| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J M Cermak, T Holler, D A Jackson, J K Blusztaj. Prenatal availability of choline modifies development of the hippocampal cholinergic system. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 12. issue 3. 1998-03-31. PMID:9506479. |
to characterize the neurochemical mechanisms that may mediate this effect, we investigated the development of indices of the cholinergic system in the hippocampus: choline acetyltransferase (chat), acetylcholinesterase (ache), synthesis of acetylcholine (ach) from choline transported by high-affinity choline uptake (hacu), and potassium-evoked ach release. |
1998-03-31 |
2023-08-12 |
rat |
| J M Cermak, T Holler, D A Jackson, J K Blusztaj. Prenatal availability of choline modifies development of the hippocampal cholinergic system. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 12. issue 3. 1998-03-31. PMID:9506479. |
this pattern of changes suggests that the hippocampus of the chd animals is characterized by fast ach recycling and efficient choline reutilization for ach synthesis, presumably to maintain adequate ach release despite the decrease of the ach pool, whereas in the chs animals ach turnover and choline recycling is slower while the evoked release of ach is high. |
1998-03-31 |
2023-08-12 |
rat |
| J M Cermak, T Holler, D A Jackson, J K Blusztaj. Prenatal availability of choline modifies development of the hippocampal cholinergic system. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 12. issue 3. 1998-03-31. PMID:9506479. |
together, the data show a complex adaptive response of the hippocampal cholinergic system to prenatal choline availability and provide a novel example of developmental plasticity in the nervous system governed by the supply of a single nutrient. |
1998-03-31 |
2023-08-12 |
rat |
| N Bourjeily, J B Suszki. Developmental cholinotoxicity of lead: loss of septal cholinergic neurons and long-term changes in cholinergic innervation of the hippocampus in perinatally lead-exposed rats. Brain research. vol 771. issue 2. 1998-01-30. PMID:9401752. |
the effects of perinatal lead exposure on choline acetyltransferase-immunoreactive (chat-ir) cell counts in the medial septum and ache-positive fiber counts in the hippocampus were examined in relation to changes in cholinergic markers in the septohippocampal pathway of the rat. |
1998-01-30 |
2023-08-12 |
rat |
| M Minami, S Kimura, T Endo, N Hamaue, M Hirafuji, H Togashi, M Matsumoto, M Yoshioka, H Saito, S Watanabe, T Kobayashi, H Okuyam. Dietary docosahexaenoic acid increases cerebral acetylcholine levels and improves passive avoidance performance in stroke-prone spontaneously hypertensive rats. Pharmacology, biochemistry, and behavior. vol 58. issue 4. 1998-01-30. PMID:9408223. |
we have recently shown that inferior performance in passive avoidance task is accompanied with decreased hippocampal choline (ch) in stroke-prone spontaneously hypertensive rats (shrsp) compared with normotensive control wistar-kyoto rats (wky). |
1998-01-30 |
2023-08-12 |
rat |
| Z Li, R Yang, Z Che. [Effects of iodine and thyroid hormone deficiency during brain development on activities of cholinergic neurone-related enzymes in central nervous system of rats]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. vol 30. issue 6. 1998-01-20. PMID:9388907. |
to study the effects of iodine and thyroid hormone deficiency during brain development on activities of enzymes of central acetyl choline metabolism, activities of choline acetylcholinetransferase (chat) and acetylcholinesterase (ache) in hippocampus and cerebral cortex, basal forebrain and cerebellum in 20-day-old rats were determined. |
1998-01-20 |
2023-08-12 |
rat |
| J W Simpkins, P S Green, K E Gridley, M Singh, N C de Fiebre, G Rajakuma. Role of estrogen replacement therapy in memory enhancement and the prevention of neuronal loss associated with Alzheimer's disease. The American journal of medicine. vol 103. issue 3A. 1997-11-04. PMID:9344403. |
we demonstrated that ovx causes a decrease in high affinity choline uptake and choline acetyltransferase activity in the hippocampus and frontal cortex; ert reverses this effect. |
1997-11-04 |
2023-08-12 |
human |
| A Köppen, J Klein, C Erb, K Löffelhol. Acetylcholine release and choline availability in rat hippocampus: effects of exogenous choline and nicotinamide. The Journal of pharmacology and experimental therapeutics. vol 282. issue 3. 1997-10-17. PMID:9316819. |
acetylcholine release and choline availability in rat hippocampus: effects of exogenous choline and nicotinamide. |
1997-10-17 |
2023-08-12 |
rat |
| A Köppen, J Klein, C Erb, K Löffelhol. Acetylcholine release and choline availability in rat hippocampus: effects of exogenous choline and nicotinamide. The Journal of pharmacology and experimental therapeutics. vol 282. issue 3. 1997-10-17. PMID:9316819. |
the influence of choline availability on acetylcholine (ach) release in the hippocampus of the awake rat was investigated using the microdialysis procedure. |
1997-10-17 |
2023-08-12 |
rat |
| A Köppen, J Klein, C Erb, K Löffelhol. Acetylcholine release and choline availability in rat hippocampus: effects of exogenous choline and nicotinamide. The Journal of pharmacology and experimental therapeutics. vol 282. issue 3. 1997-10-17. PMID:9316819. |
however, basal release of choline (1.38 pmol/min) and of ach (114 fmol/min) in the hippocampus was slightly increased in choline-supplemented animals (choline: 1.92 pmol/min; ach: 140 fmol/min). |
1997-10-17 |
2023-08-12 |
rat |
| A Köppen, J Klein, C Erb, K Löffelhol. Acetylcholine release and choline availability in rat hippocampus: effects of exogenous choline and nicotinamide. The Journal of pharmacology and experimental therapeutics. vol 282. issue 3. 1997-10-17. PMID:9316819. |
the results clearly demonstrate that, under stimulated conditions, hippocampal ach release could be facilitated when the availability of choline for ach synthesis was enhanced by dietary or pharmacological means. |
1997-10-17 |
2023-08-12 |
rat |
| M Q Holmes-McNary, R Loy, M H Mar, C D Albright, S H Zeise. Apoptosis is induced by choline deficiency in fetal brain and in PC12 cells. Brain research. Developmental brain research. vol 101. issue 1-2. 1997-10-01. PMID:9263575. |
counts of apoptotic bodies in fetal brain slices correlated inversely with choline intake of the mothers (6.2% (p < 0.01), 2.5% and 1.9% of hippocampal cells had apoptotic bodies in fetuses of dams fed the cd, control and cs diets, respectively). |
1997-10-01 |
2023-08-12 |
rat |
| A Pittaluga, A Bonfanti, M Raiter. Differential desensitization of ionotropic non-NMDA receptors having distinct neuronal location and function. Naunyn-Schmiedeberg's archives of pharmacology. vol 356. issue 1. 1997-09-05. PMID:9228187. |
the release of tritium from rat hippocampal synaptosomes prelabeled with [3h]noradrenaline ([3h]na) or [3h]5-hydroxytryptamine ([3h]5-ht) and from rat neocortex synaptosomes prelabeled with [3h]choline and the release of endogenous gaba and glutamate from rat neocortex synaptosomes were monitored during superfusion with media containing varying concentrations of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) or kainic acid. |
1997-09-05 |
2023-08-12 |
rat |
| H Kobayashi, T Watanabe, T Yasufuku, T Suzuki, S Saitoh, K Taken. Effects of systemic administration of 2-(4-phenyl-piperidino)-cyclohexanol (vesamicol) and an organophosphate DDVP on the cholinergic system in brain regions of rats. Brain research bulletin. vol 43. issue 1. 1997-09-04. PMID:9205789. |
to assess the effect of vesamicol in vivo, we examined cholinergic parameters, such as the subcellular distribution of ach, activities of enzymes, uptake of choline, and muscarinic receptor binding in the striatum, hippocampus, and cerebral cortex of rats 30 and 60 min after intraperitoneal injection of vesamicol (3 mg/kg) or of vesamicol in combination with ddvp (5 mg/kg), which was administered 10 min before vasamicol. |
1997-09-04 |
2023-08-12 |
rat |
| N Takagi, K Miyake, T Taguchi, N Sugita, K Takagi, H Tamada, S Take. Changes in cholinergic neurons and failure in learning function after microsphere embolism-induced cerebral ischemia. Brain research bulletin. vol 43. issue 1. 1997-09-04. PMID:9205800. |
in the biochemical study, acetylcholine and choline contents, and choline acetyltransferase activity were measured in the cerebral cortex and hippocampus. |
1997-09-04 |
2023-08-12 |
rat |
| L J Cooke, R J Rylet. Inhibitors of serine/threonine phosphatases increase membrane-bound choline acetyltransferase activity and enhance acetylcholine synthesis. Brain research. vol 751. issue 2. 1997-09-02. PMID:9099809. |
rat hippocampal synaptosomes were treated with either okadaic acid (10 nm) or calyculin-a (50 nm) to inhibit protein phosphatases 1 and 2a for 20 min prior to subfractionation of nerve terminals and measurement of choline acetyltransferase activity, or quantification of high-affinity choline transport and acetylcholine synthesis. |
1997-09-02 |
2023-08-12 |
rat |
| J Klein, S S Chatterjee, K Löffelhol. Phospholipid breakdown and choline release under hypoxic conditions: inhibition by bilobalide, a constituent of Ginkgo biloba. Brain research. vol 755. issue 2. 1997-08-07. PMID:9175905. |
a marked increase of choline release from rat hippocampal slices was observed when the slices were superfused with oxygen-free buffer, indicating hypoxia-induced hydrolysis of choline-containing phospholipids. |
1997-08-07 |
2023-08-12 |
rat |
| P T Wong, L H Neo, W L Teo, H Feng, Y D Xue, W H Lok. Deficits in water escape performance and alterations in hippocampal cholinergic mechanisms associated with neonatal monosodium glutamate treatment in mice. Pharmacology, biochemistry, and behavior. vol 57. issue 1-2. 1997-07-30. PMID:9164598. |
this is strongly supported by the decreased affinity of the sodium-dependent high-affinity choline uptake observed in the hippocampus. |
1997-07-30 |
2023-08-12 |
mouse |
| M M'Harzi, F Willig, C Bardelay, A M Palou, C Oberlande. Effects of RU 52583, an alpha 2-antagonist, on memory in rats with excitotoxic damage to the septal area. Pharmacology, biochemistry, and behavior. vol 56. issue 4. 1997-07-07. PMID:9130290. |
the lesion: a produced significant impairments of the animals' memory performance, b) significantly reduced the sodium-dependent high-affinity choline uptake in the hippocampal formation, and c) deeply disrupted cholinergic hippocampal theta waves. |
1997-07-07 |
2023-08-12 |
rat |
| A Steensgaard, G Ostergaard, C V Jensen, H R Lam, S Topp, O Ladefoged, P Arlien-Søborg, O Henrikse. Effect on the content of n-acetylaspartate, total creatine, choline containing compounds, and lactate in the hippocampus of rats exposed to aromatic white spirit for three weeks measured by NMR spectroscopy. Neurotoxicology. vol 17. issue 3-4. 1997-06-23. PMID:9086502. |
effect on the content of n-acetylaspartate, total creatine, choline containing compounds, and lactate in the hippocampus of rats exposed to aromatic white spirit for three weeks measured by nmr spectroscopy. |
1997-06-23 |
2023-08-12 |
human |