| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mikhail P Moshkin, Andrey E Akulov, Dmitriy V Petrovski, Olga V Saik, Evgeny D Petrovskiy, Andrey A Savelov, Igor V Koptyu. Proton magnetic resonance spectroscopy of brain metabolic shifts induced by acute administration of 2-deoxy-d-glucose and lipopolysaccharides. NMR in biomedicine. vol 27. issue 4. 2014-11-03. PMID:24493094. |
inhibition of glycolysis by means of an injection with 2-deoxy-d-glucose (2dg) reduced the levels of gamma-aminobutyric acid (gaba, p < 0.05, in comparison with control, least significant difference (lsd) test), n-acetylaspartate (naa, p < 0.05, lsd test) and choline compounds, and at the same time increased the levels of glutamate and glutamine. |
2014-11-03 |
2023-08-12 |
mouse |
| Mikhail P Moshkin, Andrey E Akulov, Dmitriy V Petrovski, Olga V Saik, Evgeny D Petrovskiy, Andrey A Savelov, Igor V Koptyu. Proton magnetic resonance spectroscopy of brain metabolic shifts induced by acute administration of 2-deoxy-d-glucose and lipopolysaccharides. NMR in biomedicine. vol 27. issue 4. 2014-11-03. PMID:24493094. |
an increase in the amounts of gaba, naa and choline compounds in the brain occurred in mice treated with lps. |
2014-11-03 |
2023-08-12 |
mouse |
| Xianrong Zhang, Junfang Wu, Huilang Liu, Xu Zhan. Age- and gender-related metabonomic alterations in striatum and cerebellar cortex in rats. Brain research. vol 1507. 2014-09-18. PMID:23454230. |
old female rats had decreased glutamate and increased creatine in striatum, while old male rats had increased choline in striatum, and increased gaba in cerebellar cortex, respectively. |
2014-09-18 |
2023-08-12 |
rat |
| K E Weaver, T L Richards, M Saenz, H Petropoulos, I Fin. Neurochemical changes within human early blind occipital cortex. Neuroscience. vol 252. 2014-06-11. PMID:23954804. |
here, using (1)h magnetic resonance spectroscopy in nine early blind and normally sighted subjects, we find that early blindness is associated with higher levels of creatine, choline and myo-inositol and indications of lower levels of gaba within the occipital cortex. |
2014-06-11 |
2023-08-12 |
human |
| A Santos-Fandila, A Zafra-Gómez, A Barranco, A Navalón, R Rueda, M Ramíre. Quantitative determination of neurotransmitters, metabolites and derivates in microdialysates by UHPLC-tandem mass spectrometry. Talanta. vol 114. 2014-03-10. PMID:23953445. |
betaine, glutamine, glutamic acid, gamma-aminobutyric acid, phosphocholine, glycerophosphocholine, cytidine 5'-diphosphocholine, choline, acetylcholine, dopamine, norepinephrine, serotonin, tyrosine, epinephrine, tryptophan and 5-hydroxyindoleacetic acid were selected as analytes. |
2014-03-10 |
2023-08-12 |
rat |
| Agata Szulc, Beata Galinska-Skok, Napoleon Waszkiewicz, Daniel Bibulowicz, Beata Konarzewska, Eugeniusz Taraso. Proton magnetic resonance spectroscopy changes after antipsychotic treatment. Current medicinal chemistry. vol 20. issue 3. 2014-01-17. PMID:23157634. |
several brain metabolites can be measured by the means of (1)h mrs: n-acetylaspartate (naa), choline containing compounds (cho), myo-inositol (mi) and glutamate (glu), glutamine (gln) and gaba (together as glx complex or separately). |
2014-01-17 |
2023-08-12 |
Not clear |
| G E De Medio, A Hamberger, A Sellström, G Porcellat. The phospholipid base-exchange system as a possible modulator of γ-aminobutyric acid transport in brain cells. Neurochemical research. vol 2. issue 5. 2013-11-26. PMID:24272239. |
the accumulation of [(3)h]gaba, at concentrations employing the high-affinity uptake system, was measured after base-exchange reactions with ethanolamine, choline, orl-serine. |
2013-11-26 |
2023-08-12 |
rabbit |
| G E De Medio, A Hamberger, A Sellström, G Porcellat. The phospholipid base-exchange system as a possible modulator of γ-aminobutyric acid transport in brain cells. Neurochemical research. vol 2. issue 5. 2013-11-26. PMID:24272239. |
serine incorporation induced an increase of gaba uptake at all the concentrations used, while choline incorporation essentially led to inhibition of gaba accumulation. |
2013-11-26 |
2023-08-12 |
rabbit |
| Hong-Mei Wang, Li-Wei Wang, Xin-Min Liu, Chang-Lu Li, Shu-Ping Xu, Ahsana-Dar Faroo. Neuroprotective effects of forsythiaside on learning and memory deficits in senescence-accelerated mouse prone (SAMP8) mice. Pharmacology, biochemistry, and behavior. vol 105. 2013-10-23. PMID:23290932. |
forsythiaside (60, 120 and 240mg/kg) was orally administered to aged (8months old) samp8 mice for 45days followed by evaluating cognitive impairment (morris water maze and step-through passive avoidance), inflammation (interleukin-1β (il-1β) and interleukin-6 (il-6) levels), oxidative stress (glutathione peroxidase (gsh-px) and total superoxide dismutase (t-sod) activities; malondialdehyde (mda) and nitric oxide (no) contents) and neurotransmitter such as norepinephrine (ne), dopamine (da), 5-hydroxytryptamine (5-ht), glutamate (glu) gamma-aminobutyric acid (gaba) and acetyl choline (ach). |
2013-10-23 |
2023-08-12 |
mouse |
| M P Moshkin, A E Akulov, D V Petrovskiĭ, O V Saĭk, E D Petrovskiĭ, A A Savelov, I V Koptu. [Magnetic resonance spectroscopy of metabolic changes in mice brain after 2-deoxy-D-glucose injection]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 98. issue 10. 2013-04-29. PMID:23401921. |
inhibition of glycolysis by means of an intraperitoneal injection with 2-deoxy-d-glucose (2dg) reduced the levels of gamma-aminobutiric acid (gaba), n-acetylaspartate (naa) and choline compounds, and at the same time increased the levels of glutamate and glutamine. |
2013-04-29 |
2023-08-12 |
mouse |
| M P Moshkin, A E Akulov, D V Petrovskiĭ, O V Saĭk, E D Petrovskiĭ, A A Savelov, I V Koptu. [Magnetic resonance spectroscopy of metabolic changes in mice brain after 2-deoxy-D-glucose injection]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 98. issue 10. 2013-04-29. PMID:23401921. |
an increase in the amounts of gaba, naa and choline compounds in the brain occurred three hours after the injection of lps. |
2013-04-29 |
2023-08-12 |
mouse |
| Sarah Biedermann, Wolfgang Weber-Fahr, Lei Zheng, Carolin Hoyer, Barbara Vollmayr, Peter Gass, Gabriele Ende, Alexander Sartoriu. Increase of hippocampal glutamate after electroconvulsive treatment: a quantitative proton MR spectroscopy study at 9.4 T in an animal model of depression. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 13. issue 6. 2013-01-07. PMID:21767208. |
thus, proton magnetic resonance spectroscopy (¹h mrs) at a 9.4 t animal system seems a promising tool to study underlying mechanisms since it allows for an accurate quantification of metabolites with distinction of glutamate, gaba and glutamine, as well as separation of taurine from choline. |
2013-01-07 |
2023-08-12 |
Not clear |
| Linn H Nilsen, Torun M Melø, Oddbjørn Saether, Menno P Witter, Ursula Sonnewal. Altered neurochemical profile in the McGill-R-Thy1-APP rat model of Alzheimer's disease: a longitudinal in vivo 1 H MRS study. Journal of neurochemistry. vol 123. issue 4. 2012-12-21. PMID:22943908. |
at age 9 months, lower levels of glutamate, gaba, n-acetylaspartate and total choline and elevated myo-inositol and taurine were found in dorsal hippocampus, whereas lower levels of glutamate, gaba, glutamine and n-acetylaspartate were found in frontal cortex. |
2012-12-21 |
2023-08-12 |
rat |
| R H Wu, R Lin, H Li, Z W Xiao, H B Rao, W H Luo, G Guo, K Huang, X G Zhang, Z J Lan. Accuracy of noninvasive quantification of brain NAA concentrations using PRESS sequence: verification in a swine model with external standard. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. vol 2005. 2012-10-02. PMID:17282459. |
the external standard method was utilized with a sphere filled with naa, gaba, glutamine, glutamate, creatine, choline chloride, and myo-inositol. |
2012-10-02 |
2023-08-12 |
Not clear |
| T Kuriyama, J Taguchi, K Kuriyam. Functional alterations in striatal cholinergic and striato-nigral gabaergic neurons following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration. Neurochemistry international. vol 16. issue 3. 2012-10-02. PMID:20504575. |
although the adminstration of mptp (50 mg/kg, once a day for 5 days) to male mice of dd strain did not induce the changes in choline and acethylcholine contents in the striatum, a decrement of gaba content in the midbrain, especially in the substantia nigra, was found in addition to a significant decrease of dopamine content in the striatum. |
2012-10-02 |
2023-08-12 |
mouse |
| T Araki, H Kato, K Shuto, T Fujiwara, Y Itoyam. Effects of vinconate on neurotransmitter receptor systems in aged rat brain. Environmental toxicology and pharmacology. vol 2. issue 4. 2012-10-02. PMID:21781741. |
[(3)h]quinuclidinyl benzilate (qnb), [(3)h]hemicholinium-3 (hc) and [(3)h]muscimol were used to label acetylcholine receptors, high-affinity choline uptake sites and γ-aminobutyric acid(a) (gaba(a)) receptors, respectively. |
2012-10-02 |
2023-08-12 |
rat |
| Rajakumar Nagarajan, Manoj K Sarma, April D Thames, Steven A Castellon, Charles H Hinkin, M Albert Thoma. 2D MR Spectroscopy Combined with Prior-Knowledge Fitting Is Sensitive to HCV-Associated Cerebral Metabolic Abnormalities. International journal of hepatology. vol 2012. 2012-08-23. PMID:22844602. |
even though highly concentrated cerebral metabolites (n-acetylaspartate, creatine, choline, glutamate/glutamine, myo-inositol) have been detected using mrs, other metabolites at low concentrations (~1-3 mm or less) including glutathione, aspartate and gaba are quite difficult to observe using 1d mrs. |
2012-08-23 |
2023-08-12 |
human |
| David J Hinton, Moonnoh R Lee, Taylor L Jacobson, Prasanna K Mishra, Mark A Frye, David A Mrazek, Slobodan I Macura, Doo-Sup Cho. Ethanol withdrawal-induced brain metabolites and the pharmacological effects of acamprosate in mice lacking ENT1. Neuropharmacology. vol 62. issue 8. 2012-08-10. PMID:22616110. |
our findings demonstrated that ethanol withdrawal reduced gaba levels and increased phosphorylated choline compounds in the mpfc of both wild-type and ent1 null mice. |
2012-08-10 |
2023-08-12 |
mouse |
| Sai P Bathena, Jiangeng Huang, Adrian A Epstein, Howard E Gendelman, Michael D Boska, Yazen Alnout. Rapid and reliable quantitation of amino acids and myo-inositol in mouse brain by high performance liquid chromatography and tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 893-894. 2012-07-26. PMID:22425384. |
to this end, a sensitive liquid chromatography tandem mass spectrometry (lc-ms/ms) method based on multiple reaction monitoring was developed to simultaneously quantify glutamine, glutamate, γ-aminobutyric acid (gaba), aspartic acid, n-acetyl aspartic acid, taurine, choline, creatine, phosphocholine and myo-inositol in mouse brain by methanol extractions. |
2012-07-26 |
2023-08-12 |
mouse |
| Mingxing Yang, Shu Wang, Fuhua Hao, Yajie Li, Huiru Tang, Xuemin Sh. NMR analysis of the rat neurochemical changes induced by middle cerebral artery occlusion. Talanta. vol 88. 2012-06-04. PMID:22265479. |
this demonstrated that experimental ischemic stroke in rats caused extensive perturbation in tricarboxylic acid cycle, gaba shunt, and metabolisms of choline and nucleic acids. |
2012-06-04 |
2023-08-12 |
rat |