| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giulia R Fois, Karl Y Bosque-Cordero, Rafael Vazquez-Torres, Cristina Miliano, Xavier Nogues, Carlos A Jimenez-Rivera, Stéphanie Caille, François George. Locus coeruleus activation during environmental novelty gates cocaine-induced long-term hyperactivity of dopamine neurons. iScience. vol 25. issue 4. 2022-04-18. PMID:35434548. |
however, how exploring a novel environment can interfere with the reward system and control cocaine impact on vta dopamine neuron plasticity is unclear. |
2022-04-18 |
2023-08-13 |
Not clear |
| Giulia R Fois, Karl Y Bosque-Cordero, Rafael Vazquez-Torres, Cristina Miliano, Xavier Nogues, Carlos A Jimenez-Rivera, Stéphanie Caille, François George. Locus coeruleus activation during environmental novelty gates cocaine-induced long-term hyperactivity of dopamine neurons. iScience. vol 25. issue 4. 2022-04-18. PMID:35434548. |
our findings indicate that lc controls vta dopamine neurons under physiological conditions but also after cocaine. |
2022-04-18 |
2023-08-13 |
Not clear |
| Maged M Harraz, Adarsha P Malla, Evan R Semenza, Maria Shishikura, Manisha Singh, Yun Hwang, In Guk Kang, Young Jun Song, Adele M Snowman, Pedro Cortés, Senthilkumar S Karuppagounder, Ted M Dawson, Valina L Dawson, Solomon H Snyde. A high-affinity cocaine binding site associated with the brain acid soluble protein 1. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 16. 2022-04-12. PMID:35412917. |
cocaine inhibition of the dopamine, serotonin, and norepinephrine transporters is relatively weak, suggesting that blockade of the amine transporters alone cannot account for the actions of cocaine, especially at low doses. |
2022-04-12 |
2023-08-13 |
Not clear |
| Sheng Gong, Nicholas Fayette, Jasper A Heinsbroek, Christopher P For. Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors. Neuron. vol 110. issue 7. 2022-04-07. PMID:35390291. |
cocaine shifts dopamine d2 receptor sensitivity to gate conditioned behaviors. |
2022-04-07 |
2023-08-13 |
Not clear |
| Abdallah Zayed, Camille Baranowski, Anne-Claire Compagnion, Cécile Vernochet, Samah Karaki, Romain Durand-de Cuttoli, Estefani Saint-Jour, Soumee Bhattacharya, Fabio Marti, Peter Vanhoutte, Moshe Yaniv, Philippe Faure, Jacques Barik, Laurence Amar, François Tronche, Sébastien Parnaudea. SWI/SNF chromatin remodeler complex within the reward pathway is required for behavioral adaptations to stress. Nature communications. vol 13. issue 1. 2022-04-05. PMID:35379786. |
the inactivation of the brg1/smarca4 gene within dopamine-innervated regions or the constitutive inactivation of the brm/smarca2 gene leads to resilience to repeated social defeat and decreases the behavioral responses to cocaine without impacting midbrain dopamine neurons activity. |
2022-04-05 |
2023-08-13 |
mouse |
| Ken W Grasing, Kim Burnell, Alok D. Biphasic reward effects are characteristic of both lorcaserin and drugs of abuse: implications for treatment of substance use disorders. Behavioural pharmacology. 2022-03-24. PMID:35324488. |
despite early promising data, it recently failed to facilitate cocaine abstinence in patients and has been compared with dopamine antagonist medications (antipsychotics). |
2022-03-24 |
2023-08-13 |
Not clear |
| Ken W Grasing, Kim Burnell, Alok D. Biphasic reward effects are characteristic of both lorcaserin and drugs of abuse: implications for treatment of substance use disorders. Behavioural pharmacology. 2022-03-24. PMID:35324488. |
in addition to not being effective treatments for cocaine use disorder, both dopamine antagonists and lorcaserin can have biphasic effects on dopamine and reward behavior. |
2022-03-24 |
2023-08-13 |
Not clear |
| Jessica L Sharp, Mark A Smit. The Effects of Drugs on Behavior Maintained by Social Contact: Role of Monoamines in Social Reinforcement. Frontiers in behavioral neuroscience. vol 15. 2022-03-10. PMID:35264935. |
to this end, male and female long-evans rats were pretreated with acute doses of the selective dopamine reuptake inhibitor, win-35,428, the selective norepinephrine reuptake inhibitor, atomoxetine, the selective serotonin reuptake inhibitor, fluoxetine, the non-selective monoamine reuptake inhibitor, cocaine, and the non-selective monoamine releasers |
2022-03-10 |
2023-08-13 |
rat |
| Sean D Regnier, Joshua A Lile, Craig R Rush, William W Stoop. Clinical neuropharmacology of cocaine reinforcement: A narrative review of human laboratory self-administration studies. Journal of the experimental analysis of behavior. 2022-03-01. PMID:35229294. |
drugs that increase extracellular dopamine tend to have the most consistent effects on cocaine self-administration. |
2022-03-01 |
2023-08-13 |
human |
| Sean D Regnier, Joshua A Lile, Craig R Rush, William W Stoop. Clinical neuropharmacology of cocaine reinforcement: A narrative review of human laboratory self-administration studies. Journal of the experimental analysis of behavior. 2022-03-01. PMID:35229294. |
the ability of nondopaminergic drugs to impact cocaine reinforcement might be related to their downstream effects on dopamine, though it is difficult to draw conclusions because pharmacologically selective compounds are not widely available for human testing. |
2022-03-01 |
2023-08-13 |
human |
| Suchan Chang, Yeonhee Ryu, Se Kyun Bang, Han Byeol Jang, DanBi Ahn, Hyung Kyu Kim, Hubert Lee, Sang Chan Kim, Bong Hyo Lee, Hee Young Ki. An Increase in Peripheral Temperature following Cocaine Administration Is Mediated through Activation of Dopamine D2 Receptor in Rats. Life (Basel, Switzerland). vol 12. issue 2. 2022-02-25. PMID:35207431. |
an increase in peripheral temperature following cocaine administration is mediated through activation of dopamine d2 receptor in rats. |
2022-02-25 |
2023-08-13 |
rat |
| Suchan Chang, Yeonhee Ryu, Se Kyun Bang, Han Byeol Jang, DanBi Ahn, Hyung Kyu Kim, Hubert Lee, Sang Chan Kim, Bong Hyo Lee, Hee Young Ki. An Increase in Peripheral Temperature following Cocaine Administration Is Mediated through Activation of Dopamine D2 Receptor in Rats. Life (Basel, Switzerland). vol 12. issue 2. 2022-02-25. PMID:35207431. |
cocaine injection caused an acute rise in peripheral body temperature, but not core body temperature, about 10 min after injection, and the temperature increases were occluded by systemic injection of dopamine d2 receptor antagonist l741,626, but not d1 receptor antagonist sch23390. |
2022-02-25 |
2023-08-13 |
rat |
| Suchan Chang, Yeonhee Ryu, Se Kyun Bang, Han Byeol Jang, DanBi Ahn, Hyung Kyu Kim, Hubert Lee, Sang Chan Kim, Bong Hyo Lee, Hee Young Ki. An Increase in Peripheral Temperature following Cocaine Administration Is Mediated through Activation of Dopamine D2 Receptor in Rats. Life (Basel, Switzerland). vol 12. issue 2. 2022-02-25. PMID:35207431. |
treatment with cocaine or bromocriptine decreased the size of skin blood vessels without affecting the expression of dopamine d2 receptors. |
2022-02-25 |
2023-08-13 |
rat |
| Suchan Chang, Yeonhee Ryu, Se Kyun Bang, Han Byeol Jang, DanBi Ahn, Hyung Kyu Kim, Hubert Lee, Sang Chan Kim, Bong Hyo Lee, Hee Young Ki. An Increase in Peripheral Temperature following Cocaine Administration Is Mediated through Activation of Dopamine D2 Receptor in Rats. Life (Basel, Switzerland). vol 12. issue 2. 2022-02-25. PMID:35207431. |
these results suggest that increased peripheral temperature in skin following cocaine injection is associated with the activation of the dopamine d2 receptor. |
2022-02-25 |
2023-08-13 |
rat |
| Hong-Ju Yang, Briana J Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L Gardner, Zheng-Xiong X. Elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a NMDA-GluN2B receptor mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-29. PMID:35091501. |
in this study, we systemically evaluated the effects of multiple glutamate transporter (glt) inhibitors on extracellular glutamate and dopamine (da) in the nucleus accumbens (nac), intravenous cocaine self-administration, intracranial brain-stimulation reward, and reinstatement of cocaine seeking in male and female rats. |
2022-01-29 |
2023-08-13 |
rat |
| Zhi-Bing You, Ewa Galaj, Francisco Alén, Bin Wang, Guo-Hua Bi, Allamar R Moore, Tristram Buck, Madeline Crissman, Sruti Pari, Zheng-Xiong Xi, Lorenzo Leggio, Roy A Wise, Eliot L Gardne. Involvement of the ghrelin system in the maintenance and reinstatement of cocaine-motivated behaviors: a role of adrenergic action at peripheral β1 receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021-12-19. PMID:34923576. |
in the present study, we show that: (1) elevation of ghrelin by cocaine plays a critical role in maintenance of cocaine self-administration and cocaine-seeking motivated by cocaine-conditioned stimuli; (2) acquisition of cocaine-taking behavior is associated with the acquisition of stimulatory effects of cocaine by cocaine-conditioned stimuli on ghrelin secretion, and with an upregulation of ghrelin receptor mrna levels in the ventral tegmental area (vta); (3) blockade of ghrelin signaling by pretreatment with jmv2959, a selective ghrelin receptor antagonist, dose-dependently inhibits reinstatement of cocaine-seeking triggered by either cocaine or yohimbine in behaviorally extinguished animals with a history of cocaine self-administration; (4) jmv2959 pretreatment also inhibits brain stimulation reward (bsr) and cocaine-potentiated bsr maintained by optogenetic stimulation of vta dopamine neurons in dat-cre mice; (5) blockade of peripheral adrenergic β1 receptors by atenolol potently attenuates the elevation in circulating ghrelin induced by cocaine and inhibits cocaine self-administration and cocaine reinstatement triggered by cocaine. |
2021-12-19 |
2023-08-13 |
mouse |
| Wonjong Lee, Jung Won Lee, Jin Mook Kim, Young-Ki Hong, Mi-Seon Kim, Sun Ok Choi, Mi Sun Kan. The abuse potential of prolintane in rodents: Behavioral pharmacology approaches. Neuropharmacology. 2021-12-13. PMID:34896117. |
prolintane (1-phenyl-2-pyrrolidinylpentane), a synthetic central nervous system (cns) stimulant, is structurally similar to amphetamine but pharmacologically acts as a dopamine reuptake inhibitor like cocaine. |
2021-12-13 |
2023-08-13 |
mouse |
| Kevin Clare, Chelsea Pan, Gloria Kim, Kicheon Park, Juan Zhao, Nora D Volkow, Zhicheng Lin, Congwu D. Cocaine Reduces the Neuronal Population While Upregulating Dopamine D2-Receptor-Expressing Neurons in Brain Reward Regions: Sex-Effects. Frontiers in pharmacology. vol 12. 2021-12-12. PMID:33912043. |
cocaine reduces the neuronal population while upregulating dopamine d2-receptor-expressing neurons in brain reward regions: sex-effects. |
2021-12-12 |
2023-08-13 |
mouse |
| Kevin Clare, Chelsea Pan, Gloria Kim, Kicheon Park, Juan Zhao, Nora D Volkow, Zhicheng Lin, Congwu D. Cocaine Reduces the Neuronal Population While Upregulating Dopamine D2-Receptor-Expressing Neurons in Brain Reward Regions: Sex-Effects. Frontiers in pharmacology. vol 12. 2021-12-12. PMID:33912043. |
addiction to cocaine is associated with dysfunction of the dopamine mesocortical system including impaired dopamine-2 receptor (d2r) signaling. |
2021-12-12 |
2023-08-13 |
mouse |
| Milky Kohno, Laura E Dennis, Holly McCready, William F Hoffma. Dopamine dysfunction in stimulant use disorders: mechanistic comparisons and implications for treatment. Molecular psychiatry. 2021-12-12. PMID:34117366. |
similarities in dopamine dysfunction between cocaine and methamphetamine use disorder but also key differences may impact treatment efficacy and outcome. |
2021-12-12 |
2023-08-13 |
Not clear |