| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D N Middlemis. The calcium channel activator, Bay K 8644, enhances K+-evoked efflux of acetylcholine and noradrenaline from rat brain slices. Naunyn-Schmiedeberg's archives of pharmacology. vol 331. issue 1. 1986-01-22. PMID:2415829. |
slices of rat brain were incubated with either (3h) choline (hippocampus) or (3h) noradrenaline (hypothalamus) and superfused with krebs buffer. |
1986-01-22 |
2023-08-11 |
rat |
| J R Zucker, H Lai, A Horit. Intraseptal microinjections of substance P and analogs potentiate pentobarbital-induced narcosis and depression of hippocampal cholinergic activity. The Journal of pharmacology and experimental therapeutics. vol 235. issue 2. 1985-12-20. PMID:2414430. |
to examine this relationship further, we microinjected sp and its analogs, [d-arg1, d-pro2, d-trp7,9, leu11]-sp and [d-pro2, d-trp7,9]-sp, intraseptally in rats pretreated with pentobarbital, and measured the duration of loss of righting reflex and change in choline uptake in hippocampal synaptosomes. |
1985-12-20 |
2023-08-11 |
rat |
| J R Zucker, H Lai, A Horit. Intraseptal microinjections of substance P and analogs potentiate pentobarbital-induced narcosis and depression of hippocampal cholinergic activity. The Journal of pharmacology and experimental therapeutics. vol 235. issue 2. 1985-12-20. PMID:2414430. |
the duration of pentobarbital-induced loss of righting reflex was prolonged and the pentobarbital-induced reduction of hippocampal choline uptake was enhanced by all three drugs. |
1985-12-20 |
2023-08-11 |
rat |
| J Micheau, T P Durkin, C Destrade, Y Rolland, R Jaffar. Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation. Pharmacology, biochemistry, and behavior. vol 23. issue 2. 1985-11-27. PMID:4059305. |
parallel neurochemical investigations showed that the treatment induced a slight (+ 10%) but significant increase in hippocampal sodium-dependent high affinity choline uptake. |
1985-11-27 |
2023-08-11 |
mouse |
| Y Finkelstein, B Koffler, J M Rabey, G M Gila. Dynamics of cholinergic synaptic mechanisms in rat hippocampus after stress. Brain research. vol 343. issue 2. 1985-11-25. PMID:4052753. |
changes in high affinity [3h]choline uptake, newly synthesized [3h]acetylcholine release and [3h]quinuclidinylbenzilate (qnb) binding were characterized in crude synaptosomal preparations from rat hippocampus immediately after different intervals of immobilization stress and at different times following chronic intermittent stress (2h once daily for 5 days). |
1985-11-25 |
2023-08-11 |
rat |
| Y Finkelstein, B Koffler, J M Rabey, G M Gila. Dynamics of cholinergic synaptic mechanisms in rat hippocampus after stress. Brain research. vol 343. issue 2. 1985-11-25. PMID:4052753. |
we conclude: presynaptic hippocampal cholinergic terminals are rapidly activated by stressful stimuli and this is expressed by an increase in choline uptake and newly synthesized acetylcholine release; after prolonged periods of stress adaptive changes in the cholinergic terminals are expressed by a reduction in choline uptake and an elevation in the number of muscarinic binding sites; and the chronic stress-induced changes are slow to recover. |
1985-11-25 |
2023-08-11 |
rat |
| D Galey, T Durkin, G Sifakis, E Kempf, R Jaffar. Facilitation of spontaneous and learned spatial behaviours following 6-hydroxydopamine lesions of the lateral septum: a cholinergic hypothesis. Brain research. vol 340. issue 1. 1985-10-03. PMID:3928092. |
neurochemical analysis revealed that 6-ohda lesioned mice exhibited a significant increase in the rate of sodium-dependent high affinity choline uptake in the hippocampus. |
1985-10-03 |
2023-08-11 |
mouse |
| S Leventer, D McKeag, M Clancy, E Wulfert, I Hani. Intracerebroventricular administration of ethylcholine mustard aziridinium ion (AF64A) reduces release of acetylcholine from rat hippocampal slices. Neuropharmacology. vol 24. issue 5. 1985-08-26. PMID:3839570. |
similarly, the activity of acetylcholinesterase and the high affinity transport of choline in the hippocampus were reduced, to 40 and 30% of control; and to 33 and 48% of control, respectively, 7 and 21 days after treatment with af64a. |
1985-08-26 |
2023-08-11 |
mouse |
| B Frieder, V E Grim. Some long-lasting neurochemical effects of prenatal or early postnatal exposure to diazepam. Journal of neurochemistry. vol 45. issue 1. 1985-07-17. PMID:2860209. |
at 60 days of age, both pre- and postnatally exposed males, but not females, show significant differences from controls in terms of choline uptake, whereas postnatally exposed females whose behavior was shown previously to be profoundly affected by the diazepam exposure showed significant increase in gamma-aminobutyric acid (gaba) uptake in the hippocampus and reduction of 5-hydroxytryptamine (5ht) uptake in the cortex at 60 days of age. |
1985-07-17 |
2023-08-11 |
rat |
| Y H Shih, T A Pugsle. The effects of various cognition-enhancing drugs on in vitro rat hippocampal synaptosomal sodium dependent high affinity choline uptake. Life sciences. vol 36. issue 22. 1985-07-02. PMID:2987637. |
the effects of various cognition-enhancing drugs on in vitro rat hippocampal synaptosomal sodium dependent high affinity choline uptake. |
1985-07-02 |
2023-08-11 |
rat |
| Y H Shih, T A Pugsle. The effects of various cognition-enhancing drugs on in vitro rat hippocampal synaptosomal sodium dependent high affinity choline uptake. Life sciences. vol 36. issue 22. 1985-07-02. PMID:2987637. |
the latter was assessed by measuring the effects of the drugs on in vitro sodium-dependent high affinity choline uptake (hacu) into rat hippocampal synaptosomes 30 minutes after their in vivo administration. |
1985-07-02 |
2023-08-11 |
rat |
| J A Miller, J A Richte. Effects of anticonvulsants in vivo on high affinity choline uptake in vitro in mouse hippocampal synaptosomes. British journal of pharmacology. vol 84. issue 1. 1985-05-10. PMID:3978310. |
effects of anticonvulsants in vivo on high affinity choline uptake in vitro in mouse hippocampal synaptosomes. |
1985-05-10 |
2023-08-11 |
mouse |
| J A Miller, J A Richte. Effects of anticonvulsants in vivo on high affinity choline uptake in vitro in mouse hippocampal synaptosomes. British journal of pharmacology. vol 84. issue 1. 1985-05-10. PMID:3978310. |
the effects of several anticonvulsant drugs on sodium-dependent high affinity choline uptake (hacu) in mouse hippocampal synaptosomes was investigated. |
1985-05-10 |
2023-08-11 |
mouse |
| F Roman, O Della Zuana, M Lonchampt, G Saint Romas, J Duhaul. [Biochemical changes in 24-month-old Wistar rats]. Comptes rendus des seances de la Societe de biologie et de ses filiales. vol 178. issue 4. 1985-04-05. PMID:6084545. |
choline acetyltransferase (cat) and acetylcholine esterase (achesterase) activities, [3h] choline uptake by a synaptosomal preparation, [3h] quinuclidinyl benzylate (qnb) binding to muscarinic cholinergic receptors have been determined in hippocampus. |
1985-04-05 |
2023-08-12 |
rat |
| D Galey, T Durkin, G Sifakis, R Jaffar. [Improvement in spontaneous and acquired spatial behaviors following lesions of septal dopaminergic afferents in mice: possible relations with hippocampal cholinergic activity]. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 299. issue 16. 1985-03-21. PMID:6440670. |
finally, 6-hydroxydopamine injected mice exhibited a substantial increase in hippocampal sodium-dependent high affinity choline uptake (+ 16.7%). |
1985-03-21 |
2023-08-12 |
mouse |
| A R Dravid, E B Van Deuse. Recovery of enzyme markers for cholinergic terminals in septo-temporal regions of the hippocampus following selective fimbrial lesions in adult rats. Brain research. vol 324. issue 1. 1985-03-18. PMID:6518381. |
the activities of choline actyltransferase and acetylcholinesterase were determined in five consecutive septo-temporal regions of the ipsilateral and contralateral hippocampus from unlesioned controls and lesioned animals at various times following lateral, medial or complete unilateral transection of the fimbrial bundle in rats. |
1985-03-18 |
2023-08-12 |
rat |
| M Kakihana, N Yamazaki, A Nagaok. Effects of idebenone (CV-2619) on the concentrations of acetylcholine and choline in various brain regions of rats with cerebral ischemia. Japanese journal of pharmacology. vol 36. issue 3. 1985-03-07. PMID:6521077. |
in the ischemic rats, a significant decrease in ach and a marked increase in choline were observed in the cerebral cortex, hippocampus, striatum, and diencephalon. |
1985-03-07 |
2023-08-12 |
rat |
| G Wenk, D Hepler, D Olto. Behavior alters the uptake of [3H]choline into acetylcholinergic neurons of the nucleus basalis magnocellularis and medial septal area. Behavioural brain research. vol 13. issue 2. 1984-12-13. PMID:6487403. |
behavioral experience changed sodium-dependent high affinity choline uptake (sdhacu) in the hippocampus and frontal cortex. |
1984-12-13 |
2023-08-12 |
rat |
| J M Johnson, D J Thompson, J D Burek, G C Haggerty, I L Dyke, C E Lower, J L Solomo. The neuroteratogenicity of procarbazine in the rat: behavioral, morphological, and neurochemical aspects. Teratology. vol 30. issue 1. 1984-11-09. PMID:6484844. |
in addition to the behavioral studies, sodium-dependent high-affinity choline uptake and choline acetyltransferase activity (cat) were measured (per mg protein) in the cortex and hippocampus of animals that had been exposed prenatally to either teratogenic or subteratogenic doses of procarbazine. |
1984-11-09 |
2023-08-12 |
rat |
| G Fontani, F Grazzi, M Meucc. Effect of piracetam plus choline treatment on hippocampal rhythmic slow activity (RSA) and behavior in rabbits. Life sciences. vol 35. issue 11. 1984-10-25. PMID:6472050. |
effect of piracetam plus choline treatment on hippocampal rhythmic slow activity (rsa) and behavior in rabbits. |
1984-10-25 |
2023-08-12 |
Not clear |