| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Suchan Chang, Yeonhee Ryu, Se Kyun Bang, Han Byeol Jang, DanBi Ahn, Hyung Kyu Kim, Hubert Lee, Sang Chan Kim, Bong Hyo Lee, Hee Young Ki. An Increase in Peripheral Temperature following Cocaine Administration Is Mediated through Activation of Dopamine D2 Receptor in Rats. Life (Basel, Switzerland). vol 12. issue 2. 2022-02-25. PMID:35207431. |
treatment with cocaine or bromocriptine decreased the size of skin blood vessels without affecting the expression of dopamine d2 receptors. |
2022-02-25 |
2023-08-13 |
rat |
| Suchan Chang, Yeonhee Ryu, Se Kyun Bang, Han Byeol Jang, DanBi Ahn, Hyung Kyu Kim, Hubert Lee, Sang Chan Kim, Bong Hyo Lee, Hee Young Ki. An Increase in Peripheral Temperature following Cocaine Administration Is Mediated through Activation of Dopamine D2 Receptor in Rats. Life (Basel, Switzerland). vol 12. issue 2. 2022-02-25. PMID:35207431. |
these results suggest that increased peripheral temperature in skin following cocaine injection is associated with the activation of the dopamine d2 receptor. |
2022-02-25 |
2023-08-13 |
rat |
| Hong-Ju Yang, Briana J Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L Gardner, Zheng-Xiong X. Elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a NMDA-GluN2B receptor mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-29. PMID:35091501. |
in this study, we systemically evaluated the effects of multiple glutamate transporter (glt) inhibitors on extracellular glutamate and dopamine (da) in the nucleus accumbens (nac), intravenous cocaine self-administration, intracranial brain-stimulation reward, and reinstatement of cocaine seeking in male and female rats. |
2022-01-29 |
2023-08-13 |
rat |
| Zhi-Bing You, Ewa Galaj, Francisco Alén, Bin Wang, Guo-Hua Bi, Allamar R Moore, Tristram Buck, Madeline Crissman, Sruti Pari, Zheng-Xiong Xi, Lorenzo Leggio, Roy A Wise, Eliot L Gardne. Involvement of the ghrelin system in the maintenance and reinstatement of cocaine-motivated behaviors: a role of adrenergic action at peripheral β1 receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021-12-19. PMID:34923576. |
in the present study, we show that: (1) elevation of ghrelin by cocaine plays a critical role in maintenance of cocaine self-administration and cocaine-seeking motivated by cocaine-conditioned stimuli; (2) acquisition of cocaine-taking behavior is associated with the acquisition of stimulatory effects of cocaine by cocaine-conditioned stimuli on ghrelin secretion, and with an upregulation of ghrelin receptor mrna levels in the ventral tegmental area (vta); (3) blockade of ghrelin signaling by pretreatment with jmv2959, a selective ghrelin receptor antagonist, dose-dependently inhibits reinstatement of cocaine-seeking triggered by either cocaine or yohimbine in behaviorally extinguished animals with a history of cocaine self-administration; (4) jmv2959 pretreatment also inhibits brain stimulation reward (bsr) and cocaine-potentiated bsr maintained by optogenetic stimulation of vta dopamine neurons in dat-cre mice; (5) blockade of peripheral adrenergic β1 receptors by atenolol potently attenuates the elevation in circulating ghrelin induced by cocaine and inhibits cocaine self-administration and cocaine reinstatement triggered by cocaine. |
2021-12-19 |
2023-08-13 |
mouse |
| Wonjong Lee, Jung Won Lee, Jin Mook Kim, Young-Ki Hong, Mi-Seon Kim, Sun Ok Choi, Mi Sun Kan. The abuse potential of prolintane in rodents: Behavioral pharmacology approaches. Neuropharmacology. 2021-12-13. PMID:34896117. |
prolintane (1-phenyl-2-pyrrolidinylpentane), a synthetic central nervous system (cns) stimulant, is structurally similar to amphetamine but pharmacologically acts as a dopamine reuptake inhibitor like cocaine. |
2021-12-13 |
2023-08-13 |
mouse |
| Kevin Clare, Chelsea Pan, Gloria Kim, Kicheon Park, Juan Zhao, Nora D Volkow, Zhicheng Lin, Congwu D. Cocaine Reduces the Neuronal Population While Upregulating Dopamine D2-Receptor-Expressing Neurons in Brain Reward Regions: Sex-Effects. Frontiers in pharmacology. vol 12. 2021-12-12. PMID:33912043. |
cocaine reduces the neuronal population while upregulating dopamine d2-receptor-expressing neurons in brain reward regions: sex-effects. |
2021-12-12 |
2023-08-13 |
mouse |
| Kevin Clare, Chelsea Pan, Gloria Kim, Kicheon Park, Juan Zhao, Nora D Volkow, Zhicheng Lin, Congwu D. Cocaine Reduces the Neuronal Population While Upregulating Dopamine D2-Receptor-Expressing Neurons in Brain Reward Regions: Sex-Effects. Frontiers in pharmacology. vol 12. 2021-12-12. PMID:33912043. |
addiction to cocaine is associated with dysfunction of the dopamine mesocortical system including impaired dopamine-2 receptor (d2r) signaling. |
2021-12-12 |
2023-08-13 |
mouse |
| Milky Kohno, Laura E Dennis, Holly McCready, William F Hoffma. Dopamine dysfunction in stimulant use disorders: mechanistic comparisons and implications for treatment. Molecular psychiatry. 2021-12-12. PMID:34117366. |
similarities in dopamine dysfunction between cocaine and methamphetamine use disorder but also key differences may impact treatment efficacy and outcome. |
2021-12-12 |
2023-08-13 |
Not clear |
| Lianwei Mu, Xiaojie Liu, Hao Yu, Mengming Hu, Vladislav Friedman, Thomas J Kelly, Li Zhao, Qing-Song Li. Ibudilast attenuates cocaine self-administration and prime- and cue-induced reinstatement of cocaine seeking in rats. Neuropharmacology. vol 201. 2021-12-11. PMID:34626665. |
to investigate potential mechanisms for ibudilast-induced attenuation of cocaine self-administration, we recorded from ventral tegmental area (vta) dopamine neurons in ex vivo midbrain slices prepared from rats that had undergone saline and cocaine self-administration. |
2021-12-11 |
2023-08-13 |
rat |
| Lianwei Mu, Xiaojie Liu, Hao Yu, Mengming Hu, Vladislav Friedman, Thomas J Kelly, Li Zhao, Qing-Song Li. Ibudilast attenuates cocaine self-administration and prime- and cue-induced reinstatement of cocaine seeking in rats. Neuropharmacology. vol 201. 2021-12-11. PMID:34626665. |
restoration of the balance between excitation and inhibition in vta dopamine neurons may contribute to the attenuation of cocaine self-administration by ibudilast. |
2021-12-11 |
2023-08-13 |
rat |
| William N Sanchez, Jose A Pochapski, Leticia F Jessen, Marek Ellenberger, Rainer K Schwarting, Donita L Robinson, Roberto Andreatini, Claudio Da Cunh. Diazepam attenuates the effects of cocaine on locomotion, 50-kHz ultrasonic vocalizations and phasic dopamine in the nucleus accumbens of rats. British journal of pharmacology. 2021-12-09. PMID:34389975. |
diazepam attenuates the effects of cocaine on locomotion, 50-khz ultrasonic vocalizations and phasic dopamine in the nucleus accumbens of rats. |
2021-12-09 |
2023-08-13 |
rat |
| Maryam Agharahimi, Ramesh B Badisa, Elizabeth Mazzio, Karam F Soliman, Carl B Goodma. Cocaine potentiates an inflammatory response in C6 astroglia-like cells. Biomedical reports. vol 14. issue 5. 2021-12-08. PMID:33786174. |
cocaine is a highly addictive drug that mediates its effect through altering dopamine metabolism in the central nervous system (cns), resulting in a feeling of euphoria. |
2021-12-08 |
2023-08-13 |
Not clear |
| Paul W Czoty, Michael A Nade. Effects of Dopamine D1-Like Receptor Ligands on Food-Cocaine Choice in Socially Housed Male Cynomolgus Monkeys. The Journal of pharmacology and experimental therapeutics. vol 379. issue 1. 2021-12-05. PMID:34272270. |
although dopamine plays a prominent role in mediating cocaine's abuse-related effects, the specific roles of dopamine receptor subtypes are not fully understood. |
2021-12-05 |
2023-08-13 |
monkey |
| Paul W Czoty, Michael A Nade. Effects of Dopamine D1-Like Receptor Ligands on Food-Cocaine Choice in Socially Housed Male Cynomolgus Monkeys. The Journal of pharmacology and experimental therapeutics. vol 379. issue 1. 2021-12-05. PMID:34272270. |
although dopamine receptors have been strongly implicated in mediating the abuse-related effects of cocaine, the roles of dopamine receptor subtypes are incompletely understood. |
2021-12-05 |
2023-08-13 |
monkey |
| Amanda L Sharpe, Marta Trzeciak, Nicole L Eliason, Harris E Blankenship, Bre' Ana M Byrd, Phillip D Douglas, Willard M Freeman, Michael J Beckstea. Repeated cocaine or methamphetamine treatment alters astrocytic CRF2 and GLAST expression in the ventral midbrain. Addiction biology. 2021-12-03. PMID:34825430. |
dopamine neurons in the substantia nigra (sn) and ventral tegmental area (vta) play a central role in the reinforcing properties of abused drugs including methamphetamine and cocaine. |
2021-12-03 |
2023-08-13 |
mouse |
| Lillian J Brady, Kirsty R Erickson, Kelsey E Lucerne, Aya Osman, Drew D Kiraly, Erin S Calipar. Granulocyte colony-stimulating factor (G-CSF) enhances cocaine effects in the nucleus accumbens via a dopamine release-based mechanism. Psychopharmacology. vol 238. issue 12. 2021-11-30. PMID:34487190. |
granulocyte colony-stimulating factor (g-csf) enhances cocaine effects in the nucleus accumbens via a dopamine release-based mechanism. |
2021-11-30 |
2023-08-13 |
Not clear |
| Lillian J Brady, Kirsty R Erickson, Kelsey E Lucerne, Aya Osman, Drew D Kiraly, Erin S Calipar. Granulocyte colony-stimulating factor (G-CSF) enhances cocaine effects in the nucleus accumbens via a dopamine release-based mechanism. Psychopharmacology. vol 238. issue 12. 2021-11-30. PMID:34487190. |
we find that systemic g-csf injection increases cocaine effects on dopamine terminals. |
2021-11-30 |
2023-08-13 |
Not clear |
| Lillian J Brady, Kirsty R Erickson, Kelsey E Lucerne, Aya Osman, Drew D Kiraly, Erin S Calipar. Granulocyte colony-stimulating factor (G-CSF) enhances cocaine effects in the nucleus accumbens via a dopamine release-based mechanism. Psychopharmacology. vol 238. issue 12. 2021-11-30. PMID:34487190. |
the enhanced dopamine levels in the presence of cocaine occur through a release-based mechanism, rather than through effects on the dopamine transporter-as uptake rates were unchanged following g-csf treatment. |
2021-11-30 |
2023-08-13 |
Not clear |
| R Logan Murphy, Laura L Locklear, M Haris Niaz, Rebecca L Walton, Alexandra D Hudson, Karl J Fryxel. Nicotine preference and affective behavior of Cd81 knockout mice. Psychopharmacology. vol 238. issue 12. 2021-11-30. PMID:34491405. |
cd81 -/- (knockout) mice have previously been reported to have reduced cocaine preference and increased striatal dopamine content and dopamine turnover, but normal learning and memory in the morris water maze. |
2021-11-30 |
2023-08-13 |
mouse |
| Ornella Valenti, Alice Zambon, Stefan Boeh. Orchestration of Dopamine Neuron Population Activity in the Ventral Tegmental Area by Caffeine: Comparison With Amphetamine. The international journal of neuropsychopharmacology. vol 24. issue 10. 2021-11-22. PMID:34278424. |
among psychostimulants, the dopamine transporter ligands amphetamine and cocaine display the highest addictive potential; the adenosine receptor antagonist caffeine is most widely consumed but less addictive. |
2021-11-22 |
2023-08-13 |
Not clear |