| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fei Duan, Zebin Xiao, Yuzhe Wang, Xinghuai Sun, Zuohua Tang, Rong Wang, Linying Guo, Weijun Tang, Tingting Liu, Peng Wang, Yang Zha. Metabolic Alterations in the Visual Pathway of Retinitis Pigmentosa Rats: A Longitudinal Multimodal MRI Study with Histopathologic Validation. NMR in biomedicine. 2022-04-28. PMID:35478360. |
our study demonstrated decreased concentrations and ratios to creatine (cr) of n-acetylaspartate (naa), glutamate (glu), γ-aminobutyric acid (gaba), taurine (tau), whereas increased myo-inositol (ins), choline (cho), in the visual cortex of rcs rats compared with those in controls (p < 0.05). |
2022-04-28 |
2023-08-13 |
rat |
| Lei Cheng, Baolin Yang, Hua Du, Tong Zhou, Yang Li, Jiajie Wu, Zhenxiao Cao, An X. Moderate intensity of static magnetic fields can alter the avoidance behavior and fat storage of Caenorhabditis elegans via serotonin. Environmental science and pollution research international. 2022-01-29. PMID:35092591. |
the total serotonin level was increased by 17.08% and 16.45% with the treatment of 0.5 t and 1 t smf, compared to the control group; however, there were minimal effects of smfs on other three neurotransmitters including choline, γ-aminobutyric acid (gaba), dopamine. |
2022-01-29 |
2023-08-13 |
human |
| Rafael do Prado Apparecido, Thiago Inácio Barros Lopes, Glaucia Braz Alcantar. NMR-based foodomics of common tubers and roots. Journal of pharmaceutical and biomedical analysis. vol 209. 2021-12-15. PMID:34906919. |
multivariate analyses showed 8 metabolites which were primary responsible for the distinction between samples, including choline, γ-aminobutyrate (gaba), glutamine, asparagine, isoleucine, fructose, glucose, and sucrose. |
2021-12-15 |
2023-08-13 |
Not clear |
| Rajakumar Nagarajan, Saadallah Ramadan, M Albert Thoma. Detection of Amide and Aromatic Proton Resonances of Human Brain Metabolites Using Localized Correlated Spectroscopy Combined with Two Different Water Suppression Schemes. Magnetic resonance insights. vol 2010. issue 4. 2021-10-20. PMID:21546981. |
the 2d cross and diagonal peak volumes were measured for several metabolites such as n-acetyl aspartate (naa), creatine (cr), free choline (ch), glutamate/glutamine (glx), aspartate (asp), myo-inositol (mi), gaba, glutathione (gsh), phosphocholine (pch), phosphoethanolamine (pe), tyrosine (tyr), lactate (lac), macromolecules (mm) and homocarnosine (car). |
2021-10-20 |
2023-08-12 |
human |
| Mónica Gros, Belén Gros, José Emilio Mesonero, Eva Latorr. Neurotransmitter Dysfunction in Irritable Bowel Syndrome: Emerging Approaches for Management. Journal of clinical medicine. vol 10. issue 15. 2021-08-10. PMID:34362210. |
a decrease of colonic mucosal serotonin transporter and a downregulation of α2 adrenoceptors are also correlated with visceral hypersensitivity and an increase of 5-hydroxyindole acetic acid levels, enhanced expression of high affinity choline transporter and lower levels of gaba. |
2021-08-10 |
2023-08-13 |
Not clear |
| Yong-Ming Wang, Ya-Hui Xiao, Wen-Lan Xi. Metabolite abnormalities in psychosis risk: A meta-analysis of proton magnetic resonance spectroscopy studies. Asian journal of psychiatry. vol 54. 2021-06-21. PMID:32653847. |
accumulating evidence implicates that individuals at high-risk of psychosis have already exhibited pathophysiological changes in brain metabolites including glutamate, gamma-aminobutyric acid (gaba), n-acetylaspartate (naa), creatine (cr), myo-inositol (mi) and choline (cho). |
2021-06-21 |
2023-08-13 |
Not clear |
| Anjana Pathania, Atul Rawat, Sitender Singh Dahiya, Saurabh Dhanda, Ravi Pratap Barnwal, Bikash Baishya, Rajat Sandhi. Journal of proteome research. vol 19. issue 9. 2021-06-17. PMID:32660248. |
furthermore, neurotransmitters such as glutamate and gaba were increased, whereas choline and myo-inositol were decreased. |
2021-06-17 |
2023-08-13 |
rat |
| Christin Helmschrodt, Susen Becker, Stefanie Perl, Anja Schulz, Angelika Richte. Development of a fast liquid chromatography-tandem mass spectrometry method for simultaneous quantification of neurotransmitters in murine microdialysate. Analytical and bioanalytical chemistry. vol 412. issue 28. 2021-05-20. PMID:32939566. |
the quantitative analysis of 11 neurotransmitters and metabolites, including serotonin (5-ht), 5-hydroxyindoleacetic acid (5-hiaa), melatonin (me), dopamine (da), levodopa (l-dopa), 3-methoxytyramine (3-mt), norepinephrine (ne), epinephrine (ep), acetylcholine (ach), choline (ch), and γ-aminobutyric acid (gaba), was performed using a biphenyl column coupled to an api-qtrap 3200 (ab sciex) mass spectrometer in positive electrospray ionization mode. |
2021-05-20 |
2023-08-13 |
mouse |
| Serguei Liachenko, Jaivijay Ram. Sex differences in the effect of acute administration of nicotine on MRS-measured metabolic profile of the rat brain. Neuroscience research. vol 157. 2021-04-28. PMID:31381938. |
nicotine administration changed taurine, gaba, myo-inositol, choline, and n-acetyl aspartate in hc, and taurine in nac. |
2021-04-28 |
2023-08-13 |
rat |
| Jan Weis, Jonas Persson, Andreas Frick, Fredrik Åhs, Maarten Versluis, Daniel Alamid. GABA quantification in human anterior cingulate cortex. PloS one. vol 16. issue 1. 2021-04-20. PMID:33449935. |
the main purpose of this study was to propose a combination of press and mega-press acquisitions for absolute gaba quantification and to compare gaba estimations obtained using total choline (tcho), total creatine (tcr), and total n-acetyl aspartate (tnaa) as the internal concentration references with water referenced quantification. |
2021-04-20 |
2023-08-13 |
human |
| Ryoki Sasaki, Naofumi Otsuru, Shota Miyaguchi, Sho Kojima, Hiraku Watanabe, Ken Ohno, Noriko Sakurai, Naoki Kodama, Daisuke Sato, Hideaki Onish. Influence of Brain-Derived Neurotrophic Factor Genotype on Short-Latency Afferent Inhibition and Motor Cortex Metabolites. Brain sciences. vol 11. issue 3. 2021-04-13. PMID:33804682. |
furthermore, the considerable inter-individual variability in inhibitory network activity typically measured by tms may be affected not only by gaba but also by other pathways, including glutamatergic and cholinergic activities; therefore, we used 3-t magnetic resonance spectroscopy (mrs) to measure the dynamics of glutamate plus glutamine (glx) and choline concentrations in the left m1, left somatosensory cortex, and right cerebellum. |
2021-04-13 |
2023-08-13 |
human |
| Louise Carton, Florent Auger, Maeva Kyheng, Maud Pétrault, Nicolas Durieux, Delphine Allorge, Olivier Cottencin, Renaud Jardri, Régis Bordet, Benjamin Rollan. Dose-dependent metabolite changes after ethanol intoxication in rat prefrontal cortex using in vivo magnetic resonance spectroscopy. Scientific reports. vol 9. issue 1. 2020-10-23. PMID:31337845. |
acute ethanol intoxication appears to result in specific dose-dependent changes in the gaba level and choline level. |
2020-10-23 |
2023-08-13 |
rat |
| Stephanie N Del Tufo, Stephen J Frost, Fumiko Hoeft, Laurie E Cutting, Peter J Molfese, Graeme F Mason, Douglas L Rothman, Robert K Fulbright, Kenneth R Pug. Neurochemistry Predicts Convergence of Written and Spoken Language: A Proton Magnetic Resonance Spectroscopy Study of Cross-Modal Language Integration. Frontiers in psychology. vol 9. 2020-09-28. PMID:30233445. |
neurometabolite concentrations of choline (cho), glutamate (glu), gamma-aminobutyric (gaba), and n- acetyl-aspartate (naa) were then measured in a subset of this sample ( |
2020-09-28 |
2023-08-13 |
Not clear |
| Kimberly L Chan, Peter B Barke. Retrospective motion compensation for edited MR spectroscopic imaging. NeuroImage. vol 202. 2020-08-25. PMID:31479753. |
the residual choline (cho) peak in the spectrum (which is well resolved from as a different chemical shift from gaba and is completely absent in a spectrum without subtraction artifact) was used as a metric of motion artifact severity. |
2020-08-25 |
2023-08-13 |
human |
| Susanne Weigend, Sebastian C Holst, Valérie Treyer, Ruth L O'Gorman Tuura, Josefine Meier, Simon M Ametamey, Alfred Buck, Hans-Peter Landol. Dynamic changes in cerebral and peripheral markers of glutamatergic signaling across the human sleep-wake cycle. Sleep. vol 42. issue 11. 2020-05-13. PMID:31304973. |
other brain metabolites (gaba, n-acetyl-aspartate, choline, glutathione) and serum bdnf levels were not altered by sleep deprivation (pall > 0.6). |
2020-05-13 |
2023-08-13 |
mouse |
| Arianna Di Lorenzo, Anatoly P Sobolev, Seyed Fazel Nabavi, Antoni Sureda, Akbar Hajizadeh Moghaddam, Sedigheh Khanjani, Carmen Di Giovanni, Jianbo Xiao, Samira Shirooie, Arold Jorel Tsetegho Sokeng, Alessandra Baldi, Luisa Mannina, Seyed Mohammad Nabavi, Maria Dagli. Antidepressive effects of a chemically characterized maqui berry extract (Aristotelia chilensis (molina) stuntz) in a mouse model of Post-stroke depression. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 129. 2019-07-29. PMID:31022478. |
a number of compounds have been first identified in maqui berry here, including malvidin-glucoside, gaba, choline and trigonelline. |
2019-07-29 |
2023-08-13 |
mouse |
| Thomas Drago, Patrick W O'Regan, Ivan Welaratne, Shane Rooney, Aoife O'Callaghan, Marissa Malkit, Elena Roman, Kirk J Levins, Lauren Alexander, Denis Barry, Erik O'Hanlon, Veronica O'Keane, Darren William Rodd. A comprehensive regional neurochemical theory in depression: a protocol for the systematic review and meta-analysis of 1H-MRS studies in major depressive disorder. Systematic reviews. vol 7. issue 1. 2019-04-09. PMID:30309391. |
in the context of major depressive disorder (mdd), mrs has revealed regional biochemical changes in gaba, glutamate, and choline across different brain compartments. |
2019-04-09 |
2023-08-13 |
Not clear |
| Agata Szulc, Magdalena Wiedlocha, Napoleon Waszkiewicz, Beata Galińska-Skok, Piotr Marcinowicz, Jacek Gierus, Anna Mosiole. Proton magnetic resonance spectroscopy changes after lithium treatment. Systematic review. Psychiatry research. Neuroimaging. vol 273. 2019-03-05. PMID:29414126. |
it enables evaluation of concentration or ratios of several metabolites, which play important roles in brain metabolism: n-acetylaspartate (naa), choline containing compounds, myo-inositol and glutamate, glutamine and gaba (together as glx complex or separately). |
2019-03-05 |
2023-08-13 |
Not clear |
| Anna Maria A P Fernandes, Pedro H Vendramini, Renan Galaverna, Nicolas V Schwab, Luciane C Alberici, Rodinei Augusti, Roger F Castilho, Marcos N Eberli. Direct Visualization of Neurotransmitters in Rat Brain Slices by Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI - MS). Journal of the American Society for Mass Spectrometry. vol 27. issue 12. 2018-09-14. PMID:27704473. |
the amino acids γ-aminobutyric (gaba), glutamate, aspartate, serine, as well as acetylcholine, dopamine, and choline were successfully imaged using a commercial desi source coupled to a hybrid quadrupole-orbitrap mass spectrometer. |
2018-09-14 |
2023-08-13 |
rat |
| Ladislav Baciak, Zdenka Gasparova, Tibor Liptaj, Ivo Jurane. In vivo magnetic resonance approach to trimethyltin induced neurodegeneration in rats. Brain research. vol 1673. 2018-05-22. PMID:28736106. |
no changes in choline metabolites (tcho), glutathione (gsh), and gaba were observed. |
2018-05-22 |
2023-08-13 |
mouse |