| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J J Arnaiz-Cot, J C González, M Sobrado, P Baldelli, E Carbone, L Gandía, A G García, J M Hernández-Guij. Allosteric modulation of alpha 7 nicotinic receptors selectively depolarizes hippocampal interneurons, enhancing spontaneous GABAergic transmission. The European journal of neuroscience. vol 27. issue 5. 2008-06-03. PMID:18312591. |
this choline action was suppressed by the gaba(a) receptor antagonist bicuculline, while the glutamatergic receptor antagonist kynurenic acid had no effect. |
2008-06-03 |
2023-08-12 |
rat |
| Erwin van Vliet, Siegfried Morath, Chantra Eskes, Jens Linge, Juri Rappsilber, Paul Honegger, Thomas Hartung, Sandra Coeck. A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine. Neurotoxicology. vol 29. issue 1. 2008-05-02. PMID:18023877. |
these were gamma-aminobutyric acid, choline, glutamine, creatine and spermine. |
2008-05-02 |
2023-08-12 |
rat |
| N De Stefano, M Filippi, D Miller, P J Pouwels, A Rovira, A Gass, C Enzinger, P M Matthews, D L Arnol. Guidelines for using proton MR spectroscopy in multicenter clinical MS studies. Neurology. vol 69. issue 20. 2007-12-07. PMID:17998486. |
also, mrs has provided evidence of chemical pathology and repair involving non-neuronal brain cells based on changes in metabolites, including choline, myo-inositol, glutamate, and gaba. |
2007-12-07 |
2023-08-12 |
Not clear |
| Tatiane Araujo Rondini, Bruno de Crudis Rodrigues, Anne Pierre de Oliveira, Jackson Cioni Bittencourt, Carol Fuzeti Elia. Melanin-concentrating hormone is expressed in the laterodorsal tegmental nucleus only in female rats. Brain research bulletin. vol 74. issue 1-3. 2007-11-13. PMID:17683785. |
using dual-label immunohistochemistry or dual-label in situ hybridization, we found that brainstem mch neurons coexpress glutamic acid decarboxylase mrna, the gamma aminobutyric acid (gaba) processing enzyme, but do not colocalize choline acetyl transferase (acetylcholine processing enzyme). |
2007-11-13 |
2023-08-12 |
rat |
| Jun Yang, Yu Yang, Hong-Tao Xu, Jian-Min Chen, Wen-Yan Liu, Bao-Cheng Li. Arginine vasopressin induces periaqueductal gray release of enkephalin and endorphin relating to pain modulation in the rat. Regulatory peptides. vol 142. issue 1-2. 2007-08-20. PMID:17341433. |
the results showed that avp elevated the concentrations of leucine-enkephalin (l-ek), methionine-enkephalin (m-ek) and beta-endorphin (beta-ep), but did not change the concentrations of dynorphina(1-13) (dyna(1-13)), oxt, classical neurotransmitters including achetylcholine (ach), choline (ch), serotonin (5-ht), gamma-aminobutyric acid (gaba), glutamate (glu), dopamine (da), norepinephrine (ne) and epinephrine (e), and their metabolic products in pag perfusion liquid. |
2007-08-20 |
2023-08-12 |
rat |
| Katherine Lymer, Kristin Haga, Ian Marshall, Napapon Sailasuta, Joanna Wardla. Reproducibility of GABA measurements using 2D J-resolved magnetic resonance spectroscopy. Magnetic resonance imaging. vol 25. issue 5. 2007-08-10. PMID:17540274. |
in each case, the 3.01-ppm gaba resonance was quantified; for comparison, the peak integrals of choline (3.2 ppm) and creatine (3.03 ppm) were recorded. |
2007-08-10 |
2023-08-12 |
human |
| Katherine Lymer, Kristin Haga, Ian Marshall, Napapon Sailasuta, Joanna Wardla. Reproducibility of GABA measurements using 2D J-resolved magnetic resonance spectroscopy. Magnetic resonance imaging. vol 25. issue 5. 2007-08-10. PMID:17540274. |
at the smallest concentration of in vivo gaba reported using other spectroscopy techniques (0.8 mm) and detected only using the surface coil, the cv for gaba was 23% and was less than 10% for choline and creatine, which compare favorably with results from published studies. |
2007-08-10 |
2023-08-12 |
human |
| Jiani Hu, Shaolin Yang, Yang Xuan, Quan Jiang, Yihong Yang, E Mark Haack. Simultaneous detection of resolved glutamate, glutamine, and gamma-aminobutyric acid at 4 T. Journal of magnetic resonance (San Diego, Calif. : 1997). vol 185. issue 2. 2007-06-27. PMID:17223596. |
the results have demonstrated that the gln, glu, and gaba signals at 2.2-2.5 ppm can be well resolved using a standard steam sequence with the optimized sequence timing parameters around {82 ms,48 ms} at 4 t, while the other main metabolites, such as n-acetyl aspartate (naa), choline (tcho), and creatine (tcr), are still preserved in the same spectrum. |
2007-06-27 |
2023-08-12 |
human |
| Tiffany J Mellott, Maximillian T Follettie, Veronica Diesl, Andrew A Hill, Ignacio Lopez-Coviella, Jan Krzysztof Blusztaj. Prenatal choline availability modulates hippocampal and cerebral cortical gene expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 7. 2007-05-30. PMID:17264169. |
prenatally choline deficient rats had the highest expression of camkiibeta, protein kinase cbeta2, and gaba(b) receptor 1 isoforms c and d in the hippocampus. |
2007-05-30 |
2023-08-12 |
rat |
| Cornelia Kiewert, Vikas Kumar, Oksana Hildmann, Misty Rueda, Joachim Hartmann, Runa S Naik, Jochen Klei. Role of GABAergic antagonism in the neuroprotective effects of bilobalide. Brain research. vol 1128. issue 1. 2007-03-27. PMID:17134681. |
bicuculline (100 microm), a competitive antagonist at gaba(a) receptors, reduced nmda-induced choline release to a small extent (-23%). |
2007-03-27 |
2023-08-12 |
rat |
| Tsz M Tsang, Ben Woodman, Gerard A McLoughlin, Julian L Griffin, Sarah J Tabrizi, Gillian P Bates, Elaine Holme. Metabolic characterization of the R6/2 transgenic mouse model of Huntington's disease by high-resolution MAS 1H NMR spectroscopy. Journal of proteome research. vol 5. issue 3. 2007-03-08. PMID:16512662. |
global increases in relative brain concentrations of osmolytes, creatine, glutamine, and lactate, and decreases in acetate and n-acetylaspartate were found together with striatal-specific lower concentrations of gaba and choline. |
2007-03-08 |
2023-08-12 |
mouse |
| Surasak Laloknam, Kimihiro Tanaka, Teerapong Buaboocha, Rungaroon Waditee, Aran Incharoensakdi, Takashi Hibino, Yoshito Tanaka, Teruhiro Takab. Halotolerant cyanobacterium Aphanothece halophytica contains a betaine transporter active at alkaline pH and high salinity. Applied and environmental microbiology. vol 72. issue 9. 2006-11-08. PMID:16957224. |
choline, gamma-aminobutyric acid, betaine aldehyde, sarcosine, dimethylglycine, and amino acids such as proline did not compete for the uptake of betaine by bett(a. halophytica). |
2006-11-08 |
2023-08-12 |
Not clear |
| S G Kalinichenko, Iu V Dudina, P A Motavki. [Neurogliaform cells: neurochemistry, spatial arrangement, and their role in the neocortical inhibitory system]. Tsitologiia. vol 48. issue 6. 2006-10-19. PMID:16893057. |
the neurogliaform cells (ngfc) localized in area 4 of the human motor cortex were found to express choline acetyl transferase (chat), gaba, and calbindin. |
2006-10-19 |
2023-08-12 |
human |
| S G Kalinichenko, I I Pushchin, I V Dyuize. Neurochemical diversity of neurogliaform cells in the human primary motor cortex. Journal of chemical neuroanatomy. vol 31. issue 4. 2006-08-11. PMID:16632327. |
neurogliaform cells of area 4 of the human motor cortex were found to express choline acetyl transferase (chat), gamma-aminobutyric acid, and calbindin. |
2006-08-11 |
2023-08-12 |
human |
| Wojciech Kulak, Wojciech Sobaniec, Joanna Smigielska-Kuzia, Bozena Kubas, Jerzy Waleck. Metabolite profile in the basal ganglia of children with cerebral palsy: a proton magnetic resonance spectroscopy study. Developmental medicine and child neurology. vol 48. issue 4. 2006-05-02. PMID:16542516. |
the relative concentrations of n-acetylaspartate (naa), choline (cho), myo-inositol (mi), and gamma-aminobutyric acid (gaba) were measured relative to creatine (cr) and different combinations of metabolites within 8cm3 brain voxels. |
2006-05-02 |
2023-08-12 |
Not clear |
| Takeshi Kanno, Takahiro Yaguchi, Satoshi Yamamoto, Hideyuki Yamamoto, Hirokazu Fujikawa, Tetsu Nagata, Akito Tanaka, Tomoyuki Nishizak. 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid stimulates GABA release from interneurons projecting to CA1 pyramidal neurons in the rat hippocampus via pre-synaptic alpha7 acetylcholine receptors. Journal of neurochemistry. vol 95. issue 3. 2005-12-13. PMID:16248884. |
dcp-la (100 nm) also enhanced gaba release triggered by choline, an agonist of alpha7 ach receptors, but not 3-[2(s)-azetidinylmethoxy] pyridine, an agonist of alpha4beta2 ach receptors. |
2005-12-13 |
2023-08-12 |
rat |
| Wen-Ying Chen, Ya Ni, Yong-Miao Pan, Qi-Xian Shi, Yu-Ying Yuan, Ai-Jun Chen, Li-Zhen Mao, Shu-Qing Yu, Eduardo R S Rolda. GABA, progesterone and zona pellucida activation of PLA2 and regulation by MEK-ERK1/2 during acrosomal exocytosis in guinea pig spermatozoa. FEBS letters. vol 579. issue 21. 2005-10-03. PMID:16098515. |
in guinea pig spermatozoa prelabelled with [14c]arachidonic acid or [14c]choline chloride, gaba stimulated a decrease in phosphatidylcholine (pc), and release of arachidonic acid and lysopc, during exocytosis. |
2005-10-03 |
2023-08-12 |
Not clear |
| T M Tsang, J L Griffin, J Haselden, C Fish, E Holme. Metabolic characterization of distinct neuroanatomical regions in rats by magic angle spinning 1H nuclear magnetic resonance spectroscopy. Magnetic resonance in medicine. vol 53. issue 5. 2005-08-16. PMID:15844164. |
relatively low concentrations of gaba in the cerebellum, high concentrations of taurine and n-acetylaspartate in the cortex, and high levels of choline, glycerophosphocholine, and phosphocholine in the hippocampus predominantly influenced the classification of the different brain regions. |
2005-08-16 |
2023-08-12 |
rat |
| Roberto Paes-de-Carvalho, Bruno V Dias, Rochele A Martins, Mariana R Pereira, Camila C Portugal, Claudia Lanfred. Activation of glutamate receptors promotes a calcium-dependent and transporter-mediated release of purines in cultured avian retinal cells: possible involvement of calcium/calmodulin-dependent protein kinase II. Neurochemistry international. vol 46. issue 6. 2005-06-30. PMID:15769546. |
the uptake of [(3)h]adenosine, but not of [(3)h]gaba or [(3)h]choline, is also blocked by 1-[n,o-bis(5-isoquinolinesulfonyl)-n-methyl-l-tyrosyl]-4-phenylpiperazine (kn62), n-[2-(n-(4-chlorocinnamyl)-n-methylaminomethyl)phenyl-n-[2-hydroxiethyl]-4-methoxybenzenesulfonamide (kn93) or the myristoylated autocamtide-2-related inhibitory peptide, suggesting that the enzyme modulates the nucleoside transporter. |
2005-06-30 |
2023-08-12 |
chicken |
| L Bianchi, E De Micheli, A Bricolo, C Ballini, M Fattori, C Venturi, F Pedata, K F Tipton, L Della Cort. Extracellular levels of amino acids and choline in human high grade gliomas: an intraoperative microdialysis study. Neurochemical research. vol 29. issue 1. 2004-08-17. PMID:14992293. |
glioblastoma growth was associated with increased concentrations of choline, gaba, isoleucine, leucine, lysine, phenylalanine, taurine, tyrosine, and valine. |
2004-08-17 |
2023-08-12 |
human |