| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E X Albuquerque, E F Pereira, M F Braga, M Alkondo. Contribution of nicotinic receptors to the function of synapses in the central nervous system: the action of choline as a selective agonist of alpha 7 receptors. Journal of physiology, Paris. vol 92. issue 3-4. 1999-01-13. PMID:9789829. |
the alpha 7-nicotinic receptor (nachr)-selective agonist choline and nachr-subtype-selective antagonists led to the discovery that activation of both alpha 7 and alpha 4 beta 2 nachrs located in ca1 interneurons in slices taken from the rat hippocampus facilitates the tetrodotoxin (ttx)-sensitive release of gamma-aminobutyric acid (gaba). |
1999-01-13 |
2023-08-12 |
rat |
| H TAKAHASHI, A NAGASHIMA, C KOSHINO, H TAKAHASH. Effects of gamma-aminobutyric acid (GABA), gamma-aminobutyryl choline (GABA-CH) and their related substances on the cortical activity. The Japanese journal of physiology. vol 9. 1998-11-01. PMID:13836632. |
effects of gamma-aminobutyric acid (gaba), gamma-aminobutyryl choline (gaba-ch) and their related substances on the cortical activity. |
1998-11-01 |
2023-08-12 |
Not clear |
| A Khateb, P Fort, S Williams, M Serafin, M Mühlethaler, B E Jone. GABAergic input to cholinergic nucleus basalis neurons. Neuroscience. vol 86. issue 3. 1998-10-29. PMID:9692729. |
gaba and its agonists were applied to electrophysiologically-identified cholinergic neurons, of which some were labelled with biocytin and confirmed to be choline acetyltransferase-immunoreactive. |
1998-10-29 |
2023-08-12 |
Not clear |
| J L do Nascimento, A L Ventura, R Paes de Carvalh. Veratridine- and glutamate-induced release of [3H]-GABA from cultured chick retina cells: possible involvement of a GAT-1-like subtype of GABA transporter. Brain research. vol 798. issue 1-2. 1998-09-11. PMID:9666133. |
the release of gaba was calcium-independent, but could be completely prevented by the substitution of sodium chloride by lithium or choline chloride in the extracellular medium, suggesting that gaba release could be triggered by multiple mechanisms that led to the flux of sodium into these cells. |
1998-09-11 |
2023-08-12 |
chicken |
| I Tamai, R Ohashi, J Nezu, H Yabuuchi, A Oku, M Shimane, Y Sai, A Tsuj. Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. The Journal of biological chemistry. vol 273. issue 32. 1998-09-10. PMID:9685390. |
octn2-mediated l-[3h]carnitine transport was inhibited by the d-isomer, acetyl-d,l-carnitine, and gamma-butyrobetaine with high affinity and by glycinebetaine with lower affinity, whereas choline, beta-hydroxybutyric acid, gamma-aminobutyric acid, lysine, and taurine were not inhibitory. |
1998-09-10 |
2023-08-12 |
human |
| L G Storchak, N G Pozdnyakova, N H Himmelreic. Differential effect of protein kinase inhibitors on calcium-dependent and calcium-independent [14C]GABA release from rat brain synaptosomes. Neuroscience. vol 85. issue 3. 1998-08-21. PMID:9639290. |
the substitution of sodium by choline in ca2+-free medium completely abolished ca2+-independent part of k+-evoked [14c]gaba release. |
1998-08-21 |
2023-08-12 |
rat |
| H P Hetherington, J W Pan, W J Chu, G F Mason, B R Newcome. Biological and clinical MRS at ultra-high field. NMR in biomedicine. vol 10. issue 8. 1998-05-21. PMID:9542734. |
in addition to the static measurements measurements of n-acetyl aspartate (naa), creatine (cr) and choline (ch) which can be performed at 1.5 t, high resolution measurements of glutamate, glutamine, gaba and the incorporation of 13c labeled glucose into glutamate are possible with improved spatial and spectral resolution. |
1998-05-21 |
2023-08-12 |
Not clear |
| D M Araujo, D C Hil. Glial cell line-derived neurotrophic factor attenuates the locomotor hypofunction and striatonigral neurochemical deficits induced by chronic systemic administration of the mitochondrial toxin 3-nitropropionic acid. Neuroscience. vol 82. issue 1. 1998-04-09. PMID:9483508. |
thus, [3h]gaba uptake and [3h]tiagabine/gaba uptake sites in striatal target tissues (globus pallidus and substantia nigra), as well as [3h]choline uptake, choline acetyltransferase activity and dopamine receptor binding in the striatum were decreased by the toxin and restored to varying degrees by glial cell line-derived neurotrophic factor administration. |
1998-04-09 |
2023-08-12 |
rat |
| D M Araujo, D C Hil. Glial cell line-derived neurotrophic factor attenuates the excitotoxin-induced behavioral and neurochemical deficits in a rodent model of Huntington's disease. Neuroscience. vol 81. issue 4. 1997-11-26. PMID:9330371. |
concomitant changes in neurotransmitter function as a result of the lesion were also observed: [3h]gaba uptake into striatal target tissues (globus pallidus and substantia nigra) was considerably reduced in the lesioned compared to the contralateral unlesioned tissues, as were [3h]choline and [3h]dopamine uptake into striatal synaptosomes. |
1997-11-26 |
2023-08-12 |
rat |
| D M Araujo, D C Hil. Glial cell line-derived neurotrophic factor attenuates the excitotoxin-induced behavioral and neurochemical deficits in a rodent model of Huntington's disease. Neuroscience. vol 81. issue 4. 1997-11-26. PMID:9330371. |
however, neurotrophin-3 (10 micrograms/day) delivery into the striatum significantly increased [3h]gaba uptake, but only modestly affected [3h]choline uptake. |
1997-11-26 |
2023-08-12 |
rat |
| N P Clarke, M D Bevan, C Cozzari, B K Hartman, J P Bola. Glutamate-enriched cholinergic synaptic terminals in the entopeduncular nucleus and subthalamic nucleus of the rat. Neuroscience. vol 81. issue 2. 1997-10-29. PMID:9300428. |
quantification of the immunogold labelling showed that choline acetyltransferase-immunopositive terminals and boutons in both regions were significantly enriched in glutamate immunoreactivity and had significantly lower levels of gaba immunoreactivity in comparison to identified gabaergic terminals. |
1997-10-29 |
2023-08-12 |
rat |
| N P Clarke, M D Bevan, C Cozzari, B K Hartman, J P Bola. Glutamate-enriched cholinergic synaptic terminals in the entopeduncular nucleus and subthalamic nucleus of the rat. Neuroscience. vol 81. issue 2. 1997-10-29. PMID:9300428. |
that associated with synaptic vesicles, was significantly greater in the choline acetyltransferase-positive terminals than identified gaba terminals, albeit significantly lower than in established glutamatergic terminals. |
1997-10-29 |
2023-08-12 |
rat |
| A Pittaluga, A Bonfanti, M Raiter. Differential desensitization of ionotropic non-NMDA receptors having distinct neuronal location and function. Naunyn-Schmiedeberg's archives of pharmacology. vol 356. issue 1. 1997-09-05. PMID:9228187. |
the release of tritium from rat hippocampal synaptosomes prelabeled with [3h]noradrenaline ([3h]na) or [3h]5-hydroxytryptamine ([3h]5-ht) and from rat neocortex synaptosomes prelabeled with [3h]choline and the release of endogenous gaba and glutamate from rat neocortex synaptosomes were monitored during superfusion with media containing varying concentrations of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) or kainic acid. |
1997-09-05 |
2023-08-12 |
rat |
| T S Haugstad, H E Karlsen, P Krajtci, B Due-Tønnessen, M Larsen, C Sandberg, O Sand, P Brandtzaeg, I A Langmoe. Efflux of gamma-aminobutyric acid caused by changes in ion concentrations and cell swelling simulating the effect of cerebral ischaemia. Acta neurochirurgica. vol 139. issue 5. 1997-08-29. PMID:9204116. |
choline (chol) but not n-methyl-d-glucamine (nmdg) substitution for sodium likewise increased gaba efflux. |
1997-08-29 |
2023-08-12 |
rat |
| J R Simon, D J Bare, B Ghetti, J A Richte. A possible role for tyrosine kinases in the regulation of the neuronal dopamine transporter in mouse striatum. Neuroscience letters. vol 224. issue 3. 1997-07-18. PMID:9131671. |
the inhibition by genistein was rapid, reversible and somewhat selective, in that genistein did not inhibit the uptake of choline or gaba under similar conditions. |
1997-07-18 |
2023-08-12 |
mouse |
| J R Keltner, L L Wald, B D Frederick, P F Rensha. In vivo detection of GABA in human brain using a localized double-quantum filter technique. Magnetic resonance in medicine. vol 37. issue 3. 1997-05-06. PMID:9055226. |
a proton mr spectral editing technique employing a spatially localized, double-quantum filter (dqf) was used to measure gamma-aminobutyric acid (gaba) in the human brain at 1.5 t. the double-quantum method provided robust, single-shot suppression of uncoupled resonances from choline, creatine, and naa and allowed detection of the gamma ch2 gaba (3.0 ppm) resonance with 30% efficiency. |
1997-05-06 |
2023-08-12 |
human |
| B E Jones, C B Boylan, M Fritsche, M Juhasz, C Jackson, S J Wiegand, C Hyman, R M Lindsay, C A Alta. A continuous striatal infusion of 6-hydroxydopamine produces a terminal axotomy and delayed behavioral effects. Brain research. vol 709. issue 2. 1997-05-01. PMID:8833764. |
the continuous infusion of 0.2 mu g 6-ohda per h did not affect the striatal uptake of [3h]%gaba, [3h]choline, or [3h]glutamate but reduced [3h]dopamine uptake by 55% within 1.5 days after the start of the infusion. |
1997-05-01 |
2023-08-12 |
rat |
| K D Moore, O Dillon-Carter, C Conejero, M Poltorak, M Chedid, C Tornatore, W J Free. In vitro properties of a newly established medulloblastoma cell line, MCD-1. Molecular and chemical neuropathology. vol 29. issue 2-3. 1997-04-02. PMID:8971690. |
the cells expressed specific uptake of glutamate, serotonin, and choline, but not gaba or dopamine. |
1997-04-02 |
2023-08-12 |
Not clear |
| S Ohkuma, M Katsura, D Z Chen, H Narihara, K Kuriyam. Nitric oxide-evoked [3H] gamma-aminobutyric acid release is mediated by two distinct release mechanisms. Brain research. Molecular brain research. vol 36. issue 1. 1997-02-06. PMID:9011749. |
in addition, the no-evoked [3h]gaba release was reduced by approximately 50% when total na+ in incubation buffer was replaced with equimolar choline, and was also completely abolished by the removal of both ca2+ and na+. |
1997-02-06 |
2023-08-12 |
mouse |
| A Aanesen, G Fried, E Andersson, C Gottlie. Carrier-mediated gamma-aminobutyric acid uptake in human spermatozoa indicating the presence of a high-affinity gamma-aminobutyric acid transport protein. Biology of reproduction. vol 54. issue 4. 1996-10-31. PMID:8924504. |
gaba uptake was reduced by equimolar substitution of nacl in the capacitating medium by kcl, choline chloride, licl, n-methyl-d-glucamine (hcl) or d-glucuronic acid (sodium salt). |
1996-10-31 |
2023-08-12 |
human |