| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ludivine Canchy, Paul Girardeau, Audrey Durand, Caroline Vouillac-Mendoza, Serge H Ahme. Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 2. 2021-06-23. PMID:32731253. |
cocaine is known to increase brain dopamine at supranormal levels in comparison to alternative nondrug rewards. |
2021-06-23 |
2023-08-13 |
rat |
| Ludivine Canchy, Paul Girardeau, Audrey Durand, Caroline Vouillac-Mendoza, Serge H Ahme. Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 2. 2021-06-23. PMID:32731253. |
according to the dopamine hypothesis of addiction, this abnormally large dopamine response would explain why cocaine use is initially highly rewarding and addictive. |
2021-06-23 |
2023-08-13 |
rat |
| Ludivine Canchy, Paul Girardeau, Audrey Durand, Caroline Vouillac-Mendoza, Serge H Ahme. Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 2. 2021-06-23. PMID:32731253. |
first, a systematic literature analysis revealed that the delays of effects of intravenous cocaine on nucleus accumbens dopamine are of the order of tens of seconds and are considerably longer than those of nondrug reward. |
2021-06-23 |
2023-08-13 |
rat |
| Ludivine Canchy, Paul Girardeau, Audrey Durand, Caroline Vouillac-Mendoza, Serge H Ahme. Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 2. 2021-06-23. PMID:32731253. |
overall, this study suggests that cocaine is indeed supranormal in reward magnitude, as postulated by the dopamine hypothesis of addiction, but is less preferred during choice because its pharmacokinetics makes it an inherently more delayed reward than the alternative. |
2021-06-23 |
2023-08-13 |
rat |
| Renan Costa Campos, Carine Dias, Florence Darlot, Martine Cado. Double dissociation between actions of dopamine D1 and D2 receptors of the ventral and dorsolateral striatum to produce reinstatement of cocaine seeking behavior. Neuropharmacology. vol 172. 2021-06-21. PMID:32335152. |
double dissociation between actions of dopamine d1 and d2 receptors of the ventral and dorsolateral striatum to produce reinstatement of cocaine seeking behavior. |
2021-06-21 |
2023-08-13 |
rat |
| Renan Costa Campos, Carine Dias, Florence Darlot, Martine Cado. Double dissociation between actions of dopamine D1 and D2 receptors of the ventral and dorsolateral striatum to produce reinstatement of cocaine seeking behavior. Neuropharmacology. vol 172. 2021-06-21. PMID:32335152. |
following repeated use, cocaine (coc) induces neuroadaptations within the dopamine (da) system, arguably underlying several aspects of coc-seeking behavior. |
2021-06-21 |
2023-08-13 |
rat |
| Chloe J Jordan, Yi He, Guo-Hua Bi, Zhi-Bing You, Jianjing Cao, Zheng-Xiong Xi, Amy Hauck Newma. (±)VK4-40, a novel dopamine D British journal of pharmacology. vol 177. issue 20. 2021-06-21. PMID:32851643. |
(±)vk4-40, a novel dopamine d despite widespread abuse of cocaine, there are no approved treatments for cocaine use disorder. |
2021-06-21 |
2023-08-13 |
Not clear |
| Chloe J Jordan, Yi He, Guo-Hua Bi, Zhi-Bing You, Jianjing Cao, Zheng-Xiong Xi, Amy Hauck Newma. (±)VK4-40, a novel dopamine D British journal of pharmacology. vol 177. issue 20. 2021-06-21. PMID:32851643. |
chronic cocaine use is associated with up-regulated dopamine d |
2021-06-21 |
2023-08-13 |
Not clear |
| Daryl A Guthrie, Carmen Klein Herenbrink, Matthew Domenic Lycas, Therese Ku, Alessandro Bonifazi, Brian T DeVree, Signe Mathiasen, Jonathan A Javitch, Jonathan B Grimm, Luke Lavis, Ulrik Gether, Amy Hauck Newma. Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter. ACS chemical neuroscience. vol 11. issue 20. 2021-06-18. PMID:32926777. |
the dopamine transporter (dat) is critical for spatiotemporal control of dopaminergic neurotransmission and is the target for therapeutic agents, including adhd medications, and abused substances, such as cocaine. |
2021-06-18 |
2023-08-13 |
Not clear |
| Margot C DeBaker, Ezequiel Marron Fernandez de Velasco, Nora M McCall, Anna M Lee, Kevin Wickma. Differential Impact of Inhibitory G-Protein Signaling Pathways in Ventral Tegmental Area Dopamine Neurons on Behavioral Sensitivity to Cocaine and Morphine. eNeuro. vol 8. issue 2. 2021-06-18. PMID:33707203. |
differential impact of inhibitory g-protein signaling pathways in ventral tegmental area dopamine neurons on behavioral sensitivity to cocaine and morphine. |
2021-06-18 |
2023-08-13 |
Not clear |
| Liang Xu, Liao Y Che. Identification of a New Allosteric Binding Site for Cocaine in Dopamine Transporter. Journal of chemical information and modeling. vol 60. issue 8. 2021-06-17. PMID:32649824. |
identification of a new allosteric binding site for cocaine in dopamine transporter. |
2021-06-17 |
2023-08-13 |
Not clear |
| Liang Xu, Liao Y Che. Identification of a New Allosteric Binding Site for Cocaine in Dopamine Transporter. Journal of chemical information and modeling. vol 60. issue 8. 2021-06-17. PMID:32649824. |
dopamine (da) transporter (dat) is a major target for psychostimulant drugs of abuse such as cocaine that competitively binds to dat, inhibits da reuptake, and consequently increases synaptic da levels. |
2021-06-17 |
2023-08-13 |
Not clear |
| Zachary D Brodnik, I Pamela Alonso, Wei Xu, Yanan Zhang, Sandhya Kortagere, Rodrigo A Españ. Hypocretin receptor 1 involvement in cocaine-associated behavior: Therapeutic potential and novel mechanistic insights. Brain research. vol 1731. 2021-06-07. PMID:30071195. |
we then present new data supporting the novel hypothesis that in addition to exerting acute actions on dopamine systems, pharmacological hypocretin manipulations also produce lasting adaptations to dopamine terminals that impact sensitivity to cocaine, and ultimately, future behavior. |
2021-06-07 |
2023-08-13 |
Not clear |
| Cigdem Aydin, Karla Frohmader, Michael Emery, Peter Blandino, Huda Aki. Chronic stress in adolescence differentially affects cocaine vulnerability in adulthood in a selectively bred rat model of individual differences: role of accumbal dopamine signaling. Stress (Amsterdam, Netherlands). vol 24. issue 3. 2021-05-27. PMID:32748678. |
chronic stress in adolescence differentially affects cocaine vulnerability in adulthood in a selectively bred rat model of individual differences: role of accumbal dopamine signaling. |
2021-05-27 |
2023-08-13 |
rat |
| Cigdem Aydin, Karla Frohmader, Michael Emery, Peter Blandino, Huda Aki. Chronic stress in adolescence differentially affects cocaine vulnerability in adulthood in a selectively bred rat model of individual differences: role of accumbal dopamine signaling. Stress (Amsterdam, Netherlands). vol 24. issue 3. 2021-05-27. PMID:32748678. |
we also determined whether accumbal dopamine signaling is involved in the interaction of stress history and cocaine by assessing the mrna levels of dopamine d1 (d1r) and d2 (d2r) receptors. |
2021-05-27 |
2023-08-13 |
rat |
| Kenneth Blum, David Baron, Thomas McLaughlin, Mark S Gol. Molecular neurological correlates of endorphinergic/dopaminergic mechanisms in reward circuitry linked to endorphinergic deficiency syndrome (EDS). Journal of the neurological sciences. vol 411. 2021-05-14. PMID:32088516. |
the role of dopamine in terms of alcohol withdrawal symptomology, cocaine craving behavior, dopamine -condensation products (tiqs), and more recently, the genetic aspects of drug-seeking and pro-dopamine regulation, provide compelling evidence of the relevant molecular neurological correlates of dopaminergic /endorphinergic mechanisms in reward circuitry due to genetic polymorphisms and epigenetic insults. |
2021-05-14 |
2023-08-13 |
Not clear |
| Robert G Lewis, Marcello Serra, Daniela Radl, Michela Gori, Catherine Tran, Sharon E Michalak, Christopher D Vanderwal, Emiliana Borrell. Dopaminergic Control of Striatal Cholinergic Interneurons Underlies Cocaine-Induced Psychostimulation. Cell reports. vol 31. issue 3. 2021-05-14. PMID:32320647. |
cocaine drastically elevates dopamine (da) levels in the striatum, a brain region that is critical to the psychomotor and rewarding properties of the drug. |
2021-05-14 |
2023-08-13 |
Not clear |
| Eugene A Kiyatki. The Critical Role of Peripheral Targets in Triggering Rapid Neural Effects of Intravenous Cocaine. Neuroscience. vol 451. 2021-05-14. PMID:33010343. |
some of these effects are mimicked by cocaine-methiodide, a cocaine analog that cannot cross the blood-brain barrier and they are resistant to dopamine (da) receptor blockade. |
2021-05-14 |
2023-08-13 |
Not clear |
| Susana Barbosa-Méndez, Gilberto Pérez-Sánchez, Enrique Becerril-Villanueva, Alberto Salazar-Juáre. Melatonin decreases cocaine-induced locomotor sensitization and cocaine-conditioned place preference in rats. Journal of psychiatric research. vol 132. 2021-05-14. PMID:33080430. |
additionally, dopamine levels were determined in the ventral striatum, the prefrontal cortex (pfc), and the ventral tegmental area (vta) by hplc in animals treated with melatonin and cocaine. |
2021-05-14 |
2023-08-13 |
rat |
| Maged M Harraz, Prasun Guha, In Guk Kang, Evan R Semenza, Adarsha P Malla, Young Jun Song, Luke Reilly, Isaac Treisman, Pedro Cortés, Mark A Coggiano, Vijayabhaskar Veeravalli, Rana Rais, Gianluigi Tanda, Solomon H Snyde. Cocaine-induced locomotor stimulation involves autophagic degradation of the dopamine transporter. Molecular psychiatry. vol 26. issue 2. 2021-05-14. PMID:33414501. |
cocaine exerts its stimulant effect by inhibiting dopamine reuptake leading to increased dopamine signaling. |
2021-05-14 |
2023-08-13 |
mouse |