| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Soumyabrata Munshi, J Amiel Rosenkranz, Aaron Caccamise, Marina E Wolf, Claire M Corbett, Jessica A Lowet. Cocaine and chronic stress exposure produce an additive increase in neuronal activity in the basolateral amygdala. Addiction biology. vol 26. issue 1. 2021-09-09. PMID:31750602. |
given that glutamatergic projections from the bla to the nucleus accumbens are critical for the incubation of cue-induced cocaine craving, we hypothesized that cocaine withdrawal and chronic stress exposure produce separate increases that additively increase bla neuronal activity. |
2021-09-09 |
2023-08-13 |
rat |
| Jessica K Shaw, I Pamela Alonso, Stacia I Lewandowski, Marion O Scott, Bethan M O'Connor, Shaili Aggarwal, Mariella De Biasi, Ole V Mortensen, Rodrigo A Españ. Individual differences in dopamine uptake in the dorsomedial striatum prior to cocaine exposure predict motivation for cocaine in male rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 10. 2021-08-27. PMID:33953341. |
using in vivo voltammetry, we first generated baseline profiles of da release and uptake in the dorsomedial striatum (dms) and nucleus accumbens of drug-naïve male rats prior to exposing them to cocaine using conditioned place preference (cpp) or operant self-administration. |
2021-08-27 |
2023-08-13 |
rat |
| Sumin Sohn, Sunghyun Kim, Ju Hwan Yang, Eun Sang Cho. Linking of NMDA receptors and mGluR5 in the nucleus accumbens core to repeated cocaine-induced 50-kHz ultrasonic vocalization in rats. Addiction biology. 2021-08-25. PMID:34378829. |
this study demonstrated the linking of glutamate receptors in the nucleus accumbens (nac) to vocal expression of 50-khz usv calls after repeated cocaine administration in freely moving rats. |
2021-08-25 |
2023-08-13 |
rat |
| Jessica L Huebschman, Megan C Davis, Catherina Tovar Pensa, Yuhong Guo, Laura N Smit. The fragile X mental retardation protein promotes adjustments in cocaine self-administration that preserve reinforcement level. The European journal of neuroscience. vol 54. issue 3. 2021-08-20. PMID:34133054. |
additionally, we find an fmrp target, the activity-regulated cytoskeleton-associated protein (arc), to be significantly reduced in synaptic cellular fractions prepared from the nucleus accumbens of fmr1 ko, compared with wt, mice following operant tasks reinforced with cocaine but not food. |
2021-08-20 |
2023-08-13 |
mouse |
| Shannon L Cole, Ramesh Chandra, Maya Harris, Ishan Patel, Torrance Wang, Hyunjae Kim, Leah Jensen, Scott J Russo, Gustavo Turecki, Amy M Gancarz-Kausch, David M Dietz, Mary Kay Lob. Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation. Molecular brain. vol 14. issue 1. 2021-08-12. PMID:34187517. |
recent studies demonstrate that cocaine affects mitochondrial dynamics and morphological characteristics within the nucleus accumbens (nac). |
2021-08-12 |
2023-08-13 |
human |
| Wei Guo, Hailei Long, Qian Bu, Yinglan Zhao, Hongbo Wang, Jingwei Tian, Xiaobo Ce. Role of BRD4 phosphorylation in the nucleus accumbens in relapse to cocaine-seeking behavior in mice. Addiction biology. vol 25. issue 5. 2021-08-11. PMID:31364211. |
in this study, we found that brd4 phosphorylation in the nucleus accumbens (nac) was closely related to the maintenance of cocaine reinforcement and relapse in different cocaine exposure paradigms. |
2021-08-11 |
2023-08-13 |
mouse |
| Patricia Irizar, Natalia Albein-Urios, José Miguel Martínez-González, Antonio Verdejo-Garcia, Valentina Lorenzett. Unpacking common and distinct neuroanatomical alterations in cocaine dependent versus pathological gambling. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 33. 2021-08-10. PMID:32088112. |
cocaine dependent participants had lower nucleus accumbens and medial orbitofrontal cortex volumes than pathological gamblers (ps <.05, ds = 0.51 and 0.72), with the latter being predicted by higher negative urgency scores. |
2021-08-10 |
2023-08-13 |
human |
| Horia Pribiag, Sora Shin, Eric Hou-Jen Wang, Fangmiao Sun, Paul Datta, Alexander Okamoto, Hayden Guss, Akanksha Jain, Xiao-Yun Wang, Bruna De Freitas, Patrick Honma, Stefan Pate, Varoth Lilascharoen, Yulong Li, Byung Kook Li. Ventral pallidum DRD3 potentiates a pallido-habenular circuit driving accumbal dopamine release and cocaine seeking. Neuron. vol 109. issue 13. 2021-07-23. PMID:34048697. |
here, we demonstrate that dopamine receptor d3 (drd3)-dependent plasticity in the ventral pallidum (vp) drives potentiation of dopamine release in the nucleus accumbens during relapse to cocaine seeking after abstinence. |
2021-07-23 |
2023-08-13 |
Not clear |
| Silas A Buck, Mary M Torregrossa, Ryan W Logan, Zachary Freyber. Roles of dopamine and glutamate co-release in the nucleus accumbens in mediating the actions of drugs of abuse. The FEBS journal. vol 288. issue 5. 2021-07-20. PMID:32702182. |
here, we summarize how drugs of abuse, particularly cocaine, opioids, and alcohol, alter da release in the nucleus accumbens medial shell, examine the potential role of da/glutamate co-release in mediating these effects, and discuss future directions for further investigating these mechanisms. |
2021-07-20 |
2023-08-13 |
Not clear |
| Santiago Cuesta, Alejandrina Funes, Alejandra M Pacchion. Social Isolation in Male Rats During Adolescence Inhibits the Wnt/β-Catenin Pathway in the Prefrontal Cortex and Enhances Anxiety and Cocaine-Induced Plasticity in Adulthood. Neuroscience bulletin. vol 36. issue 6. 2021-07-19. PMID:32078732. |
furthermore, after the expression of cocaine sensitization, isolated rats showed an increase in this pathway in the nucleus accumbens. |
2021-07-19 |
2023-08-13 |
rat |
| Bethania Mongi-Bragato, María Paula Avalos, Andrea S Guzmán, Constanza García-Keller, Flavia A Bollati, Liliana M Cancel. Endogenous enkephalin is necessary for cocaine-induced alteration in glutamate transmission within the nucleus accumbens. The European journal of neuroscience. vol 53. issue 5. 2021-06-28. PMID:33159343. |
altered glutamate transmission within the nucleus accumbens (nac) has been proposed as a central mechanism underlying behavioural sensitisation associated with repeated cocaine exposure. |
2021-06-28 |
2023-08-13 |
mouse |
| Daiana Rigoni, Maria P Avalos, Maria J Boezio, Andrea S Guzmán, Gaston D Calfa, Eduardo M Perassi, Silvia M Pierotti, Mariano Bisbal, Constanza Garcia-Keller, Liliana M Cancela, Flavia Bollat. Stress-induced vulnerability to develop cocaine addiction depends on cofilin modulation. Neurobiology of stress. vol 15. 2021-06-26. PMID:34169122. |
the actin cytoskeleton remodeling in the nucleus accumbens (na) has been implicated in the expression of stress-induced cross-sensitization with cocaine. |
2021-06-26 |
2023-08-13 |
rat |
| Yanaira Alonso-Caraballo, Tracy L Fetterly, Emily T Jorgensen, Allison M Nieto, Travis E Brown, Carrie R Ferrari. Sex specific effects of "junk-food" diet on calcium permeable AMPA receptors and silent synapses in the nucleus accumbens core. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 3. 2021-06-23. PMID:32731252. |
cp-ampars in the nucleus accumbens (nac) mediate cue-triggered motivation for food and cocaine. |
2021-06-23 |
2023-08-13 |
rat |
| Ludivine Canchy, Paul Girardeau, Audrey Durand, Caroline Vouillac-Mendoza, Serge H Ahme. Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 2. 2021-06-23. PMID:32731253. |
first, a systematic literature analysis revealed that the delays of effects of intravenous cocaine on nucleus accumbens dopamine are of the order of tens of seconds and are considerably longer than those of nondrug reward. |
2021-06-23 |
2023-08-13 |
rat |
| Jerome A J Becker, Lucie P Pellissier, Yannick Corde, Thibaut Laboute, Audrey Léauté, Jorge Gandía, Julie Le Merre. Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure in male mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 7. 2021-06-23. PMID:33349673. |
transcriptional regulation of marker genes of medium spiny neurons (msns) allowed best discriminating between 4-week morphine and cocaine abstinence in the nucleus accumbens (nac). |
2021-06-23 |
2023-08-13 |
mouse |
| Lan-Yuan Zhang, Yue-Qing Zhou, Zhi-Peng Yu, Xiao-Qin Zhang, Jie Shi, Hao-Wei She. Restoring glutamate homeostasis in the nucleus accumbens via endocannabinoid-mimetic drug prevents relapse to cocaine seeking behavior in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 5. 2021-06-23. PMID:33514875. |
restoring glutamate homeostasis in the nucleus accumbens via endocannabinoid-mimetic drug prevents relapse to cocaine seeking behavior in rats. |
2021-06-23 |
2023-08-13 |
rat |
| José Pedro Prieto, Ximena López Hill, Jessika Urbanavicius, Verónica Sanchez, Xavier Nadal, Cecilia Scorz. Cannabidiol Prevents the Expression of the Locomotor Sensitization and the Metabolic Changes in the Nucleus Accumbens and Prefrontal Cortex Elicited by the Combined Administration of Cocaine and Caffeine in Rats. Neurotoxicity research. vol 38. issue 2. 2021-06-14. PMID:32415526. |
cannabidiol prevents the expression of the locomotor sensitization and the metabolic changes in the nucleus accumbens and prefrontal cortex elicited by the combined administration of cocaine and caffeine in rats. |
2021-06-14 |
2023-08-13 |
rat |
| Benoît Forget, Romain Icick, Jonathan Robert, Caroline Correia, Marie S Prevost, Marc Gielen, Pierre-Jean Corringer, Frank Bellivier, Florence Vorspan, Morgane Besson, Uwe Masko. Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients. Progress in neurobiology. vol 197. 2021-06-11. PMID:32841724. |
to investigate the link between this subunit and cud, we submitted rats knockout for the α5 subunit gene (α5ko), or carrying the α5snp, to cocaine self-administration (sa) and showed that the acquisition of cocaine-sa was impaired in α5snp rats while α5ko rats exhibited enhanced cocaine-induced relapse associated with altered neuronal activity in the nucleus accumbens. |
2021-06-11 |
2023-08-13 |
human |
| Yao Q Wang, Yanhua H Huang, Saju Balakrishnan, Lidong Liu, Yu Tian Wang, Eric J Nestler, Oliver M Schlüter, Yan Don. AMPA and NMDA Receptor Trafficking at Cocaine-Generated Synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 9. 2021-06-11. PMID:33436529. |
cocaine experience generates ampa receptor (ampar)-silent synapses in the nucleus accumbens (nac), which are thought to be new synaptic contacts enriched in glun2b-containing nmda receptors (nmdars). |
2021-06-11 |
2023-08-13 |
mouse |
| Natalie N Nawarawong, Christopher M Olse. Within-animal comparisons of novelty and cocaine neuronal ensemble overlap in the nucleus accumbens and prefrontal cortex. Behavioural brain research. vol 379. 2021-04-30. PMID:31614186. |
within-animal comparisons of novelty and cocaine neuronal ensemble overlap in the nucleus accumbens and prefrontal cortex. |
2021-04-30 |
2023-08-13 |
mouse |