| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R B Gibb. Effects of gonadal hormone replacement on measures of basal forebrain cholinergic function. Neuroscience. vol 101. issue 4. 2001-03-01. PMID:11113342. |
repeated administration of estradiol (2-25 microg/250 g body weight) for two or four weeks, and continuous estrogen administration for four weeks and six months, produced no significant changes in choline acetyltransferase activity or high affinity choline uptake in the hippocampus, frontal cortex or olfactory bulbs. |
2001-03-01 |
2023-08-12 |
rat |
| R B Gibb. Effects of gonadal hormone replacement on measures of basal forebrain cholinergic function. Neuroscience. vol 101. issue 4. 2001-03-01. PMID:11113342. |
continuous estrogen administration for 13 months produced a significant decrease in high affinity choline uptake across all regions with the largest effect (-28.1%) detected in the hippocampus. |
2001-03-01 |
2023-08-12 |
rat |
| Y Yang, Z Liu, J M Cermak, P Tandon, M R Sarkisian, C E Stafstrom, J C Neill, J K Blusztajn, G L Holme. Protective effects of prenatal choline supplementation on seizure-induced memory impairment. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 22. 2001-02-22. PMID:11069978. |
neither the seizures nor the prenatal availability of choline had any effect on hippocampal choline acetyltransferase or acetylcholinesterase activities. |
2001-02-22 |
2023-08-12 |
rat |
| D Montoya, H S Swartzwelde. Prenatal choline supplementation alters hippocampal N-methyl-D-aspartate receptor-mediated neurotransmission in adult rats. Neuroscience letters. vol 296. issue 2-3. 2001-02-15. PMID:11108987. |
prenatal choline supplementation alters hippocampal n-methyl-d-aspartate receptor-mediated neurotransmission in adult rats. |
2001-02-15 |
2023-08-12 |
rat |
| D Montoya, H S Swartzwelde. Prenatal choline supplementation alters hippocampal N-methyl-D-aspartate receptor-mediated neurotransmission in adult rats. Neuroscience letters. vol 296. issue 2-3. 2001-02-15. PMID:11108987. |
manipulation of dietary choline levels in pregnant rats has been shown to result in enduring alterations in memory and hippocampal function of the offspring, but the mechanisms underlying these effects remain unclear. |
2001-02-15 |
2023-08-12 |
rat |
| D Montoya, H S Swartzwelde. Prenatal choline supplementation alters hippocampal N-methyl-D-aspartate receptor-mediated neurotransmission in adult rats. Neuroscience letters. vol 296. issue 2-3. 2001-02-15. PMID:11108987. |
hippocampal slices were prepared from adult rats that were offspring of dams fed control, choline supplemented, or choline deficient diets on days 12-17 of gestation. |
2001-02-15 |
2023-08-12 |
rat |
| R H Schmidt, K J Scholten, P H Maugha. Cognitive impairment and synaptosomal choline uptake in rats following impact acceleration injury. Journal of neurotrauma. vol 17. issue 12. 2001-02-08. PMID:11186227. |
on day 7, choline uptake was determined in synaptosomes from hippocampus, a parietal cortex, and entorhinal cortex. |
2001-02-08 |
2023-08-12 |
rat |
| R H Schmidt, K J Scholten, P H Maugha. Cognitive impairment and synaptosomal choline uptake in rats following impact acceleration injury. Journal of neurotrauma. vol 17. issue 12. 2001-02-08. PMID:11186227. |
there was no change in synaptosomal choline uptake in any of the forebrain regions in the severe injury group, but a slight (14%) decrease in the hippocampus and parietal cortex of the moderate injury group. |
2001-02-08 |
2023-08-12 |
rat |
| P H Maughan, K J Scholten, R H Schmid. Recovery of water maze performance in aged versus young rats after brain injury with the impact acceleration model. Journal of neurotrauma. vol 17. issue 12. 2001-02-08. PMID:11186228. |
no differences were noted in entorhinal cortex or hippocampal choline uptake. |
2001-02-08 |
2023-08-12 |
rat |
| D A Montoya, A M White, C L Williams, J K Blusztajn, W H Meck, H S Swartzwelde. Prenatal choline exposure alters hippocampal responsiveness to cholinergic stimulation in adulthood. Brain research. Developmental brain research. vol 123. issue 1. 2001-01-09. PMID:11020547. |
prenatal choline exposure alters hippocampal responsiveness to cholinergic stimulation in adulthood. |
2001-01-09 |
2023-08-12 |
rat |
| D A Montoya, A M White, C L Williams, J K Blusztajn, W H Meck, H S Swartzwelde. Prenatal choline exposure alters hippocampal responsiveness to cholinergic stimulation in adulthood. Brain research. Developmental brain research. vol 123. issue 1. 2001-01-09. PMID:11020547. |
depending upon the measures assessed, prenatal choline supplementation tends to promote excitatory synaptic efficacy in hippocampal circuits while prenatal choline deficiency diminishes it. |
2001-01-09 |
2023-08-12 |
rat |
| D A Montoya, A M White, C L Williams, J K Blusztajn, W H Meck, H S Swartzwelde. Prenatal choline exposure alters hippocampal responsiveness to cholinergic stimulation in adulthood. Brain research. Developmental brain research. vol 123. issue 1. 2001-01-09. PMID:11020547. |
transverse hippocampal slices were prepared from adult offspring of dams fed choline supplemented, choline deficient, or control diets. |
2001-01-09 |
2023-08-12 |
rat |
| D A Montoya, A M White, C L Williams, J K Blusztajn, W H Meck, H S Swartzwelde. Prenatal choline exposure alters hippocampal responsiveness to cholinergic stimulation in adulthood. Brain research. Developmental brain research. vol 123. issue 1. 2001-01-09. PMID:11020547. |
prenatally choline deficient animals yielded significantly fewer electrophysiological viable hippocampal slices than did animals from either of the other two treatment groups. |
2001-01-09 |
2023-08-12 |
rat |
| D A Montoya, A M White, C L Williams, J K Blusztajn, W H Meck, H S Swartzwelde. Prenatal choline exposure alters hippocampal responsiveness to cholinergic stimulation in adulthood. Brain research. Developmental brain research. vol 123. issue 1. 2001-01-09. PMID:11020547. |
these results suggest that gaba receptor-mediated inhibition remains intact after prenatal choline manipulations, and that enhancement of the excitatory responsiveness of hippocampal circuits in slices from prenatally choline supplemented rats may be related in part to an increase in cholinergic tone within the ca1 circuit. |
2001-01-09 |
2023-08-12 |
rat |
| E Gazyakan, U Disko, A Haaf, B Heimrich, R Jackisc. Postnatal development of opioid receptors modulating acetylcholine release in hippocampus and septum of the rat. Brain research. Developmental brain research. vol 123. issue 2. 2001-01-09. PMID:11042342. |
at any postnatal age, the electrically evoked overflow of tritium from slices preincubated with [(3)h]choline was highest in the db, followed by the ms and the hippocampus. |
2001-01-09 |
2023-08-12 |
rat |
| E X Albuquerque, E F Pereira, A Mike, H M Eisenberg, A Maelicke, M Alkondo. Neuronal nicotinic receptors in synaptic functions in humans and rats: physiological and clinical relevance. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942040. |
the patch-clamp technique was used to record responses triggered by the non-selective agonist ach and the alpha7-nachr-selective agonist choline in interneurons of human cerebral cortical and rat hippocampal slices. |
2001-01-03 |
2023-08-12 |
human |
| S Kimura, H Saito, M Minami, H Togashi, N Nakamura, M Nemoto, H S Parve. Pathogenesis of vascular dementia in stroke-prone spontaneously hypertensive rats. Toxicology. vol 153. issue 1-3. 2001-01-03. PMID:11090955. |
hippocampal levels of acetylcholine and choline in shrsp decreased significantly as compared with those in wky. |
2001-01-03 |
2023-08-12 |
human |
| A Mike, N G Castro, E X Albuquerqu. Choline and acetylcholine have similar kinetic properties of activation and desensitization on the alpha7 nicotinic receptors in rat hippocampal neurons. Brain research. vol 882. issue 1-2. 2000-12-28. PMID:11056195. |
choline and acetylcholine have similar kinetic properties of activation and desensitization on the alpha7 nicotinic receptors in rat hippocampal neurons. |
2000-12-28 |
2023-08-12 |
rat |
| D Braida, M Sal. Cannabinoid-induced working memory impairment is reversed by a second generation cholinesterase inhibitor in rats. Neuroreport. vol 11. issue 9. 2000-12-22. PMID:10884065. |
cannabinoids which impair rat working memory appear to inhibit hippocampal extracellular acetylcholine (ach) release and reduce choline uptake through an interaction with cb1 cannabinoid receptors. |
2000-12-22 |
2023-08-12 |
rat |
| M Maier, J Mellers, B Toone, M Trimble, M A Ro. Schizophrenia, temporal lobe epilepsy and psychosis: an in vivo magnetic resonance spectroscopy and imaging study of the hippocampus/amygdala complex. Psychological medicine. vol 30. issue 3. 2000-11-01. PMID:10883713. |
we have used proton magnetic resonance imaging and spectroscopy to measure hippocampus/amygdala volumes and anterior hippocampal metabolite concentrations (n-acetyl aspartate (naa), creatine/phosphocreatine and choline) in subjects with temporal lobe epilepsy (tle), schizophrenia and in normal controls. |
2000-11-01 |
2023-08-12 |
human |