| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Thomas, K Yue, N Binesh, P Davanzo, A Kumar, B Siegel, M Frye, J Curran, R Lufkin, P Martin, B Guz. Localized two-dimensional shift correlated MR spectroscopy of human brain. Magnetic resonance in medicine. vol 46. issue 1. 2001-09-13. PMID:11443711. |
the j cross-peaks due to n-acetyl aspartate (naa), glutamate/glutamine (glx), myo-inositol (mi), creatine (cr), choline (ch), aspartate (asp), gamma-aminobutyrate (gaba), taurine (tau), glutathione (gsh), threonine (thr), and macromolecules (mm) were identified. |
2001-09-13 |
2023-08-12 |
human |
| J H Bothwell, C Rae, R M Dixon, P Styles, K K Bhako. Hypo-osmotic swelling-activated release of organic osmolytes in brain slices: implications for brain oedema in vivo. Journal of neurochemistry. vol 77. issue 6. 2001-07-19. PMID:11413246. |
we found that acute hypo-osmotic shock causes decreases in the levels of a range of intracellular amino acids and amino acid derivatives, n-acetyl-aspartate, creatine, gaba, glutamate, hypotaurine, and also in the levels of the methylamines glycerol-phosphorylcholine, phosphorylcholine and choline. |
2001-07-19 |
2023-08-12 |
rat |
| Igor D Grachev, Bruce E Fredrickson, Vania A Apkaria. Abnormal brain chemistry in chronic back pain: an in vivo proton magnetic resonance spectroscopy study. Pain. vol 89. issue 1. 2001-05-21. PMID:11113288. |
in vivo (1)h-mrs was used to measure relative concentrations of n-acetyl aspartate, creatine, choline, glutamate, glutamine, gamma-aminobutyric acid, inositol, glucose and lactate in relation to the concentration of creatine. |
2001-05-21 |
2023-08-12 |
human |
| Y Ke, B M Cohen, J Y Bang, M Yang, P F Rensha. Assessment of GABA concentration in human brain using two-dimensional proton magnetic resonance spectroscopy. Psychiatry research. vol 100. issue 3. 2001-03-15. PMID:11120443. |
based on phantom measurements, a gaba resonance peak located at 2.94 ppm, 7.45 hz, in j-resolved 2d mrs overlaps the least with other resonance peaks which arise from n-acetylaspartate, choline, creatine, glutamate and glutamine. |
2001-03-15 |
2023-08-12 |
human |
| I D Grachev, A V Apkaria. Anxiety in healthy humans is associated with orbital frontal chemistry. Molecular psychiatry. vol 5. issue 5. 2001-02-01. PMID:11032381. |
the relative concentrations of n-acetyl aspartate, choline, glutamate, glutamine, gamma-aminobutyric acid, inositol, glucose and lactate were measured relative to creatine within six 8-cm3 brain voxels localized to: thalamus, cingulate, insula, sensorimotor, dorsolateral prefrontal, and orbital frontal cortices (ofc) in the left hemisphere. |
2001-02-01 |
2023-08-12 |
human |
| D A Montoya, A M White, C L Williams, J K Blusztajn, W H Meck, H S Swartzwelde. Prenatal choline exposure alters hippocampal responsiveness to cholinergic stimulation in adulthood. Brain research. Developmental brain research. vol 123. issue 1. 2001-01-09. PMID:11020547. |
these results suggest that gaba receptor-mediated inhibition remains intact after prenatal choline manipulations, and that enhancement of the excitatory responsiveness of hippocampal circuits in slices from prenatally choline supplemented rats may be related in part to an increase in cholinergic tone within the ca1 circuit. |
2001-01-09 |
2023-08-12 |
rat |
| H T Kha, D I Finkelstein, D V Pow, A J Lawrence, M K Horn. Study of projections from the entopeduncular nucleus to the thalamus of the rat. The Journal of comparative neurology. vol 426. issue 3. 2000-11-30. PMID:10992243. |
these were subsequently immunohistochemically labeled for choline acetyl transferase, gamma-aminobutyric acid (gaba), and glutamate. |
2000-11-30 |
2023-08-12 |
rat |
| A Köfalvi, B Sperlágh, T Zelles, E S Viz. Long-lasting facilitation of 4-amino-n-[2,3-(3)H]butyric acid ([(3)H]GABA) release from rat hippocampal slices by nicotinic receptor activation. The Journal of pharmacology and experimental therapeutics. vol 295. issue 2. 2000-11-21. PMID:11046076. |
acetylcholine (0.03-3 mm), and the alpha 7 subtype-selective agonist choline (0.1-10 mm), also potentiated stimulus-evoked release of [(3)h]gaba, whereas 1,1-dimethyl-4-phenilpiperazinium iodide failed to increase the tritium outflow significantly. |
2000-11-21 |
2023-08-12 |
rat |
| I D Grachev, A V Apkaria. Chemical heterogeneity of the living human brain: a proton MR spectroscopy study on the effects of sex, age, and brain region. NeuroImage. vol 11. issue 5 Pt 1. 2000-06-28. PMID:10806041. |
the relative concentrations of n-acetyl aspartate, choline, glutamate, glutamine, gaba, inositol, glucose, and lactate were measured relative to creatine within 8-cm(3) brain voxels. |
2000-06-28 |
2023-08-12 |
human |
| N I Nechipurenko, T V Dudina, A I Elkina, Iu B Elki. [Pathogenetic basis for the use of GABA-ergic preparations in combination with atropine during chronic pain syndrome in patients with neurologic manifestations of lumbar osteochondrosis]. Voprosy meditsinskoi khimii. vol 46. issue 1. 2000-06-09. PMID:10802884. |
the intensity of neuronal uptake of 3h- or 14c-labeled gaba, glycine, noradrenaline, choline and glucocorticoid receptor binding were investigated in different structures of the rabbit cns by simulating chronic pain syndrome. |
2000-06-09 |
2023-08-12 |
rabbit |
| T Schirmer, D P Aue. On the reliability of quantitative clinical magnetic resonance spectroscopy of the human brain. NMR in biomedicine. vol 13. issue 1. 2000-03-31. PMID:10668051. |
eighty-four in vitro and 30 single-subject examinations were statistically evaluated after quantification, including the calculation of the coefficients of variations (cv) for choline (cho), creatine (cr), myo-inositol (mi), lactate (lac), n-acetyl-aspartate (naa) and unresolved glutamine, glutamate and gaba (glx). |
2000-03-31 |
2023-08-12 |
human |
| J Pfeuffer, I Tkác, S W Provencher, R Gruette. Toward an in vivo neurochemical profile: quantification of 18 metabolites in short-echo-time (1)H NMR spectra of the rat brain. Journal of magnetic resonance (San Diego, Calif. : 1997). vol 141. issue 1. 1999-12-15. PMID:10527748. |
choline groups, phosphorylethanolamine, glucose, glutathione, gamma-aminobutyric acid, n-acetylaspartylglutamate, and alanine were below 13%, whereas aspartate and scyllo-inositol were below 22%. |
1999-12-15 |
2023-08-12 |
rat |
| E Reisner, M Nöldner, S Rossner, S S Chatterjee, V Bigl, R Schlieb. Acute effect of KA-672, a putative cognitive enhancer, on neurotransmitter receptor binding in mouse brain. Neuroscience letters. vol 274. issue 3. 1999-12-06. PMID:10548421. |
no effects of ka-672 treatment on n-methyl-d-aspartate, kainate, gaba(a) and benzodiazepine receptor as well as m2-muscarinic cholinergic and high-affinity choline uptake binding were observed. |
1999-12-06 |
2023-08-12 |
mouse |
| W Le, O M Conneely, L Zou, Y He, O Saucedo-Cardenas, J Jankovic, D R Mosier, S H Appe. Selective agenesis of mesencephalic dopaminergic neurons in Nurr1-deficient mice. Experimental neurology. vol 159. issue 2. 1999-11-19. PMID:10506516. |
the levels of glu and gaba and the activity of choline acetyl transferase in the brains of nurr1-/- mice were not significantly altered. |
1999-11-19 |
2023-08-12 |
mouse |
| N C Patel, W B Carden, M E Bickfor. Synaptic targets of cholinergic terminals in the cat lateral posterior nucleus. The Journal of comparative neurology. vol 410. issue 1. 1999-09-03. PMID:10397393. |
we examined profiles in the neuropil of the lateral division of the lateral posterior (lp) nucleus of the cat stained with antibodies against choline acetyl transferase (chat) or gamma-aminobutyric acid (gaba), and several differences in the synaptic circuitry of the lateral lp nucleus compared with the pulvinar nucleus and lateral geniculate nucleus (lgn) were identified. |
1999-09-03 |
2023-08-12 |
cat |
| H Hutchings, K P Stahmann, S Roels, E A Espeso, W E Timberlake, H N Arst, J Tilbur. The multiply-regulated gabA gene encoding the GABA permease of Aspergillus nidulans: a score of exons. Molecular microbiology. vol 32. issue 3. 1999-07-02. PMID:10320578. |
the predicted protein contains 517 residues and shows 30.3% overall identity with a putative gaba permease of arabidopsis thaliana, 29.6% identity with the yeast choline transporter and 23.4% identity with the yeast uga4 gaba permease. |
1999-07-02 |
2023-08-12 |
human |
| J W Phillis, D Song, M H O'Rega. Effects of hyperosmolarity and ion substitutions on amino acid efflux from the ischemic rat cerebral cortex. Brain research. vol 828. issue 1-2. 1999-06-30. PMID:10320719. |
during ischemia nmdg substitution increased glutamate and gaba efflux and choline enhanced the release of aspartate, glutamate, gaba and taurine. |
1999-06-30 |
2023-08-12 |
rat |
| I Tkác, Z Starcuk, I Y Choi, R Gruette. In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time. Magnetic resonance in medicine. vol 41. issue 4. 1999-06-29. PMID:10332839. |
the entire chemical shift range of 1h spectrum was observable, including resolved resonances from alanine, aspartate, choline group, creatine, gaba, glucose, glutamate, glutamine, myo-inositol, lactate, n-acetylaspartate, n-acetylaspartylglutamate, phosphocreatine, and taurine. |
1999-06-29 |
2023-08-12 |
rat |
| M Alkondon, E F Pereira, H M Eisenberg, E X Albuquerqu. Choline and selective antagonists identify two subtypes of nicotinic acetylcholine receptors that modulate GABA release from CA1 interneurons in rat hippocampal slices. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 7. 1999-04-13. PMID:10087082. |
choline and selective antagonists identify two subtypes of nicotinic acetylcholine receptors that modulate gaba release from ca1 interneurons in rat hippocampal slices. |
1999-04-13 |
2023-08-12 |
rat |
| M Yasumatsu, T Yazawa, M Otokawa, K Kuwasawa, H Hasegawa, Y Aihar. Monoamines, amino acids and acetylcholine in the preoptic area and anterior hypothalamus of rats: measurements of tissue extracts and in vivo microdialysates. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 121. issue 1. 1999-01-21. PMID:9883566. |
the extracts contained norepinephrine, epinephrine, 3,4-dihydroxyphenylacetic acid (dopac), dopamine, 5-hydroxyindoleacetic acid (5-hiaa), homovanillic acid (hva), 5-hydroxytryptamine (5-ht), aspartate, glutamate, gaba, acetylcholine (ach) and choline. |
1999-01-21 |
2023-08-12 |
rat |