| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brian M Kile, Paul L Walsh, Zoé A McElligott, Elizabeth S Bucher, Thomas S Guillot, Ali Salahpour, Marc G Caron, R Mark Wightma. Optimizing the Temporal Resolution of Fast-Scan Cyclic Voltammetry. ACS chemical neuroscience. vol 3. issue 4. 2021-10-21. PMID:22708011. |
however, fscv collection at 10 hz and 60 hz provide identical results when a dopamine transporter (dat) blocker such as cocaine is bath applied. |
2021-10-21 |
2023-08-12 |
mouse |
| C S Planeta, L B Lepsch, R Alves, C Scavon. Influence of the dopaminergic system, CREB, and transcription factor-κB on cocaine neurotoxicity. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 46. issue 11. 2021-10-21. PMID:24141554. |
the mechanism by which cocaine causes neurological damage is complex and involves interactions of the drug with several neurotransmitter systems, such as the increase of extracellular levels of dopamine and free radicals, and modulation of transcription factors. |
2021-10-21 |
2023-08-12 |
Not clear |
| C S Planeta, L B Lepsch, R Alves, C Scavon. Influence of the dopaminergic system, CREB, and transcription factor-κB on cocaine neurotoxicity. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 46. issue 11. 2021-10-21. PMID:24141554. |
gbr 12909 (an inhibitor of dopamine reuptake), lidocaine (a local anesthetic), and dopamine did not activate nf-κb in the same way as cocaine. |
2021-10-21 |
2023-08-12 |
Not clear |
| Martín Indarte, Yi Liu, Jeffry D Madura, Christopher K Surrat. Receptor-Based Discovery of a Plasmalemmal Monoamine Transporter Inhibitor via High Throughput Docking and Pharmacophore Modeling. ACS chemical neuroscience. vol 1. issue 3. 2021-10-20. PMID:20352074. |
recognition of psychostimulants such as cocaine and the amphetamines by the dopamine transporter (dat) protein is principally responsible for the euphoria and addiction associated with these drugs. |
2021-10-20 |
2023-08-12 |
Not clear |
| Martín Indarte, Yi Liu, Jeffry D Madura, Christopher K Surrat. Receptor-Based Discovery of a Plasmalemmal Monoamine Transporter Inhibitor via High Throughput Docking and Pharmacophore Modeling. ACS chemical neuroscience. vol 1. issue 3. 2021-10-20. PMID:20352074. |
although a very weak dopamine uptake inhibitor itself, this compound reduced by three fold the potency of cocaine in inhibiting dat-mediated cellular uptake of dopamine. |
2021-10-20 |
2023-08-12 |
Not clear |
| Monique A Makos, Kyung-An Han, Michael L Heien, Andrew G Ewin. Using In Vivo Electrochemistry to Study the Physiological Effects of Cocaine and Other Stimulants on the Drosophila melanogaster Dopamine Transporter. ACS chemical neuroscience. vol 1. issue 1. 2021-10-20. PMID:20352129. |
using in vivo electrochemistry to study the physiological effects of cocaine and other stimulants on the drosophila melanogaster dopamine transporter. |
2021-10-20 |
2023-08-12 |
mouse |
| Monique A Makos, Kyung-An Han, Michael L Heien, Andrew G Ewin. Using In Vivo Electrochemistry to Study the Physiological Effects of Cocaine and Other Stimulants on the Drosophila melanogaster Dopamine Transporter. ACS chemical neuroscience. vol 1. issue 1. 2021-10-20. PMID:20352129. |
clearance of exogenously applied dopamine was significantly decreased in the protocerebral anterior medial area of the wild-type fly following treatment with cocaine, amphetamine, methamphetamine, or methylphenidate. |
2021-10-20 |
2023-08-12 |
mouse |
| Monique A Makos, Kyung-An Han, Michael L Heien, Andrew G Ewin. Using In Vivo Electrochemistry to Study the Physiological Effects of Cocaine and Other Stimulants on the Drosophila melanogaster Dopamine Transporter. ACS chemical neuroscience. vol 1. issue 1. 2021-10-20. PMID:20352129. |
furthermore, we found 10 mum to be a sufficient physiological cocaine concentration to significantly alter dopamine transporter uptake in the drosophila central nervous system. |
2021-10-20 |
2023-08-12 |
mouse |
| Jonathan L Katz, Tsung-Ping Su, Takato Hiranita, Teruo Hayashi, Gianluigi Tanda, Theresa Kopajtic, Shang-Yi Tsa. A Role for Sigma Receptors in Stimulant Self Administration and Addiction. Pharmaceuticals (Basel, Switzerland). vol 4. issue 6. 2021-10-20. PMID:21904468. |
the data suggest that the self administration of σr agonists is independent of dopamine and the findings are discussed in light of a hypothesis that cocaine has both intracellular actions mediated by σrs, as well as extracellular actions mediated through conventionally studied mechanisms. |
2021-10-20 |
2023-08-12 |
human |
| Savalan Babapoor-Farrokhran, Aditi Kalla, Deanna Gill, Asma Gulab, Sahil Banka, Sanjog Kalr. Peripheral Administration of Nitroglycerin in Pulseless Ventricular Tachycardia due to Cocaine-Induced Coronary Vasospasm. Cardiovascular toxicology. vol 21. issue 6. 2021-10-01. PMID:33534027. |
cocaine blocks the presynaptic reuptake of norepinephrine and dopamine. |
2021-10-01 |
2023-08-13 |
Not clear |
| WojciechB Solecki, Michał Wilczkowski, Kamil Pradel, Karolina Karwowska, Michał Kielbinski, Gniewosz Drwięga, Katarzyna Zajda, Tomasz Blasiak, Zbigniew Soltys, Zenon Rajfur, Klaudia Szklarczyk, Ryszard Przewłock. Effects of brief inhibition of the ventral tegmental area dopamine neurons on the cocaine seeking during abstinence. Addiction biology. vol 25. issue 6. 2021-09-28. PMID:31478293. |
effects of brief inhibition of the ventral tegmental area dopamine neurons on the cocaine seeking during abstinence. |
2021-09-28 |
2023-08-13 |
Not clear |
| Michael Wolter, Thomas Lapointe, Brett Melanson, Nana Baidoo, Travis Francis, Boyer D Winters, Francesco Ler. Memory enhancing effects of nicotine, cocaine, and their conditioned stimuli; effects of beta-adrenergic and dopamine D2 receptor antagonists. Psychopharmacology. vol 238. issue 9. 2021-09-28. PMID:34175982. |
memory enhancing effects of nicotine, cocaine, and their conditioned stimuli; effects of beta-adrenergic and dopamine d2 receptor antagonists. |
2021-09-28 |
2023-08-13 |
rat |
| Joy M Schmitz, Robert Suchting, Charles E Green, Heather E Webber, Jessica Vincent, F Gerard Moeller, Scott D Lan. The effects of combination levodopa-ropinirole on cognitive improvement and treatment outcome in individuals with cocaine use disorder: A bayesian mediation analysis. Drug and alcohol dependence. vol 225. 2021-09-22. PMID:34102508. |
chronic cocaine users show impairments in cognitive processes associated with dopamine (da) circuitry. |
2021-09-22 |
2023-08-13 |
Not clear |
| Limei Chen, He Chen, Yanli Xing, Juan L. ABCC1 regulates cocaine-associated memory, spine plasticity and GluA1 and GluA2 surface expression. Neuroreport. vol 32. issue 10. 2021-09-20. PMID:34029289. |
we also investigated the role of abcc1 in ampa receptors (ampars) surface expression in primary prefrontal cortex (pfc) neurons following dopamine treatment, which was used to mimic exposure to cocaine. |
2021-09-20 |
2023-08-13 |
Not clear |
| Renee A Rotolo, Rose E Presby, Olivia Tracy, Sokaina Asar, Jen-Hau Yang, Merce Correa, Fraser Murray, John D Salamon. The novel atypical dopamine transport inhibitor CT-005404 has pro-motivational effects in neurochemical and inflammatory models of effort-based dysfunctions related to psychopathology. Neuropharmacology. vol 183. 2021-09-13. PMID:32956676. |
while drugs that block dopamine transport (dat) reportedly have positive motivational effects, dat inhibitors such as cocaine and amphetamines produce undesirable side effects. |
2021-09-13 |
2023-08-13 |
rat |
| Mireia Casanovas, Mireia Jiménez-Rosés, Arnau Cordomí, Alejandro Lillo, Ignacio Vega-Quiroga, Joan Izquierdo, Mireia Medrano, Katia Gysling, Leonardo Pardo, Gemma Navarro, Rafael Franc. Discovery of a macromolecular complex mediating the hunger suppressive actions of cocaine: Structural and functional properties. Addiction biology. vol 26. issue 5. 2021-09-10. PMID:33559278. |
cocaine not only increases brain dopamine levels but also activates the sigma |
2021-09-10 |
2023-08-13 |
Not clear |
| Yukari Nakamura, Sophie Longueville, Akinori Nishi, Denis Hervé, Jean-Antoine Girault, Yuki Nakamur. Dopamine D1 receptor-expressing neurons activity is essential for locomotor and sensitizing effects of a single injection of cocaine. The European journal of neuroscience. vol 54. issue 4. 2021-09-10. PMID:34273137. |
dopamine d1 receptor-expressing neurons activity is essential for locomotor and sensitizing effects of a single injection of cocaine. |
2021-09-10 |
2023-08-13 |
mouse |
| Yukari Nakamura, Sophie Longueville, Akinori Nishi, Denis Hervé, Jean-Antoine Girault, Yuki Nakamur. Dopamine D1 receptor-expressing neurons activity is essential for locomotor and sensitizing effects of a single injection of cocaine. The European journal of neuroscience. vol 54. issue 4. 2021-09-10. PMID:34273137. |
dopamine d1 receptors play an important role in the effects of cocaine. |
2021-09-10 |
2023-08-13 |
mouse |
| Oscar Solís, Patricia García-Sanz, Ana B Martín, Noelia Granado, Adrián Sanz-Magro, Petar Podlesniy, Ramón Trullas, M Gustavo Murer, Rafael Maldonado, Rosario Moratall. Behavioral sensitization and cellular responses to psychostimulants are reduced in D2R knockout mice. Addiction biology. vol 26. issue 1. 2021-09-09. PMID:31833146. |
repeated cocaine exposure causes long-lasting neuroadaptations that involve alterations in cellular signaling and gene expression mediated by dopamine in different brain regions, such as the striatum. |
2021-09-09 |
2023-08-13 |
mouse |
| Amy Hauck Newman, Therese Ku, Chloe J Jordan, Alessandro Bonifazi, Zheng-Xiong X. New Drugs, Old Targets: Tweaking the Dopamine System to Treat Psychostimulant Use Disorders. Annual review of pharmacology and toxicology. vol 61. 2021-09-09. PMID:33411583. |
as both cocaine and methamphetamine rapidly increase dopamine (da) levels in mesolimbic brain regions, leading to euphoria that in some can lead to addiction, targets in which this increased dopaminergic tone may be mitigated have been explored. |
2021-09-09 |
2023-08-13 |
Not clear |