| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michela Tessari, Maria Pilla, Michela Andreoli, Daniel M Hutcheson, Christian A Heidbrede. Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking. European journal of pharmacology. vol 499. issue 1-2. 2005-02-16. PMID:15363959. |
previous studies in metabotropic glutamate 5 receptor (mglu5 receptor) deficient mice have indicated the importance of this receptor in the self-administration of cocaine and locomotor sensitisation to this stimulant. |
2005-02-16 |
2023-08-12 |
mouse |
| Peter W Kalivas, Karen K Szumlinski, Paul Worle. Homer2 gene deletion in mice produces a phenotype similar to chronic cocaine treated rats. Neurotoxicity research. vol 6. issue 5. 2005-01-26. PMID:15545022. |
homer2 deletion also caused mice to show reduced basal extracellular glutamate in the nucleus accumbens and a sensitized increase in extracellular glutamate in response to a cocaine injection. |
2005-01-26 |
2023-08-12 |
mouse |
| Peter W Kalivas, Karen K Szumlinski, Paul Worle. Homer2 gene deletion in mice produces a phenotype similar to chronic cocaine treated rats. Neurotoxicity research. vol 6. issue 5. 2005-01-26. PMID:15545022. |
in contrast to glutamate, homer2 ko mice showed a normal increase in extracellular dopamine following a cocaine challenge injection. |
2005-01-26 |
2023-08-12 |
mouse |
| Peter W Kalivas, Karen K Szumlinski, Paul Worle. Homer2 gene deletion in mice produces a phenotype similar to chronic cocaine treated rats. Neurotoxicity research. vol 6. issue 5. 2005-01-26. PMID:15545022. |
the parallel between the effect of homer2 gene deletion and chronic cocaine administration on behavioral and glutamatergic neurochemical responses to cocaine supports involvement of homer proteins and glutamate transmission in the sensitization of behavior produced by repeated cocaine. |
2005-01-26 |
2023-08-12 |
mouse |
| L E O'Dell, L H Parson. Serotonin1B receptors in the ventral tegmental area modulate cocaine-induced increases in nucleus accumbens dopamine levels. The Journal of pharmacology and experimental therapeutics. vol 311. issue 2. 2005-01-25. PMID:15226384. |
there was no effect of either local cp 93,129 or peripheral cocaine on vta glutamate efflux. |
2005-01-25 |
2023-08-12 |
rat |
| Jason M Williams, Jeffery D Stekete. Cocaine increases medial prefrontal cortical glutamate overflow in cocaine-sensitized rats: a time course study. The European journal of neuroscience. vol 20. issue 6. 2004-12-20. PMID:15355331. |
cocaine increases medial prefrontal cortical glutamate overflow in cocaine-sensitized rats: a time course study. |
2004-12-20 |
2023-08-12 |
human |
| Jason M Williams, Jeffery D Stekete. Cocaine increases medial prefrontal cortical glutamate overflow in cocaine-sensitized rats: a time course study. The European journal of neuroscience. vol 20. issue 6. 2004-12-20. PMID:15355331. |
the current studies evaluated a time course of the effects of cocaine on extracellular glutamate levels within the medial prefrontal cortex (mpfc) following increasing periods of withdrawal from repeated cocaine exposure. |
2004-12-20 |
2023-08-12 |
human |
| Jason M Williams, Jeffery D Stekete. Cocaine increases medial prefrontal cortical glutamate overflow in cocaine-sensitized rats: a time course study. The European journal of neuroscience. vol 20. issue 6. 2004-12-20. PMID:15355331. |
animals that were withdrawn from repeated daily cocaine for 1 day and 7 days displayed an augmentation in cocaine-induced mpfc glutamate levels compared to saline and acute control subjects, which were similarly unaffected by cocaine challenge. |
2004-12-20 |
2023-08-12 |
human |
| Jason M Williams, Jeffery D Stekete. Cocaine increases medial prefrontal cortical glutamate overflow in cocaine-sensitized rats: a time course study. The European journal of neuroscience. vol 20. issue 6. 2004-12-20. PMID:15355331. |
at the 7 day time point, a subset of animals that received repeated cocaine did not express behavioural sensitization, nor did these animals exhibit the enhancement in mpfc glutamate in response to cocaine challenge. |
2004-12-20 |
2023-08-12 |
human |
| Jason M Williams, Jeffery D Stekete. Cocaine increases medial prefrontal cortical glutamate overflow in cocaine-sensitized rats: a time course study. The European journal of neuroscience. vol 20. issue 6. 2004-12-20. PMID:15355331. |
these data suggest that repeated cocaine administration transiently increases cocaine-induced glutamate levels in the mpfc during the first week of withdrawal, which may play an important role in the development of behavioural sensitization to cocaine. |
2004-12-20 |
2023-08-12 |
human |
| Karen K Szumlinski, Marlin H Dehoff, Shin H Kang, Kelly A Frys, Kevin D Lominac, Matthias Klugmann, Jason Rohrer, William Griffin, Shigenobu Toda, Nicolas P Champtiaux, Thomas Berry, Jian C Tu, Stephanie E Shealy, Matthew J During, Lawrence D Middaugh, Paul F Worley, Peter W Kaliva. Homer proteins regulate sensitivity to cocaine. Neuron. vol 43. issue 3. 2004-11-02. PMID:15294147. |
here, we report that deletion of homer1 or homer2 in mice caused the same increase in sensitivity to cocaine-induced locomotion, conditioned reward, and augmented extracellular glutamate in nucleus accumbens as that elicited by withdrawal from repeated cocaine administration. |
2004-11-02 |
2023-08-12 |
mouse |
| Karen K Szumlinski, Marlin H Dehoff, Shin H Kang, Kelly A Frys, Kevin D Lominac, Matthias Klugmann, Jason Rohrer, William Griffin, Shigenobu Toda, Nicolas P Champtiaux, Thomas Berry, Jian C Tu, Stephanie E Shealy, Matthew J During, Lawrence D Middaugh, Paul F Worley, Peter W Kaliva. Homer proteins regulate sensitivity to cocaine. Neuron. vol 43. issue 3. 2004-11-02. PMID:15294147. |
further analysis of homer2 ko mice revealed extensive additional behavioral and neurochemical similarities to cocaine-sensitized animals, including accelerated acquisition of cocaine self-administration and altered regulation of glutamate by metabotropic glutamate receptors and cystine/glutamate exchange. |
2004-11-02 |
2023-08-12 |
mouse |
| Prathiba Jayaram, Jeffery D Stekete. Effects of repeated cocaine on medial prefrontal cortical GABAB receptor modulation of neurotransmission in the mesocorticolimbic dopamine system. Journal of neurochemistry. vol 90. issue 4. 2004-10-28. PMID:15287889. |
baclofen minimally affected glutamate levels in the medial prefrontal cortex, nucleus accumbens or ventral tegmental area of control animals, but dose-dependently increased glutamate levels in each of these regions in animals sensitized to cocaine. |
2004-10-28 |
2023-08-12 |
Not clear |
| Andrew J Mcgeehan, Patricia H Janak, M Foster Oliv. Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice. Psychopharmacology. vol 174. issue 2. 2004-10-19. PMID:14726993. |
the present study was conducted to examine the effects of the selective type-5 metabotropic glutamate receptor (mglur5) antagonist 6-methyl-2-(phenylethynyl)pyridine (mpep) on the acute locomotor stimulant effects of cocaine, d-amphetamine, and the dopamine reuptake inhibitor gbr12909. |
2004-10-19 |
2023-08-12 |
mouse |
| J D Kreuter, B J Mattson, B Wang, Z-B You, B T Hop. Cocaine-induced Fos expression in rat striatum is blocked by chloral hydrate or urethane. Neuroscience. vol 127. issue 1. 2004-10-14. PMID:15219685. |
chloral hydrate attenuated basal levels of glutamate by 70%, while cocaine had no effect on glutamate levels. |
2004-10-14 |
2023-08-12 |
rat |
| Marco A S Baptista, Rémi Martin-Fardon, Friedbert Weis. Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 20. 2004-09-10. PMID:15152032. |
preferential effects of the metabotropic glutamate 2/3 receptor agonist ly379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer. |
2004-09-10 |
2023-08-12 |
rat |
| Peter W Kaliva. Glutamate systems in cocaine addiction. Current opinion in pharmacology. vol 4. issue 1. 2004-07-14. PMID:15018835. |
glutamate systems in cocaine addiction. |
2004-07-14 |
2023-08-12 |
Not clear |
| Carlos A Paladini, Jennifer M Mitchell, John T Williams, Gregory P Mar. Cocaine self-administration selectively decreases noradrenergic regulation of metabotropic glutamate receptor-mediated inhibition in dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 22. 2004-07-09. PMID:15175391. |
cocaine self-administration selectively decreases noradrenergic regulation of metabotropic glutamate receptor-mediated inhibition in dopamine neurons. |
2004-07-09 |
2023-08-12 |
rat |
| Carlos A Paladini, Jennifer M Mitchell, John T Williams, Gregory P Mar. Cocaine self-administration selectively decreases noradrenergic regulation of metabotropic glutamate receptor-mediated inhibition in dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 22. 2004-07-09. PMID:15175391. |
the present study measured short-term (3 d) and long-term (14 d) access to cocaine, by self-administration or passive exposure, and the regulation of metabotropic glutamate receptor (mglur)-mediated inhibition of dopamine cells in rat midbrain slices. |
2004-07-09 |
2023-08-12 |
rat |
| Wenxue Tang, Michael Wesley, Willard M Freeman, Bill Liang, Scott E Hemb. Alterations in ionotropic glutamate receptor subunits during binge cocaine self-administration and withdrawal in rats. Journal of neurochemistry. vol 89. issue 4. 2004-06-04. PMID:15140200. |
alterations in ionotropic glutamate receptor subunits during binge cocaine self-administration and withdrawal in rats. |
2004-06-04 |
2023-08-12 |
rat |