| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lianwei Mu, Xiaojie Liu, Hao Yu, Mengming Hu, Vladislav Friedman, Thomas J Kelly, Li Zhao, Qing-Song Li. Ibudilast attenuates cocaine self-administration and prime- and cue-induced reinstatement of cocaine seeking in rats. Neuropharmacology. vol 201. 2021-12-11. PMID:34626665. |
to investigate potential mechanisms for ibudilast-induced attenuation of cocaine self-administration, we recorded from ventral tegmental area (vta) dopamine neurons in ex vivo midbrain slices prepared from rats that had undergone saline and cocaine self-administration. |
2021-12-11 |
2023-08-13 |
rat |
| Lianwei Mu, Xiaojie Liu, Hao Yu, Mengming Hu, Vladislav Friedman, Thomas J Kelly, Li Zhao, Qing-Song Li. Ibudilast attenuates cocaine self-administration and prime- and cue-induced reinstatement of cocaine seeking in rats. Neuropharmacology. vol 201. 2021-12-11. PMID:34626665. |
restoration of the balance between excitation and inhibition in vta dopamine neurons may contribute to the attenuation of cocaine self-administration by ibudilast. |
2021-12-11 |
2023-08-13 |
rat |
| William N Sanchez, Jose A Pochapski, Leticia F Jessen, Marek Ellenberger, Rainer K Schwarting, Donita L Robinson, Roberto Andreatini, Claudio Da Cunh. Diazepam attenuates the effects of cocaine on locomotion, 50-kHz ultrasonic vocalizations and phasic dopamine in the nucleus accumbens of rats. British journal of pharmacology. 2021-12-09. PMID:34389975. |
diazepam attenuates the effects of cocaine on locomotion, 50-khz ultrasonic vocalizations and phasic dopamine in the nucleus accumbens of rats. |
2021-12-09 |
2023-08-13 |
rat |
| Maryam Agharahimi, Ramesh B Badisa, Elizabeth Mazzio, Karam F Soliman, Carl B Goodma. Cocaine potentiates an inflammatory response in C6 astroglia-like cells. Biomedical reports. vol 14. issue 5. 2021-12-08. PMID:33786174. |
cocaine is a highly addictive drug that mediates its effect through altering dopamine metabolism in the central nervous system (cns), resulting in a feeling of euphoria. |
2021-12-08 |
2023-08-13 |
Not clear |
| Paul W Czoty, Michael A Nade. Effects of Dopamine D1-Like Receptor Ligands on Food-Cocaine Choice in Socially Housed Male Cynomolgus Monkeys. The Journal of pharmacology and experimental therapeutics. vol 379. issue 1. 2021-12-05. PMID:34272270. |
although dopamine plays a prominent role in mediating cocaine's abuse-related effects, the specific roles of dopamine receptor subtypes are not fully understood. |
2021-12-05 |
2023-08-13 |
monkey |
| Paul W Czoty, Michael A Nade. Effects of Dopamine D1-Like Receptor Ligands on Food-Cocaine Choice in Socially Housed Male Cynomolgus Monkeys. The Journal of pharmacology and experimental therapeutics. vol 379. issue 1. 2021-12-05. PMID:34272270. |
although dopamine receptors have been strongly implicated in mediating the abuse-related effects of cocaine, the roles of dopamine receptor subtypes are incompletely understood. |
2021-12-05 |
2023-08-13 |
monkey |
| Amanda L Sharpe, Marta Trzeciak, Nicole L Eliason, Harris E Blankenship, Bre' Ana M Byrd, Phillip D Douglas, Willard M Freeman, Michael J Beckstea. Repeated cocaine or methamphetamine treatment alters astrocytic CRF2 and GLAST expression in the ventral midbrain. Addiction biology. 2021-12-03. PMID:34825430. |
dopamine neurons in the substantia nigra (sn) and ventral tegmental area (vta) play a central role in the reinforcing properties of abused drugs including methamphetamine and cocaine. |
2021-12-03 |
2023-08-13 |
mouse |
| Lillian J Brady, Kirsty R Erickson, Kelsey E Lucerne, Aya Osman, Drew D Kiraly, Erin S Calipar. Granulocyte colony-stimulating factor (G-CSF) enhances cocaine effects in the nucleus accumbens via a dopamine release-based mechanism. Psychopharmacology. vol 238. issue 12. 2021-11-30. PMID:34487190. |
granulocyte colony-stimulating factor (g-csf) enhances cocaine effects in the nucleus accumbens via a dopamine release-based mechanism. |
2021-11-30 |
2023-08-13 |
Not clear |
| Lillian J Brady, Kirsty R Erickson, Kelsey E Lucerne, Aya Osman, Drew D Kiraly, Erin S Calipar. Granulocyte colony-stimulating factor (G-CSF) enhances cocaine effects in the nucleus accumbens via a dopamine release-based mechanism. Psychopharmacology. vol 238. issue 12. 2021-11-30. PMID:34487190. |
we find that systemic g-csf injection increases cocaine effects on dopamine terminals. |
2021-11-30 |
2023-08-13 |
Not clear |
| Lillian J Brady, Kirsty R Erickson, Kelsey E Lucerne, Aya Osman, Drew D Kiraly, Erin S Calipar. Granulocyte colony-stimulating factor (G-CSF) enhances cocaine effects in the nucleus accumbens via a dopamine release-based mechanism. Psychopharmacology. vol 238. issue 12. 2021-11-30. PMID:34487190. |
the enhanced dopamine levels in the presence of cocaine occur through a release-based mechanism, rather than through effects on the dopamine transporter-as uptake rates were unchanged following g-csf treatment. |
2021-11-30 |
2023-08-13 |
Not clear |
| R Logan Murphy, Laura L Locklear, M Haris Niaz, Rebecca L Walton, Alexandra D Hudson, Karl J Fryxel. Nicotine preference and affective behavior of Cd81 knockout mice. Psychopharmacology. vol 238. issue 12. 2021-11-30. PMID:34491405. |
cd81 -/- (knockout) mice have previously been reported to have reduced cocaine preference and increased striatal dopamine content and dopamine turnover, but normal learning and memory in the morris water maze. |
2021-11-30 |
2023-08-13 |
mouse |
| Ornella Valenti, Alice Zambon, Stefan Boeh. Orchestration of Dopamine Neuron Population Activity in the Ventral Tegmental Area by Caffeine: Comparison With Amphetamine. The international journal of neuropsychopharmacology. vol 24. issue 10. 2021-11-22. PMID:34278424. |
among psychostimulants, the dopamine transporter ligands amphetamine and cocaine display the highest addictive potential; the adenosine receptor antagonist caffeine is most widely consumed but less addictive. |
2021-11-22 |
2023-08-13 |
Not clear |
| Juan L Gomez, Jordi Bonaventura, Jacqueline Keighron, Kelsey M Wright, Dondre L Marable, Lionel A Rodriguez, Sherry Lam, Meghan L Carlton, Randall J Ellis, Chloe J Jordan, Guo-Hua Bi, Oscar Solis, Marco Pignatelli, Michael J Bannon, Zheng-Xiong Xi, Gianluigi Tanda, Michael Michaelide. Synaptic Zn Translational psychiatry. vol 11. issue 1. 2021-11-20. PMID:34750356. |
synaptic zn cocaine binds to the dopamine (da) transporter (dat) to regulate cocaine reward and seeking behavior. |
2021-11-20 |
2023-08-13 |
Not clear |
| Lindsey N Friend, Bridget Wu, Jeffrey G Edward. Acute cocaine exposure occludes long-term depression in ventral tegmental area GABA neurons. Neurochemistry international. vol 145. 2021-11-18. PMID:33617930. |
furthermore, chronic cocaine decreased ampa/nmda ratios at glutamate synapses onto vta gaba cells, compared to vehicle injection controls, the opposite change noted in dopamine cells. |
2021-11-18 |
2023-08-13 |
mouse |
| Kaifu Gao, Dong Chen, Alfred J Robison, Guo-Wei We. Proteome-Informed Machine Learning Studies of Cocaine Addiction. The journal of physical chemistry letters. vol 12. issue 45. 2021-11-18. PMID:34752088. |
the main challenge is the intricate molecular mechanisms of cocaine addiction, involving synergistic interactions among proteins upstream and downstream of the dopamine transporter. |
2021-11-18 |
2023-08-13 |
Not clear |
| Tristan J Hynes, Kelly M Hrelja, Brett A Hathaway, Celine D Hounjet, Chloe S Chernoff, Sophie A Ebsary, Graeme D Betts, Brittney Russell, Lawrence Ma, Sukhbir Kaur, Catharine A Winstanle. Dopamine neurons gate the intersection of cocaine use, decision making, and impulsivity. Addiction biology. vol 26. issue 6. 2021-11-10. PMID:33559379. |
dopamine neurons gate the intersection of cocaine use, decision making, and impulsivity. |
2021-11-10 |
2023-08-13 |
rat |
| Tristan J Hynes, Kelly M Hrelja, Brett A Hathaway, Celine D Hounjet, Chloe S Chernoff, Sophie A Ebsary, Graeme D Betts, Brittney Russell, Lawrence Ma, Sukhbir Kaur, Catharine A Winstanle. Dopamine neurons gate the intersection of cocaine use, decision making, and impulsivity. Addiction biology. vol 26. issue 6. 2021-11-10. PMID:33559379. |
we then trained rats in our cued rat gambling task (crgt), inhibiting dopamine neurons throughout task acquisition and performance, before allowing them to self-administer cocaine in the same diurnal period as crgt sessions. |
2021-11-10 |
2023-08-13 |
rat |
| Tristan J Hynes, Kelly M Hrelja, Brett A Hathaway, Celine D Hounjet, Chloe S Chernoff, Sophie A Ebsary, Graeme D Betts, Brittney Russell, Lawrence Ma, Sukhbir Kaur, Catharine A Winstanle. Dopamine neurons gate the intersection of cocaine use, decision making, and impulsivity. Addiction biology. vol 26. issue 6. 2021-11-10. PMID:33559379. |
inhibiting vta dopamine neurons also prevented cocaine-induced changes in decision making in both sexes, but nevertheless drove all animals to consume more cocaine. |
2021-11-10 |
2023-08-13 |
rat |
| Ying Duan, Yiming Meng, Wenjie Du, Ming Li, Jianjun Zhang, Jing Liang, Yonghui Li, Nan Sui, Fang She. Increased cocaine motivation in tree shrews is modulated by striatal dopamine D1 receptor-mediated upregulation of Ca Addiction biology. vol 26. issue 6. 2021-11-10. PMID:33987939. |
increased cocaine motivation in tree shrews is modulated by striatal dopamine d1 receptor-mediated upregulation of ca the progressively increased motivation for cocaine during abstinence is closely associated with the dysfunction of dopamine (da) system. |
2021-11-10 |
2023-08-13 |
Not clear |
| Sheng Gong, Nicholas Fayette, Jasper A Heinsbroek, Christopher P For. Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors. Neuron. vol 109. issue 21. 2021-11-09. PMID:34506723. |
cocaine shifts dopamine d2 receptor sensitivity to gate conditioned behaviors. |
2021-11-09 |
2023-08-13 |
Not clear |