| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Rodaros, D A Caruana, S Amir, J Stewar. Corticotropin-releasing factor projections from limbic forebrain and paraventricular nucleus of the hypothalamus to the region of the ventral tegmental area. Neuroscience. vol 150. issue 1. 2008-03-28. PMID:17961928. |
crf is released in the ventral tegmental area (vta), the cell body region of the mesocorticolimbic dopaminergic neurons, in response to acute stress and plays a role in stress-activation of appetitive behavior [wang b, shaham y, zitzman d, azari s, wise ra, you zb (2005) cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: a role in stress-induced relapse to drug seeking. |
2008-03-28 |
2023-08-12 |
rat |
| Rachel D Groth, Jason P Weick, Katherine C Bradley, Jessie I Luoma, Bharathi Aravamudan, Jason R Klug, Mark J Thomas, Paul G Mermelstei. D1 dopamine receptor activation of NFAT-mediated striatal gene expression. The European journal of neuroscience. vol 27. issue 1. 2008-03-18. PMID:18184313. |
consistent with these in-vitro data, repeated exposure to cocaine triggers striatal nfatc4 nuclear translocation and the up-regulation of inositol-1,4,5-trisphosphate receptor type 1 and glutamate receptor subunit 2 gene expression in vivo, suggesting that cocaine-induced increases in gene expression may be partially mediated through activation of nfat-dependent transcription. |
2008-03-18 |
2023-08-12 |
rat |
| Sung Min Ahn, Soo Woon Kim, Eun Sang Cho. Cocaine increases immunoglobulin heavy chain binding protein and caspase-12 expression in the rat dorsal striatum. Psychopharmacology. vol 195. issue 3. 2008-02-08. PMID:17849098. |
cocaine increases endoplasmic reticulum (er) stress protein expression via glutamate and dopamine receptor activation in the dorsal striatum. |
2008-02-08 |
2023-08-12 |
rat |
| Aric Madayag, Doug Lobner, Kristen S Kau, John R Mantsch, Omer Abdulhameed, Matthew Hearing, Mark D Grier, David A Bake. Repeated N-acetylcysteine administration alters plasticity-dependent effects of cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 51. 2008-01-14. PMID:18094234. |
cocaine produces a persistent reduction in cystine-glutamate exchange via system x(c)- in the nucleus accumbens that may contribute to pathological glutamate signaling linked to addiction. |
2008-01-14 |
2023-08-12 |
Not clear |
| Ruey-Kuang Cheng, Yusuf M Ali, Warren H Mec. Ketamine "unlocks" the reduced clock-speed effects of cocaine following extended training: evidence for dopamine--glutamate interactions in timing and time perception. Neurobiology of learning and memory. vol 88. issue 2. 2007-12-07. PMID:17513138. |
ketamine "unlocks" the reduced clock-speed effects of cocaine following extended training: evidence for dopamine--glutamate interactions in timing and time perception. |
2007-12-07 |
2023-08-12 |
rat |
| Tommaso Fellin, Marcello D'Ascenzo, Philip G Haydo. Astrocytes control neuronal excitability in the nucleus accumbens. TheScientificWorldJournal. vol 7. 2007-12-06. PMID:17982581. |
though accumulating evidence shows that the metabotropic glutamate receptor 5 (mglur5) mediates some of the actions of extracellular glutamate after cocaine use, the cellular events underlying this action are poorly understood. |
2007-12-06 |
2023-08-12 |
Not clear |
| Catharine A Winstanley, Quincey LaPlant, David E H Theobald, Thomas A Green, Ryan K Bachtell, Linda I Perrotti, Ralph J DiLeone, Scott J Russo, William J Garth, David W Self, Eric J Nestle. DeltaFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 39. 2007-11-07. PMID:17898221. |
gene microarray analyses identified potential molecular mechanisms underlying this behavioral change, including an increase in transcription of metabotropic glutamate receptor subunit 5 and gaba(a) receptors as well as substance p. identification of deltafosb in the ofc as a mediator of tolerance to the effects of cocaine on cognition provides fundamentally new insight into the transcriptional modifications associated with addiction. |
2007-11-07 |
2023-08-12 |
rat |
| Zhi-Bing You, Bin Wang, Dawnya Zitzman, Soraya Azari, Roy A Wis. A role for conditioned ventral tegmental glutamate release in cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 39. 2007-11-07. PMID:17898226. |
a role for conditioned ventral tegmental glutamate release in cocaine seeking. |
2007-11-07 |
2023-08-12 |
rat |
| Zhi-Bing You, Bin Wang, Dawnya Zitzman, Soraya Azari, Roy A Wis. A role for conditioned ventral tegmental glutamate release in cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 39. 2007-11-07. PMID:17898226. |
initiation of cocaine self-administration in rats was associated with release of glutamate in the ventral tegmental area (vta). |
2007-11-07 |
2023-08-12 |
rat |
| Zhi-Bing You, Bin Wang, Dawnya Zitzman, Soraya Azari, Roy A Wis. A role for conditioned ventral tegmental glutamate release in cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 39. 2007-11-07. PMID:17898226. |
the glutamate release was transient, despite continued cocaine intake. |
2007-11-07 |
2023-08-12 |
rat |
| Zhi-Bing You, Bin Wang, Dawnya Zitzman, Soraya Azari, Roy A Wis. A role for conditioned ventral tegmental glutamate release in cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 39. 2007-11-07. PMID:17898226. |
similar glutamate release was seen in rats earning, for the first time, unexpected saline rather than expected cocaine. |
2007-11-07 |
2023-08-12 |
rat |
| Zhi-Bing You, Bin Wang, Dawnya Zitzman, Soraya Azari, Roy A Wis. A role for conditioned ventral tegmental glutamate release in cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 39. 2007-11-07. PMID:17898226. |
vta glutamate release was not seen in similarly trained rats earning saline instead of cocaine for the 13th time. |
2007-11-07 |
2023-08-12 |
rat |
| Zhi-Bing You, Bin Wang, Dawnya Zitzman, Soraya Azari, Roy A Wis. A role for conditioned ventral tegmental glutamate release in cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 39. 2007-11-07. PMID:17898226. |
vta glutamate release was also seen in similarly trained rats that received yoked rather than earned cocaine injections on test day. |
2007-11-07 |
2023-08-12 |
rat |
| Zhi-Bing You, Bin Wang, Dawnya Zitzman, Soraya Azari, Roy A Wis. A role for conditioned ventral tegmental glutamate release in cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 39. 2007-11-07. PMID:17898226. |
vta glutamate release was not seen in a group of rats that had never earned cocaine but had received yoked injections during the training period. |
2007-11-07 |
2023-08-12 |
rat |
| Zhi-Bing You, Bin Wang, Dawnya Zitzman, Soraya Azari, Roy A Wis. A role for conditioned ventral tegmental glutamate release in cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 39. 2007-11-07. PMID:17898226. |
glutamate release was also not seen in a group of rats that received yoked injections but had no previous experience with cocaine. |
2007-11-07 |
2023-08-12 |
rat |
| Zhi-Bing You, Bin Wang, Dawnya Zitzman, Soraya Azari, Roy A Wis. A role for conditioned ventral tegmental glutamate release in cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 39. 2007-11-07. PMID:17898226. |
blockade of vta glutamate receptors appeared to attenuate the rewarding effects of intravenous cocaine injections and blocked almost completely the conditioned responding normally seen during extinction trials. |
2007-11-07 |
2023-08-12 |
rat |
| Zhi-Bing You, Bin Wang, Dawnya Zitzman, Soraya Azari, Roy A Wis. A role for conditioned ventral tegmental glutamate release in cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 39. 2007-11-07. PMID:17898226. |
these findings indicate that vta glutamate release is a conditioned response dependent on an associative process and is not a simple consequence of previous cocaine exposure. |
2007-11-07 |
2023-08-12 |
rat |
| Amy C Boudreau, Jeremy M Reimers, Michael Milovanovic, Marina E Wol. Cell surface AMPA receptors in the rat nucleus accumbens increase during cocaine withdrawal but internalize after cocaine challenge in association with altered activation of mitogen-activated protein kinases. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 39. 2007-11-07. PMID:17898233. |
glutamate receptor 1 (glur1) and glur2 surface/intracellular (s/i) ratios were increased after 14 d of withdrawal in sensitized rats but were decreased 24 h after challenge with cocaine (which elicited a sensitized locomotor response) or saline (which elicited conditioned locomotion). |
2007-11-07 |
2023-08-12 |
rat |
| Nanping Wu, Carlos Cepeda, Xiaoxi Zhuang, Michael S Levin. Altered corticostriatal neurotransmission and modulation in dopamine transporter knock-down mice. Journal of neurophysiology. vol 98. issue 1. 2007-10-02. PMID:17522168. |
in wts amphetamine and cocaine reduced the frequency of spontaneous glutamate currents and these effects appeared to be mediated by activation of d2 receptors. |
2007-10-02 |
2023-08-12 |
mouse |
| Karen K Szumlinski, Andrew Liu, Jeffery H Penzner, Kevin D Lomina. Protracted 'pro-addictive' phenotype produced in mice by pre-adolescent phenylpropanolamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 8. 2007-09-26. PMID:17251912. |
pre-adolescent ppa exposure completely prevented the capacity of cocaine to elevate extracellular levels of catecholamines in the nucleus accumbens, but facilitated the development of cocaine-induced glutamate sensitization. |
2007-09-26 |
2023-08-12 |
mouse |