| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Ladinsky, S Consolo, A Zatta, A Vezzan. Mode of action of gamma-butyrolactone on the central cholinergic system. Naunyn-Schmiedeberg's archives of pharmacology. vol 322. issue 1. 1983-06-23. PMID:6843688. |
by comparison, gamma-hydroxybutyric acid (ghba), an active metabolite which shares with gbl the capacity to produce a somnolent state and depress impulse flow in the dopaminergic nigroneostriatal pathway, had no effect on either striatal acetylcholine content or on hippocampal high affinity choline uptake. |
1983-06-23 |
2023-08-12 |
rat |
| R B Mailman, M R Krigman, G D Frye, I Hani. Effects of postnatal trimethyltin or triethyltin treatment on CNS catecholamine, GABA, and acetylcholine systems in the rat. Journal of neurochemistry. vol 40. issue 5. 1983-05-27. PMID:6834067. |
accordingly, the concentration of gamma-aminobutyric acid (gaba) was decreased in the hippocampus; however, acetylcholine and choline concentrations were unaffected. |
1983-05-27 |
2023-08-12 |
rat |
| P D Hrdina, K Elson-Hartma. Effect of chronic treatment with amitriptyline and haloperidol on high affinity uptake of choline by synaptosomes from various regions of rat brain. Neuropharmacology. vol 21. issue 12. 1983-03-11. PMID:7155314. |
changes in high affinity uptake of choline were determined in crude synaptosomal (p2) preparations from cerebral cortex, striatum and hippocampus of rats given either single or repeated (for 7, 14 or 21 days) doses of amitriptyline (5 mg/kg/day) or haloperidol (1 mg/kg/day). |
1983-03-11 |
2023-08-12 |
rat |
| P D Hrdina, K Elson-Hartma. Effect of chronic treatment with amitriptyline and haloperidol on high affinity uptake of choline by synaptosomes from various regions of rat brain. Neuropharmacology. vol 21. issue 12. 1983-03-11. PMID:7155314. |
a single dose of amitripytyline failed to affect the high affinity choline uptake in the cortex and hippocampus and produced a slight (11%) decrease in the uptake of choline in the striatum. |
1983-03-11 |
2023-08-12 |
rat |
| P D Hrdina, K Elson-Hartma. Effect of chronic treatment with amitriptyline and haloperidol on high affinity uptake of choline by synaptosomes from various regions of rat brain. Neuropharmacology. vol 21. issue 12. 1983-03-11. PMID:7155314. |
in the hippocampus, high affinity choline uptake was enhanced after 7 days but returned to control values or was decreased after 14 and 21 days of treatment, respectively. |
1983-03-11 |
2023-08-12 |
rat |
| S L Hartgraves, P L Mensah, P H Kell. Regional decreases of cortical choline acetyltransferase after lesions of the septal area and in the area of nucleus basalis magnocellularis. Neuroscience. vol 7. issue 10. 1983-02-14. PMID:7177378. |
choline acetyltransferase and [3h]choline uptake have been measured in neocortical regions and hippocampus one week after lesions which destroyed the septum bilaterally, and after unilateral lesions in the area of nucleus basalis magnocellularis. |
1983-02-14 |
2023-08-12 |
Not clear |
| B A Trommer, D E Schmidt, L Wecke. Exogenous choline enhances the synthesis of acetylcholine only under conditions of increased cholinergic neuronal activity. Journal of neurochemistry. vol 39. issue 6. 1983-01-07. PMID:7142996. |
on fluphenazine- and pentylenetetrazol-induced alterations in the concentration of acetylcholine (ach) and/or the rate of sodium-dependent high-affinity choline uptake (hacu) in rat striatum and hippocampus was studied. |
1983-01-07 |
2023-08-12 |
rat |
| B A Trommer, D E Schmidt, L Wecke. Exogenous choline enhances the synthesis of acetylcholine only under conditions of increased cholinergic neuronal activity. Journal of neurochemistry. vol 39. issue 6. 1983-01-07. PMID:7142996. |
in the hippocampus, prior administration of choline prevented the pentylenetetrazol-induced increase in the rate of hacu and attenuated the effect of pentylenetetrazol on the levels of ach. |
1983-01-07 |
2023-08-12 |
rat |
| J A Richter, J M Gormley, J R Holtman, J R Simo. High-affinity choline uptake in the hippocampus: its relationship to the physiological state produced by administration of barbiturates and other treatments. Journal of neurochemistry. vol 39. issue 5. 1982-12-03. PMID:7150428. |
high-affinity choline uptake in the hippocampus: its relationship to the physiological state produced by administration of barbiturates and other treatments. |
1982-12-03 |
2023-08-12 |
rat |
| J A Richter, J M Gormley, J R Holtman, J R Simo. High-affinity choline uptake in the hippocampus: its relationship to the physiological state produced by administration of barbiturates and other treatments. Journal of neurochemistry. vol 39. issue 5. 1982-12-03. PMID:7150428. |
choline uptake in hippocampal synaptosomes was not inhibited by pentobarbital administration when rats were decapitated immediately upon loss of the righting reflex (3-4 min) even though it was inhibited at later times post-injection, when the rats were still unable to right themselves. |
1982-12-03 |
2023-08-12 |
rat |
| J A Richter, J M Gormley, J R Holtman, J R Simo. High-affinity choline uptake in the hippocampus: its relationship to the physiological state produced by administration of barbiturates and other treatments. Journal of neurochemistry. vol 39. issue 5. 1982-12-03. PMID:7150428. |
at 7 min after injection, levels of pentobarbital in the hippocampus (and other brain regions) were correlated with the degree of inhibition of choline uptake up to about 50% inhibition; however, greater inhibition could not be achieved with much higher brain levels of the drug. |
1982-12-03 |
2023-08-12 |
rat |
| J A Richter, J M Gormle. Inhibition of high affinity choline uptake in the hippocampus: studies on the site of pentobarbital action. The Journal of pharmacology and experimental therapeutics. vol 222. issue 3. 1982-10-29. PMID:7108774. |
inhibition of high affinity choline uptake in the hippocampus: studies on the site of pentobarbital action. |
1982-10-29 |
2023-08-12 |
Not clear |
| J A Richter, J M Gormle. Inhibition of high affinity choline uptake in the hippocampus: studies on the site of pentobarbital action. The Journal of pharmacology and experimental therapeutics. vol 222. issue 3. 1982-10-29. PMID:7108774. |
pentobarbital (pb) administered in vivo results in an inhibition of high affinity choline uptake measured in hippocampal synaptosomes in vitro. |
1982-10-29 |
2023-08-12 |
Not clear |
| J A Richter, J M Gormle. Inhibition of high affinity choline uptake in the hippocampus: studies on the site of pentobarbital action. The Journal of pharmacology and experimental therapeutics. vol 222. issue 3. 1982-10-29. PMID:7108774. |
localized injections of pb into the hippocampus did not result in an inhibition of choline uptake in that region. |
1982-10-29 |
2023-08-12 |
Not clear |
| J A Richter, J M Gormle. Inhibition of high affinity choline uptake in the hippocampus: studies on the site of pentobarbital action. The Journal of pharmacology and experimental therapeutics. vol 222. issue 3. 1982-10-29. PMID:7108774. |
lesions of the medial septal region (containing the cell bodies of the cholinergic neurons which project to the hippocampus) blocked the ability of peripherally administered pb to inhibit hippocampal choline uptake. |
1982-10-29 |
2023-08-12 |
Not clear |
| J A Richter, J M Gormle. Inhibition of high affinity choline uptake in the hippocampus: studies on the site of pentobarbital action. The Journal of pharmacology and experimental therapeutics. vol 222. issue 3. 1982-10-29. PMID:7108774. |
thus, the drug may act at a site which projects into the septum from a caudal region to cause the inhibition of choline uptake in the hippocampus. |
1982-10-29 |
2023-08-12 |
Not clear |
| J Simpson, L Smar. Sodium-dependent choline binding in rat hippocampal synaptosomes. European journal of pharmacology. vol 80. issue 2-3. 1982-10-21. PMID:7106183. |
sodium-dependent choline binding in rat hippocampal synaptosomes. |
1982-10-21 |
2023-08-12 |
rat |
| J Simpson, L Smar. Sodium-dependent choline binding in rat hippocampal synaptosomes. European journal of pharmacology. vol 80. issue 2-3. 1982-10-21. PMID:7106183. |
the binding of radiolabelled choline to lysed rat hippocampal synaptosomes was investigated. |
1982-10-21 |
2023-08-12 |
rat |
| P Bagnoli, A Beaudet, M Stella, M Cuéno. Selective retrograde labeling of cholinergic neurons with [3H]choline. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 1. issue 7. 1982-10-21. PMID:7346577. |
[3h]choline injection in the rat hippocampus leads to perikaryal retrograde labeling in the ipsilateral medial septal nuclease and nucleus of the diagonal band, thus delineating an established cholinergic pathway, while only diffuse presumably anterograde labeling was observed in the lateral septum, the entorhinal cortex, and the opposite hippocampus. |
1982-10-21 |
2023-08-12 |
rat |
| A Vezzani, A Zatta, H Ladinsky, S Caccia, S Garattini, S Consol. Effect of dimethylamino-2-ethoxyimino-2-adamantane (CM 54903), a non-polar dimethylaminoethanol analog, on brain regional cholinergic neurochemical parameters. Biochemical pharmacology. vol 31. issue 9. 1982-09-10. PMID:7104032. |
brian regional choline contents were unaltered as were the acetylcholine turnover rates in the striatum and hippocampus. |
1982-09-10 |
2023-08-12 |
rat |