| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Renee A Rotolo, Rose E Presby, Olivia Tracy, Sokaina Asar, Jen-Hau Yang, Merce Correa, Fraser Murray, John D Salamon. The novel atypical dopamine transport inhibitor CT-005404 has pro-motivational effects in neurochemical and inflammatory models of effort-based dysfunctions related to psychopathology. Neuropharmacology. vol 183. 2021-09-13. PMID:32956676. |
while drugs that block dopamine transport (dat) reportedly have positive motivational effects, dat inhibitors such as cocaine and amphetamines produce undesirable side effects. |
2021-09-13 |
2023-08-13 |
rat |
| Mireia Casanovas, Mireia Jiménez-Rosés, Arnau Cordomí, Alejandro Lillo, Ignacio Vega-Quiroga, Joan Izquierdo, Mireia Medrano, Katia Gysling, Leonardo Pardo, Gemma Navarro, Rafael Franc. Discovery of a macromolecular complex mediating the hunger suppressive actions of cocaine: Structural and functional properties. Addiction biology. vol 26. issue 5. 2021-09-10. PMID:33559278. |
cocaine not only increases brain dopamine levels but also activates the sigma |
2021-09-10 |
2023-08-13 |
Not clear |
| Yukari Nakamura, Sophie Longueville, Akinori Nishi, Denis Hervé, Jean-Antoine Girault, Yuki Nakamur. Dopamine D1 receptor-expressing neurons activity is essential for locomotor and sensitizing effects of a single injection of cocaine. The European journal of neuroscience. vol 54. issue 4. 2021-09-10. PMID:34273137. |
dopamine d1 receptor-expressing neurons activity is essential for locomotor and sensitizing effects of a single injection of cocaine. |
2021-09-10 |
2023-08-13 |
mouse |
| Yukari Nakamura, Sophie Longueville, Akinori Nishi, Denis Hervé, Jean-Antoine Girault, Yuki Nakamur. Dopamine D1 receptor-expressing neurons activity is essential for locomotor and sensitizing effects of a single injection of cocaine. The European journal of neuroscience. vol 54. issue 4. 2021-09-10. PMID:34273137. |
dopamine d1 receptors play an important role in the effects of cocaine. |
2021-09-10 |
2023-08-13 |
mouse |
| Oscar Solís, Patricia García-Sanz, Ana B Martín, Noelia Granado, Adrián Sanz-Magro, Petar Podlesniy, Ramón Trullas, M Gustavo Murer, Rafael Maldonado, Rosario Moratall. Behavioral sensitization and cellular responses to psychostimulants are reduced in D2R knockout mice. Addiction biology. vol 26. issue 1. 2021-09-09. PMID:31833146. |
repeated cocaine exposure causes long-lasting neuroadaptations that involve alterations in cellular signaling and gene expression mediated by dopamine in different brain regions, such as the striatum. |
2021-09-09 |
2023-08-13 |
mouse |
| Amy Hauck Newman, Therese Ku, Chloe J Jordan, Alessandro Bonifazi, Zheng-Xiong X. New Drugs, Old Targets: Tweaking the Dopamine System to Treat Psychostimulant Use Disorders. Annual review of pharmacology and toxicology. vol 61. 2021-09-09. PMID:33411583. |
as both cocaine and methamphetamine rapidly increase dopamine (da) levels in mesolimbic brain regions, leading to euphoria that in some can lead to addiction, targets in which this increased dopaminergic tone may be mitigated have been explored. |
2021-09-09 |
2023-08-13 |
Not clear |
| Robert W Seaman, Michelle R Doyle, Agnieszka Sulima, Kenner C Rice, Gregory T Collin. Discriminative stimulus effects of 3,4-methylenedioxypyrovalerone (MDPV) and structurally related synthetic cathinones. Behavioural pharmacology. vol 32. issue 5. 2021-09-06. PMID:33587482. |
these studies used male sprague-dawley rats trained to discriminate mdpv from saline to evaluate the substitution profiles of structurally related synthetic cathinones, cocaine, and other direct-acting dopamine and noradrenergic receptor agonists in order to characterize the relative contributions of dopamine, norepinephrine and serotonin to the discriminative stimulus effects of mdpv. |
2021-09-06 |
2023-08-13 |
rat |
| Robert W Seaman, Michelle R Doyle, Agnieszka Sulima, Kenner C Rice, Gregory T Collin. Discriminative stimulus effects of 3,4-methylenedioxypyrovalerone (MDPV) and structurally related synthetic cathinones. Behavioural pharmacology. vol 32. issue 5. 2021-09-06. PMID:33587482. |
as expected, each of the cathinones and cocaine dose-dependently increased mdpv-appropriate responding, with a rank-order potency that was positively correlated with their potency to inhibit dopamine and norepinephrine, but not serotonin, a relationship that is consistent with the rank order to maintain self-administration. |
2021-09-06 |
2023-08-13 |
rat |
| Durairaj Ragu Varman, Mark A Subler, Jolene J Windle, Lankupalle D Jayanthi, Sammanda Ramamoorth. Novelty-induced hyperactivity and suppressed cocaine induced locomotor activation in mice lacking threonine 53 phosphorylation of dopamine transporter. Behavioural brain research. vol 408. 2021-09-02. PMID:33794225. |
novelty-induced hyperactivity and suppressed cocaine induced locomotor activation in mice lacking threonine 53 phosphorylation of dopamine transporter. |
2021-09-02 |
2023-08-13 |
mouse |
| Jessica K Shaw, I Pamela Alonso, Stacia I Lewandowski, Marion O Scott, Bethan M O'Connor, Shaili Aggarwal, Mariella De Biasi, Ole V Mortensen, Rodrigo A Españ. Individual differences in dopamine uptake in the dorsomedial striatum prior to cocaine exposure predict motivation for cocaine in male rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 10. 2021-08-27. PMID:33953341. |
individual differences in dopamine uptake in the dorsomedial striatum prior to cocaine exposure predict motivation for cocaine in male rats. |
2021-08-27 |
2023-08-13 |
rat |
| Jessica K Shaw, I Pamela Alonso, Stacia I Lewandowski, Marion O Scott, Bethan M O'Connor, Shaili Aggarwal, Mariella De Biasi, Ole V Mortensen, Rodrigo A Españ. Individual differences in dopamine uptake in the dorsomedial striatum prior to cocaine exposure predict motivation for cocaine in male rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 10. 2021-08-27. PMID:33953341. |
here, we prospectively measured dopamine (da) neurotransmission prior to cocaine exposure to predict the onset and course of cocaine use. |
2021-08-27 |
2023-08-13 |
rat |
| Camilla Bellone, Michael Loureiro, Christian Lüsche. Drug-Evoked Synaptic Plasticity of Excitatory Transmission in the Ventral Tegmental Area. Cold Spring Harbor perspectives in medicine. vol 11. issue 4. 2021-08-25. PMID:32341062. |
here, we discuss cocaine-evoked synaptic plasticity of glutamatergic transmission onto dopamine (da) neurons of the ventral tegmental area (vta) as one of the earliest traces after a first injection of cocaine. |
2021-08-25 |
2023-08-13 |
Not clear |
| Susana Paredes-Zúñiga, Fernando Ormeño, Miguel L Allend. Triadimefon triggers circling behavior and conditioned place preference/aversion in zebrafish in a dose dependent manner. Neurotoxicology and teratology. vol 86. 2021-08-25. PMID:33839247. |
for vertebrates, one of its side effects is the binding to the dopamine transporter increasing the levels of synaptic dopamine, similarly to cocaine. |
2021-08-25 |
2023-08-13 |
zebrafish |
| Aaron Caccamise, Erik Van Newenhizen, John R Mantsc. Neurochemical mechanisms and neurocircuitry underlying the contribution of stress to cocaine seeking. Journal of neurochemistry. vol 157. issue 5. 2021-08-24. PMID:33660857. |
crf promotes the activation of vta dopamine neurons that innervate the prelimbic prefrontal cortex resulting in d1 receptor-dependent excitation of a pathway to the nucleus accumbens core that mediates cocaine seeking. |
2021-08-24 |
2023-08-13 |
Not clear |
| Zhijun Diao, Yuanyuan Di, Meilin Wu, Chenyang Zhai, Mengsi Kang, Yongfeng Li, Yingxun Liu, Chunling Wei, Qiaohua Zheng, Jing Han, Zhiqiang Liu, Yingfang Tian, Wei Re. Single Exposure to Cocaine Impairs Reinforcement Learning by Potentiating the Activity of Neurons in the Direct Striatal Pathway in Mice. Neuroscience bulletin. vol 37. issue 8. 2021-08-18. PMID:33905097. |
either a single exposure to cocaine or reinforcement learning potentiates the glutamatergic synapses on msns expressing the striatal dopamine 1 (d1) receptor (d1-msns). |
2021-08-18 |
2023-08-13 |
mouse |
| Patricia Rivera, Jesús Aranda, Francisco Alén, Antonio Vargas, Antonia Serrano, Francisco Javier Pavón, Laura Orio, Leticia Rubio, Rosario Moratalla, Fernando Rodríguez de Fonseca, Juan Suáre. Sex-specific behavioral and neurogenic responses to cocaine in mice lacking and blocking dopamine D1 or dopamine D2 receptors. The Journal of comparative neurology. vol 529. issue 8. 2021-08-16. PMID:33047300. |
sex-specific behavioral and neurogenic responses to cocaine in mice lacking and blocking dopamine d1 or dopamine d2 receptors. |
2021-08-16 |
2023-08-13 |
mouse |
| Patricia Rivera, Jesús Aranda, Francisco Alén, Antonio Vargas, Antonia Serrano, Francisco Javier Pavón, Laura Orio, Leticia Rubio, Rosario Moratalla, Fernando Rodríguez de Fonseca, Juan Suáre. Sex-specific behavioral and neurogenic responses to cocaine in mice lacking and blocking dopamine D1 or dopamine D2 receptors. The Journal of comparative neurology. vol 529. issue 8. 2021-08-16. PMID:33047300. |
however, the sex-specific role of dopamine d1 and d2 receptors (d1r, d2r) in the deleterious effect of cocaine on adult neurogenesis has not been described yet. |
2021-08-16 |
2023-08-13 |
mouse |
| Shannon L Cole, Ramesh Chandra, Maya Harris, Ishan Patel, Torrance Wang, Hyunjae Kim, Leah Jensen, Scott J Russo, Gustavo Turecki, Amy M Gancarz-Kausch, David M Dietz, Mary Kay Lob. Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation. Molecular brain. vol 14. issue 1. 2021-08-12. PMID:34187517. |
further, mitochondria are differentially regulated by cocaine in dopamine receptor-1 containing medium spiny neurons (d1-msns) vs dopamine receptor-2 (d2)-msns. |
2021-08-12 |
2023-08-13 |
human |
| Fernando B de Moura, Alexander Sherwood, Thomas E Prisinzano, Carol A Paronis, Jack Bergman, Stephen J Kohu. Reinforcing effects of synthetic cathinones in rhesus monkeys: Dose-response and behavioral economic analyses. Pharmacology, biochemistry, and behavior. vol 202. 2021-08-10. PMID:33444603. |
the reinforcing effects of selected cathinones (e.g., mdpv, αpvp, mcat, and methylone) with a range of pharmacological effects at dopamine and serotonin transporters were compared to cocaine and mdma using dose-response analysis under a simple fr schedule and behavioral economic procedures that generated demand curves for two doses of each drug. |
2021-08-10 |
2023-08-13 |
human |
| Anna Terem, Ben Jerry Gonzales, Noa Peretz-Rivlin, Reut Ashwal-Fluss, Noa Bleistein, Maria Del Mar Reus-Garcia, Diptendu Mukherjee, Maya Groysman, Ami Citr. Claustral Neurons Projecting to Frontal Cortex Mediate Contextual Association of Reward. Current biology : CB. vol 30. issue 18. 2021-08-09. PMID:32707061. |
this strategy resolves the role of a defined network of claustrum neurons expressing dopamine d1 receptors and projecting to frontal cortex in the acquisition of cocaine conditioned-place preference and real-time optogenetic conditioned-place preference. |
2021-08-09 |
2023-08-13 |
Not clear |