| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Tang, S Nag, S Y W Shiu, S F Pan. The effects of melatonin and Ginkgo biloba extract on memory loss and choline acetyltransferase activities in the brain of rats infused intracerebroventricularly with beta-amyloid 1-40. Life sciences. vol 71. issue 22. 2002-12-03. PMID:12354581. |
orally administered ginkgo biloba extract, however, partially reversed the memory deficit and the decrease in choline actyltransferase activities in the hippocampus. |
2002-12-03 |
2023-08-12 |
rat |
| Rachel Katz-Brull, Alexei R Koudinov, Hadassa Degan. Choline in the aging brain. Brain research. vol 951. issue 2. 2002-11-25. PMID:12270493. |
the in vitro studies revealed that in the aged cortex and the aged hippocampus the activity of the low-affinity choline uptake increased, possibly compensating for a decrease in the high-affinity uptake activity and the rate of choline diffusion. |
2002-11-25 |
2023-08-12 |
rat |
| Noah J Sandstrom, Rebekah Loy, Christina L William. Prenatal choline supplementation increases NGF levels in the hippocampus and frontal cortex of young and adult rats. Brain research. vol 947. issue 1. 2002-10-21. PMID:12144847. |
prenatal choline supplementation increases ngf levels in the hippocampus and frontal cortex of young and adult rats. |
2002-10-21 |
2023-08-12 |
rat |
| Noah J Sandstrom, Rebekah Loy, Christina L William. Prenatal choline supplementation increases NGF levels in the hippocampus and frontal cortex of young and adult rats. Brain research. vol 947. issue 1. 2002-10-21. PMID:12144847. |
female sprague-dawley rats received approximately 300 mg/kg per day of choline chloride through their drinking water on days 11 of pregnancy through birth and the level of nerve growth factor (ngf) in the hippocampus and frontal cortex of their male offspring was measured at 20 and 90 days of age. |
2002-10-21 |
2023-08-12 |
rat |
| Noah J Sandstrom, Rebekah Loy, Christina L William. Prenatal choline supplementation increases NGF levels in the hippocampus and frontal cortex of young and adult rats. Brain research. vol 947. issue 1. 2002-10-21. PMID:12144847. |
prenatal choline supplementation caused significant increases in hippocampal ngf levels at 20 and 90 days of age, while levels of ngf in the frontal cortex were elevated in choline-supplemented rats at 20 days of age, but not 90 days of age. |
2002-10-21 |
2023-08-12 |
rat |
| H Terasawa, T Hirai, T Ninomiya, Y Ikeda, T Ishijima, T Yajima, N Hamaue, Y Nagase, Y Kang, M Minam. Influence of tooth-loss and concomitant masticatory alterations on cholinergic neurons in rats: immunohistochemical and biochemical studies. Neuroscience research. vol 43. issue 4. 2002-10-10. PMID:12135780. |
biochemical assay showed no statistically significant differences in choline concentrations in the hippocampus between the control and the molar crown-less group both at 15 and at 35 weeks post-treatment. |
2002-10-10 |
2023-08-12 |
rat |
| N S L Perry, P J Houghton, P Jenner, A Keith, E K Perr. Salvia lavandulaefolia essential oil inhibits cholinesterase in vivo. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 9. issue 1. 2002-09-25. PMID:11926204. |
choline esterase activity was measured post mortem in three areas of the brain, both in the absence and presence of tepp, a specific butylcholine esterase inhibitor, and was found to be significantly reduced in the striatum with both doses and also in the hippocampus at the higher dose. |
2002-09-25 |
2023-08-12 |
rat |
| C Weis, W A Kaufmann, C Humpe. Lipid-mediated in vivo gene transfer replaces the loss of choline acetyltransferase activity after unilateral fimbria-fornix aspiration. Cell transplantation. vol 10. issue 8. 2002-09-05. PMID:11814110. |
in conclusion, our data provide evidence that lipid-mediated gene transfer using fugene is a useful tool to replace loss of choline acetyltranseferase activity in the hippocampus after fimbria-fornix aspiration; however, the lack of good gene transfer efficiency and the transient nature of expression limit its use for clinical applications. |
2002-09-05 |
2023-08-12 |
Not clear |
| G J Blatt, C M Fitzgerald, J T Guptill, A B Booker, T L Kemper, M L Bauma. Density and distribution of hippocampal neurotransmitter receptors in autism: an autoradiographic study. Journal of autism and developmental disorders. vol 31. issue 6. 2002-07-16. PMID:11814263. |
in contrast, the density and distribution of the other six receptors studied (3[h]-80h-dpat labeled 5-ht1a receptors, 3[h]-ketanserin labeled 5-ht2 receptors, 3[h]-pirenzepine labled m1 receptors, 3[h]-hemicholinium labeled high affinity choline uptake sites, 3[h]-mk801 labeled nmda receptors, and 3[h]-kainate labeled kainate receptors) in the hippocampus did not demonstrate any statistically significant differences in binding. |
2002-07-16 |
2023-08-12 |
Not clear |
| Anja Birthelmer, Esther Dommes, Hélène Jeltsch, Jean-Christophe Cassel, Rolf Jackisc. Septal grafts and evoked acetylcholine release in the rat hippocampus after 192 IgG-saporin lesions. Neuroreport. vol 13. issue 7. 2002-07-16. PMID:12004202. |
between 6 and 10 months later, we assessed baseline and electrically-evoked release of tritium in hippocampal slices preloaded with [(3)h]choline, and the uptake of [(3)h]choline, [(3)h]noradrenaline and [(3)h]serotonin by hippocampal synaptosomes. |
2002-07-16 |
2023-08-12 |
rat |
| Anja Birthelmer, Esther Dommes, Hélène Jeltsch, Jean-Christophe Cassel, Rolf Jackisc. Septal grafts and evoked acetylcholine release in the rat hippocampus after 192 IgG-saporin lesions. Neuroreport. vol 13. issue 7. 2002-07-16. PMID:12004202. |
the lesions reduced the accumulation of [(3)h]choline by approximately 40%, the evoked release of [(3)h]acetylcholine by approximately 90%, and the uptake of [(3)h]choline by synaptosomes by 90% in the dorsal hippocampus, but increased the relative baseline release of [(3)h]choline by +43%, and the synaptosomal uptake of [(3)h]noradrenaline (66%) and [(3)h]serotonin (58%) in the ventral hippocampus. |
2002-07-16 |
2023-08-12 |
rat |
| Gregory L Holmes, Yili Yang, Zhao Liu, Jennifer M Cermak, Matthew R Sarkisian, Carl E Stafstrom, John C Neill, Jan K Blusztaj. Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus. Epilepsy research. vol 48. issue 1-2. 2002-04-02. PMID:11823105. |
moreover, the activity of hippocampal choline acetyltransferase was 18% lower in the choline deficient animals as compared with the other two groups. |
2002-04-02 |
2023-08-12 |
rat |
| Y Avraham, S Hao, S Mendelson, O Bonne, E M Berr. Diet restriction in mice causes a decrease in hippocampal choline uptake and muscarinic receptors that is restored by administration of tyrosine: interaction between cholinergic and adrenergic receptors influencing cognitive function. Nutritional neuroscience. vol 4. issue 2. 2002-03-19. PMID:11842883. |
diet restriction in mice causes a decrease in hippocampal choline uptake and muscarinic receptors that is restored by administration of tyrosine: interaction between cholinergic and adrenergic receptors influencing cognitive function. |
2002-03-19 |
2023-08-12 |
mouse |
| A Savas, P C Warnke, T Ginap, T J Feuerstein, C B Osterta. The effects of continuous and single-dose radiation on choline uptake in organotypic tissue slice cultures of rabbit hippocampus. Neurological research. vol 23. issue 6. 2002-02-27. PMID:11547941. |
the effects of continuous and single-dose radiation on choline uptake in organotypic tissue slice cultures of rabbit hippocampus. |
2002-02-27 |
2023-08-12 |
rabbit |
| A Savas, P C Warnke, T Ginap, T J Feuerstein, C B Osterta. The effects of continuous and single-dose radiation on choline uptake in organotypic tissue slice cultures of rabbit hippocampus. Neurological research. vol 23. issue 6. 2002-02-27. PMID:11547941. |
transverse slices of hippocampus were dynamically incubated in a cerebrospinal fluid-like culture medium for 72 h. to study the changes in choline uptake longitudinally, the slice cultures were processed with 0.1 microm [3h]-choline, and tritium accumulation was counted. |
2002-02-27 |
2023-08-12 |
rabbit |
| A Savas, P C Warnke, T Ginap, T J Feuerstein, C B Osterta. The effects of continuous and single-dose radiation on choline uptake in organotypic tissue slice cultures of rabbit hippocampus. Neurological research. vol 23. issue 6. 2002-02-27. PMID:11547941. |
these results demonstrate that the delivery of continuous but relatively low-dose rate gamma irradiation is more efficacious than single high-dose external irradiation on high-affinity choline uptake in hippocampal nervous tissue. |
2002-02-27 |
2023-08-12 |
rabbit |
| A Nakamura, Y Suzuki, H Umegaki, H Ikari, T Tajima, H Endo, A Iguch. Dietary restriction of choline reduces hippocampal acetylcholine release in rats: in vivo microdialysis study. Brain research bulletin. vol 56. issue 6. 2002-02-27. PMID:11786247. |
dietary restriction of choline reduces hippocampal acetylcholine release in rats: in vivo microdialysis study. |
2002-02-27 |
2023-08-12 |
rat |
| A Nakamura, Y Suzuki, H Umegaki, H Ikari, T Tajima, H Endo, A Iguch. Dietary restriction of choline reduces hippocampal acetylcholine release in rats: in vivo microdialysis study. Brain research bulletin. vol 56. issue 6. 2002-02-27. PMID:11786247. |
from the results of our study, we speculate that long-term dietary restriction of choline can affect extra- and intracellular sources of substrates required for acetylcholine synthesis, and eventually limit the ability to release acetylcholine in the hippocampus. |
2002-02-27 |
2023-08-12 |
rat |
| A Nakamura, Y Suzuki, H Umegaki, H Ikari, T Tajima, H Endo, A Iguch. Dietary restriction of choline reduces hippocampal acetylcholine release in rats: in vivo microdialysis study. Brain research bulletin. vol 56. issue 6. 2002-02-27. PMID:11786247. |
the vulnerability of the mechanism in the hippocampus to dietary choline restriction is indicated by impaired mnemonic performance we observed. |
2002-02-27 |
2023-08-12 |
rat |
| M Alkondon, E X Albuquerqu. Nicotinic acetylcholine receptor alpha7 and alpha4beta2 subtypes differentially control GABAergic input to CA1 neurons in rat hippocampus. Journal of neurophysiology. vol 86. issue 6. 2002-01-28. PMID:11731559. |
using whole cell patch-clamp recording and post hoc identification of neuronal types in rat hippocampal slices, we show that brief (12-s) nachr activation by ach (1 mm) or choline (10 mm) enhances the frequency of gabaergic pscs in both pyramidal neurons and ca1 interneurons. |
2002-01-28 |
2023-08-12 |
rat |