| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kurt D Kausch, Anatoly P Sobolev, Ravinder K Goyal, Tahira Fatima, Rekha Laila-Beevi, Robert A Saftner, Avtar K Handa, Autar K Matto. Methyl jasmonate deficiency alters cellular metabolome, including the aminome of tomato (Solanum lycopersicum L.) fruit. Amino acids. vol 42. issue 2-3. 2012-05-31. PMID:21814797. |
during on-shelf ripening, transgenic fruits were significantly reduced in the content of 19 out of 30 metabolites examined, including ile, val, ala, thr, asn tyr, glu, gln, his, phe, trp, gaba, citrate, succinate, myo-inositol, unidentified compound b, nucleic acid compound nucl1, choline, and trigonelline as compared to the wild-type azygous counterparts. |
2012-05-31 |
2023-08-12 |
Not clear |
| Luigi Servillo, Alfonso Giovane, Maria Luisa Balestrieri, Andrea Bata-Csere, Domenico Cautela, Domenico Castald. Betaines in fruits of Citrus genus plants. Journal of agricultural and food chemistry. vol 59. issue 17. 2012-05-23. PMID:21838291. |
l-proline, n-methyl-l-proline (hygric acid), n,n-dimethyl-l-proline (stachydrine), 4-hydroxy-l-prolinebetaine (betonicine), 4-hydroxy-l-proline, γ-aminobutyric acid (gaba), 3-carboxypropyltrimethylammonium (gababet), n-methylnicotinic acid (trigonelline), and choline in the fruit juices of yellow orange, blood orange, lemon, mandarin, bitter orange (citrus aurantium), chinotto (citrus myrtifolia), and grapefruit were analyzed by sensitive hplc-esi-tandem mass spectrometry procedure. |
2012-05-23 |
2023-08-12 |
Not clear |
| John G Mielke, Tarun K Ahuja, Tanya Comas, Geoffrey A R Mealin. Choline-mediated depression of hippocampal synaptic transmission. Nutritional neuroscience. vol 14. issue 5. 2011-12-20. PMID:22005282. |
the ability of choline to increase paired-pulse facilitation, and the inability of applied gamma-aminobutyric acid (gaba) to mediate further depression of fepsps, suggests that the principal mechanism of choline's action was on the facilitation of neurotransmitter release. |
2011-12-20 |
2023-08-12 |
Not clear |
| John G Mielke, Tarun K Ahuja, Tanya Comas, Geoffrey A R Mealin. Choline-mediated depression of hippocampal synaptic transmission. Nutritional neuroscience. vol 14. issue 5. 2011-12-20. PMID:22005282. |
our study provides evidence that choline can depress population-level activity, quite likely by facilitating the release of gaba from interneurons, and may thereby influence hippocampal function. |
2011-12-20 |
2023-08-12 |
Not clear |
| Roberto Romero González, Remedios Fernández Fernández, José Luis Martínez Vidal, Antonia Garrido Frenich, María Luz Gómez Pére. Development and validation of an ultra-high performance liquid chromatography-tandem mass-spectrometry (UHPLC-MS/MS) method for the simultaneous determination of neurotransmitters in rat brain samples. Journal of neuroscience methods. vol 198. issue 2. 2011-10-07. PMID:21459108. |
a simple method for the simultaneous determination of glutamate, γ-aminobutyric acid (gaba), choline, acetylcholine, dopamine, 5-hydroxyindole-3-acetic (5-hiaa), serotonin, 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) was developed by using ultra-high performance liquid chromatography coupled with tandem mass spectrometry (uhplc-ms/ms). |
2011-10-07 |
2023-08-12 |
rat |
| Roberto Romero González, Remedios Fernández Fernández, José Luis Martínez Vidal, Antonia Garrido Frenich, María Luz Gómez Pére. Development and validation of an ultra-high performance liquid chromatography-tandem mass-spectrometry (UHPLC-MS/MS) method for the simultaneous determination of neurotransmitters in rat brain samples. Journal of neuroscience methods. vol 198. issue 2. 2011-10-07. PMID:21459108. |
therefore, the method was successfully applied for the quantitative determination of neurotransmitters in several rat brain regions (prefrontal cortex, striatum, nucleus accumbens and amygdala), detecting glutamate, gaba and choline at concentrations higher than 1000 μg/g, 30 μg/g and 100 μg/g respectively, whereas the other compounds were found at lower concentrations. |
2011-10-07 |
2023-08-12 |
rat |
| Fangfang Chen, Jingtao Zhang, Xiushi Song, Jian Yang, Heping Li, Huiru Tang, Yu-Cai Lia. Combined metabonomic and quantitative real-time PCR analyses reveal systems metabolic changes of Fusarium graminearum induced by Tri5 gene deletion. Journal of proteome research. vol 10. issue 5. 2011-09-06. PMID:21413710. |
these changes involved both carbon and nitrogen metabolisms including alterations in gaba shunt, tca cycle, shikimate pathway, and metabolisms of lipids, amino acids, inositol, choline, pyrimidine, and purine. |
2011-09-06 |
2023-08-12 |
Not clear |
| Joanna Śmigielska-Kuzia, Leszek Boćkowski, Wojciech Sobaniec, Wojciech Kułak, Krzysztof Sendrowsk. Amino acid metabolic processes in the temporal lobes assessed by proton magnetic resonance spectroscopy (1H MRS) in children with Down syndrome. Pharmacological reports : PR. vol 62. issue 6. 2011-08-10. PMID:21273664. |
metabolites, such as n-acetylaspartate (naa), glutamate-glutamine complex (glx), choline (cho), myoinositol (mi) and γ-aminobutyric acid (gaba), were determined in both temporal lobes with reference to the internal marker creatine (cr). |
2011-08-10 |
2023-08-12 |
Not clear |
| Hongpeng Yang, Wei Pang, Hao Lu, Daomei Cheng, Xianzhong Yan, Yiyong Cheng, Yugang Jian. Comparison of metabolic profiling of cyanidin-3-O-galactoside and extracts from blueberry in aged mice. Journal of agricultural and food chemistry. vol 59. issue 5. 2011-06-30. PMID:21302942. |
compared with those in the control group, the levels of choline and gaba in the brain from the bbe group were obviously increased, whereas glutamate and phosphocholine in the bbe group were significantly decreased. |
2011-06-30 |
2023-08-12 |
mouse |
| Xi-Jian Zhou, Jun Yang, Fu-Lin Yan, Da-Xin Wang, Xiang-Yong Li, Xiao-Qiang Fan, Fang Hao, Xi-Qing Yan, Xue-Ping Li, Hui Li, Wen-Yan Liu, Bao-Cheng Li. Norepinephrine plays an important role in antinociceptive modulation of hypothalamic paraventricular nucleus in the rat. The International journal of neuroscience. vol 120. issue 6. 2010-09-14. PMID:20504214. |
the results showed: (1) pain stimulation increased norepinephrine (ne), but not epinephrine, dopamine (da), 3,4-dihydroxyphenylacetic acid (da metabolic product), homovanilic acid (da metabolic product), serotonin (5-ht), 5-hydroxyindoleacetic acid (5-ht metabolic product), acetycholine (ach), choline (ach metabolic product), gamma-aminobutyric acid (gaba), and l-glutamate acid concentrations in the pvn perfusion liquid; (2) pvn stimulation with l-glutamate sodium, which excited local neurons only, did not influence the concentrations of the studied classical neurotransmitter and metabolic product in the pvn perfusion liquid; (3) microinjection of ne, epinephrine, or l-glutamate sodium into the pvn elevated pain threshold, and local administration of gaba decreased pain threshold in a dose-dependent manner, but pvn administration of ach, da, or 5-ht did not change pain threshold; (4) microinjection of phentolamine (alpha-receptor antagonist) or mk801 [nmda-receptor antagonist] into the pvn reduced pain threshold, and local administration of bicuculline (gaba-receptor antagonist) raised pain threshold, but pvn administration of propranolol (beta-receptor antagonist), atropine (muscarinic cholinergic receptor antagonist), 6-oh gallamine (nicotinic cholinergic receptor antagonist), fluperidol (da-receptor antagonist), or cyproheptadine (5-ht-receptor antagonist) did not alter pain threshold. |
2010-09-14 |
2023-08-12 |
rat |
| O P Sidhu, Sanjay Annarao, Uday Pathre, S K Snehi, S K Raj, Raja Roy, Rakesh Tuli, C L Khetrapa. Metabolic and histopathological alterations of Jatropha mosaic begomovirus-infected Jatropha curcas L. by HR-MAS NMR spectroscopy and magnetic resonance imaging. Planta. vol 232. issue 1. 2010-09-13. PMID:20372923. |
the viral stress also significantly increases the concentrations of alanine, arginine, glutamine, valine, gaba and choline as compared to healthy ones. |
2010-09-13 |
2023-08-12 |
Not clear |
| Stacey Carmody, Lorraine Brenna. Effects of pentylenetetrazole-induced seizures on metabolomic profiles of rat brain. Neurochemistry international. vol 56. issue 2. 2010-07-08. PMID:19913064. |
in the hippocampus of ptz-kindled animals the metabolites changing included lactate, succinate, gaba, naa, choline and taurine. |
2010-07-08 |
2023-08-12 |
rat |
| Stacey Carmody, Lorraine Brenna. Effects of pentylenetetrazole-induced seizures on metabolomic profiles of rat brain. Neurochemistry international. vol 56. issue 2. 2010-07-08. PMID:19913064. |
analysis of the cerebellum of ptz-kindled animals revealed changes in lactate, myo-inositol, choline, gaba, creatine, succinate, phosphocholine and gpc. |
2010-07-08 |
2023-08-12 |
rat |
| Bindesh Shrestha, Peter Nemes, Javad Nazarian, Yetrib Hathout, Eric P Hoffman, Akos Verte. Direct analysis of lipids and small metabolites in mouse brain tissue by AP IR-MALDI and reactive LAESI mass spectrometry. The Analyst. vol 135. issue 4. 2010-06-11. PMID:20349540. |
major brain lipids including cholesterol, various phospholipid species (glycerophosphocholines, sphingomyelin and phosphatidylethanolamines) along with numerous metabolites, for example g-aminobutyric acid (gaba), creatine and choline, were identified in a typical mass spectrum. |
2010-06-11 |
2023-08-12 |
mouse |
| Hui Zhang, Wei Wang, Wei Gao, Yali Ge, Jinsong Zhang, Shengxi Wu, Lixian X. Effect of propofol on the levels of neurotransmitters in normal human brain: a magnetic resonance spectroscopy study. Neuroscience letters. vol 467. issue 3. 2010-02-10. PMID:19853639. |
magnetic resonance spectroscopy (mrs) was performed to evaluate neurotransmitters (choline compounds (cho), creatine (cr), glutamate (glu), gamma-aminobutyric acid (gaba) and n-acetyl aspartate (naa)) changes in brains following propofol anesthesia. |
2010-02-10 |
2023-08-12 |
human |
| Shonagh K O'Leary-Moore, Matthew P Galloway, Andrew P McMechan, Susan Irtenkauf, John H Hannigan, Scott E Bowe. Neurochemical changes after acute binge toluene inhalation in adolescent and adult rats: a high-resolution magnetic resonance spectroscopy study. Neurotoxicology and teratology. vol 31. issue 6. 2010-01-07. PMID:19628036. |
in contrast to these minimal effects in adolescents, binge toluene exposure altered several neurochemical parameters in young adult rats, including decreased levels of choline and gaba in the frontal cortex and striatum and lowered glutamine and naa levels in the frontal cortex. |
2010-01-07 |
2023-08-12 |
rat |
| Jang-Eun Lee, Geum-Sook Hwang, Frans Van Den Berg, Cherl-Ho Lee, Young-Shick Hon. Evidence of vintage effects on grape wines using 1H NMR-based metabolomic study. Analytica chimica acta. vol 648. issue 1. 2009-09-18. PMID:19616691. |
the metabolites contributing to the differentiation were identified as 2,3-butandiol, lactic acid, alanine, proline, gamma-aminobutyric acid (gaba), choline, and polyphenols, by complementary pca loading plot. |
2009-09-18 |
2023-08-12 |
Not clear |
| Jun Yang, Huifeng Yuan, Jiegen Chu, Yu Yang, Hongtao Xu, Gen Wang, Wen-Yan Liu, Bao-Cheng Li. Arginine vasopressin antinociception in the rat nucleus raphe magnus is involved in the endogenous opiate peptide and serotonin system. Peptides. vol 30. issue 7. 2009-09-17. PMID:19540433. |
the results showed that (1) in the nrm perfuse liquid, pain stimulation could increase the concentrations of avp, leucine-enkephalin (l-ek), methionine-enkephalin (m-ek), beta-endorphin (beta-ep), serotonin (5-ht) and 5-hydroxyindoleacetic acid (5-hiaa), but not change the concentrations of dynorphina(1-13) (dyna(1-13)), oxytocin, achetylcholine, choline, gamma-aminobutyric acid, glutamate, dopamine, 3,4-dihydroxyphenylacetic acid, homovanilic acid, norepinephrine and epinephrine; (2) in the nrm perfuse liquid, avp increased the concentrations of l-ek, m-ek, beta-ep, dyna(1-13), 5-ht and 5-hiaa, but did not change the concentrations of oxytocin and the other studied neurotransmitters; (3) avp antinociception in the nrm was attenuated by cypoheptadine (a 5-ht-receptor antagonist) or naloxone (an opiate receptor antagonist), but was not influenced by the other studied receptor antagonists. |
2009-09-17 |
2023-08-12 |
rat |
| Natalie J Carter, Paul L McCormac. Duloxetine: a review of its use in the treatment of generalized anxiety disorder. CNS drugs. vol 23. issue 6. 2009-08-18. PMID:19480470. |
it has a low affinity for neuronal receptors, such as alpha(1)- and alpha(2)-adrenergic, dopamine d(2), histamine h(1), muscarinic, opioid and serotonin receptors, as well as ion channel binding sites and other neurotransmitter transporters, such as choline and gaba transporters. |
2009-08-18 |
2023-08-12 |
human |
| Hong-Seok Son, Geum-Sook Hwang, Won-Mok Park, Young-Shick Hong, Cherl-Ho Le. Metabolomic characterization of malolactic fermentation and fermentative behaviors of wine yeasts in grape wine. Journal of agricultural and food chemistry. vol 57. issue 11. 2009-07-28. PMID:19441817. |
metabolites such as glycerol, lactate, 2,3-butanediol, succinate, leucine, isoleucine, alanine, valine, proline, choline, gamma-aminobutyric acid (gaba), and polyphenols contributed to the differentiations. |
2009-07-28 |
2023-08-12 |
Not clear |