| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Kimur. [Antihypertensive effect of docosahexaenoic acid in stroke-prone spontaneously hypertensive rats]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 120. issue 7. 2000-10-10. PMID:10920715. |
moreover, dha-treated shrsp maintain the normal levels of acetylcholine and choline concentrations in the hippocampus and cerebral cortex. |
2000-10-10 |
2023-08-12 |
rat |
| S Z Ipekoğlu, L Büyükuysal, I H Ulus, E Korfal. Effects of fetal septal grafts on memory and learning performance with hippocampal acetylcholine and choline metabolism in fimbria transected rats. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 2. 2000-09-21. PMID:10847560. |
effects of fetal septal grafts on memory and learning performance with hippocampal acetylcholine and choline metabolism in fimbria transected rats. |
2000-09-21 |
2023-08-12 |
rat |
| S Z Ipekoğlu, L Büyükuysal, I H Ulus, E Korfal. Effects of fetal septal grafts on memory and learning performance with hippocampal acetylcholine and choline metabolism in fimbria transected rats. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 2. 2000-09-21. PMID:10847560. |
six months after grafting, both basal and stimulated acetylcholine (ach) and choline (ch) release and their tissue levels were measured in ipsilateral hippocampal slices. |
2000-09-21 |
2023-08-12 |
rat |
| C D Herzog, C Gandhi, P Bhattacharya, T J Wals. Effects of intraseptal zolpidem and chlordiazepoxide on spatial working memory and high-affinity choline uptake in the hippocampus. Neurobiology of learning and memory. vol 73. issue 2. 2000-05-09. PMID:10704326. |
effects of intraseptal zolpidem and chlordiazepoxide on spatial working memory and high-affinity choline uptake in the hippocampus. |
2000-05-09 |
2023-08-12 |
rat |
| C D Herzog, C Gandhi, P Bhattacharya, T J Wals. Effects of intraseptal zolpidem and chlordiazepoxide on spatial working memory and high-affinity choline uptake in the hippocampus. Neurobiology of learning and memory. vol 73. issue 2. 2000-05-09. PMID:10704326. |
male sprague-dawley rats were cannulated and then artificial csf, chlordiazepoxide (cdp: 8 or 12 microg), or zolpidem (4, 8, or 12 microg) was injected into the ms. spatial working memory was assessed in a delay radial-arm maze task and the activity of cholinergic neurons in the ms was evaluated by high-affinity choline uptake (ha-chu) in the hippocampus. |
2000-05-09 |
2023-08-12 |
rat |
| M Frotscher, I Vida, R Bende. Evidence for the existence of non-GABAergic, cholinergic interneurons in the rodent hippocampus. Neuroscience. vol 96. issue 1. 2000-04-17. PMID:10683406. |
none of the choline acetyltransferase-immunoreactive neurons in the various layers of the hippocampus proper and fascia dentata were found to co-localize glutamate decarboxylase messenger rna. |
2000-04-17 |
2023-08-12 |
Not clear |
| A Zapata, J L Capdevila, R Trulla. Role of high-affinity choline uptake on extracellular choline and acetylcholine evoked by NMDA. Synapse (New York, N.Y.). vol 35. issue 4. 2000-03-13. PMID:10657037. |
despite this reduction of presynaptic cholinergic function, perfusion of nmda (300 microm) by retrodialysis produced an increase in hippocampal extracellular choline (249 +/- 22% of basal levels) that was similar to that observed in sham controls (301 +/- 35%). |
2000-03-13 |
2023-08-12 |
rat |
| O Weichel, M Hilgert, S S Chatterjee, M Lehr, J Klei. Bilobalide, a constituent of Ginkgo biloba, inhibits NMDA-induced phospholipase A2 activation and phospholipid breakdown in rat hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. vol 360. issue 6. 2000-01-28. PMID:10619176. |
in rat hippocampal slices superfused with magnesium-free buffer, glutamate (1 mm) caused the release of large amounts of choline due to phospholipid breakdown. |
2000-01-28 |
2023-08-12 |
rat |
| O Weichel, M Hilgert, S S Chatterjee, M Lehr, J Klei. Bilobalide, a constituent of Ginkgo biloba, inhibits NMDA-induced phospholipase A2 activation and phospholipid breakdown in rat hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. vol 360. issue 6. 2000-01-28. PMID:10619176. |
nmda also caused a release of choline in vivo when infused into the hippocampus of freely moving rats by retrograde dialysis. |
2000-01-28 |
2023-08-12 |
rat |
| J P Jones, W H Meck, C L Williams, W A Wilson, H S Swartzwelde. Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation. Brain research. Developmental brain research. vol 118. issue 1-2. 2000-01-27. PMID:10611515. |
choline availability to the developing rat fetus alters adult hippocampal long-term potentiation. |
2000-01-27 |
2023-08-12 |
rat |
| J P Jones, W H Meck, C L Williams, W A Wilson, H S Swartzwelde. Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation. Brain research. Developmental brain research. vol 118. issue 1-2. 2000-01-27. PMID:10611515. |
to determine if the behavioral effects of choline are related to physiological changes in hippocampus, the effect of perinatal choline supplementation or deficiency on long-term potentiation (ltp) was examined in hippocampal slices of 6-8 and 12-14 month old rats born to dams consuming a control, choline-supplemented, or a choline-free diet during pregnancy. |
2000-01-27 |
2023-08-12 |
rat |
| J P Jones, W H Meck, C L Williams, W A Wilson, H S Swartzwelde. Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation. Brain research. Developmental brain research. vol 118. issue 1-2. 2000-01-27. PMID:10611515. |
results reveal that alterations in the availability of dietary choline during discrete periods of development lead to changes in hippocampal electrophysiology that last well into adulthood. |
2000-01-27 |
2023-08-12 |
rat |
| R H Schmidt, K J Scholten, P H Maugha. Time course for recovery of water maze performance and central cholinergic innervation after fluid percussion injury. Journal of neurotrauma. vol 16. issue 12. 2000-01-20. PMID:10619193. |
synaptosomal choline uptake was significantly decreased by 15-27% in the ipsilateral hippocampus and parietal cortex 3 and 7 days following injury, but not by 3 weeks or thereafter. |
2000-01-20 |
2023-08-12 |
rat |
| R C Tee. The influences of rearing environment and neonatal choline dietary supplementation on spatial learning and memory in adult rats. Behavioural brain research. vol 105. issue 2. 1999-12-15. PMID:10563491. |
in a second experiment, both cr, and neonatal choline treatment facilitated performance on a dswsh radial arm maze (ram) task previously found to be sensitive to hippocampal and/or medial prefrontal lesions. |
1999-12-15 |
2023-08-12 |
rat |
| R C Tees, E Mohammad. The effects of neonatal choline dietary supplementation on adult spatial and configural learning and memory in rats. Developmental psychobiology. vol 35. issue 3. 1999-12-10. PMID:10531535. |
in a second experiment, neonatally treated choline rats performed significantly better than controls in acquiring a visual transverse patterning discrimination task previously found to be sensitive to hippocampal and/or frontal damage. |
1999-12-10 |
2023-08-12 |
rat |
| R Suhr, E Balse, A Haaf, C Kelche, J C Cassel, R Jackisc. Modulation of acetylcholine and 5-hydroxytryptamine release in hippocampal slices of rats with fimbria-fornix lesions and intrahippocampal grafts containing cholinergic and/or serotonergic neurons. Brain research bulletin. vol 50. issue 1. 1999-11-10. PMID:10507467. |
hippocampal slices of these rats (5-9 month after surgery) were preincubated with [3h]choline or [3h]5-ht, superfused continuously (in the presence of hemicholinium-3 or fluvoxamine) and stimulated electrically (360 pulses, 2 ms, 3 hz, 26-28 ma) in order to study the presynaptic modulation of acetylcholine (ach) and serotonin (5-ht) release. |
1999-11-10 |
2023-08-12 |
rat |
| T Ogasawara, Y Itoh, M Tamura, T Mushiroi, Y Ukai, M Kise, K Kimur. Involvement of cholinergic and GABAergic systems in the reversal of memory disruption by NS-105, a cognition enhancer. Pharmacology, biochemistry, and behavior. vol 64. issue 1. 1999-10-21. PMID:10494996. |
furthermore, effects of ns-105 on in vivo release of acetylcholine (ach) in the cerebral cortex, high-affinity choline uptake (hacu) of the cerebral cortex in rats with lesion of nbm, hacu of the hippocampus in rats treated with pentobarbital and activity of choline acetyltransferase (chat) of the cerebral cortex in rats with lesion of nbm were examined. |
1999-10-21 |
2023-08-12 |
rat |
| J M Cermak, J K Blusztajn, W H Meck, C L Williams, C M Fitzgerald, D L Rosene, R Lo. Prenatal availability of choline alters the development of acetylcholinesterase in the rat hippocampus. Developmental neuroscience. vol 21. issue 2. 1999-10-19. PMID:10449981. |
prenatal availability of choline alters the development of acetylcholinesterase in the rat hippocampus. |
1999-10-19 |
2023-08-12 |
rat |
| C D Albright, C B Friedrich, E C Brown, M H Mar, S H Zeise. Maternal dietary choline availability alters mitosis, apoptosis and the localization of TOAD-64 protein in the developing fetal rat septum. Brain research. Developmental brain research. vol 115. issue 2. 1999-09-13. PMID:10407130. |
maternal changes in dietary choline availability alter brain biochemistry and hippocampal development in the offspring resulting in lifelong behavioral changes in the offspring. |
1999-09-13 |
2023-08-12 |
rat |
| C D Albright, C B Friedrich, E C Brown, M H Mar, S H Zeise. Maternal dietary choline availability alters mitosis, apoptosis and the localization of TOAD-64 protein in the developing fetal rat septum. Brain research. Developmental brain research. vol 115. issue 2. 1999-09-13. PMID:10407130. |
these results show that dietary choline availability during pregnancy alters the timing of mitosis, apoptosis and the early commitment to neuronal differentiation by progenitor cells in regions of the fetal brain septum, as well as hippocampus, two brain regions known to be associated with learning and memory. |
1999-09-13 |
2023-08-12 |
rat |