| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zheng-Xiong Xi, Jeremy G Gilbert, Xiao-Qing Peng, Arlene C Pak, Xia Li, Eliot L Gardne. Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 33. 2006-09-12. PMID:16914679. |
given the importance of dopamine, glutamate, and gaba in cocaine reward and relapse, we studied the effects of am251 [n-(piperidin-1-yl)-5-(4-iodophonyl)-1-(2,4-dichlorophenyl)-4-methyl-1h-pyrazole-3-carboxamide], a novel highly selective cb1 receptor antagonist, on cocaine-primed reinstatement of drug-seeking behavior and on cocaine-induced changes in extracellular da, glutamate, and gaba in the nucleus accumbens (nac) under reinstatement conditions. |
2006-09-12 |
2023-08-12 |
rat |
| Zhen Li, Lin Gao, Qiang Liu, Cong Cao, Xiu Lan Sun, Jian Hua Ding, Gang H. Aquaporin-4 knockout regulated cocaine-induced behavior and neurochemical changes in mice. Neuroscience letters. vol 403. issue 3. 2006-09-01. PMID:16797122. |
the results reveal that aqp4 deletion attenuated locomotor activity in acute and repeated cocaine exposure mice, and induced a decrease of extracellular dopamine and glutamate levels in the nucleus accumbens (nac), a brain region known to be critically involved in the addictive properties of cocaine. |
2006-09-01 |
2023-08-12 |
mouse |
| Zhen Li, Lin Gao, Qiang Liu, Cong Cao, Xiu Lan Sun, Jian Hua Ding, Gang H. Aquaporin-4 knockout regulated cocaine-induced behavior and neurochemical changes in mice. Neuroscience letters. vol 403. issue 3. 2006-09-01. PMID:16797122. |
therefore, aqp4 may play a role in regulating extracellular cocaine-induced dopamine and glutamate release in the brain reward center, and in turn aqp4 deletion may attenuate cocaine reinforcement and dependence. |
2006-09-01 |
2023-08-12 |
mouse |
| A S Adewale, D M Platt, R D Spealma. Pharmacological stimulation of group ii metabotropic glutamate receptors reduces cocaine self-administration and cocaine-induced reinstatement of drug seeking in squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 318. issue 2. 2006-08-31. PMID:16675638. |
pharmacological stimulation of group ii metabotropic glutamate receptors reduces cocaine self-administration and cocaine-induced reinstatement of drug seeking in squirrel monkeys. |
2006-08-31 |
2023-08-12 |
monkey |
| A S Adewale, D M Platt, R D Spealma. Pharmacological stimulation of group ii metabotropic glutamate receptors reduces cocaine self-administration and cocaine-induced reinstatement of drug seeking in squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 318. issue 2. 2006-08-31. PMID:16675638. |
group ii metabotropic glutamate receptors (mglurs) have been implicated in regulating the psychopharmacologic effects of cocaine and other drugs of abuse. |
2006-08-31 |
2023-08-12 |
monkey |
| b' Pia B\\xc3\\xa4ckstr\\xc3\\xb6m, Petri Hyyti\\xc3\\xa. Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 4. 2006-05-25. PMID:16123768.' |
ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. |
2006-05-25 |
2023-08-12 |
rat |
| b' Pia B\\xc3\\xa4ckstr\\xc3\\xb6m, Petri Hyyti\\xc3\\xa. Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 4. 2006-05-25. PMID:16123768.' |
these results suggest that conditioned influences on cocaine seeking depend on glutamate transmission. |
2006-05-25 |
2023-08-12 |
rat |
| Karen K Szumlinski, Kenneth E Abernathy, Erik B Oleson, Matthias Klugmann, Kevin D Lominac, Dao-Yao He, Dorit Ron, Matthew During, Peter W Kaliva. Homer isoforms differentially regulate cocaine-induced neuroplasticity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 4. 2006-05-25. PMID:16160706. |
the long vs short homer isoforms were overexpressed in the rat nucleus accumbens during drug abstinence, and the adaptations elicited by repeated cocaine on glutamate transmission and motor behavior were measured. |
2006-05-25 |
2023-08-12 |
rat |
| Karen K Szumlinski, Kenneth E Abernathy, Erik B Oleson, Matthias Klugmann, Kevin D Lominac, Dao-Yao He, Dorit Ron, Matthew During, Peter W Kaliva. Homer isoforms differentially regulate cocaine-induced neuroplasticity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 4. 2006-05-25. PMID:16160706. |
it was found that both chronic and acute overexpression of constitutive, but not short, homer isoforms abolished cocaine-induced sensitization of locomotor hyperactivity and prevented the development of glutamate abnormalities in the accumbens, including the reduction in basal extracellular glutamate content and the sensitized glutamate response to a subsequent cocaine challenge injection. |
2006-05-25 |
2023-08-12 |
rat |
| Kevin D Lominac, Erik B Oleson, Matthew Pava, Matthias Klugmann, Martin K Schwarz, Peter H Seeburg, Matthew J During, Paul F Worley, Peter W Kalivas, Karen K Szumlinsk. Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 50. 2006-05-11. PMID:16354916. |
homer1a overexpression did not influence pfc basal glutamate content but blunted the glutamate response to cocaine in wild-type mice. |
2006-05-11 |
2023-08-12 |
mouse |
| Brad A Grueter, Heather B Gosnell, Christopher M Olsen, Nicole L Schramm-Sapyta, Tanya Nekrasova, Gary E Landreth, Danny G Winde. Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 12. 2006-04-14. PMID:16554472. |
extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration. |
2006-04-14 |
2023-08-12 |
Not clear |
| R Izawa, M Jaber, V Deroche-Gamonet, I Sillaber, C Kellendonk, M Le Moal, F Tronche, P V Piazz. Gene expression regulation following behavioral sensitization to cocaine in transgenic mice lacking the glucocorticoid receptor in the brain. Neuroscience. vol 137. issue 3. 2006-04-12. PMID:16326019. |
in contrast, mutant mice showed altered response in mrna levels of n-methyl-d-aspartate, glur5 and glur6 glutamate receptor subunits as well as of enkephalin following cocaine administration. |
2006-04-12 |
2023-08-12 |
mouse |
| Ivan Goussakov, Elena H Chartoff, Evgeny Tsvetkov, Lyle P Gerety, Edward G Meloni, William A Carlezon, Vadim Y Bolshako. LTP in the lateral amygdala during cocaine withdrawal. The European journal of neuroscience. vol 23. issue 1. 2006-04-06. PMID:16420433. |
synaptic enhancements during periods of cocaine withdrawal are mechanistically similar to ltp induced with electrical stimulation in control slices, as both forms of synaptic plasticity involve an increase in glutamate release. |
2006-04-06 |
2023-08-12 |
rat |
| Yasuyoshi Iso, Ewa Grajkowska, Jarda T Wroblewski, Jared Davis, Nicholas E Goeders, Kenneth M Johnson, Subramaniam Sanker, Bryan L Roth, Werner Tueckmantel, Alan P Kozikowsk. Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications. Journal of medicinal chemistry. vol 49. issue 3. 2006-03-29. PMID:16451073. |
synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications. |
2006-03-29 |
2023-08-12 |
Not clear |
| Louk J M J Vanderschuren, Patricia Di Ciano, Barry J Everit. Involvement of the dorsal striatum in cue-controlled cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 38. 2006-03-10. PMID:16177034. |
nucleus accumbens dopamine (da) neurotransmission plays an important role in the reinforcing effect of cocaine itself, but, unlike nucleus accumbens glutamate, it seems not to mediate the conditioned reinforcing properties of cocaine-paired stimuli. |
2006-03-10 |
2023-08-12 |
Not clear |
| Louk J M J Vanderschuren, Patricia Di Ciano, Barry J Everit. Involvement of the dorsal striatum in cue-controlled cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 38. 2006-03-10. PMID:16177034. |
therefore, the aim of the present study was to evaluate the role of da and glutamate transmission in the dorsal striatum in cue-controlled cocaine seeking. |
2006-03-10 |
2023-08-12 |
Not clear |
| Scott E Hemby, Brian Horman, Wenxue Tan. Differential regulation of ionotropic glutamate receptor subunits following cocaine self-administration. Brain research. vol 1064. issue 1-2. 2006-03-07. PMID:16277980. |
differential regulation of ionotropic glutamate receptor subunits following cocaine self-administration. |
2006-03-07 |
2023-08-12 |
Not clear |
| Scott E Hemby, Brian Horman, Wenxue Tan. Differential regulation of ionotropic glutamate receptor subunits following cocaine self-administration. Brain research. vol 1064. issue 1-2. 2006-03-07. PMID:16277980. |
previous examination of binge cocaine self-administration and 2 week withdrawal from cocaine self-administration on ionotropic glutamate receptor subunit (iglurs) protein levels revealed significant alterations in iglur protein levels that differed between the mesocorticolimbic and nigrostriatal pathways. |
2006-03-07 |
2023-08-12 |
Not clear |
| Bin Wang, Yavin Shaham, Dawnya Zitzman, Soraya Azari, Roy A Wise, Zhi-Bing Yo. Cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: a role in stress-induced relapse to drug seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 22. 2006-03-02. PMID:15930388. |
cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: a role in stress-induced relapse to drug seeking. |
2006-03-02 |
2023-08-12 |
rat |
| Javier Lluch, Marta Rodríguez-Arias, María A Aguilar, José Miñarr. Role of dopamine and glutamate receptors in cocaine-induced social effects in isolated and grouped male OF1 mice. Pharmacology, biochemistry, and behavior. vol 82. issue 3. 2006-03-02. PMID:16313950. |
as dopamine (da) and glutamate seem to be involved in some of cocaine's effects, an attempt was made to assess whether a range of associated receptors influenced the social impacts of this drug of abuse. |
2006-03-02 |
2023-08-12 |
mouse |