| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert W Seaman, Michelle R Doyle, Agnieszka Sulima, Kenner C Rice, Gregory T Collin. Discriminative stimulus effects of 3,4-methylenedioxypyrovalerone (MDPV) and structurally related synthetic cathinones. Behavioural pharmacology. vol 32. issue 5. 2021-09-06. PMID:33587482. |
these studies used male sprague-dawley rats trained to discriminate mdpv from saline to evaluate the substitution profiles of structurally related synthetic cathinones, cocaine, and other direct-acting dopamine and noradrenergic receptor agonists in order to characterize the relative contributions of dopamine, norepinephrine and serotonin to the discriminative stimulus effects of mdpv. |
2021-09-06 |
2023-08-13 |
rat |
| Robert W Seaman, Michelle R Doyle, Agnieszka Sulima, Kenner C Rice, Gregory T Collin. Discriminative stimulus effects of 3,4-methylenedioxypyrovalerone (MDPV) and structurally related synthetic cathinones. Behavioural pharmacology. vol 32. issue 5. 2021-09-06. PMID:33587482. |
as expected, each of the cathinones and cocaine dose-dependently increased mdpv-appropriate responding, with a rank-order potency that was positively correlated with their potency to inhibit dopamine and norepinephrine, but not serotonin, a relationship that is consistent with the rank order to maintain self-administration. |
2021-09-06 |
2023-08-13 |
rat |
| Durairaj Ragu Varman, Mark A Subler, Jolene J Windle, Lankupalle D Jayanthi, Sammanda Ramamoorth. Novelty-induced hyperactivity and suppressed cocaine induced locomotor activation in mice lacking threonine 53 phosphorylation of dopamine transporter. Behavioural brain research. vol 408. 2021-09-02. PMID:33794225. |
novelty-induced hyperactivity and suppressed cocaine induced locomotor activation in mice lacking threonine 53 phosphorylation of dopamine transporter. |
2021-09-02 |
2023-08-13 |
mouse |
| Jessica K Shaw, I Pamela Alonso, Stacia I Lewandowski, Marion O Scott, Bethan M O'Connor, Shaili Aggarwal, Mariella De Biasi, Ole V Mortensen, Rodrigo A Españ. Individual differences in dopamine uptake in the dorsomedial striatum prior to cocaine exposure predict motivation for cocaine in male rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 10. 2021-08-27. PMID:33953341. |
individual differences in dopamine uptake in the dorsomedial striatum prior to cocaine exposure predict motivation for cocaine in male rats. |
2021-08-27 |
2023-08-13 |
rat |
| Jessica K Shaw, I Pamela Alonso, Stacia I Lewandowski, Marion O Scott, Bethan M O'Connor, Shaili Aggarwal, Mariella De Biasi, Ole V Mortensen, Rodrigo A Españ. Individual differences in dopamine uptake in the dorsomedial striatum prior to cocaine exposure predict motivation for cocaine in male rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 10. 2021-08-27. PMID:33953341. |
here, we prospectively measured dopamine (da) neurotransmission prior to cocaine exposure to predict the onset and course of cocaine use. |
2021-08-27 |
2023-08-13 |
rat |
| Camilla Bellone, Michael Loureiro, Christian Lüsche. Drug-Evoked Synaptic Plasticity of Excitatory Transmission in the Ventral Tegmental Area. Cold Spring Harbor perspectives in medicine. vol 11. issue 4. 2021-08-25. PMID:32341062. |
here, we discuss cocaine-evoked synaptic plasticity of glutamatergic transmission onto dopamine (da) neurons of the ventral tegmental area (vta) as one of the earliest traces after a first injection of cocaine. |
2021-08-25 |
2023-08-13 |
Not clear |
| Susana Paredes-Zúñiga, Fernando Ormeño, Miguel L Allend. Triadimefon triggers circling behavior and conditioned place preference/aversion in zebrafish in a dose dependent manner. Neurotoxicology and teratology. vol 86. 2021-08-25. PMID:33839247. |
for vertebrates, one of its side effects is the binding to the dopamine transporter increasing the levels of synaptic dopamine, similarly to cocaine. |
2021-08-25 |
2023-08-13 |
zebrafish |
| Aaron Caccamise, Erik Van Newenhizen, John R Mantsc. Neurochemical mechanisms and neurocircuitry underlying the contribution of stress to cocaine seeking. Journal of neurochemistry. vol 157. issue 5. 2021-08-24. PMID:33660857. |
crf promotes the activation of vta dopamine neurons that innervate the prelimbic prefrontal cortex resulting in d1 receptor-dependent excitation of a pathway to the nucleus accumbens core that mediates cocaine seeking. |
2021-08-24 |
2023-08-13 |
Not clear |
| Zhijun Diao, Yuanyuan Di, Meilin Wu, Chenyang Zhai, Mengsi Kang, Yongfeng Li, Yingxun Liu, Chunling Wei, Qiaohua Zheng, Jing Han, Zhiqiang Liu, Yingfang Tian, Wei Re. Single Exposure to Cocaine Impairs Reinforcement Learning by Potentiating the Activity of Neurons in the Direct Striatal Pathway in Mice. Neuroscience bulletin. vol 37. issue 8. 2021-08-18. PMID:33905097. |
either a single exposure to cocaine or reinforcement learning potentiates the glutamatergic synapses on msns expressing the striatal dopamine 1 (d1) receptor (d1-msns). |
2021-08-18 |
2023-08-13 |
mouse |
| Patricia Rivera, Jesús Aranda, Francisco Alén, Antonio Vargas, Antonia Serrano, Francisco Javier Pavón, Laura Orio, Leticia Rubio, Rosario Moratalla, Fernando Rodríguez de Fonseca, Juan Suáre. Sex-specific behavioral and neurogenic responses to cocaine in mice lacking and blocking dopamine D1 or dopamine D2 receptors. The Journal of comparative neurology. vol 529. issue 8. 2021-08-16. PMID:33047300. |
sex-specific behavioral and neurogenic responses to cocaine in mice lacking and blocking dopamine d1 or dopamine d2 receptors. |
2021-08-16 |
2023-08-13 |
mouse |
| Patricia Rivera, Jesús Aranda, Francisco Alén, Antonio Vargas, Antonia Serrano, Francisco Javier Pavón, Laura Orio, Leticia Rubio, Rosario Moratalla, Fernando Rodríguez de Fonseca, Juan Suáre. Sex-specific behavioral and neurogenic responses to cocaine in mice lacking and blocking dopamine D1 or dopamine D2 receptors. The Journal of comparative neurology. vol 529. issue 8. 2021-08-16. PMID:33047300. |
however, the sex-specific role of dopamine d1 and d2 receptors (d1r, d2r) in the deleterious effect of cocaine on adult neurogenesis has not been described yet. |
2021-08-16 |
2023-08-13 |
mouse |
| Shannon L Cole, Ramesh Chandra, Maya Harris, Ishan Patel, Torrance Wang, Hyunjae Kim, Leah Jensen, Scott J Russo, Gustavo Turecki, Amy M Gancarz-Kausch, David M Dietz, Mary Kay Lob. Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation. Molecular brain. vol 14. issue 1. 2021-08-12. PMID:34187517. |
further, mitochondria are differentially regulated by cocaine in dopamine receptor-1 containing medium spiny neurons (d1-msns) vs dopamine receptor-2 (d2)-msns. |
2021-08-12 |
2023-08-13 |
human |
| Fernando B de Moura, Alexander Sherwood, Thomas E Prisinzano, Carol A Paronis, Jack Bergman, Stephen J Kohu. Reinforcing effects of synthetic cathinones in rhesus monkeys: Dose-response and behavioral economic analyses. Pharmacology, biochemistry, and behavior. vol 202. 2021-08-10. PMID:33444603. |
the reinforcing effects of selected cathinones (e.g., mdpv, αpvp, mcat, and methylone) with a range of pharmacological effects at dopamine and serotonin transporters were compared to cocaine and mdma using dose-response analysis under a simple fr schedule and behavioral economic procedures that generated demand curves for two doses of each drug. |
2021-08-10 |
2023-08-13 |
human |
| Anna Terem, Ben Jerry Gonzales, Noa Peretz-Rivlin, Reut Ashwal-Fluss, Noa Bleistein, Maria Del Mar Reus-Garcia, Diptendu Mukherjee, Maya Groysman, Ami Citr. Claustral Neurons Projecting to Frontal Cortex Mediate Contextual Association of Reward. Current biology : CB. vol 30. issue 18. 2021-08-09. PMID:32707061. |
this strategy resolves the role of a defined network of claustrum neurons expressing dopamine d1 receptors and projecting to frontal cortex in the acquisition of cocaine conditioned-place preference and real-time optogenetic conditioned-place preference. |
2021-08-09 |
2023-08-13 |
Not clear |
| Jing Deng, Kyungbo Kim, Xirong Zheng, Linyue Shang, Chang-Guo Zhan, Fang Zhen. Cocaine hydrolase blocks cocaine-induced dopamine transporter trafficking to the plasma membrane. Addiction biology. 2021-08-07. PMID:34363291. |
cocaine hydrolase blocks cocaine-induced dopamine transporter trafficking to the plasma membrane. |
2021-08-07 |
2023-08-13 |
rat |
| Jing Deng, Kyungbo Kim, Xirong Zheng, Linyue Shang, Chang-Guo Zhan, Fang Zhen. Cocaine hydrolase blocks cocaine-induced dopamine transporter trafficking to the plasma membrane. Addiction biology. 2021-08-07. PMID:34363291. |
cocaine blocks dopamine uptake via dopamine transporter (dat) on plasma membrane of neuron cells and, as a result, produces the high and induces dat trafficking to plasma membrane which contributes to the drug seeking or craving. |
2021-08-07 |
2023-08-13 |
rat |
| Ahmed Hasbi, Meenalochani Sivasubramanian, Marija Milenkovic, Kristina Komarek, Bertha K Madras, Susan R Georg. Dopamine D1-D2 receptor heteromer expression in key brain regions of rat and higher species: Upregulation in rat striatum after cocaine administration. Neurobiology of disease. vol 143. 2021-08-05. PMID:32679312. |
dopamine d1-d2 receptor heteromer expression in key brain regions of rat and higher species: upregulation in rat striatum after cocaine administration. |
2021-08-05 |
2023-08-13 |
rat |
| Marie A Doyle, Vedrana Bali, Andrew L Eagle, Ali R Stark, Barbara Fallon, Rachael L Neve, A J Robison, Michelle S Mazei-Robiso. Serum- and glucocorticoid-inducible kinase 1 activity in ventral tegmental area dopamine neurons regulates cocaine conditioned place preference but not cocaine self-administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 9. 2021-08-04. PMID:34007042. |
serum- and glucocorticoid-inducible kinase 1 activity in ventral tegmental area dopamine neurons regulates cocaine conditioned place preference but not cocaine self-administration. |
2021-08-04 |
2023-08-13 |
Not clear |
| Horia Pribiag, Sora Shin, Eric Hou-Jen Wang, Fangmiao Sun, Paul Datta, Alexander Okamoto, Hayden Guss, Akanksha Jain, Xiao-Yun Wang, Bruna De Freitas, Patrick Honma, Stefan Pate, Varoth Lilascharoen, Yulong Li, Byung Kook Li. Ventral pallidum DRD3 potentiates a pallido-habenular circuit driving accumbal dopamine release and cocaine seeking. Neuron. vol 109. issue 13. 2021-07-23. PMID:34048697. |
ventral pallidum drd3 potentiates a pallido-habenular circuit driving accumbal dopamine release and cocaine seeking. |
2021-07-23 |
2023-08-13 |
Not clear |
| Horia Pribiag, Sora Shin, Eric Hou-Jen Wang, Fangmiao Sun, Paul Datta, Alexander Okamoto, Hayden Guss, Akanksha Jain, Xiao-Yun Wang, Bruna De Freitas, Patrick Honma, Stefan Pate, Varoth Lilascharoen, Yulong Li, Byung Kook Li. Ventral pallidum DRD3 potentiates a pallido-habenular circuit driving accumbal dopamine release and cocaine seeking. Neuron. vol 109. issue 13. 2021-07-23. PMID:34048697. |
here, we demonstrate that dopamine receptor d3 (drd3)-dependent plasticity in the ventral pallidum (vp) drives potentiation of dopamine release in the nucleus accumbens during relapse to cocaine seeking after abstinence. |
2021-07-23 |
2023-08-13 |
Not clear |