| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zachary D Brodnik, Wei Xu, Aashita Batra, Stacia I Lewandowski, Christina M Ruiz, Ole V Mortensen, Sandhya Kortagere, Stephen V Mahler, Rodrigo A Españ. Chemogenetic Manipulation of Dopamine Neurons Dictates Cocaine Potency at Distal Dopamine Transporters. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 45. 2021-02-01. PMID:33046544. |
the reinforcing efficacy of cocaine is largely determined by its capacity to inhibit the dopamine transporter (dat), and emerging evidence suggests that differences in cocaine potency are linked to several symptoms of cocaine use disorder. |
2021-02-01 |
2023-08-13 |
Not clear |
| Carolyn G Sweeney, Patrick J Kearney, Rita R Fagan, Lindsey A Smith, Nicholas C Bolden, Rubing Zhao-Shea, Iris V Rivera, Jenya Kolpakova, Jun Xie, Guangping Gao, Andrew R Tapper, Gilles E Martin, Haley E Melikia. Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 2. 2020-12-28. PMID:31277075. |
conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for rit2 gtpase in acute cocaine response and striatal function. |
2020-12-28 |
2023-08-13 |
Not clear |
| Zachary D Brodnik, Emily M Black, Rodrigo A Españ. Accelerated development of cocaine-associated dopamine transients and cocaine use vulnerability following traumatic stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 3. 2020-12-28. PMID:31539899. |
accelerated development of cocaine-associated dopamine transients and cocaine use vulnerability following traumatic stress. |
2020-12-28 |
2023-08-13 |
rat |
| Zachary D Brodnik, Emily M Black, Rodrigo A Españ. Accelerated development of cocaine-associated dopamine transients and cocaine use vulnerability following traumatic stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 3. 2020-12-28. PMID:31539899. |
we paired this model with in vivo fast scan cyclic voltammetry in freely moving rats to test for differences in dopamine signaling in the nucleus accumbens core at baseline, in response to a single dose of cocaine, and in response to cocaine-paired cues. |
2020-12-28 |
2023-08-13 |
rat |
| Zachary D Brodnik, Emily M Black, Rodrigo A Españ. Accelerated development of cocaine-associated dopamine transients and cocaine use vulnerability following traumatic stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 3. 2020-12-28. PMID:31539899. |
together, our studies demonstrate that susceptibility to traumatic stress is associated with a cocaine use-vulnerable phenotype and suggests that differences in phasic dopamine signaling architecture may contribute to the process by which this vulnerability occurs. |
2020-12-28 |
2023-08-13 |
rat |
| Clifford M Cassidy, Kenneth M Carpenter, Anna B Konova, Victoria Cheung, Alexander Grassetti, Luigi Zecca, Anissa Abi-Dargham, Diana Martinez, Guillermo Horg. Evidence for Dopamine Abnormalities in the Substantia Nigra in Cocaine Addiction Revealed by Neuromelanin-Sensitive MRI. The American journal of psychiatry. vol 177. issue 11. 2020-12-14. PMID:32854531. |
evidence for dopamine abnormalities in the substantia nigra in cocaine addiction revealed by neuromelanin-sensitive mri. |
2020-12-14 |
2023-08-13 |
human |
| Clifford M Cassidy, Kenneth M Carpenter, Anna B Konova, Victoria Cheung, Alexander Grassetti, Luigi Zecca, Anissa Abi-Dargham, Diana Martinez, Guillermo Horg. Evidence for Dopamine Abnormalities in the Substantia Nigra in Cocaine Addiction Revealed by Neuromelanin-Sensitive MRI. The American journal of psychiatry. vol 177. issue 11. 2020-12-14. PMID:32854531. |
the authors investigated the nm-mri signal in individuals with cocaine use disorder, compared with age- and sex-matched control subjects, based on previous imaging studies showing that this disorder is associated with blunted presynaptic striatal dopamine. |
2020-12-14 |
2023-08-13 |
human |
| Tinkara Pirc Marolt, Barbara Kramar, Klara Bulc Rozman, Dušan Šuput, Irina Milisa. Aripiprazole reduces liver cell division. PloS one. vol 15. issue 10. 2020-12-08. PMID:33104743. |
effects of aripiprazole on dopamine regulation are being tested as a treatment for patients with a dual diagnosis of schizophrenia and addictions, often cocaine dependence. |
2020-12-08 |
2023-08-13 |
Not clear |
| Charles W Bradberr. Neuromelanin MRI: Dark Substance Shines a Light on Dopamine Dysfunction and Cocaine Use. The American journal of psychiatry. vol 177. issue 11. 2020-12-01. PMID:33135472. |
neuromelanin mri: dark substance shines a light on dopamine dysfunction and cocaine use. |
2020-12-01 |
2023-08-13 |
Not clear |
| Wilber Romero-Fernandez, Zilong Zhou, Sarah Beggiato, Karolina Wydra, Malgorzata Filip, Sergio Tanganelli, Dasiel O Borroto-Escuela, Luca Ferraro, Kjell Fux. Acute cocaine treatment enhances the antagonistic allosteric adenosine A2A-dopamine D2 receptor-receptor interactions in rat dorsal striatum without increasing significantly extracellular dopamine levels. Pharmacological reports : PR. vol 72. issue 2. 2020-11-27. PMID:32124388. |
acute cocaine treatment enhances the antagonistic allosteric adenosine a2a-dopamine d2 receptor-receptor interactions in rat dorsal striatum without increasing significantly extracellular dopamine levels. |
2020-11-27 |
2023-08-13 |
rat |
| Domen Pregeljc, Diana Teodorescu-Perijoc, Robert Vianello, Nejc Umek, Janez Mavr. How Important Is the Use of Cocaine and Amphetamines in the Development of Parkinson Disease? A Computational Study. Neurotoxicity research. vol 37. issue 3. 2020-11-20. PMID:31828739. |
by considering three transport pathways (dopamine transporter (dat), vesicular transporter (vt), and exocytosis), four simulated scenarios were investigated: homeostasis, application of cocaine, methamphetamine, and reserpine. |
2020-11-20 |
2023-08-13 |
human |
| Domen Pregeljc, Diana Teodorescu-Perijoc, Robert Vianello, Nejc Umek, Janez Mavr. How Important Is the Use of Cocaine and Amphetamines in the Development of Parkinson Disease? A Computational Study. Neurotoxicity research. vol 37. issue 3. 2020-11-20. PMID:31828739. |
per computational inference, the cytosol dopamine concentration was noted to increase in the case of methamphetamine and reserpine, but was practically unchanged in the case of the cocaine administration. |
2020-11-20 |
2023-08-13 |
human |
| Domen Pregeljc, Diana Teodorescu-Perijoc, Robert Vianello, Nejc Umek, Janez Mavr. How Important Is the Use of Cocaine and Amphetamines in the Development of Parkinson Disease? A Computational Study. Neurotoxicity research. vol 37. issue 3. 2020-11-20. PMID:31828739. |
accordingly, our study suggests that amphetamines and other substances that block vt, but not cocaine or substances that only block dat, may be etiologically important in the cytosolic dopamine mediation of neurodegeneration in parkinson disease/parkinsonism. |
2020-11-20 |
2023-08-13 |
human |
| Francesco Napolitano, Arianna De Rosa, Rosita Russo, Anna Di Maio, Martina Garofalo, Mauro Federici, Sara Migliarini, Ada Ledonne, Francesca Romana Rizzo, Luigi Avallone, Tommaso Nuzzo, Tommaso Biagini, Massimo Pasqualetti, Nicola Biagio Mercuri, Tommaso Mazza, Angela Chambery, Alessandro Usiell. The striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses. Scientific reports. vol 9. issue 1. 2020-11-05. PMID:31653935. |
despite dramatic striatal alterations associated to cocaine exposure, our data did not reveal any significant changes in midbrain dopaminergic neurons as a lack of rhes did not affect: (i) dat activity; (ii) d2r-dependent regulation of girk; and (iii) d2r-dependent regulation of dopamine release. |
2020-11-05 |
2023-08-13 |
mouse |
| Maria Carolina Velasquez-Martinez, Bermary Santos-Vera, Maria E Velez-Hernandez, Rafael Vazquez-Torres, Carlos A Jimenez-River. Alpha-1 Adrenergic Receptors Modulate Glutamate and GABA Neurotransmission onto Ventral Tegmental Dopamine Neurons during Cocaine Sensitization. International journal of molecular sciences. vol 21. issue 3. 2020-11-05. PMID:31991781. |
alpha-1 adrenergic receptors modulate glutamate and gaba neurotransmission onto ventral tegmental dopamine neurons during cocaine sensitization. |
2020-11-05 |
2023-08-13 |
Not clear |
| Maria Carolina Velasquez-Martinez, Bermary Santos-Vera, Maria E Velez-Hernandez, Rafael Vazquez-Torres, Carlos A Jimenez-River. Alpha-1 Adrenergic Receptors Modulate Glutamate and GABA Neurotransmission onto Ventral Tegmental Dopamine Neurons during Cocaine Sensitization. International journal of molecular sciences. vol 21. issue 3. 2020-11-05. PMID:31991781. |
taken together, these data suggest that α1-ars may enhance da neuronal excitability after repeated cocaine administration through the reduction of gaba inhibition onto vta dopamine (da) neurons even in the absence of α1-ars' function on glutamate release and protein kinase c (pkc) activation. |
2020-11-05 |
2023-08-13 |
Not clear |
| Courtney M Keller, Nicholas E Goeder. Lack of effect of the combination of metyrapone and oxazepam on brain dopamine. Brain research. vol 1724. 2020-10-29. PMID:31491421. |
further, the combination of these two drugs produced no effect on dopamine in the absence of cocaine. |
2020-10-29 |
2023-08-13 |
human |
| Courtney M Keller, Nicholas E Goeder. Lack of effect of the combination of metyrapone and oxazepam on brain dopamine. Brain research. vol 1724. 2020-10-29. PMID:31491421. |
together, these studies demonstrate that met-ox does not exert its effects by altering dopamine, suggesting that it might be possible to treat cocaine use disorder without affecting dopamine, which would lead to reduced side effects and increased compliance. |
2020-10-29 |
2023-08-13 |
human |
| Ze-Gang Ma, Nan Jiang, Yuan-Bing Huang, Xiao-Kuang Ma, Jason Brek Eaton, Ming Gao, Yong-Chang Chang, Ronald J Lukas, Paul Whiteaker, Janet Neisewander, Jie W. Cocaine potently blocks neuronal α Acta pharmacologica Sinica. vol 41. issue 2. 2020-10-23. PMID:31399700. |
it is well known that the dopamine (da) transporter is its major target; but cocaine also acts on other targets including nicotinic acetylcholine receptors (nachrs). |
2020-10-23 |
2023-08-13 |
Not clear |
| Umar Farooque, Nduka Okorie, Saurabh Kataria, Syed Furqan Shah, Vijaya Chaitanya Bollampall. Cocaine-Induced Headache: A Review of Pathogenesis, Presentation, Diagnosis, and Management. Cureus. vol 12. issue 8. 2020-10-03. PMID:33005542. |
cocaine causes vasoconstriction by stimulation of the sympathetic nervous system and decreases the reuptake of epinephrine, norepinephrine, serotonin, and dopamine. |
2020-10-03 |
2023-08-13 |
Not clear |