| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A M Issa, S Gauthier, B Collie. Effects of the phosphatase inhibitors calyculin A and okadaic acid on acetylcholine synthesis and content of rat hippocampal formation. Journal of neurochemistry. vol 66. issue 5. 1997-01-14. PMID:8780019. |
with hippocampal slices, calyculin a (50 nm) and okadaic acid (50 nm) reduced significantly (p < 0.01) the synthesis of [3h]ach from [3h]choline. |
1997-01-14 |
2023-08-12 |
rat |
| A M Issa, S Gauthier, B Collie. Effects of the phosphatase inhibitors calyculin A and okadaic acid on acetylcholine synthesis and content of rat hippocampal formation. Journal of neurochemistry. vol 66. issue 5. 1997-01-14. PMID:8780019. |
both high-affinity and low-affinity [3h]choline uptake by hippocampal synaptosomes were reduced significantly in a concentration-dependent manner in the presence of calyculin a or okadaic acid; these agents reduced vmax values for high- and low-affinity choline uptake (p < 0.01) with no significant change in km values (p > 0.1), indicating a noncompetitive inhibition. |
1997-01-14 |
2023-08-12 |
rat |
| J A Saydoff, R Zacze. Blockade of N- and Q-type Ca2+ channels inhibit K(+)-evoked [3H]acetylcholine release in rat hippocampal slices. Brain research bulletin. vol 40. issue 4. 1997-01-02. PMID:8842414. |
in the present study, we examined the contribution of specific ca2+ channels to k(+)-evoked hippocampal acetylcholine (ach) release using [3h]choline loaded hippocampal slices. |
1997-01-02 |
2023-08-12 |
rat |
| K Kinoshita, K Kawashima, Y Kawashima, I Fukuchi, M Yamamura, Y Matsuok. Effect of TA-0910, a novel thyrotropin-releasing hormone analog, on in vivo acetylcholine release and turnover in rat brain. Japanese journal of pharmacology. vol 71. issue 2. 1996-12-31. PMID:8835640. |
caused a marked dose-dependent increase in extracellular ach levels and a decrease in choline levels in the hippocampus of freely moving rats. |
1996-12-31 |
2023-08-12 |
rat |
| F Amenta, E Bronzetti, A Ricci, S Sagratella, A Scotti de Carolis, D Zacche. Nucleus basalis magnocellularis lesions decrease histochemically reactive zinc stores in the rat brain: effect of choline alphoscerate treatment. European journal of histochemistry : EJH. vol 39. issue 4. 1996-12-13. PMID:8835182. |
treatment with choline alphoscerate, which is a precursor in the biosynthesis of brain phospholipids that increases the bioavailability of acetylcholine in the nervous tissue, restored, in part, the density and pattern of sulphide-silver positive fibres in the fronto-parietal cortex and in the hippocampus. |
1996-12-13 |
2023-08-12 |
rat |
| M Misztal, J Skangiel-Kramska, G Niewiadomska, W Danys. Subchronic intraventricular infusion of quinolinic acid produces working memory impairment--a model of progressive excitotoxicity. Neuropharmacology. vol 35. issue 4. 1996-12-03. PMID:8793907. |
autoradiography in the hippocampus revealed a decrease in [3h]hemicholinium and [3h]quinuclidinyl benzilate (qnb) binding to choline uptake sites and muscarinic receptors respectively. |
1996-12-03 |
2023-08-12 |
Not clear |
| M Misztal, T Frankiewicz, C G Parsons, W Danys. Learning deficits induced by chronic intraventricular infusion of quinolinic acid--protection by MK-801 and memantine. European journal of pharmacology. vol 296. issue 1. 1996-11-06. PMID:8720470. |
autoradiography revealed a decrease in the density of choline uptake sites in the hippocampus. |
1996-11-06 |
2023-08-12 |
Not clear |
| J C Cassel, H Jeltsch, B Neufang, D Lauth, B Szabo, R Jackisc. Downregulation of muscarinic- and 5-HT1B-mediated modulation of [3H]acetylcholine release in hippocampal slices of rats with fimbria-fornix lesions and intrahippocampal grafts of septal origin. Brain research. vol 704. issue 2. 1996-10-31. PMID:8788910. |
between 6.5 and 8 months after grafting, both the [3h]choline accumulation and the electrically evoked [3h]acetylcholine ([3h]ach) release were assessed in hippocampal slices. |
1996-10-31 |
2023-08-12 |
rat |
| Y Cao, K S Wilcox, C E Martin, T L Rachinsky, J Eberwine, M A Dichte. Presence of mRNA for glutamic acid decarboxylase in both excitatory and inhibitory neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 18. 1996-10-24. PMID:8790419. |
hippocampal neurons in culture did not contain mrna for two other neurotransmitter synthesizing enzymes, tyrosine hydroxylase, and choline acetyl transferase. |
1996-10-24 |
2023-08-12 |
Not clear |
| T J Walsh, R M Kelly, K D Dougherty, R W Stackman, R G Wiley, C L Kutsche. Behavioral and neurobiological alterations induced by the immunotoxin 192-IgG-saporin: cholinergic and non-cholinergic effects following i.c.v. injection. Brain research. vol 702. issue 1-2. 1996-10-22. PMID:8846082. |
both doses of 192-saporin produced a 60-80% decrease in high affinity choline transport in the hippocampus and cortex without altering this parameter in the striatum. |
1996-10-22 |
2023-08-12 |
rat |
| T Bessho, K Takashina, R Tabata, C Ohshima, H Chaki, H Yamabe, M Egawa, A Tobe, K Sait. Effect of the novel high affinity choline uptake enhancer 2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b] quinolin-4-yl)acetoamide on deficits of water maze learning in rats. Arzneimittel-Forschung. vol 46. issue 4. 1996-10-16. PMID:8740080. |
mkc-231(10(-10)-10(-6) moll) significantly increased high affinity choline uptake (hacu) when it was incubated with the hippocampal synaptosomes of ethylcholine mustard aziridinium ion (af64a) treated rats, but not of normal rats. |
1996-10-16 |
2023-08-12 |
rat |
| A Köppen, J Klein, B H Schmidt, F J van der Staay, K Löffelhol. Effects of nicotinamide on central cholinergic transmission and on spatial learning in rats. Pharmacology, biochemistry, and behavior. vol 53. issue 4. 1996-09-30. PMID:8801579. |
in the hippocampus, the nicotinamide-induced increase in choline was associated with an increase in the release of acetylcholine under stimulated conditions. |
1996-09-30 |
2023-08-12 |
rat |
| A Iwashita, H Hisajima, Y Notsu, M Okuhar. Effects of basic fibroblast growth factor and ganglioside GM1 on neuronal survival in primary cultures and on eight-arm radial maze task in adult rats following partial fimbria transections. Naunyn-Schmiedeberg's archives of pharmacology. vol 353. issue 3. 1996-08-23. PMID:8692291. |
however, when they were given simultaneously, the number of working memory errors decreased significantly, in spite of no amelioration for hippocampal choline acetyl transferase (chat) depletion. |
1996-08-23 |
2023-08-12 |
rat |
| M Maier, M A Ron, G J Barker, P S Toft. Proton magnetic resonance spectroscopy: an in vivo method of estimating hippocampal neuronal depletion in schizophrenia. Psychological medicine. vol 25. issue 6. 1996-07-11. PMID:8637950. |
two other metabolites, choline and creatine showed bilateral reduction in schizophrenics and these achieved significance in the left hippocampus. |
1996-07-11 |
2023-08-12 |
human |
| H M Vargas, D J Jende. Elevation of cerebrospinal fluid choline levels by nicotinamide involves the enzymatic formation of N1-methylnicotinamide in brain tissue. Life sciences. vol 58. issue 22. 1996-07-10. PMID:8637429. |
csf choline levels peaked 2 hours after nicotinamide administration and were accompanied by increases in striatal, cortical, hippocampal and plasma choline levels. |
1996-07-10 |
2023-08-12 |
rat |
| T G Fong, V Vogelsberg, N H Neff, M Hadjiconstantino. GM1 and NGF synergism on choline acetyltransferase and choline uptake in aged brain. Neurobiology of aging. vol 16. issue 6. 1996-06-14. PMID:8622782. |
in the brain of aged rats high affinity choline uptake (hachu) of the striatum, hippocampus, and frontal cortex is lower than in young rats, while choline acetyltransferase (chat) activity is lower in striatum and frontal cortex. |
1996-06-14 |
2023-08-12 |
rat |
| Z Kristofiková, E Fales, E Majer, J Klaschk. (3H)hemicholinium-3 binding sites in postmortem brains of human patients with Alzheimer's disease and multi-infarct dementia. Experimental gerontology. vol 30. issue 2. 1996-04-03. PMID:8591807. |
(3h)hemicholinium-3 ((3h)hch-3), a potent, selective, and competitive inhibitor of the high-affinity choline uptake process was used for the detection of high-affinity choline carriers in the hippocampus (gyrus parahippocampalis), neocortex (gyrus frontalis medius), and cerebellum (lobulus semilunaris inferior) in autopsy samples of people with alzheimer's disease, multi-infarct dementia and from other psychiatric and nonpsychiatric patients. |
1996-04-03 |
2023-08-12 |
human |
| J C Fowle. Choline substitution for sodium triggers glutamate and adenosine release from rat hippocampal slices. Neuroscience letters. vol 197. issue 2. 1996-02-22. PMID:8552289. |
choline substitution for sodium triggers glutamate and adenosine release from rat hippocampal slices. |
1996-02-22 |
2023-08-12 |
rat |
| J C Fowle. Choline substitution for sodium triggers glutamate and adenosine release from rat hippocampal slices. Neuroscience letters. vol 197. issue 2. 1996-02-22. PMID:8552289. |
substituting choline for sodium resulted in an extracellularly recorded transient depolarization and increased efflux of glutamate and adenosine from rat hippocampal slices. |
1996-02-22 |
2023-08-12 |
rat |
| S Rossner, R Schliebs, W Härtig, V Big. 192IGG-saporin-induced selective lesion of cholinergic basal forebrain system: neurochemical effects on cholinergic neurotransmission in rat cerebral cortex and hippocampus. Brain research bulletin. vol 38. issue 4. 1996-02-08. PMID:8535860. |
intracerebroventricular injection of 4 micrograms 192igg-saporin conjugate resulted in a selective loss of cholinergic cells in the basal forebrain nuclei 1 week after application, which was accompanied by decreased activities of choline acetyltransferase and by reduced high-affinity uptake of [3h]choline into cholinergic nerve terminals in the cerebral cortex and hippocampus, as well as by a significant activation of micro- and to a lesser extent of astroglial cells in the hippocampus, but hardly in the cerebral cortex.. |
1996-02-08 |
2023-08-12 |
rat |