| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ellie-Anna Minogianis, Waqqas M Shams, Omar S Mabrouk, Jenny-Marie T Wong, Wayne G Brake, Robert T Kennedy, Patrick du Souich, Anne-Noël Samah. Varying the rate of intravenous cocaine infusion influences the temporal dynamics of both drug and dopamine concentrations in the striatum. The European journal of neuroscience. vol 50. issue 3. 2020-06-30. PMID:29757478. |
infusion rate did not significantly influence peak concentrations of cocaine or dopamine, but concentrations increased faster following 5-s infusions. |
2020-06-30 |
2023-08-13 |
rat |
| Ellie-Anna Minogianis, Waqqas M Shams, Omar S Mabrouk, Jenny-Marie T Wong, Wayne G Brake, Robert T Kennedy, Patrick du Souich, Anne-Noël Samah. Varying the rate of intravenous cocaine infusion influences the temporal dynamics of both drug and dopamine concentrations in the striatum. The European journal of neuroscience. vol 50. issue 3. 2020-06-30. PMID:29757478. |
thus, small differences in the rate of cocaine delivery influence both the rate of rise of drug and dopamine concentrations, and psychomotor activity. |
2020-06-30 |
2023-08-13 |
rat |
| Ellie-Anna Minogianis, Waqqas M Shams, Omar S Mabrouk, Jenny-Marie T Wong, Wayne G Brake, Robert T Kennedy, Patrick du Souich, Anne-Noël Samah. Varying the rate of intravenous cocaine infusion influences the temporal dynamics of both drug and dopamine concentrations in the striatum. The European journal of neuroscience. vol 50. issue 3. 2020-06-30. PMID:29757478. |
a faster rate of rise of drug and dopamine concentrations might be an important issue in making rapidly delivered cocaine more addictive. |
2020-06-30 |
2023-08-13 |
rat |
| Annika H Runegaard, Kathrine Louise Jensen, Gitta Wörtwein, Ulrik Gethe. Initial rewarding effects of cocaine and amphetamine assessed in a day using the single-exposure place preference protocol. The European journal of neuroscience. vol 50. issue 3. 2020-06-30. PMID:30044020. |
in rodents, only a single dose of cocaine or amphetamine is required to cause a marked increase in extracellular dopamine, induce hyperlocomotion and cause persistent plasticity changes within dopaminergic neurons of the ventral tegmental area (vta). |
2020-06-30 |
2023-08-13 |
mouse |
| Jacqueline D Keighron, JoLynn B Giancola, Rachel J Shaffer, Emily M DeMarco, Mark A Coggiano, Rachel D Slack, Amy Hauck Newman, Gianluigi Tand. Distinct effects of (R)-modafinil and its (R)- and (S)-fluoro-analogs on mesolimbic extracellular dopamine assessed by voltammetry and microdialysis in rats. The European journal of neuroscience. vol 50. issue 3. 2020-06-30. PMID:30402972. |
modafinil (mod), like cocaine, is a dopamine reuptake inhibitor and one of the few drugs evaluated in clinical trials that has shown promise for the treatment of cocaine or methamphetamine use disorders in some patient subpopulations. |
2020-06-30 |
2023-08-13 |
rat |
| Predrag Kalaba, Marija Ilić, Nilima Y Aher, Vladimir Dragačević, Marcus Wieder, Martin Zehl, Judith Wackerlig, Stanislav Beyl, Simone B Sartori, Karl Ebner, Alexander Roller, Natalie Lukic, Tetyana Beryozkina, Eduardo Rene Perez Gonzalez, Philip Neill, Jawad Akbar Khan, Vasiliy Bakulev, Johann Jakob Leban, Steffen Hering, Christian Pifl, Nicolas Singewald, Jana Lubec, Ernst Urban, Harald H Sitte, Thierry Langer, Gert Lube. Structure-Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters. Journal of medicinal chemistry. vol 63. issue 1. 2020-06-29. PMID:31841637. |
atypical dopamine reuptake inhibitors, such as modafinil, are used for the treatment of sleeping disorders and investigated as potential therapeutics against cocaine addiction and for cognitive enhancement. |
2020-06-29 |
2023-08-13 |
Not clear |
| Brandon L Warren, Louisa Kane, Marco Venniro, Pooja Selvam, Richard Quintana-Feliciano, Michael P Mendoza, Rajtarun Madangopal, Lauren Komer, Leslie R Whitaker, F Javier Rubio, Jennifer M Bossert, Daniele Caprioli, Yavin Shaham, Bruce T Hop. Separate vmPFC Ensembles Control Cocaine Self-Administration Versus Extinction in Rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 37. 2020-06-25. PMID:31331999. |
functional disconnection experiments (daun02 lesioning of vmpfc and acute dopamine d1-receptor blockade with sch39166 in nac core or shell) confirm that vmpfc ensembles interact with nac core versus shell to play dissociable roles in cocaine self-administration versus extinction, respectively. |
2020-06-25 |
2023-08-13 |
rat |
| Linda D Simmler, Randy D Blakel. The SERT Met172 Mouse: An Engineered Model To Elucidate the Contributions of Serotonin Signaling to Cocaine Action. ACS chemical neuroscience. vol 10. issue 7. 2020-06-11. PMID:30817127. |
it is well-known that essential aspects of cocaine's addictive actions involve the drug's ability to block the presynaptic dopamine (da) transporter (dat), thereby elevating extracellular levels of da in brain circuits that subserve reward, reinforcement, and habit. |
2020-06-11 |
2023-08-13 |
mouse |
| Nora M McCall, Ezequiel Marron Fernandez de Velasco, Kevin Wickma. GIRK Channel Activity in Dopamine Neurons of the Ventral Tegmental Area Bidirectionally Regulates Behavioral Sensitivity to Cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 19. 2020-06-11. PMID:30837265. |
girk channel activity in dopamine neurons of the ventral tegmental area bidirectionally regulates behavioral sensitivity to cocaine. |
2020-06-11 |
2023-08-13 |
Not clear |
| Xuefeng Zhang, David A Nielsen, Coreen B Domingo, Daryl I Shorter, Ellen M Nielsen, Thomas R Koste. Pharmacogenetics of Dopamine β-Hydroxylase in cocaine dependence therapy with doxazosin. Addiction biology. vol 24. issue 3. 2020-05-18. PMID:29498170. |
pharmacogenetics of dopamine β-hydroxylase in cocaine dependence therapy with doxazosin. |
2020-05-18 |
2023-08-13 |
Not clear |
| Olga Trubetckaia, Ariana E Lane, Liping Qian, Ping Zhou, Diane A Lan. Alpha-synuclein is strategically positioned for afferent modulation of midbrain dopamine neurons and is essential for cocaine preference. Communications biology. vol 2. 2020-05-18. PMID:31754648. |
alpha-synuclein is strategically positioned for afferent modulation of midbrain dopamine neurons and is essential for cocaine preference. |
2020-05-18 |
2023-08-13 |
Not clear |
| Yoki Nakamura, Dilyan I Dryanovski, Yuriko Kimura, Shelley N Jackson, Amina S Woods, Yuko Yasui, Shang-Yi Tsai, Sachin Patel, Daniel P Covey, Tsung-Ping Su, Carl R Lupic. Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion. eLife. vol 8. 2020-05-05. PMID:31596232. |
recent evidence suggests that cocaine stimulates synthesis of the endocannabinoid 2-arachidonoylglycerol (2-ag) in midbrain, increasing dopamine neuron activity via disinhibition. |
2020-05-05 |
2023-08-13 |
mouse |
| Małgorzata Frankowska, Joanna Miszkiel, Lucyna Pomierny-Chamioło, Bartosz Pomierny, Andrea Celeste Borelli, Agata Suder, Małgorzata Fili. Extinction training following cocaine or MDMA self-administration produces discrete changes in D Pharmacological reports : PR. vol 71. issue 5. 2020-04-30. PMID:31408786. |
extinction training following cocaine or mdma self-administration produces discrete changes in d several studies strongly support the role of the dopamine d |
2020-04-30 |
2023-08-13 |
Not clear |
| Jeremiah Ramos, Caroline Hernandez-Casner, Bryan Cruz, Katherine M Serafin. Sex differences in high fat diet-induced impairments to striatal Akt signaling and enhanced sensitivity to the behavioral effects of dopamine D Physiology & behavior. vol 203. 2020-04-27. PMID:29154786. |
sex differences in high fat diet-induced impairments to striatal akt signaling and enhanced sensitivity to the behavioral effects of dopamine d eating a high fat laboratory chow enhances sensitivity of rats to the behavioral effects of drugs that act on dopamine systems (e.g., cocaine). |
2020-04-27 |
2023-08-13 |
human |
| Jeremiah Ramos, Caroline Hernandez-Casner, Bryan Cruz, Katherine M Serafin. Sex differences in high fat diet-induced impairments to striatal Akt signaling and enhanced sensitivity to the behavioral effects of dopamine D Physiology & behavior. vol 203. 2020-04-27. PMID:29154786. |
eating high fat chow enhances sensitivity of female rats to drugs that act indirectly on dopamine receptors (e.g., cocaine); however, less is known about sensitivity of females to drugs that act directly on dopamine receptors (e.g., quinpirole). |
2020-04-27 |
2023-08-13 |
human |
| Chloe J Jordan, Bree A Humburg, Eric B Thorndike, Anver Basha Shaik, Zheng-Xiong Xi, Michael H Baumann, Amy Hauck Newman, Charles W Schindle. Newly Developed Dopamine D The Journal of pharmacology and experimental therapeutics. vol 371. issue 3. 2020-04-27. PMID:31562201. |
newly developed dopamine d opioid and cocaine abuse are major public health burdens. |
2020-04-27 |
2023-08-13 |
Not clear |
| Alexander G Zestos, Colleen Carpenter, Youngsoo Kim, Malcolm J Low, Robert T Kennedy, Margaret E Gneg. Ruboxistaurin Reduces Cocaine-Stimulated Increases in Extracellular Dopamine by Modifying Dopamine-Autoreceptor Activity. ACS chemical neuroscience. vol 10. issue 4. 2020-04-24. PMID:30384585. |
cocaine blocks normal uptake function at the dopamine transporter (dat), thus increasing extracellular dopamine. |
2020-04-24 |
2023-08-13 |
mouse |
| Alexander G Zestos, Colleen Carpenter, Youngsoo Kim, Malcolm J Low, Robert T Kennedy, Margaret E Gneg. Ruboxistaurin Reduces Cocaine-Stimulated Increases in Extracellular Dopamine by Modifying Dopamine-Autoreceptor Activity. ACS chemical neuroscience. vol 10. issue 4. 2020-04-24. PMID:30384585. |
because cocaine activity is highly regulated by dopamine autoreceptors, we examined whether ruboxistaurin was acting at the level of the d2 autoreceptor. |
2020-04-24 |
2023-08-13 |
mouse |
| Alexander G Zestos, Colleen Carpenter, Youngsoo Kim, Malcolm J Low, Robert T Kennedy, Margaret E Gneg. Ruboxistaurin Reduces Cocaine-Stimulated Increases in Extracellular Dopamine by Modifying Dopamine-Autoreceptor Activity. ACS chemical neuroscience. vol 10. issue 4. 2020-04-24. PMID:30384585. |
therefore, the inhibition of pkcβ reduces dopamine overflow and locomotor activity stimulated by both cocaine and amphetamine, but the mechanism of action differs for each stimulant. |
2020-04-24 |
2023-08-13 |
mouse |
| T Lee Gilman, W Anthony Owens, Christina M George, Lauren Metzel, Melissa Vitela, Livia Ferreira, Melodi A Bowman, Georgianna G Gould, Glenn M Toney, Lynette C Daw. Age- and Sex-Specific Plasticity in Dopamine Transporter Function Revealed by Food Restriction and Exercise in a Rat Activity-Based Anorexia Paradigm. The Journal of pharmacology and experimental therapeutics. vol 371. issue 2. 2020-04-24. PMID:31481515. |
significance statement: adolescent rats exhibit a distinctive, sex-specific plasticity in dopamine transporter function and cocaine response after food restriction and exercise access; this plasticity is both absent in adults and not attributable to changes in dopamine transporter expression levels. |
2020-04-24 |
2023-08-13 |
human |