| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Köppen, J Klein, T Holler, K Löffelhol. Synergistic effect of nicotinamide and choline administration on extracellular choline levels in the brain. The Journal of pharmacology and experimental therapeutics. vol 266. issue 2. 1993-09-17. PMID:8355203. |
in the present study we applied the microdialysis technique to measure the concentration of extracellular choline in the rat hippocampus. |
1993-09-17 |
2023-08-12 |
rat |
| A Köppen, J Klein, T Holler, K Löffelhol. Synergistic effect of nicotinamide and choline administration on extracellular choline levels in the brain. The Journal of pharmacology and experimental therapeutics. vol 266. issue 2. 1993-09-17. PMID:8355203. |
additional experiments demonstrated that neither nicotinamide nor n-methylnicotinamide (100 microm) have an influence on the uptake, metabolism or release of choline in the hippocampal slice preparation. |
1993-09-17 |
2023-08-12 |
rat |
| C G Benishi. Actions of ginsenoside Rb1 on choline uptake in central cholinergic nerve endings. Neurochemistry international. vol 21. issue 1. 1993-06-24. PMID:1338897. |
however, chronic (3 day) administration of rb1 did increase the number of choline uptake sites in the hippocampus, and to a lesser extent in the cortex. |
1993-06-24 |
2023-08-11 |
rat |
| G Guzmán-Godínez, R Schlieb. Effect of kainic acid administration to prepubescent rats on cholinergic markers in selected brain regions of adult rats. Neurochemistry international. vol 21. issue 3. 1993-06-24. PMID:1338902. |
with regard to the hypothesis that cholinergic mechanisms play a crucial role in cognitive processes, m1- and m2-muscarinic acetylcholine receptors, choline acetyltransferase, and high-affinity choline uptake as well as benzodiazepine receptors were studied in selected cortical regions (frontal, temporal, somatosensory, visual, piriform cortex), in amygdala, hippocampus, and in the nucleus basalis of meynert from adult rats, which received at the age of 25 days a single dosage of 11 mg/kg, s.c. kainic acid. |
1993-06-24 |
2023-08-11 |
rat |
| T J Walsh, R W Stackman, D F Emerich, L A Taylo. Intraseptal injection of GABA and benzodiazepine receptor ligands alters high-affinity choline transport in the hippocampus. Brain research bulletin. vol 31. issue 3-4. 1993-06-11. PMID:8387864. |
intraseptal injection of gaba and benzodiazepine receptor ligands alters high-affinity choline transport in the hippocampus. |
1993-06-11 |
2023-08-12 |
rat |
| T J Walsh, R W Stackman, D F Emerich, L A Taylo. Intraseptal injection of GABA and benzodiazepine receptor ligands alters high-affinity choline transport in the hippocampus. Brain research bulletin. vol 31. issue 3-4. 1993-06-11. PMID:8387864. |
injection of gaba and benzodiazepine (bdz) agonists and antagonists into the medial septum produced bidirectional alterations in hippocampal high-affinity choline transport (hacht). |
1993-06-11 |
2023-08-12 |
rat |
| K Toide, M Shinoda, M Takase, K Iwata, H Yoshid. Effects of a novel thyrotropin-releasing hormone analogue, JTP-2942, on extracellular acetylcholine and choline levels in the rat frontal cortex and hippocampus. European journal of pharmacology. vol 233. issue 1. 1993-05-19. PMID:8472746. |
effects of a novel thyrotropin-releasing hormone analogue, jtp-2942, on extracellular acetylcholine and choline levels in the rat frontal cortex and hippocampus. |
1993-05-19 |
2023-08-12 |
rat |
| K Toide, M Shinoda, M Takase, K Iwata, H Yoshid. Effects of a novel thyrotropin-releasing hormone analogue, JTP-2942, on extracellular acetylcholine and choline levels in the rat frontal cortex and hippocampus. European journal of pharmacology. vol 233. issue 1. 1993-05-19. PMID:8472746. |
the effects of a novel thyrotropin-releasing hormone (trh) analogue, n alpha-[(1s,2r)-2-methyl-4-oxocyclopentanecarbonyl]-l-histidyl-l-pr olinamide (jtp-2942) on acetylcholine (ach) release and on the extracellular choline level were investigated in rat frontal cortex and hippocampus by microdialysis, and were compared with effects of trh. |
1993-05-19 |
2023-08-12 |
rat |
| K Toide, M Shinoda, M Takase, K Iwata, H Yoshid. Effects of a novel thyrotropin-releasing hormone analogue, JTP-2942, on extracellular acetylcholine and choline levels in the rat frontal cortex and hippocampus. European journal of pharmacology. vol 233. issue 1. 1993-05-19. PMID:8472746. |
investigation of the effects of jtp-2942 (0.001-1 mm) and trh (1 and 10 mm) on ach release and choline levels when perfused through the dialysis probe revealed that jtp-2942 had a greater effect than trh in both the frontal cortex and the hippocampus. |
1993-05-19 |
2023-08-12 |
rat |
| K Toide, M Shinoda, M Takase, K Iwata, H Yoshid. Effects of a novel thyrotropin-releasing hormone analogue, JTP-2942, on extracellular acetylcholine and choline levels in the rat frontal cortex and hippocampus. European journal of pharmacology. vol 233. issue 1. 1993-05-19. PMID:8472746. |
oral administration of jtp-2942 at a dose of 10 mg/kg markedly and persistently increased the release of ach and at doses of 1-10 mg/kg decreased the extracellular choline level in the frontal cortex and hippocampus. |
1993-05-19 |
2023-08-12 |
rat |
| J C Cassel, B Neufang, C Kelche, H Jeltsch, B E Will, G Hertting, R Jackisc. Effects of grafts containing cholinergic and/or serotonergic neurons on cholinergic, serotonergic and noradrenergic markers in the denervated rat hippocampus. Brain research. vol 604. issue 1-2. 1993-04-26. PMID:7681347. |
six months after grafting, high affinity synaptosomal uptake of choline (hacu) and serotonin (hasu), choline acetyltransferase (chat) activity and, using hplc, the content of serotonin ([5-ht]), 5-hydroxyindolacetic acid ([5-hiaa]) and noradrenaline ([na]) were determined in three rostro-caudal segments of the hippocampus (designated hereafter as the dorsal, the 'middle' and the ventral segments). |
1993-04-26 |
2023-08-12 |
rat |
| G L Dunbar, R J Rylett, B M Schmidt, R C Sinclair, L R William. Hippocampal choline acetyltransferase activity correlates with spatial learning in aged rats. Brain research. vol 604. issue 1-2. 1993-04-26. PMID:8457854. |
the present study assessed spatial learning performance in a water maze task as a function of choline acetyltransferase and high-affinity choline uptake specific activity (the two phenotypic markers for cholinergic neurons) in frontal cortex, hippocampus and striatum of aged male fischer-344 rats. |
1993-04-26 |
2023-08-12 |
rat |
| S Davis, A L Markowska, G L Wenk, C A Barne. Acetyl-L-carnitine: behavioral, electrophysiological, and neurochemical effects. Neurobiology of aging. vol 14. issue 1. 1993-04-12. PMID:8095700. |
after completion of electrophysiological testing, each rat was sacrificed and investigated for age- or drug-related changes in three neurotransmitter markers; including, nmda-sensitive glutamate receptors, high affinity choline uptake, and adenosine receptor number in the neocortex, hippocampus or caudate nucleus. |
1993-04-12 |
2023-08-12 |
rat |
| S Davis, A L Markowska, G L Wenk, C A Barne. Acetyl-L-carnitine: behavioral, electrophysiological, and neurochemical effects. Neurobiology of aging. vol 14. issue 1. 1993-04-12. PMID:8095700. |
induction of hippocampal lte was reduced in 24 mo-ac rats and nmda receptor number and high-affinity choline uptake in the frontal cortex was increased. |
1993-04-12 |
2023-08-12 |
rat |
| K W Lange, F R Wells, P Jenner, C D Marsde. Altered muscarinic and nicotinic receptor densities in cortical and subcortical brain regions in Parkinson's disease. Journal of neurochemistry. vol 60. issue 1. 1993-01-25. PMID:8417140. |
in comparison with control tissues, choline acetyl-transferase activity was reduced in the frontal cortex and hippocampus and unchanged in the caudate nucleus and putamen of parkinsonian patients. |
1993-01-25 |
2023-08-12 |
human |
| T P Durki. GABAergic mediation of indirect transsynaptic control over basal and spatial memory testing-induced activation of septo-hippocampal cholinergic activity in mice. Behavioural brain research. vol 50. issue 1-2. 1993-01-06. PMID:1333220. |
the effects of acute in vivo injections of either muscimol (20-500 ng/0.2 microliter), bicuculline (100 ng-1 micrograms/0.2 microliter) or saline vehicle (0.2 microliter) into the medial septum on septo-hippocampal cholinergic activity were evaluated using measures of hippocampal high affinity choline uptake at 30 min post-injection in two main groups of mice. |
1993-01-06 |
2023-08-11 |
mouse |
| T P Durkin, A Touman. Septo-hippocampal and nBM-cortical cholinergic neurones exhibit differential time-courses of activation as a function of both type and duration of spatial memory testing in mice. Behavioural brain research. vol 50. issue 1-2. 1993-01-06. PMID:1333222. |
cholinergic activity in vivo in the hippocampus or frontal cortex of mice was quantified using measures of sodium-dependent high-affinity choline uptake at two different times (30 s and 15 min) following specific spatial working or reference memory testing in an 8-arm radial maze. |
1993-01-06 |
2023-08-11 |
mouse |
| P A Lapchak, D J Jenden, F Heft. Pharmacological stimulation reveals recombinant human nerve growth factor-induced increases of in vivo hippocampal cholinergic function measured in rats with partial fimbrial transections. Neuroscience. vol 50. issue 4. 1992-12-29. PMID:1448201. |
in animals chronically treated with nerve growth factor, the levels of endogenous choline, endogenous acetylcholine, [2h4]choline and [2h4]acetylcholine accumulated in the hippocampus on the lesioned side were not significantly different from those on the contralateral unlesioned side or from values measured in animals treated with cytochrome c, a control protein. |
1992-12-29 |
2023-08-11 |
human |
| P A Lapchak, D J Jenden, F Heft. Pharmacological stimulation reveals recombinant human nerve growth factor-induced increases of in vivo hippocampal cholinergic function measured in rats with partial fimbrial transections. Neuroscience. vol 50. issue 4. 1992-12-29. PMID:1448201. |
first, in nerve growth factor-treated animals administered the general stimulant pentylenetetrazole (10 mg/kg) 2 min prior to measuring in vivo cholinergic parameters, we observed a significant increase in the hippocampal content of [2h4]choline in both lesioned and unlesioned hippocampi. |
1992-12-29 |
2023-08-11 |
human |
| P A Lapchak, D J Jenden, F Heft. Pharmacological stimulation reveals recombinant human nerve growth factor-induced increases of in vivo hippocampal cholinergic function measured in rats with partial fimbrial transections. Neuroscience. vol 50. issue 4. 1992-12-29. PMID:1448201. |
although chronic recombinant human nerve growth factor treatment induced increases of hippocampal [2h4]choline levels, there were no concomitant increases in the level of [2h4]acetylcholine. |
1992-12-29 |
2023-08-11 |
human |