| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L B Kozell, C K Meshu. The effects of acute or repeated cocaine administration on nerve terminal glutamate within the rat mesolimbic system. Neuroscience. vol 106. issue 1. 2001-12-04. PMID:11564413. |
cocaine administration alters glutamate function within several brain regions. |
2001-12-04 |
2023-08-12 |
rat |
| L B Kozell, C K Meshu. The effects of acute or repeated cocaine administration on nerve terminal glutamate within the rat mesolimbic system. Neuroscience. vol 106. issue 1. 2001-12-04. PMID:11564413. |
using quantitative electron microscopic immunocytochemistry, the present study investigated the effect of repeated intermittent cocaine (resulting in behavioral sensitization) or acute cocaine administration on the density of glutamate immunogold labeling within nerve terminals. |
2001-12-04 |
2023-08-12 |
rat |
| L B Kozell, C K Meshu. The effects of acute or repeated cocaine administration on nerve terminal glutamate within the rat mesolimbic system. Neuroscience. vol 106. issue 1. 2001-12-04. PMID:11564413. |
on the challenge day, most (75%) animals that received cocaine repeatedly showed a heightened locomotor response to cocaine compared to the first day of cocaine administration, and were considered behaviorally sensitized.three days after the challenge, glutamate immunogold labeling was quantified in nerve terminals making asymmetrical synaptic contacts within the core and shell of the nucleus accumbens, ventral tegmental area and medial prefrontal cortex. |
2001-12-04 |
2023-08-12 |
rat |
| L B Kozell, C K Meshu. The effects of acute or repeated cocaine administration on nerve terminal glutamate within the rat mesolimbic system. Neuroscience. vol 106. issue 1. 2001-12-04. PMID:11564413. |
in the ventral tegmental area, glutamate immunolabeling was significantly higher in the cocaine-sensitized compared to the acute cocaine group. |
2001-12-04 |
2023-08-12 |
rat |
| L B Kozell, C K Meshu. The effects of acute or repeated cocaine administration on nerve terminal glutamate within the rat mesolimbic system. Neuroscience. vol 106. issue 1. 2001-12-04. PMID:11564413. |
this study indicates that acute cocaine administration significantly decreases nerve terminal glutamate immunoreactivity in the nucleus accumbens. |
2001-12-04 |
2023-08-12 |
rat |
| C J Swanson, D A Baker, D Carson, P F Worley, P W Kaliva. Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: a potential role for Homer. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 22. 2001-12-04. PMID:11698615. |
repeated cocaine administration attenuates group i metabotropic glutamate receptor-mediated glutamate release and behavioral activation: a potential role for homer. |
2001-12-04 |
2023-08-12 |
Not clear |
| C J Swanson, D A Baker, D Carson, P F Worley, P W Kaliva. Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: a potential role for Homer. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 22. 2001-12-04. PMID:11698615. |
the present study aimed to characterize a functional role for group i metabotropic glutamate receptors (mglurs) in the nucleus accumbens and the capacity of repeated cocaine to elicit long-term changes in group i mglur function. |
2001-12-04 |
2023-08-12 |
Not clear |
| C J Swanson, D A Baker, D Carson, P F Worley, P W Kaliva. Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: a potential role for Homer. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 22. 2001-12-04. PMID:11698615. |
at 3 weeks after discontinuing 1 week of daily cocaine injections, the capacity of dhpg to induce glutamate release was markedly reduced. |
2001-12-04 |
2023-08-12 |
Not clear |
| C J Swanson, D A Baker, D Carson, P F Worley, P W Kaliva. Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: a potential role for Homer. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 22. 2001-12-04. PMID:11698615. |
signaling through group i mglurs is regulated, in part, by homer proteins, and it was found that the blunting of group i mglur-induced glutamate release and motor activity after repeated cocaine was associated with a reduction in homer1b/c protein that was selective for the medial nucleus accumbens. |
2001-12-04 |
2023-08-12 |
Not clear |
| M E Gneg. Ca2+/calmodulin signaling in NMDA-induced synaptic plasticity. Critical reviews in neurobiology. vol 14. issue 2. 2001-09-06. PMID:11513244. |
although amphetamine and cocaine increase synaptic monoamines, glutamate is involved in the induction and expression of the sensitization. |
2001-09-06 |
2023-08-12 |
Not clear |
| B S Slusher, A Thomas, M Paul, C A Schad, C R Ashb. Expression and acquisition of the conditioned place preference response to cocaine in rats is blocked by selective inhibitors of the enzyme N-acetylated-alpha-linked-acidic dipeptidase (NAALADASE). Synapse (New York, N.Y.). vol 41. issue 1. 2001-08-09. PMID:11354010. |
3.4.17.21), which cleaves glutamate from the dipeptide n-acetyl-aspartyl-glutamate (naag), on the conditioned place preference (cpp) response to cocaine in male rats. |
2001-08-09 |
2023-08-12 |
rat |
| Y Zhang, T M Loonam, P A Noailles, J A Angul. Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458542. |
acute injection of methamphetamine or cocaine did not change extracellular levels of glutamate in the neostriatum. |
2001-08-02 |
2023-08-12 |
rat |
| Y Zhang, T M Loonam, P A Noailles, J A Angul. Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458542. |
cocaine challenge (early withdrawal) increased glutamate overflow in the caudate putamen and the nucleus accumbens. |
2001-08-02 |
2023-08-12 |
rat |
| Y Zhang, T M Loonam, P A Noailles, J A Angul. Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458542. |
in the ventral tegmental area and the substantia nigra compacta, acute methamphetamine exposure decreased glutamate overflow, but acute cocaine exposure increased it. |
2001-08-02 |
2023-08-12 |
rat |
| K Eckermann, A Beasley, P Yang, O Gaytan, A Swann, N Dafn. Methylphenidate sensitization is modulated by valproate. Life sciences. vol 69. issue 1. 2001-07-05. PMID:11411804. |
glutamate, dopamine, and gaba have been implicated in the underlying mechanism of sensitization to stimulants such as amphetamine and cocaine. |
2001-07-05 |
2023-08-12 |
rat |
| T Yamamoto, K Yabuuchi, T Yamaguchi, M Nakamich. [Animal models of drug dependence using the drug self-administration method]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 117. issue 1. 2001-05-10. PMID:11233296. |
given that an ampa receptor antagonist, but not dopamine antagonist, prevented cocaine-seeking behavior induced by cocaine, glutamate transmission in the nucleus accumbens is thought to be important for expression of craving or drug-seeking behavior. |
2001-05-10 |
2023-08-12 |
Not clear |
| S R Howes, J W Dalley, C H Morrison, T W Robbins, B J Everit. Leftward shift in the acquisition of cocaine self-administration in isolation-reared rats: relationship to extracellular levels of dopamine, serotonin and glutamate in the nucleus accumbens and amygdala-striatal FOS expression. Psychopharmacology. vol 151. issue 1. 2000-12-28. PMID:10958117. |
leftward shift in the acquisition of cocaine self-administration in isolation-reared rats: relationship to extracellular levels of dopamine, serotonin and glutamate in the nucleus accumbens and amygdala-striatal fos expression. |
2000-12-28 |
2023-08-12 |
rat |
| G M Sizemore, C Co, J E Smit. Ventral pallidal extracellular fluid levels of dopamine, serotonin, gamma amino butyric acid, and glutamate during cocaine self-administration in rats. Psychopharmacology. vol 150. issue 4. 2000-11-30. PMID:10958080. |
ventral pallidal extracellular fluid levels of dopamine, serotonin, gamma amino butyric acid, and glutamate during cocaine self-administration in rats. |
2000-11-30 |
2023-08-12 |
rat |
| T S Shippenberg, W Rea, B S Slushe. Modulation of behavioral sensitization to cocaine by NAALADase inhibition. Synapse (New York, N.Y.). vol 38. issue 2. 2000-11-28. PMID:11018790. |
the present study sought to determine whether inhibition of naaladase, an enzyme that cleaves glutamate from the endogenous neuropeptide, n-acetyl-aspartyl-glutamate (naag), attenuates sensitization to the psychomotor stimulant effects of cocaine. |
2000-11-28 |
2023-08-12 |
rat |
| K Bell, P Duffy, P W Kaliva. Context-specific enhancement of glutamate transmission by cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 3. 2000-10-11. PMID:10942857. |
context-specific enhancement of glutamate transmission by cocaine. |
2000-10-11 |
2023-08-12 |
rat |