| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheng Gong, Nicholas Fayette, Jasper A Heinsbroek, Christopher P For. Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors. Neuron. vol 109. issue 21. 2021-11-09. PMID:34506723. |
here, we describe how a 7-day exposure to cocaine alters dopamine signaling by selectively reducing the sensitivity, but not the expression, of nucleus accumbens d2-msn d2rs via an alteration in the relative expression and coupling of g protein subunits. |
2021-11-09 |
2023-08-13 |
Not clear |
| Sheng Gong, Nicholas Fayette, Jasper A Heinsbroek, Christopher P For. Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors. Neuron. vol 109. issue 21. 2021-11-09. PMID:34506723. |
these findings identify an initial maladaptive change in sensitivity by which mesolimbic dopamine signals are encoded by d2rs following cocaine exposure. |
2021-11-09 |
2023-08-13 |
Not clear |
| Tyler W E Steele, Zachary Spires, Charles B Jones, Richard A Glennon, Małgorzata Dukat, Jose M Elti. Non-conserved residues dictate dopamine transporter selectivity for the potent synthetic cathinone and psychostimulant MDPV. Neuropharmacology. vol 200. 2021-11-09. PMID:34619165. |
3,4-methylenedioxypyrovalerone (mdpv) and its analogs are illicit psychostimulants of this class that are ∼50-fold more potent than cocaine at inhibiting the human dopamine transporter (hdat). |
2021-11-09 |
2023-08-13 |
human |
| Angela M Thomas, Kaley J Cargile, Jannelle A Lunn, Lisa E Bake. Characterization of 3,4-methylenedioxypyrovalerone discrimination in female Sprague-Dawley rats. Behavioural pharmacology. vol 32. issue 6. 2021-11-05. PMID:34397448. |
stimulus substitution was assessed with mdpv and its enantiomers, other synthetic cathinones [alpha pyrrolidinopentiophenone-hydrochloride(α-pvp), 4-methylmethcathinone (4-mmc)], other dopamine agonists (cocaine, [+)-methamphetamine] and serotonin agonists [mdma, lysergic acid diethylamide (lsd)] stimulus antagonism was assessed with the dopamine d1 receptor antagonist, sch 23390 and the d2 receptor antagonist, haloperidol. |
2021-11-05 |
2023-08-13 |
rat |
| Kunjumon Ittira Vadakka. Framework for internal sensation of pleasure using constraints from disparate findings in nucleus accumbens. World journal of psychiatry. vol 11. issue 10. 2021-11-05. PMID:34733636. |
by extending these findings and by using disparate third person observations in nac from several studies, present work provides a framework of a mechanism that generates internal sensation of pleasure that can provide interconnected explanations for: (1) ability to induce robust long-term depression (ltd) in nac from naïve animals; (2) impaired ability to induce ltd in "addicted" state; (3) attenuation of postsynaptic potentials by cocaine; and (4) reduced firing of medium spiny neurons in response to cocaine or dopamine. |
2021-11-05 |
2023-08-13 |
Not clear |
| Kuo Hao Lee, Andrew D Fant, Jiqing Guo, Andy Guan, Joslyn Jung, Mary Kudaibergenova, Williams E Miranda, Therese Ku, Jianjing Cao, Soren Wacker, Henry J Duff, Amy Hauck Newman, Sergei Y Noskov, Lei Sh. Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach. Journal of chemical information and modeling. vol 61. issue 9. 2021-10-22. PMID:34420294. |
psychostimulant drugs, such as cocaine, inhibit dopamine reuptake via blockading the dopamine transporter (dat), which is the primary mechanism underpinning their abuse. |
2021-10-22 |
2023-08-13 |
human |
| Brian M Kile, Paul L Walsh, Zoé A McElligott, Elizabeth S Bucher, Thomas S Guillot, Ali Salahpour, Marc G Caron, R Mark Wightma. Optimizing the Temporal Resolution of Fast-Scan Cyclic Voltammetry. ACS chemical neuroscience. vol 3. issue 4. 2021-10-21. PMID:22708011. |
however, fscv collection at 10 hz and 60 hz provide identical results when a dopamine transporter (dat) blocker such as cocaine is bath applied. |
2021-10-21 |
2023-08-12 |
mouse |
| C S Planeta, L B Lepsch, R Alves, C Scavon. Influence of the dopaminergic system, CREB, and transcription factor-κB on cocaine neurotoxicity. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 46. issue 11. 2021-10-21. PMID:24141554. |
the mechanism by which cocaine causes neurological damage is complex and involves interactions of the drug with several neurotransmitter systems, such as the increase of extracellular levels of dopamine and free radicals, and modulation of transcription factors. |
2021-10-21 |
2023-08-12 |
Not clear |
| C S Planeta, L B Lepsch, R Alves, C Scavon. Influence of the dopaminergic system, CREB, and transcription factor-κB on cocaine neurotoxicity. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 46. issue 11. 2021-10-21. PMID:24141554. |
gbr 12909 (an inhibitor of dopamine reuptake), lidocaine (a local anesthetic), and dopamine did not activate nf-κb in the same way as cocaine. |
2021-10-21 |
2023-08-12 |
Not clear |
| Martín Indarte, Yi Liu, Jeffry D Madura, Christopher K Surrat. Receptor-Based Discovery of a Plasmalemmal Monoamine Transporter Inhibitor via High Throughput Docking and Pharmacophore Modeling. ACS chemical neuroscience. vol 1. issue 3. 2021-10-20. PMID:20352074. |
recognition of psychostimulants such as cocaine and the amphetamines by the dopamine transporter (dat) protein is principally responsible for the euphoria and addiction associated with these drugs. |
2021-10-20 |
2023-08-12 |
Not clear |
| Martín Indarte, Yi Liu, Jeffry D Madura, Christopher K Surrat. Receptor-Based Discovery of a Plasmalemmal Monoamine Transporter Inhibitor via High Throughput Docking and Pharmacophore Modeling. ACS chemical neuroscience. vol 1. issue 3. 2021-10-20. PMID:20352074. |
although a very weak dopamine uptake inhibitor itself, this compound reduced by three fold the potency of cocaine in inhibiting dat-mediated cellular uptake of dopamine. |
2021-10-20 |
2023-08-12 |
Not clear |
| Monique A Makos, Kyung-An Han, Michael L Heien, Andrew G Ewin. Using In Vivo Electrochemistry to Study the Physiological Effects of Cocaine and Other Stimulants on the Drosophila melanogaster Dopamine Transporter. ACS chemical neuroscience. vol 1. issue 1. 2021-10-20. PMID:20352129. |
using in vivo electrochemistry to study the physiological effects of cocaine and other stimulants on the drosophila melanogaster dopamine transporter. |
2021-10-20 |
2023-08-12 |
mouse |
| Monique A Makos, Kyung-An Han, Michael L Heien, Andrew G Ewin. Using In Vivo Electrochemistry to Study the Physiological Effects of Cocaine and Other Stimulants on the Drosophila melanogaster Dopamine Transporter. ACS chemical neuroscience. vol 1. issue 1. 2021-10-20. PMID:20352129. |
clearance of exogenously applied dopamine was significantly decreased in the protocerebral anterior medial area of the wild-type fly following treatment with cocaine, amphetamine, methamphetamine, or methylphenidate. |
2021-10-20 |
2023-08-12 |
mouse |
| Monique A Makos, Kyung-An Han, Michael L Heien, Andrew G Ewin. Using In Vivo Electrochemistry to Study the Physiological Effects of Cocaine and Other Stimulants on the Drosophila melanogaster Dopamine Transporter. ACS chemical neuroscience. vol 1. issue 1. 2021-10-20. PMID:20352129. |
furthermore, we found 10 mum to be a sufficient physiological cocaine concentration to significantly alter dopamine transporter uptake in the drosophila central nervous system. |
2021-10-20 |
2023-08-12 |
mouse |
| Jonathan L Katz, Tsung-Ping Su, Takato Hiranita, Teruo Hayashi, Gianluigi Tanda, Theresa Kopajtic, Shang-Yi Tsa. A Role for Sigma Receptors in Stimulant Self Administration and Addiction. Pharmaceuticals (Basel, Switzerland). vol 4. issue 6. 2021-10-20. PMID:21904468. |
the data suggest that the self administration of σr agonists is independent of dopamine and the findings are discussed in light of a hypothesis that cocaine has both intracellular actions mediated by σrs, as well as extracellular actions mediated through conventionally studied mechanisms. |
2021-10-20 |
2023-08-12 |
human |
| Savalan Babapoor-Farrokhran, Aditi Kalla, Deanna Gill, Asma Gulab, Sahil Banka, Sanjog Kalr. Peripheral Administration of Nitroglycerin in Pulseless Ventricular Tachycardia due to Cocaine-Induced Coronary Vasospasm. Cardiovascular toxicology. vol 21. issue 6. 2021-10-01. PMID:33534027. |
cocaine blocks the presynaptic reuptake of norepinephrine and dopamine. |
2021-10-01 |
2023-08-13 |
Not clear |
| WojciechB Solecki, Michał Wilczkowski, Kamil Pradel, Karolina Karwowska, Michał Kielbinski, Gniewosz Drwięga, Katarzyna Zajda, Tomasz Blasiak, Zbigniew Soltys, Zenon Rajfur, Klaudia Szklarczyk, Ryszard Przewłock. Effects of brief inhibition of the ventral tegmental area dopamine neurons on the cocaine seeking during abstinence. Addiction biology. vol 25. issue 6. 2021-09-28. PMID:31478293. |
effects of brief inhibition of the ventral tegmental area dopamine neurons on the cocaine seeking during abstinence. |
2021-09-28 |
2023-08-13 |
Not clear |
| Michael Wolter, Thomas Lapointe, Brett Melanson, Nana Baidoo, Travis Francis, Boyer D Winters, Francesco Ler. Memory enhancing effects of nicotine, cocaine, and their conditioned stimuli; effects of beta-adrenergic and dopamine D2 receptor antagonists. Psychopharmacology. vol 238. issue 9. 2021-09-28. PMID:34175982. |
memory enhancing effects of nicotine, cocaine, and their conditioned stimuli; effects of beta-adrenergic and dopamine d2 receptor antagonists. |
2021-09-28 |
2023-08-13 |
rat |
| Joy M Schmitz, Robert Suchting, Charles E Green, Heather E Webber, Jessica Vincent, F Gerard Moeller, Scott D Lan. The effects of combination levodopa-ropinirole on cognitive improvement and treatment outcome in individuals with cocaine use disorder: A bayesian mediation analysis. Drug and alcohol dependence. vol 225. 2021-09-22. PMID:34102508. |
chronic cocaine users show impairments in cognitive processes associated with dopamine (da) circuitry. |
2021-09-22 |
2023-08-13 |
Not clear |
| Limei Chen, He Chen, Yanli Xing, Juan L. ABCC1 regulates cocaine-associated memory, spine plasticity and GluA1 and GluA2 surface expression. Neuroreport. vol 32. issue 10. 2021-09-20. PMID:34029289. |
we also investigated the role of abcc1 in ampa receptors (ampars) surface expression in primary prefrontal cortex (pfc) neurons following dopamine treatment, which was used to mimic exposure to cocaine. |
2021-09-20 |
2023-08-13 |
Not clear |