| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V Blanchard, R Raisman-Vozari, S Vyas, P P Michel, F Javoy-Agid, G Uhl, Y Agi. Differential expression of tyrosine hydroxylase and membrane dopamine transporter genes in subpopulations of dopaminergic neurons of the rat mesencephalon. Brain research. Molecular brain research. vol 22. issue 1-4. 1994-07-25. PMID:7912404. |
neuronal dopamine concentration is regulated in large part by tyrosine hydroxylase (th), the rate-limiting enzyme of dopamine synthesis, and by the dopamine reuptake system. |
1994-07-25 |
2023-08-12 |
rat |
| J M Desce, G Godeheu, T Galli, J Glowinski, A Chéram. Opposite presynaptic regulations by glutamate through NMDA receptors of dopamine synthesis and release in rat striatal synaptosomes. Brain research. vol 640. issue 1-2. 1994-07-21. PMID:7911726. |
it is proposed that both an activation of a cyclic nucleotide phosphodiesterase and a dephosphorylation of tyrosine hydroxylase linked to the influx of calcium through nmda receptors is responsible for the inhibition of dopamine synthesis by glutamate and that calcineurin could play a critical role in these processes. |
1994-07-21 |
2023-08-12 |
rat |
| W Maruyama, M Nao. Inhibition of tyrosine hydroxylase by a dopamine neurotoxin, 1-methyl-4-phenylpyridinium ion: depletion of allostery to the biopterin cofactor. Life sciences. vol 55. issue 3. 1994-07-19. PMID:7911964. |
inhibition of tyrosine hydroxylase by a dopamine neurotoxin, 1-methyl-4-phenylpyridinium ion: depletion of allostery to the biopterin cofactor. |
1994-07-19 |
2023-08-12 |
human |
| J Nguyen-Legros, M Krieger, A Simo. Immunohistochemical localization of L-dopa and aromatic L-amino acid-decarboxylase in the rat retina. Investigative ophthalmology & visual science. vol 35. issue 7. 1994-07-11. PMID:8206708. |
the purpose of this study was threefold: to determine if some catecholaminergic amacrine cells of the rat retina use l-dopa as their neurotransmitter, especially the small (2ca) cells that are immunoreactive to tyrosine hydroxylase but not to dopamine; to understand better the possible existence of serotoninergic cells in the rat retina; and to clarify the role of serotonin in the metabolism of melatonin. |
1994-07-11 |
2023-08-12 |
rat |
| S Roder, J Ciriell. Collateral axonal projections to limbic structures from ventrolateral medullary A1 noradrenergic neurons. Brain research. vol 638. issue 1-2. 1994-07-07. PMID:7515319. |
brainstem sections were then processed immunohistochemically for the identification of cell bodies containing the catecholamine biosynthetic enzymes tyrosine hydroxylase, dopamine beta-hydroxylase (dbh) or phenylethanolamine-n-methyltransferase (pnmt). |
1994-07-07 |
2023-08-12 |
rat |
| G Jotwani, K Itoh, S Wadhw. Immunohistochemical localization of tyrosine hydroxylase, substance P, neuropeptide-Y and leucine-enkephalin in developing human retinal amacrine cells. Brain research. Developmental brain research. vol 77. issue 2. 1994-06-09. PMID:7513625. |
prenatal changes in the neurotransmitter/neuromodulator profiles of tyrosine hydroxylase (for dopamine), substance p, neuropeptide y, and leucine-enkephalin were studied in developing human retinal amacrine cells by the use of immunohistochemical techniques. |
1994-06-09 |
2023-08-12 |
human |
| H Tsukada, K J Lindner, P Hartvig, B Långströ. Effect of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin on the extracellular levels of dopamine and serotonin in the rat striatum: a microdialysis study with tyrosine or tryptophan infusion. Brain research. vol 635. issue 1-2. 1994-06-09. PMID:7909718. |
the in vivo measurement of dopa accumulation during nsd 1015 perfusion suggests that the enhancement of dopamine concentration in ecf induced by tyrosine infusion and 6r-bh4 might be attributable to an increase in tyrosine hydroxylase activity in striatum. |
1994-06-09 |
2023-08-12 |
rat |
| A de Bartolomeis, M C Austin, G A Goodwin, L P Spear, D Pickar, J N Crawle. Dopaminergic and peptidergic mRNA levels in juvenile rat brain after prenatal cocaine treatment. Brain research. Molecular brain research. vol 21. issue 3-4. 1994-06-01. PMID:7909578. |
levels of mrna for the dopamine transporter, tyrosine hydroxylase, cholecystokinin, d1 and d2 dopamine receptors and enkephalin were quantitated in relevant dopaminergic regions of forebrain and midbrain of offspring that were sacrificed on postnatal day 21. |
1994-06-01 |
2023-08-12 |
rat |
| A de Bartolomeis, M C Austin, G A Goodwin, L P Spear, D Pickar, J N Crawle. Dopaminergic and peptidergic mRNA levels in juvenile rat brain after prenatal cocaine treatment. Brain research. Molecular brain research. vol 21. issue 3-4. 1994-06-01. PMID:7909578. |
in the present animal model, cocaine exposure in utero had no significant effect on mrna levels of the dopamine transporter, d1 or d2 dopamine receptors, enkephalin, tyrosine hydroxylase, or cholecystokinin in juvenile rats. |
1994-06-01 |
2023-08-12 |
rat |
| P M Groves, J C Linder, S J Youn. 5-hydroxydopamine-labeled dopaminergic axons: three-dimensional reconstructions of axons, synapses and postsynaptic targets in rat neostriatum. Neuroscience. vol 58. issue 3. 1994-06-01. PMID:8170539. |
in contrast, recent studies using tyrosine hydroxylase or dopamine antibody techniques indicate that presumed dopaminergic axons form small symmetric contacts. |
1994-06-01 |
2023-08-12 |
rat |
| C J Phelps, M Y Vaccarella, M I Romero, D L Hurle. Postnatal reduction in number of hypothalamic tuberoinfundibular dopaminergic neurons in prolactin-deficient dwarf mice. Neuroendocrinology. vol 59. issue 3. 1994-05-19. PMID:7909141. |
accompanying this pituitary deficiency is a marked reduction of dopamine (da) and its rate-limiting synthetic enzyme tyrosine hydroxylase (th) in prl-regulating tuberoinfundibular hypothalamic neurons. |
1994-05-19 |
2023-08-12 |
mouse |
| S Kikuchi, S U Ki. Glutamate neurotoxicity in mesencephalic dopaminergic neurons in culture. Journal of neuroscience research. vol 36. issue 5. 1994-04-29. PMID:7908339. |
cultures were exposed to glutamate for 10 min and evaluated for glutamate neurotoxicity (gnt) 18-24 hr later by tyrosine hydroxylase (th) immunostaining, microtubule associated protein-2 (map2) immunostaining, and radiolabeled dopamine uptake assay. |
1994-04-29 |
2023-08-12 |
mouse |
| M Akil, D A Lewi. The dopaminergic innervation of monkey entorhinal cortex. Cerebral cortex (New York, N.Y. : 1991). vol 3. issue 6. 1994-04-26. PMID:7907902. |
in this study, immunohistochemical methods and antibodies directed against tyrosine hydroxylase (th) and dopamine were used to determine the organization of da axons in the erc of macaque monkeys. |
1994-04-26 |
2023-08-12 |
monkey |
| L J Freedman, M D Cassel. Distribution of dopaminergic fibers in the central division of the extended amygdala of the rat. Brain research. vol 633. issue 1-2. 1994-04-25. PMID:7511034. |
the distribution of dopaminergic fibers in the principal components of the central extended amygdala (central amygdaloid nucleus (ce), substantia innominata, and bed nucleus of the stria terminalis (bnst)), was studied using immunocytochemistry against tyrosine hydroxylase, dopamine beta-hydroxylase and dopamine. |
1994-04-25 |
2023-08-12 |
rat |
| G Nikkhah, M G Cunningham, A Jödicke, U Knappe, A Björklun. Improved graft survival and striatal reinnervation by microtransplantation of fetal nigral cell suspensions in the rat Parkinson model. Brain research. vol 633. issue 1-2. 1994-04-25. PMID:7907929. |
dopamine neuron survival (as assessed by tyrosine hydroxylase immunohistochemistry at 4 months after transplantation) was 2.8-fold greater in the micro grafts as compared to the macro grafts. |
1994-04-25 |
2023-08-12 |
rat |
| G M Seigel, F Junn, D M Gas. Neurotrophic effects of amnion explants co-cultured with rat mesencephalon. Brain research. Developmental brain research. vol 77. issue 1. 1994-04-19. PMID:7907534. |
tyrosine hydroxylase immunocytochemistry, western immunoblot and [3h]dopamine uptake studies revealed significant neurotrophic effects on e14m dopaminergic neurons over 14 days in culture. |
1994-04-19 |
2023-08-12 |
rat |
| C L Barr, J L Kennedy, J B Lichter, H H Van Tol, L Wetterberg, K J Livak, K K Kid. Alleles at the dopamine D4 receptor locus do not contribute to the genetic susceptibility to schizophrenia in a large Swedish kindred. American journal of medical genetics. vol 48. issue 4. 1994-04-18. PMID:8135305. |
linkage to schizophrenia was tested by linkage analyses of 6 polymorphic markers (at 4 loci) in chromosome 11p15.5 including the dopamine d4 receptor (drd4) and the tyrosine hydroxylase (th) loci. |
1994-04-18 |
2023-08-12 |
Not clear |
| K Akiyama, K Yabe, D Suto. Quantitative immunohistochemical distributions of tyrosine hydroxylase and calmodulin in the brains of spontaneously hypertensive rats. The Kitasato archives of experimental medicine. vol 65. issue 4. 1994-04-07. PMID:1364239. |
combining this finding and our previous reports, we also suggest that the lower dopamine levels seen in the neostriatum and nucleus accumbens regions of shr may result from the decrease in tyrosine hydroxylase and/or calmodulin levels in these regions in addition to the abnormality of calcium metabolism, and low levels of dopamine may produce an increase in blood pressure through functions of cerebral dopaminergic neurons and peripheral sympathetic nerves. |
1994-04-07 |
2023-08-11 |
rat |
| H A Jinnah, B E Wojcik, M Hunt, N Narang, K Y Lee, M Goldstein, J K Wamsley, P J Langlais, T Friedman. Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 3 Pt 1. 1994-04-07. PMID:7509865. |
the decrease in dopamine was accompanied by a decrease in tyrosine hydroxylase (th) activity, the rate-limiting step in dopamine synthesis. |
1994-04-07 |
2023-08-12 |
mouse |
| W M Duan, H Widner, A Björklund, P Brundi. Sequential intrastriatal grafting of allogeneic embryonic dopamine-rich neuronal tissue in adult rats: will the second graft be rejected? Neuroscience. vol 57. issue 2. 1994-03-29. PMID:7906872. |
tyrosine hydroxylase immunocytochemistry was used to assess dopamine cell survival and graft size. |
1994-03-29 |
2023-08-12 |
rat |