vol 51. issue 12. 2010-03-17. PMID:20141035. |
the influence of dopamine on the haloperidol of bhk-21 cells being in suspension or attached to substrate was investigated. |
2010-03-17 |
2023-08-12 |
Not clear |
| V S Shubina, M B Abramova, V P Lavrovskaia, L L Pavlik, E I Lezhnev, D A Moshko. [The influence of dopamine on the ultrastructure of BHK-21 cells]. Tsitologiia. vol 51. issue 12. 2010-03-17. PMID:20141035. |
finally, it was established that the preliminary blockade of cellular d2 receptors with haloperidol neither affected the ultrastructure of bhk-21 cells nor prevented the following effect of dopamine. |
2010-03-17 |
2023-08-12 |
Not clear |
| Felice Iasevoli, Carmine Tomasetti, Alberto Ambesi-Impiombato, Giovanni Muscettola, Andrea de Bartolomei. Dopamine receptor subtypes contribution to Homer1a induction: insights into antipsychotic molecular action. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 5. 2010-03-12. PMID:19243698. |
in this study, we explored homer1a expression induced by selective antagonists at dopamine receptors (sch-23390, d(1) receptor selective antagonist, 0.5 mg/kg; l-741,626, d(2) receptor selective antagonist, 2 mg/kg; u-99194, d(3) receptor selective antagonist, 5 mg/kg; l-745,870, d(4) receptor selective antagonist, 3 mg/kg), haloperidol (0.8 mg/kg), and terguride (0.5 mg/kg), a partial agonist at d(2) receptors. |
2010-03-12 |
2023-08-12 |
Not clear |
| Julien Vezoli, Emmanuel Procy. Frontal feedback-related potentials in nonhuman primates: modulation during learning and under haloperidol. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 50. 2010-01-26. PMID:20016082. |
in addition, using the dopamine antagonist haloperidol we observe a selective effect on frp amplitude that is absent for pure sensory-related potentials. |
2010-01-26 |
2023-08-12 |
monkey |
| Andrea G Gillman, Joseph K Leffel, Ann E K Kosobud, William Timberlak. Fentanyl, but not haloperidol, entrains persisting circadian activity episodes when administered at 24- and 31-h intervals. Behavioural brain research. vol 205. issue 1. 2010-01-12. PMID:19595707. |
the present study tested the entrainment effects of fentanyl, an opioid agonist with a noted abuse liability, and haloperidol, an anti-psychotic dopamine antagonist without apparent abuse liability. |
2010-01-12 |
2023-08-12 |
rat |
| Liesbeth A Bruins Slot, Fabrice Lestienne, Catherine Grevoz-Barret, Adrian Newman-Tancredi, Didier Cussa. F15063, a potential antipsychotic with dopamine D(2)/D(3) receptor antagonist and 5-HT(1A) receptor agonist properties: influence on immediate-early gene expression in rat prefrontal cortex and striatum. European journal of pharmacology. vol 620. issue 1-3. 2009-12-31. PMID:19695244. |
we investigated the effects of the putative antipsychotic drug n-[(2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)ethyl]-3-(cyclopent-1-enyl)-benzylamine (f15063), a compound that targets both dopamine d(2) and serotonin 5-ht(1a) receptors, in comparison with haloperidol and clozapine on rat mrna expression of ieg i.e. |
2009-12-31 |
2023-08-12 |
rat |
| Changjiu Zhao, Ming L. The receptor mechanisms underlying the disruptive effects of haloperidol and clozapine on rat maternal behavior: a double dissociation between dopamine D(2) and 5-HT(2A/2C) receptors. Pharmacology, biochemistry, and behavior. vol 93. issue 4. 2009-11-27. PMID:19539643. |
the receptor mechanisms underlying the disruptive effects of haloperidol and clozapine on rat maternal behavior: a double dissociation between dopamine d(2) and 5-ht(2a/2c) receptors. |
2009-11-27 |
2023-08-12 |
rat |
| Changjiu Zhao, Ming L. The receptor mechanisms underlying the disruptive effects of haloperidol and clozapine on rat maternal behavior: a double dissociation between dopamine D(2) and 5-HT(2A/2C) receptors. Pharmacology, biochemistry, and behavior. vol 93. issue 4. 2009-11-27. PMID:19539643. |
postpartum rats were administered with haloperidol (0.2 mg/kg, sc) or clozapine (10.0 mg/kg, sc) together with either vehicle (saline or water), quinpirole (a selective dopamine d(2)/d(3) agonist, 0.5 or 1.0 mg/kg, sc), or 2,5-dimethoxy-4-iodo-amphetamine (doi, a selective 5-ht(2a/2c) agonist, 1.0 or 2.5 mg/kg, sc), and their maternal behaviors were tested at different time points before and after drug administration. |
2009-11-27 |
2023-08-12 |
rat |
| Changjiu Zhao, Ming L. The receptor mechanisms underlying the disruptive effects of haloperidol and clozapine on rat maternal behavior: a double dissociation between dopamine D(2) and 5-HT(2A/2C) receptors. Pharmacology, biochemistry, and behavior. vol 93. issue 4. 2009-11-27. PMID:19539643. |
specifically, haloperidol disrupts maternal behavior primarily by blocking dopamine d(2) receptors, whereas clozapine exerts its disruptive effect primarily by blocking the 5-ht(2a/2c) receptors. |
2009-11-27 |
2023-08-12 |
rat |
| K Inada, J S Farrington, S S Moy, B H Koller, G E Dunca. Assessment of NMDA receptor activation in vivo by Fos induction after challenge with the direct NMDA agonist (tetrazol-5-yl)glycine: effects of clozapine and haloperidol. Journal of neural transmission (Vienna, Austria : 1996). vol 114. issue 7. 2009-11-23. PMID:17318306. |
the relatively high dose (1 mg/kg) of haloperidol required to block effects of tzg suggests that this action may not be related to the d(2) dopamine receptor-blocking properties, since maximal d(2) receptor blockade was probably achieved by the 0.5 mg/kg dose of haloperidol. |
2009-11-23 |
2023-08-12 |
mouse |