| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeremiah Ramos, Caroline Hernandez-Casner, Bryan Cruz, Katherine M Serafin. Sex differences in high fat diet-induced impairments to striatal Akt signaling and enhanced sensitivity to the behavioral effects of dopamine D Physiology & behavior. vol 203. 2020-04-27. PMID:29154786. |
eating high fat chow enhances sensitivity of female rats to drugs that act indirectly on dopamine receptors (e.g., cocaine); however, less is known about sensitivity of females to drugs that act directly on dopamine receptors (e.g., quinpirole). |
2020-04-27 |
2023-08-13 |
human |
| Chloe J Jordan, Bree A Humburg, Eric B Thorndike, Anver Basha Shaik, Zheng-Xiong Xi, Michael H Baumann, Amy Hauck Newman, Charles W Schindle. Newly Developed Dopamine D The Journal of pharmacology and experimental therapeutics. vol 371. issue 3. 2020-04-27. PMID:31562201. |
newly developed dopamine d opioid and cocaine abuse are major public health burdens. |
2020-04-27 |
2023-08-13 |
Not clear |
| Alexander G Zestos, Colleen Carpenter, Youngsoo Kim, Malcolm J Low, Robert T Kennedy, Margaret E Gneg. Ruboxistaurin Reduces Cocaine-Stimulated Increases in Extracellular Dopamine by Modifying Dopamine-Autoreceptor Activity. ACS chemical neuroscience. vol 10. issue 4. 2020-04-24. PMID:30384585. |
cocaine blocks normal uptake function at the dopamine transporter (dat), thus increasing extracellular dopamine. |
2020-04-24 |
2023-08-13 |
mouse |
| Alexander G Zestos, Colleen Carpenter, Youngsoo Kim, Malcolm J Low, Robert T Kennedy, Margaret E Gneg. Ruboxistaurin Reduces Cocaine-Stimulated Increases in Extracellular Dopamine by Modifying Dopamine-Autoreceptor Activity. ACS chemical neuroscience. vol 10. issue 4. 2020-04-24. PMID:30384585. |
because cocaine activity is highly regulated by dopamine autoreceptors, we examined whether ruboxistaurin was acting at the level of the d2 autoreceptor. |
2020-04-24 |
2023-08-13 |
mouse |
| Alexander G Zestos, Colleen Carpenter, Youngsoo Kim, Malcolm J Low, Robert T Kennedy, Margaret E Gneg. Ruboxistaurin Reduces Cocaine-Stimulated Increases in Extracellular Dopamine by Modifying Dopamine-Autoreceptor Activity. ACS chemical neuroscience. vol 10. issue 4. 2020-04-24. PMID:30384585. |
therefore, the inhibition of pkcβ reduces dopamine overflow and locomotor activity stimulated by both cocaine and amphetamine, but the mechanism of action differs for each stimulant. |
2020-04-24 |
2023-08-13 |
mouse |
| T Lee Gilman, W Anthony Owens, Christina M George, Lauren Metzel, Melissa Vitela, Livia Ferreira, Melodi A Bowman, Georgianna G Gould, Glenn M Toney, Lynette C Daw. Age- and Sex-Specific Plasticity in Dopamine Transporter Function Revealed by Food Restriction and Exercise in a Rat Activity-Based Anorexia Paradigm. The Journal of pharmacology and experimental therapeutics. vol 371. issue 2. 2020-04-24. PMID:31481515. |
significance statement: adolescent rats exhibit a distinctive, sex-specific plasticity in dopamine transporter function and cocaine response after food restriction and exercise access; this plasticity is both absent in adults and not attributable to changes in dopamine transporter expression levels. |
2020-04-24 |
2023-08-13 |
human |
| Ashley E Lepack, Craig T Werner, Andrew F Stewart, Sasha L Fulton, Ping Zhong, Lorna A Farrelly, Alexander C W Smith, Aarthi Ramakrishnan, Yang Lyu, Ryan M Bastle, Jennifer A Martin, Swarup Mitra, Richard M O'Connor, Zi-Jun Wang, Henrik Molina, Gustavo Turecki, Li Shen, Zhen Yan, Erin S Calipari, David M Dietz, Paul J Kenny, Ian Maz. Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking. Science (New York, N.Y.). vol 368. issue 6487. 2020-04-17. PMID:32273471. |
vulnerability to relapse during periods of attempted abstinence from cocaine use is hypothesized to result from the rewiring of brain reward circuitries, particularly ventral tegmental area (vta) dopamine neurons. |
2020-04-17 |
2023-08-13 |
rat |
| Ashley E Lepack, Craig T Werner, Andrew F Stewart, Sasha L Fulton, Ping Zhong, Lorna A Farrelly, Alexander C W Smith, Aarthi Ramakrishnan, Yang Lyu, Ryan M Bastle, Jennifer A Martin, Swarup Mitra, Richard M O'Connor, Zi-Jun Wang, Henrik Molina, Gustavo Turecki, Li Shen, Zhen Yan, Erin S Calipari, David M Dietz, Paul J Kenny, Ian Maz. Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking. Science (New York, N.Y.). vol 368. issue 6487. 2020-04-17. PMID:32273471. |
how cocaine exposures act on midbrain dopamine neurons to precipitate addiction-relevant changes in gene expression is unclear. |
2020-04-17 |
2023-08-13 |
rat |
| Marco D Carpenter, Qiwen Hu, Allison M Bond, Sonia I Lombroso, Kyle S Czarnecki, Carissa J Lim, Hongjun Song, Mathieu E Wimmer, R Christopher Pierce, Elizabeth A Helle. Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes. Nature communications. vol 11. issue 1. 2020-04-08. PMID:31980629. |
cocaine activated the transcription factor, nr4a1, and its target gene, cartpt, a key molecule involved in dopamine metabolism. |
2020-04-08 |
2023-08-13 |
mouse |
| Ahmed Elkashef, James Robert Brašić, Louis R Cantelina, Roberta Kahn, Nora Chiang, Weiguo Ye, Yun Zhou, Jurij Mojsiak, Kimberly R Warren, Andrew Crabb, John Hilton, Dean F Wong, Frank Vocc. A cholecystokinin B receptor antagonist and cocaine interaction, phase I study. CNS neuroscience & therapeutics. vol 25. issue 1. 2020-04-06. PMID:29923314. |
rpr 102681, a cholecystokinin-b antagonist, increased dopamine (da) release and reduced cocaine self-administration in animals. |
2020-04-06 |
2023-08-13 |
Not clear |
| Jacqueline-Marie N Ferland, Tristan J Hynes, Celine D Hounjet, David Lindenbach, Cole Vonder Haar, Wendy K Adams, Anthony G Phillips, Catharine A Winstanle. Prior Exposure to Salient Win-Paired Cues in a Rat Gambling Task Increases Sensitivity to Cocaine Self-Administration and Suppresses Dopamine Efflux in Nucleus Accumbens: Support for the Reward Deficiency Hypothesis of Addiction. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 10. 2020-03-23. PMID:30626700. |
prior exposure to salient win-paired cues in a rat gambling task increases sensitivity to cocaine self-administration and suppresses dopamine efflux in nucleus accumbens: support for the reward deficiency hypothesis of addiction. |
2020-03-23 |
2023-08-13 |
rat |
| June P Kampangkaew, Catherine J Spellicy, Ellen M Nielsen, Mark J Harding, An Ye, Sara C Hamon, Thomas R Kosten, David A Nielse. Pharmacogenetic role of dopamine transporter (SLC6A3) variation on response to disulfiram treatment for cocaine addiction. The American journal on addictions. vol 28. issue 4. 2020-03-20. PMID:31087723. |
pharmacogenetic role of dopamine transporter (slc6a3) variation on response to disulfiram treatment for cocaine addiction. |
2020-03-20 |
2023-08-13 |
Not clear |
| Sorinel A Oprisan, Xandre Clementsmith, Tamas Tompa, Antonieta Lavi. Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice. PloS one. vol 14. issue 10. 2020-03-16. PMID:31618234. |
the goal of this study was to investigate the effects of acute cocaine injection or dopamine (da) receptor antagonists on the medial prefrontal cortex (mpfc) gamma oscillations and their relationship to short term neuroadaptation that may mediate addiction. |
2020-03-16 |
2023-08-13 |
mouse |
| Suchan Chang, Yu Fan, Joo Hyun Shin, Yeonhee Ryu, Mi Seon Kim, Scott C Steffensen, Hyung Kyu Kim, Jin Mook Kim, Bong Hyo Lee, Eun Young Jang, Chae Ha Yang, Hee Young Ki. Unpleasant Sound Elicits Negative Emotion and Reinstates Drug Seeking. Molecular neurobiology. vol 56. issue 11. 2020-03-12. PMID:31073951. |
this study investigated in rats (male sprague-dawley rats) if aversive sounds modulate dopamine (da) transmission in the mesolimbic reward system and cocaine reinforcement. |
2020-03-12 |
2023-08-13 |
rat |
| Earnest S Kim, K Matthew Latta. Context-Dependent and Context-Independent Effects of D1 Receptor Antagonism in the Basolateral and Central Amygdala during Cocaine Self-Administration. eNeuro. vol 6. issue 4. 2020-03-06. PMID:31358512. |
here we investigate the effects of dopamine d1 receptor blockade in the bla and the cea during asymptotic performance of cocaine self-administration and in a novel application of contextual renewal under continued access conditions. |
2020-03-06 |
2023-08-13 |
rat |
| Martin O Job, Jonathan L Kat. A behavioral economic analysis of the effects of rimcazole on reinforcing effects of cocaine injection and food presentation in rats. Psychopharmacology. vol 236. issue 12. 2020-03-03. PMID:31399853. |
rimcazole, a σ-receptor antagonist with affinity for the dopamine transporter (dat), decreases rates of cocaine self-administration at doses lower than those that affect food-reinforced responding. |
2020-03-03 |
2023-08-13 |
rat |
| Erin M McConnell, Katelyn Ventura, Zach Dwyer, Vernon Hunt, Anna Koudrina, Matthew R Holahan, Maria C DeRos. In Vivo Use of a Multi-DNA Aptamer-Based Payload/Targeting System To Study Dopamine Dysregulation in the Central Nervous System. ACS chemical neuroscience. vol 10. issue 1. 2020-02-18. PMID:30160936. |
in a behavioral experiment using cocaine administration to induce elevated concentrations of neural dopamine, systemic pretreatment with the dopamine aptamer-loaded liposomes reduced cocaine-induced hyperlocomotion. |
2020-02-18 |
2023-08-13 |
Not clear |
| Dasiel O Borroto-Escuela, Manuel Narváez, Wilber Romero-Fernández, Luca Pinton, Karolina Wydra, Malgorzata Filip, Sarah Beggiato, Sergio Tanganelli, Luca Ferraro, Kjell Fux. Acute Cocaine Enhances Dopamine D Molecular neurobiology. vol 56. issue 10. 2020-01-30. PMID:30972626. |
acute cocaine enhances dopamine d the current study was performed to establish the actions of nanomolar concentrations of cocaine, not blocking the dopamine transporter, on dopamine d2 receptor (d |
2020-01-30 |
2023-08-13 |
Not clear |
| Gene-Jack Wang, Corinde E Wiers, Elena Shumay, Dardo Tomasi, Kai Yuan, Christopher T Wong, Jean Logan, Joanna S Fowler, Nora D Volko. Expectation effects on brain dopamine responses to methylphenidate in cocaine use disorder. Translational psychiatry. vol 9. issue 1. 2020-01-15. PMID:30770780. |
expectation effects on brain dopamine responses to methylphenidate in cocaine use disorder. |
2020-01-15 |
2023-08-13 |
human |
| Rajesh Narendran, Savannah Tollefson, Michael L Himes, Jennifer Paris, Brian Lopresti, Roberto Ciccocioppo, N Scott Maso. Nociceptin Receptors Upregulated in Cocaine Use Disorder: A Positron Emission Tomography Imaging Study Using [ The American journal of psychiatry. vol 176. issue 6. 2019-12-30. PMID:31055968. |
it also inhibits the release of a wide array of neurotransmitters, including dopamine and glutamate, which allows for it to block the rewarding properties of cocaine. |
2019-12-30 |
2023-08-13 |
Not clear |