| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Vezzani, A Zatta, H Ladinsky, S Caccia, S Garattini, S Consol. Effect of dimethylamino-2-ethoxyimino-2-adamantane (CM 54903), a non-polar dimethylaminoethanol analog, on brain regional cholinergic neurochemical parameters. Biochemical pharmacology. vol 31. issue 9. 1982-09-10. PMID:7104032. |
cm 54903 was found to be a competitive, reversible inhibitor of the sodium-dependent high affinity uptake of choline by crude hippocampal and striatal synaptosomal preparations showing an ic50 of 10 microm in vitro. |
1982-09-10 |
2023-08-12 |
rat |
| A Vezzani, A Zatta, H Ladinsky, S Caccia, S Garattini, S Consol. Effect of dimethylamino-2-ethoxyimino-2-adamantane (CM 54903), a non-polar dimethylaminoethanol analog, on brain regional cholinergic neurochemical parameters. Biochemical pharmacology. vol 31. issue 9. 1982-09-10. PMID:7104032. |
despite the fact that the drug readily crosses the blood-brain barrier and achieves brain concentrations several-fold greater than its in vitro ic50, cm 54903 did not inhibit choline uptake in vivo although it was capable of preventing the pentylenetetrazol-stimulated choline uptake by hippocampal synaptosomes. |
1982-09-10 |
2023-08-12 |
rat |
| A Fisher, C R Mantione, D J Abraham, I Hani. Long-term central cholinergic hypofunction induced in mice by ethylcholine aziridinium ion (AF64A) in vivo. The Journal of pharmacology and experimental therapeutics. vol 222. issue 1. 1982-08-26. PMID:6896342. |
seven days after a single injection of 65 nmol of af64a i.c.v., there was a significant decrease in acetylcholine content in the cortex, striatum and hippocampus, but no change in choline levels. |
1982-08-26 |
2023-08-12 |
mouse |
| P L Wood, A Péloqui. Increases in choline levels in rat brain elicited by meclofenoxate. Neuropharmacology. vol 21. issue 4. 1982-08-07. PMID:6806676. |
in the hippocampus, this elevation in choline was accompanied by a new elevated steady state level in acetylcholine (ach). |
1982-08-07 |
2023-08-12 |
rat |
| P L Wood, A Péloqui. Increases in choline levels in rat brain elicited by meclofenoxate. Neuropharmacology. vol 21. issue 4. 1982-08-07. PMID:6806676. |
lesions of striatal neurons with kainic acid and of hippocampal cholinergic nerve endings with surgical section of the fimbria indicated that the changes in choline levels were mainly extraneuronal. |
1982-08-07 |
2023-08-12 |
rat |
| N Brunello, D L Cheney, E Cost. Increase in exogenous choline fails to elevate the content or turnover rate of cortical, striatal, or hippocampal acetylcholine. Journal of neurochemistry. vol 38. issue 4. 1982-05-21. PMID:7062035. |
increase in exogenous choline fails to elevate the content or turnover rate of cortical, striatal, or hippocampal acetylcholine. |
1982-05-21 |
2023-08-12 |
rat |
| N Brunello, D L Cheney, E Cost. Increase in exogenous choline fails to elevate the content or turnover rate of cortical, striatal, or hippocampal acetylcholine. Journal of neurochemistry. vol 38. issue 4. 1982-05-21. PMID:7062035. |
the content of choline and acetylcholine and the turnover rate of acetylcholine in striatum, hippocampus, and cerebral cortex were measured following changes in dietary choline, intraperitoneal choline, or intravenous infusion of choline. |
1982-05-21 |
2023-08-12 |
rat |
| N Brunello, D L Cheney, E Cost. Increase in exogenous choline fails to elevate the content or turnover rate of cortical, striatal, or hippocampal acetylcholine. Journal of neurochemistry. vol 38. issue 4. 1982-05-21. PMID:7062035. |
indeed, in hippocampus, choline decreased the turnover rate of acetylcholine. |
1982-05-21 |
2023-08-12 |
rat |
| L A Barker, S D Glick, J P Green, J Khandelwa. Acetylcholine metabolism in the rat hippocampus and striatum following one-trial passive training. Neuropharmacology. vol 21. issue 2. 1982-05-21. PMID:7063112. |
the steady state levels of acetylcholine and choline and the synthesis of acetylcholine in the hippocampus and striatum of rat brain have been determined after one-trial passive avoidance training. |
1982-05-21 |
2023-08-12 |
rat |
| L A Barker, S D Glick, J P Green, J Khandelwa. Acetylcholine metabolism in the rat hippocampus and striatum following one-trial passive training. Neuropharmacology. vol 21. issue 2. 1982-05-21. PMID:7063112. |
steady state levels of acetylcholine and choline were not altered, but the rate of acetylcholine synthesis was significantly elevated in the striatum but not significantly elevated in the hippocampus at one hour after training. |
1982-05-21 |
2023-08-12 |
rat |
| K A Sherman, J E Kuster, R L Dean, R T Bartus, E Friedma. Presynaptic cholinergic mechanisms in brain of aged rats with memory impairments. Neurobiology of aging. vol 2. issue 2. 1982-01-20. PMID:7197758. |
sodium-dependent high affinity choline uptake was found to be decreased by 22% in hippocampus of 23-26 month old animals as compared to 6 month old controls. |
1982-01-20 |
2023-08-12 |
rat |
| K A Sherman, J E Kuster, R L Dean, R T Bartus, E Friedma. Presynaptic cholinergic mechanisms in brain of aged rats with memory impairments. Neurobiology of aging. vol 2. issue 2. 1982-01-20. PMID:7197758. |
prior depolarization of hippocampal or cortical synaptosomes with k+ resulted in stimulation of choline uptake which was similar in aged rats and young controls. |
1982-01-20 |
2023-08-12 |
rat |
| K A Sherman, J E Kuster, R L Dean, R T Bartus, E Friedma. Presynaptic cholinergic mechanisms in brain of aged rats with memory impairments. Neurobiology of aging. vol 2. issue 2. 1982-01-20. PMID:7197758. |
no age-related differences were observed either in hippocampal, cortical, striatal acetylcholine or choline concentrations, or in the activity of choline acetyltransferase in hippocampus. |
1982-01-20 |
2023-08-12 |
rat |
| R T Bartus, R L Dean, K A Sherman, E Friedman, B Bee. Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats. Neurobiology of aging. vol 2. issue 2. 1982-01-20. PMID:7301036. |
animals in each group were tested behaviorally for retention of a one trial passive avoidance task, and biochemically to determine changes in choline and acetylcholine levels in hippocampus, cortex and striatum. |
1982-01-20 |
2023-08-12 |
human |
| R T Bartus, R L Dean, K A Sherman, E Friedman, B Bee. Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats. Neurobiology of aging. vol 2. issue 2. 1982-01-20. PMID:7301036. |
no significant changes following choline administration were observed in the hippocampus. |
1982-01-20 |
2023-08-12 |
human |
| R T Bartus, R L Dean, K A Sherman, E Friedman, B Bee. Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats. Neurobiology of aging. vol 2. issue 2. 1982-01-20. PMID:7301036. |
however, piracetam alone markedly increased choline content in hippocampus (88%) and tended to decrease acetylcholine levels (19%). |
1982-01-20 |
2023-08-12 |
human |
| J J Valdes, C F Mactutus, R N Cory, W R Camero. Lateralization of norepinephrine, serotonin and choline uptake into hippocampal synaptosomes of sinistral rats. Physiology & behavior. vol 27. issue 2. 1982-01-09. PMID:7301970. |
lateralization of norepinephrine, serotonin and choline uptake into hippocampal synaptosomes of sinistral rats. |
1982-01-09 |
2023-08-12 |
rat |
| C Lindamood, B K Colasant. Interaction between impulse-flow and delta 9-tetrahydrocannabinol within the septal-hippocampal cholinergic pathway of rat brain. The Journal of pharmacology and experimental therapeutics. vol 219. issue 2. 1981-12-21. PMID:6270316. |
the role of the cholinergic cell bodies of the medial septum in the transsynaptic reduction of nerve activity elicited by delta 9-tetrahydrocannabinol (thc) in the septal-hippocampal cholinergic pathway was assessed by measuring the ability of delta 9-thc to reduce sodium-dependent high affinity choline uptake in rat hippocampus 2 hr after electrolytic destruction of the cholinergic cell bodies in the septum. |
1981-12-21 |
2023-08-12 |
rat |
| C Lindamood, B K Colasant. Interaction between impulse-flow and delta 9-tetrahydrocannabinol within the septal-hippocampal cholinergic pathway of rat brain. The Journal of pharmacology and experimental therapeutics. vol 219. issue 2. 1981-12-21. PMID:6270316. |
to test if delta 9-thc required impulse-flow in order to reduce the activity or the septal-hippocampal cholinergic pathway, the ability of delta 9-thc to reduce choline uptake in hippocampus of rats with cingulate bundle transections, another surgical procedure which reduces impulse-flow iun the septal-hippocampal cholinergic pathway, was measured. |
1981-12-21 |
2023-08-12 |
rat |
| C Lindamood, B K Colasant. Interaction between impulse-flow and delta 9-tetrahydrocannabinol within the septal-hippocampal cholinergic pathway of rat brain. The Journal of pharmacology and experimental therapeutics. vol 219. issue 2. 1981-12-21. PMID:6270316. |
in cingulate bundle-transected rats, delta 9-thc did not reduce choline uptake in hippocampus. |
1981-12-21 |
2023-08-12 |
rat |