| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Ojika, S H Appe. Neurotrophic effects of hippocampal extracts on medial septal nucleus in vitro. Proceedings of the National Academy of Sciences of the United States of America. vol 81. issue 8. 1984-06-07. PMID:6585816. |
soluble extracts from rat hippocampus enhance cholinergic activity (choline acetyltransferase, choline uptake, acetylcholine synthesis) of the rat medial septal nucleus cultured in serum-free defined medium. |
1984-06-07 |
2023-08-12 |
rat |
| S Garattini, G L Forloni, S Tirelli, H Ladinsky, S Consol. Neurochemical effects of minaprine, a novel psychotropic drug, on the central cholinergic system of the rat. Psychopharmacology. vol 82. issue 3. 1984-05-30. PMID:6425901. |
after in vivo administration the drug did not affect sodium-dependent high affinity choline uptake by a hippocampal homogenate. |
1984-05-30 |
2023-08-12 |
rat |
| G C Haggerty, J A Richter, R B Forne. The effects of an in vivo administration of phencyclidine on sodium-dependent high affinity choline uptake in rat hippocampus and striatum in vitro. Neuropharmacology. vol 22. issue 12A. 1984-03-14. PMID:6664468. |
the effects of an in vivo administration of phencyclidine on sodium-dependent high affinity choline uptake in rat hippocampus and striatum in vitro. |
1984-03-14 |
2023-08-12 |
rat |
| G C Haggerty, J A Richter, R B Forne. The effects of an in vivo administration of phencyclidine on sodium-dependent high affinity choline uptake in rat hippocampus and striatum in vitro. Neuropharmacology. vol 22. issue 12A. 1984-03-14. PMID:6664468. |
the effect of phencyclidine and other drugs on sodium-dependent high-affinity uptake of choline in the rat hippocampus and/or striatum was investigated and related to the behavioral changes induced by these agents. |
1984-03-14 |
2023-08-12 |
rat |
| G C Haggerty, J A Richter, R B Forne. The effects of an in vivo administration of phencyclidine on sodium-dependent high affinity choline uptake in rat hippocampus and striatum in vitro. Neuropharmacology. vol 22. issue 12A. 1984-03-14. PMID:6664468. |
in contrast to atropine (40.0 mg/kg), which increased the uptake of choline in synaptosomes from both the rat hippocampus and striatum, the administration of phencyclidine (54.4 mg/kg), 30 min prior to sacrifice, caused a significant decrease in the uptake of choline in synaptosomes from rat striatum (but not hippocampus). |
1984-03-14 |
2023-08-12 |
rat |
| R J Rylett, M J Ball, E H Colhou. Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer's disease. Brain research. vol 289. issue 1-2. 1984-03-12. PMID:6661641. |
evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with alzheimer's disease. |
1984-03-12 |
2023-08-12 |
human |
| R J Rylett, M J Ball, E H Colhou. Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer's disease. Brain research. vol 289. issue 1-2. 1984-03-12. PMID:6661641. |
a regional difference in high-affinity choline transport was observed in purified synaptosomes prepared from brains of mentally normal controls; the velocities of sodium-dependent and hemicholinium-sensitive choline uptake into synaptosomes from hippocampus were about twice as great as that into synaptosomes from frontal cortex, indicating a greater relative density of cholinergic innervation in the hippocampus. |
1984-03-12 |
2023-08-12 |
human |
| R J Rylett, M J Ball, E H Colhou. Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer's disease. Brain research. vol 289. issue 1-2. 1984-03-12. PMID:6661641. |
hippocampal and neocortical cholinergic nerve cell endings, prepared as synaptosomes, from brains of patients with alzheimer's disease, also accumulated choline by a high-affinity mechanism; however, the velocity of uptake into both brain areas was decreased in comparison with controls. |
1984-03-12 |
2023-08-12 |
human |
| R J Rylett, M J Ball, E H Colhou. Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer's disease. Brain research. vol 289. issue 1-2. 1984-03-12. PMID:6661641. |
choline transport into synaptosomes from alzheimer frontal cortex was reduced approximately 50%, while uptake into alzheimer hippocampal synaptosomes represented only 20% of the control activity. |
1984-03-12 |
2023-08-12 |
human |
| M E Goldman, C K Erickso. Effects of acute and chronic administration of antidepressant drugs on the central cholinergic nervous system. Comparison with anticholinergic drugs. Neuropharmacology. vol 22. issue 10. 1984-01-27. PMID:6646355. |
acute administration of amitriptyline or atropine (highly potent anticholinergics) increased the level of high affinity uptake of choline in the hippocampus and striatum. |
1984-01-27 |
2023-08-12 |
rat |
| R Langnickel, R Bluth, W Oelssne. Various dose-dependent influences of apomorphine on the acetylcholine turnover in striatum and mesolimbic areas of rat brain. Biomedica biochimica acta. vol 42. issue 7-8. 1984-01-27. PMID:6651810. |
the content of acetylcholine and choline and the acetylcholine turnover rates were determined in olfactory tubercle, n. accumbens, striatum and hippocampus after the administration of various doses of apomorphine. |
1984-01-27 |
2023-08-12 |
rat |
| M Marchi, P Paudice, A Caviglia, M Raiter. Is acetylcholine release from striatal nerve endings regulated by muscarinic autoreceptors? European journal of pharmacology. vol 91. issue 1. 1983-11-23. PMID:6617739. |
synaptosomes prepared from cerebral cortex, hippocampus or corpus striatum were prelabeled with [3h]choline and the inhibitory effect of exogenous acetylcholine on the ca2+-dependent release of [3h]acetylcholine evoked by 15 mm kcl was analyzed by superfusion. |
1983-11-23 |
2023-08-12 |
rat |
| J A Romano, T M Shi. Cholinergic mechanisms of analgesia produced by physostigmine, morphine and cold water swimming. Neuropharmacology. vol 22. issue 7. 1983-11-23. PMID:6621812. |
levels of acetylcholine (ach) and choline (ch) in six brain areas (brain stem, cerebral cortex, hippocampus, midbrain, cerebellum and striatum) were analyzed by gas chromatograph-mass spectrometer. |
1983-11-23 |
2023-08-12 |
rat |
| J A Romano, T M Shi. Cholinergic mechanisms of analgesia produced by physostigmine, morphine and cold water swimming. Neuropharmacology. vol 22. issue 7. 1983-11-23. PMID:6621812. |
levels of choline were elevated by morphine in the cerebellum, cortex and hippocampus, while cold water swimming elevated levels of choline in the cerebellum, cortex, striatum and hippocampus. |
1983-11-23 |
2023-08-12 |
rat |
| S Yamada, M Isogai, H Okudaira, E Hayash. Regional adaptation of muscarinic receptors and choline uptake in brain following repeated administration of diisopropylfluorophosphate and atropine. Brain research. vol 268. issue 2. 1983-09-20. PMID:6871685. |
the specific [3h]qnb binding and high-affinity uptake of [14c]choline in 8 brain regions (cerebral cortex, hippocampus, hypothalamus, thalamus, striatum, midbrain, cerebellum and brainstem) after repeated administration of dfp and atropine to guinea-pigs were simultaneously measured. |
1983-09-20 |
2023-08-12 |
Not clear |
| S Yamada, M Isogai, H Okudaira, E Hayash. Regional adaptation of muscarinic receptors and choline uptake in brain following repeated administration of diisopropylfluorophosphate and atropine. Brain research. vol 268. issue 2. 1983-09-20. PMID:6871685. |
in addition to the receptor alteration, high affinity uptake of [14c]choline in the hippocampus and striatum was significantly decreased by dfp treatment, while that in the striatum increased by atropine treatment. |
1983-09-20 |
2023-08-12 |
Not clear |
| G M Gilad, J M Rabey, L Shenkma. Strain-dependent and stress-induced changes in rat hippocampal cholinergic system. Brain research. vol 267. issue 1. 1983-08-26. PMID:6860942. |
the study demonstrates that in the hippocampus of inbred wistar-kyoto (wky) rats [3h]choline uptake is 38% higher than in brown-norway (bn) rats. |
1983-08-26 |
2023-08-12 |
rat |
| G M Gilad, J M Rabey, L Shenkma. Strain-dependent and stress-induced changes in rat hippocampal cholinergic system. Brain research. vol 267. issue 1. 1983-08-26. PMID:6860942. |
we conclude that: (1) choline accumulation is directly related to choline acetyltransferase activity in hippocampal synaptosomes; (2) maximum cholinergic muscarinic binding capacity is inversely related to the above two presynaptic activities and (3) immobilization stress results in a decreased choline accumulation and may lead to an increased qnb binding. |
1983-08-26 |
2023-08-12 |
rat |
| H Ladinsky, S Consolo, A Zatta, A Vezzan. Mode of action of gamma-butyrolactone on the central cholinergic system. Naunyn-Schmiedeberg's archives of pharmacology. vol 322. issue 1. 1983-06-23. PMID:6843688. |
gamma-butylactone (gbl), a drug depressing the central nervous system, produced marked increases in acetylcholine contents in rat brain hemispheric regions (striatum, hippocampus, cortex) and in striatal choline content without modifying choline acetyltransferase or acetylcholinesterase activities. |
1983-06-23 |
2023-08-12 |
rat |
| H Ladinsky, S Consolo, A Zatta, A Vezzan. Mode of action of gamma-butyrolactone on the central cholinergic system. Naunyn-Schmiedeberg's archives of pharmacology. vol 322. issue 1. 1983-06-23. PMID:6843688. |
in the hippocampus gbl also strongly decreased the acetylcholine turnover rate and inhibited the high affinity uptake of choline. |
1983-06-23 |
2023-08-12 |
rat |