| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Albiñana, J G Luengo, A M Baraibar, M D Muñoz, L Gandía, J M Solís, J M Hernández-Guij. Choline induces opposite changes in pyramidal neuron excitability and synaptic transmission through a nicotinic receptor-independent process in hippocampal slices. Pflugers Archiv : European journal of physiology. vol 469. issue 5-6. 2018-03-05. PMID:28176016. |
additionally, this choline-mediated effect was not prevented by either selective antagonists of gaba receptors or hemicholinium, a choline uptake inhibitor. |
2018-03-05 |
2023-08-13 |
mouse |
| Jaivijay Ramu, Tetyana Konak, Serguei Liachenk. Magnetic resonance spectroscopic analysis of neurometabolite changes in the developing rat brain at 7T. Brain research. vol 1651. 2017-07-28. PMID:27663970. |
some differences between our data and the published literature were observed in the concentrations and dynamics of phosphocreatine, myo-inositol, and gaba in the hippocampus and creatine, gaba, glutamine, choline and n-acetyl-aspartate in the cortex. |
2017-07-28 |
2023-08-13 |
rat |
| Allison S Brandt, Paul G Unschuld, Subechhya Pradhan, Issel Anne L Lim, Gregory Churchill, Ashley D Harris, Jun Hua, Peter B Barker, Christopher A Ross, Peter C M van Zijl, Richard A E Edden, Russell L Margoli. Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A (1)H MRS Study at 7 Tesla. Schizophrenia research. vol 172. issue 1-3. 2016-12-27. PMID:26925800. |
no changes were detected in levels of glutamine, n-acetylaspartate, n-acetylaspartylglutamic acid, myo-inositol, gaba, glutathione, total creatine, and total choline. |
2016-12-27 |
2023-08-13 |
Not clear |
| A D Harris, H S Singer, A Horska, T Kline, M Ryan, R A E Edden, E M Mahon. GABA and Glutamate in Children with Primary Complex Motor Stereotypies: An 1H-MRS Study at 7T. AJNR. American journal of neuroradiology. vol 37. issue 3. 2016-11-07. PMID:26542237. |
to further clarify potential neurochemical alterations, gamma-aminobutyric acid (gaba), glutamate, glutamine, n-acetylaspartate, and choline levels were measured in 4 frontostriatal regions by using (1)h mrs at 7t. |
2016-11-07 |
2023-08-13 |
Not clear |
| Jittima Gotts, Lucy Atkinson, Ian J Edwards, Yuchio Yanagawa, Susan A Deuchars, Jim Deuchar. Co-expression of GAD67 and choline acetyltransferase reveals a novel neuronal phenotype in the mouse medulla oblongata. Autonomic neuroscience : basic & clinical. vol 193. 2016-08-28. PMID:26015156. |
to determine the distribution of the enzymes responsible for the production of gaba and acetylcholine in areas involved in autonomic control in the mouse brainstem, we used a transgenic mouse expressing green fluorescent protein (gfp) in glutamate decarboxylase 67 (gad67) neurones, combined with choline acetyl transferase (chat) immunohistochemistry. |
2016-08-28 |
2023-08-13 |
mouse |
| Dominik Strzelecki, Michał Podgórski, Olga Kałużyńska, Ludomir Stefańczyk, Magdalena Kotlicka-Antczak, Agnieszka Gmitrowicz, Piotr Grzela. Adding Sarcosine to Antipsychotic Treatment in Patients with Stable Schizophrenia Changes the Concentrations of Neuronal and Glial Metabolites in the Left Dorsolateral Prefrontal Cortex. International journal of molecular sciences. vol 16. issue 10. 2016-07-22. PMID:26501260. |
the aim of the study was to evaluate the influence of a six-month course of sarcosine therapy on the concentration of metabolites (naa, n-acetylaspartate; glx, complex of glutamate, glutamine and γ-aminobutyric acid (gaba); mi, myo-inositol; cr, creatine; cho, choline) in the left dorso-lateral prefrontal cortex (dlpfc) in patients with stable schizophrenia. |
2016-07-22 |
2023-08-13 |
Not clear |
| Dominik Strzelecki, Michał Podgórski, Olga Kałużyńska, Oliwia Gawlik-Kotelnicka, Ludomir Stefańczyk, Magdalena Kotlicka-Antczak, Agnieszka Gmitrowicz, Piotr Grzela. Supplementation of Antipsychotic Treatment with the Amino Acid Sarcosine Influences Proton Magnetic Resonance Spectroscopy Parameters in Left Frontal White Matter in Patients with Schizophrenia. Nutrients. vol 7. issue 10. 2016-06-28. PMID:26506383. |
to evaluate the concentrations of brain metabolites (naa, n-acetylaspartate; glx, complex of glutamate, glutamine, and γ-aminobutyric acid (gaba); mi, myo-inositol; cr, creatine; cho, choline) in the left frontal wm, proton nuclear magnetic resonance (¹h-nmr) spectroscopy was used. |
2016-06-28 |
2023-08-13 |
Not clear |
| Lejun Lin, Bofeng Cao, Zhiying Xu, Yanbin Sui, Jiao Chen, Qiang Luan, Ruifang Yang, Shanchun Li, Ke Feng L. In vivo HMRS and lipidomic profiling reveals comprehensive changes of hippocampal metabolism during aging in mice. Biochemical and biophysical research communications. vol 470. issue 1. 2016-06-07. PMID:26707637. |
we found n-acetylaspartic acid (naa), gama-aminobutyric acid (gaba), glutamate/glutamine, taurine, choline, sphingolipids (sms), phosphatidylethanolamines (pes), phosphatidylinositols (pis), phosphatidylglycerols (pgs) and phosphatidylserines (pss), all of them decreasing with the aging process in mice hippocampus. |
2016-06-07 |
2023-08-13 |
mouse |
| Lai Wei, Rong Xue, Panpan Zhang, Yijie Wu, Xiaojing Li, Fengkui Pe. (1)H NMR-Based Metabolomics and Neurotoxicity Study of Cerebrum and Cerebellum in Rats Treated with Cinnabar, a Traditional Chinese Medicine. Omics : a journal of integrative biology. vol 19. issue 8. 2016-04-29. PMID:26110755. |
the metabolite variations induced by cinnabar were characterized by increased levels of glutamate, glutamine, myo-inositol, and choline, as well as decreased levels of gaba, taurine, naa, and naag in tissue extracts of the cerebellum and cerebrum. |
2016-04-29 |
2023-08-13 |
rat |
| Talitha C Ford, David P Crewthe. A Comprehensive Review of the (1)H-MRS Metabolite Spectrum in Autism Spectrum Disorder. Frontiers in molecular neuroscience. vol 9. 2016-03-25. PMID:27013964. |
the literature reports reduced n-acetylaspartate (naa), glutamate and glutamine (glx), γ-aminobutyric acid (gaba), creatine and choline, and increased glutamate for children with asd. |
2016-03-25 |
2023-08-13 |
Not clear |
| William Sedley, Jehill Parikh, Richard A E Edden, Valerie Tait, Andrew Blamire, Timothy D Griffith. Human Auditory Cortex Neurochemistry Reflects the Presence and Severity of Tinnitus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 44. 2016-02-12. PMID:26538652. |
tinnitus severity and hearing loss were correlated positively with rac choline but not gaba. |
2016-02-12 |
2023-08-13 |
human |
| Anjali Chauhan, Uma Sharma, Naranamangalam R Jagannathan, Yogendra Kumar Gupt. Rapamycin ameliorates brain metabolites alterations after transient focal ischemia in rats. European journal of pharmacology. vol 757. 2016-02-04. PMID:25814258. |
in the vehicle group, we observed increased lactate levels and decreased levels of glutamate/glutamine, choline containing compounds, creatine/phosphocreatine (cr/pcr), taurine, myo-inositol, γ-amino butryic acid (gaba), n-aspartyl aspartate (naa), purine and pyrimidine metabolites. |
2016-02-04 |
2023-08-13 |
rat |
| Anjali Chauhan, Uma Sharma, Naranamangalam R Jagannathan, Yogendra Kumar Gupt. Rapamycin ameliorates brain metabolites alterations after transient focal ischemia in rats. European journal of pharmacology. vol 757. 2016-02-04. PMID:25814258. |
in rapamycin treated rats, there was increase in the levels of choline containing compounds, naa, myo-inositol, glutamate/glutamine, gaba, cr/pcr and taurine as compared to those of vehicle control (p<0.05). |
2016-02-04 |
2023-08-13 |
rat |
| Pan He, Zhen-Yu Li, Sheng-Ci Fan, Fu-Sheng Zhang, Xue-Mei Qin, Guo-Jun D. [Between Hengshanhuangqi and Chuanhuangqi based on metabolomics and ITS2 sequences]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 48. issue 10. 2016-01-25. PMID:24417088. |
hh contained more aspartic acid, gaba, citric acid, astragaloside iv and calycosin-7-o-beta-d-glucoside, while ch contained more threonine, alanine, acetic acid, choline, arginine, fructose and sucrose. |
2016-01-25 |
2023-08-12 |
Not clear |
| Chunjiang Li, Qingwei Wang, Lanlan Li, Yun Liu, Hongwei Dia. Arachidonic acid attenuates learning and memory dysfunction induced by repeated isoflurane anesthesia in rats. International journal of clinical and experimental medicine. vol 8. issue 8. 2015-11-09. PMID:26550146. |
additionally, ara increased the activities of choline acetyl transferase (chat), superoxide dismutase (sod), glutathione peroxidase (gsh-px) and the levels of acetycholine (ach) and γ-amino-butyric acid (gaba), whereas decreased the activity of acetylcholine esterase (ache), the content of glutamate (glu) and malondialdehyde (mda), and the radio of glu/gaba. |
2015-11-09 |
2023-08-13 |
rat |
| Sara Tufi, Marja Lamoree, Jacob de Boer, Pim Leonard. Simultaneous analysis of multiple neurotransmitters by hydrophilic interaction liquid chromatography coupled to tandem mass spectrometry. Journal of chromatography. A. vol 1395. 2015-07-31. PMID:25869798. |
an optimized and validated hilic-ms/ms method based on the zic-chilic column is proposed for the simultaneous detection and quantification of twenty compounds consisting of neurotransmitters, precursors and metabolites: 3-methoxytyramine (3-mt), 5-hydroxyindoleacetic acid (5-hiaa), 5-hydroxy-l-tripthophan, acetylcholine, choline, l-3,4-dihydroxyphenylalanine (l-dopa), dopamine, epinephrine, γ-aminobutyric acid (gaba), glutamate, glutamine, histamine, histidine, l-tryptophan, l-tyrosine, norepinephrine, normetanephrine, phenylalanine, serotonin and tyramine. |
2015-07-31 |
2023-08-13 |
Not clear |
| Dan-Dan Wei, Ge-Dong, Ping-Ping Guo, Jun-Song Wang, Ming-Hui Li, Ming-Hua Yang, Ling-Yi Kon. A bird's eye view of anisatin induced convulsive seizures in brain by a (1)H NMR based metabolic approach. Molecular bioSystems. vol 10. issue 11. 2015-06-18. PMID:25133938. |
orthogonal partial least squares-discriminant analysis (opls-da) revealed many differential metabolites that indicated metabolic disturbance in neurotransmission and neuromodulation (gaba, glutamate, glutamine, and taurine), stress of reactive oxygen species (ros) (ascorbate, phosphatidylcholine, choline, and ethanolamine), energy metabolism (nad(+)i.e., nicotinamide-adenine dinucleotide, lactate, citrate, fumarate, creatine/phosphocreatine, and creatinine), amino acid metabolism (leucine, isoleucine, valine, phenylalanine, tyrosine, tryptophan, alanine, threonine, and glycine) and nucleic acid metabolism (nad(+), nicotinamide/niacinamide, adenosine, and guanosine). |
2015-06-18 |
2023-08-13 |
mouse |
| b' S Kratochv\\xc3\\xadlov\\xc3\\xa1, A Skoch, M Dezortov\\xc3\\xa1, E Svehl\\xc3\\xadkov\\xc3\\xa1, M Hill, J Brunov\\xc3\\xa1, M H\\xc3\\xa1jek, T Pelik\\xc3\\xa1nov\\xc3\\xa. Effect of acute hyperinsulinemia on brain metabolism evaluated by 1H MR spectroscopy--a pilot study. Physiological research. vol 63. issue 4. 2015-05-15. PMID:24702495.' |
in group d, significantly lower basal concentrations of n-acetylaspartate (p=0.02), choline (p=0.03), creatine (p=0.002) and inositol (p=0.007) were detected compared to c. after the induction of hyperinsulinemia, concentrations of choline, creatine, gaba, inositol, lactate, naa and composite signal glutamate + glutamine (glx) stayed stable. |
2015-05-15 |
2023-08-13 |
Not clear |
| Marta R M Lima, Sílvia O Diaz, Inês Lamego, Michael A Grusak, Marta W Vasconcelos, Ana M Gi. Nuclear magnetic resonance metabolomics of iron deficiency in soybean leaves. Journal of proteome research. vol 13. issue 6. 2015-01-22. PMID:24738838. |
statistically relevant metabolite changes upon fe deficiency included higher levels of alanine, asparagine/aspartate, threonine, valine, gaba, acetate, choline, ethanolamine, hypoxanthine, trigonelline, and polyphenols and lower levels of citrate, malate, ethanol, methanol, chlorogenate, and 3-methyl-2-oxovalerate. |
2015-01-22 |
2023-08-13 |
Not clear |
| Saroj Sharma, Tapas C Nag, Alok Thakar, Daya N Bhardwaj, Tara Sankar Ro. The aging human cochlear nucleus: Changes in the glial fibrillary acidic protein, intracellular calcium regulatory proteins, GABA neurotransmitter and cholinergic receptor. Journal of chemical neuroanatomy. vol 56. 2014-12-18. PMID:24412669. |
the morphometry and semiquantitative analysis of intensity of expression of glial fibrillary acidic protein (gfap), calcium binding proteins (calbindin, calretinin and parvalbumin), gamma amino butyric acid (gaba) and nicotinic acetyl choline receptor (nachr) beta 2 immunostaining were carried out in all three sub-divisions of the human cn from birth to 90 years. |
2014-12-18 |
2023-08-12 |
human |