| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A G Panayiotou, E Kamilari, M Griffin, T Tyllis, N Georgiou, D Bond, D Hoppensteadt, J Fareed, A Nicolaide. Association between serum levels of pro-metalloproteinase 1, tissue inhibitor of metalloproteinases 1 and 2 and prevalent cardiovascular disease in a population-based study. International angiology : a journal of the International Union of Angiology. vol 32. issue 6. 2014-07-01. PMID:24212294. |
the aim of the study was to test the association between circulating levels of matrix prometalloproteinase1 (pro-mmp1) and its tissue inhibitors timp1 and timp2 with prevalent cardiovascular events. |
2014-07-01 |
2023-08-12 |
Not clear |
| Myoung-Gwi Ryou, Gourav Roy Choudhury, Ali Winters, Luokun Xie, Robert T Mallet, Shao-Hua Yan. Pyruvate minimizes rtPA toxicity from in vitro oxygen-glucose deprivation and reoxygenation. Brain research. vol 1530. 2014-04-23. PMID:23891792. |
measured variables included cellular viability (calcein am and annexin-v/propidium iodide), reactive oxygen species (ros; mitosox red and 2',7'-dichlorofluorescein diacetate), nadph, nadp(+) and atp contents (spectrophotometry), matrix metalloproteinase-2 (mmp2) activities (gelatin zymography), and cellular contents of mmp2, tissue inhibitor of metalloproteinase-2 (timp2), and phosphor-activation of anti-apoptotic p70s6 kinase, akt and erk (immunoblot). |
2014-04-23 |
2023-08-12 |
Not clear |
| Elena Ioana Braicu, Khayal Gasimli, Rolf Richter, Mani Nassir, Sherko Kümmel, Jens-Uwe Blohmer, Isil Yalcinkaya, Radoslav Chekerov, Iulia Ignat, Andra Ionescu, Monika Mentze, Christina Fotopoulou, Carmen Pop, Werner Lichtenegger, Jalid Sehoul. Role of serum VEGFA, TIMP2, MMP2 and MMP9 in monitoring response to adjuvant radiochemotherapy in patients with primary cervical cancer--results of a companion protocol of the randomized NOGGO-AGO phase III clinical trial. Anticancer research. vol 34. issue 1. 2014-03-25. PMID:24403492. |
the aim of the current study was to analyze the type of variations in expression profiles of matrix metalloproteinase 2 (mmp2), matrix metalloproteinase 9 (mmp9), tissue inhibitor of metalloproteinase 2 (timp2), and vascular endothelial growth factor a (vegfa) before and after radiochemotherapy in patients with locally advanced figo stage ib-iib cervical cancer. |
2014-03-25 |
2023-08-12 |
Not clear |
| Diego Crespo, Kousik Pramanick, Frederick W Goetz, Josep V Plana. Luteinizing hormone stimulation of in vitro ovulation in brook trout (Salvelinus fontinalis) involves follicle contraction and activation of proteolytic genes. General and comparative endocrinology. vol 188. 2014-01-17. PMID:23500674. |
interestingly, the expression of tissue inhibitor of matrix metalloproteinase 2 (timp2), a known regulator of mmp2 activity, paralleled that of mmp2, suggesting the existence of a controlled mechanism of mmp2 action. |
2014-01-17 |
2023-08-12 |
Not clear |
| Xiao-bao Jin, Han-fang Mei, Qiao-hong Pu, Juan Shen, Xue-mei Lu, Fu-jiang Chu, Jia-yong Zh. Effects of Musca domestica cecropin on the adhesion and migration of human hepatocellular carcinoma BEL-7402 cells. Biological & pharmaceutical bulletin. vol 36. issue 6. 2014-01-07. PMID:23502934. |
western blotting and quantitative polymerase chain reaction (qpcr) were carried out to determine the expression levels of proteins related to adhesion and migration, such as matrix metalloproteinase-2 (mmp2), tissue inhibitors of metalloproteinase-2 (timp2), and epithelial cadherin (e-cadherin). |
2014-01-07 |
2023-08-12 |
human |
| Giovanni Luca Gravina, Andrea Mancini, Guido Ranieri, Boris Di Pasquale, Francesco Marampon, Luigi Di Clemente, Enrico Ricevuto, Claudio Festucci. Phenotypic characterization of human prostatic stromal cells in primary cultures derived from human tissue samples. International journal of oncology. vol 42. issue 6. 2013-12-23. PMID:23589051. |
timp1, timp2 and timp3 were secreted in elevated amounts in the bph- compared to the pca-derived stromal cultures, suggesting the differential regulation of extracellular matrix (ecm) degradation. |
2013-12-23 |
2023-08-12 |
human |
| Fuxin Yi, Weimin Ni, Wenda Liu, Xiaodong Pan, Xiubin Han, Lei Yang, Xiangquan Kong, Rui Ma, Rui Chan. SPAG9 is overexpressed in human astrocytoma and promotes cell proliferation and invasion. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 5. 2013-11-26. PMID:23696027. |
in addition, mrna and protein levels of matrix metallopeptidase 9 (mmp9) were downregulated, while the levels of tissue inhibitor of metalloproteinase 1 (timp1) and timp2 were not changed, indicating that spag9 might regulate invasion through mmp9. |
2013-11-26 |
2023-08-12 |
human |
| Yiyu He, Xiaoya Zhou, Xiaoxin Zheng, Xuejun Jian. Exogenous high-mobility group box 1 protein prevents postinfarction adverse myocardial remodeling through TGF-β/Smad signaling pathway. Journal of cellular biochemistry. vol 114. issue 7. 2013-10-29. PMID:23355476. |
the expressions of collagen i, collagen iii, and tissue inhibitor of metalloproteinase 2 (timp2) were also decreased, while the matrix metalloproteinases 2 (mmp2) and mmp9 expressions were upregulated by hmgb1 injection (p < 0.05) compared with control group. |
2013-10-29 |
2023-08-12 |
rat |
| Ji-Hong Shi, Hao Guan, Shan Shi, Wei-Xia Cai, Xiao-Zhi Bai, Xiao-Long Hu, Xiao-Bin Fang, Jia-Qi Liu, Ke Tao, Xiong-Xiang Zhu, Chao-Wu Tang, Da-Hai H. Protection against TGF-β1-induced fibrosis effects of IL-10 on dermal fibroblasts and its potential therapeutics for the reduction of skin scarring. Archives of dermatological research. vol 305. issue 4. 2013-10-22. PMID:23321694. |
in this study, human dermal fibroblasts stimulated with tgf-β1 were treated with il-10 to analyze the mrna and some of proteins' expression levels of type i collagen (col1), type iii collagen (col3), alpha-smooth muscle actin (α-sma), matrix metalloproteinase-1 (mmp1), mmp2, mmp8 and tissue inhibitor of metalloproteinase 1 (timp1), timp2 by real-time pcr and western blot, to observe α-sma-positive fibroblasts by immunocytochemistry. |
2013-10-22 |
2023-08-12 |
human |
| Jinghua Peng, Xuemei Li, Qin Feng, Liang Chen, Lili Xu, Yiyang H. Anti-fibrotic effect of Cordyceps sinensis polysaccharide: Inhibiting HSC activation, TGF-β1/Smad signalling, MMPs and TIMPs. Experimental biology and medicine (Maywood, N.J.). vol 238. issue 6. 2013-10-17. PMID:23918878. |
in the present study, the effects of cs-ps on hepatic stellate cell (hsc) activation, transforming growth factor-β1 (tgf-β1)/smad pathway, as well as matrix metalloproteinase (mmp) 2, mmp9 and tissue inhibitor of metalloproteinase (timp) 1, timp2, were investigated in liver fibrosis in rats induced by carbon tetrachloride (ccl4). |
2013-10-17 |
2023-08-12 |
rat |
| Yinmei Dai, Wei Xia, Tao Song, Xueting Su, Jie Li, Shaohua Li, Ying Chen, Wei Wang, Hongmei Ding, Xuemei Liu, Hui Li, Qiang Zhao, Ningsheng Sha. MicroRNA-200b is overexpressed in endometrial adenocarcinomas and enhances MMP2 activity by downregulating TIMP2 in human endometrial cancer cell line HEC-1A cells. Nucleic acid therapeutics. vol 23. issue 1. 2013-09-06. PMID:23205572. |
using reverse gelatin zymography, we showed that mir-200b enhances matrix metallopeptidase 2 (mmp2) activity by downregulating timp2 expression in hec-1a cells. |
2013-09-06 |
2023-08-12 |
human |
| Xiu-Feng Wang, Jia Du, Tian-Ling Zhang, Qian-Mei Zhou, Yi-Yu Lu, Hui Zhang, Shi-Bing S. Inhibitory Effects of PC-SPESII Herbal Extract on Human Breast Cancer Metastasis. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-07-23. PMID:23878609. |
western blot analysis of whole-cell extracts revealed that the levels of proteolytic proteins associated with matrix and base membrane degradation (mmp-2, mmp-9, and upa) were decreased and the levels of their endogenous inhibitors (timp1 and timp2) were increased. |
2013-07-23 |
2023-08-12 |
human |
| Aleksandar Sokolović, Carlos M Rodriguez-Ortigosa, Lysbeth Ten Bloemendaal, Ronald P J Oude Elferink, Jesús Prieto, Piter J Bosm. Insulin-like growth factor 1 enhances bile-duct proliferation and fibrosis in Abcb4(-/-) mice. Biochimica et biophysica acta. vol 1832. issue 6. 2013-07-01. PMID:23416526. |
excessive extracellular matrix deposition was favored by raise in timp1 and timp2, while a reduction of tpa expression indicated lower tissue remodeling. |
2013-07-01 |
2023-08-12 |
mouse |
| Takashi Saitou, Keiko Itano, Daisuke Hoshino, Naohiko Koshikawa, Motoharu Seiki, Kazuhisa Ichikawa, Takashi Suzuk. Control and inhibition analysis of complex formation processes. Theoretical biology & medical modelling. vol 9. 2013-05-23. PMID:22863329. |
matrix metalloproteinase 2 (mmp2) activation occurs via a mechanism involving complex formation that consists of membrane type 1 mmp (mt1-mmp), tissue inhibitor of matrix metalloproteinase 2 (timp2) and mmp2. |
2013-05-23 |
2023-08-12 |
Not clear |
| Khaled Khoufache, Patrick Kibangou Bondza, Noria Harir, Marleen Daris, Mathieu Leboeuf, Jacques Mailloux, Madeleine Lemyre, Warren Foster, Ali Akou. Soluble human IL-1 receptor type 2 inhibits ectopic endometrial tissue implantation and growth: identification of a novel potential target for endometriosis treatment. The American journal of pathology. vol 181. issue 4. 2013-02-06. PMID:22841820. |
interestingly, treatment with silr2 (5 μg/kg) led to a concomitant upregulation of matrix metalloproteinases natural inhibitors (timp1 and timp2) and down-regulation of bclii, a potent anti-apoptotic protein. |
2013-02-06 |
2023-08-12 |
mouse |
| A M Ledgard, M C Berg, W H McMillan, G Smolenski, A J Peterso. Effect of asynchronous transfer on bovine embryonic development and relationship with early cycle uterine proteome profiles. Reproduction, fertility, and development. vol 24. issue 7. 2013-01-21. PMID:22935157. |
myostatin was present in only in day 9 ulf, whereas tissue inhibitor of matrix metalloproteinase 2 (timp2) and legumain were only detected in day 14 ulf. |
2013-01-21 |
2023-08-12 |
cattle |
| Anna Sokalska, Amanda Cress, Kaylon L Bruner-Tran, Kevin G Osteen, Hugh S Taylor, Israel Ortega, Antoni J Duleb. Simvastatin decreases invasiveness of human endometrial stromal cells. Biology of reproduction. vol 87. issue 1. 2012-11-30. PMID:22492974. |
the present study was undertaken to investigate the effect of simvastatin on hes cell invasiveness and on expression of selected genes relevant to invasiveness: matrix metalloproteinase 2 (mmp2), mmp3, tissue inhibitor of matrix metalloproteinase 2 (timp2), and cd44. |
2012-11-30 |
2023-08-12 |
mouse |
| Tsai-Der Chuang, Harekrushna Panda, Xiaoping Luo, Nasser Chegin. miR-200c is aberrantly expressed in leiomyomas in an ethnic-dependent manner and targets ZEBs, VEGFA, TIMP2, and FBLN5. Endocrine-related cancer. vol 19. issue 4. 2012-11-13. PMID:22685266. |
given the regulatory functions of zebs, vegfa, fbln5, and timp2 on cellular activities that promote cellular transition, angiogenesis, and matrix remodeling, we concluded that altered expression of mir-200c may have a significant impact on the outcome of lyo growth, maintenance of their mesenchymal and fibrotic characteristics, and possibly their associated symptoms. |
2012-11-13 |
2023-08-12 |
Not clear |
| Meng Mi, Shanshan Shi, Tianfang Li, Jonathan Holz, Yi-Jang Lee, Tzong-Jen Sheu, Qiande Liao, Tao Xia. TIMP2 deficient mice develop accelerated osteoarthritis via promotion of angiogenesis upon destabilization of the medial meniscus. Biochemical and biophysical research communications. vol 423. issue 2. 2012-09-17. PMID:22664108. |
loss of timp2 led to increased periarticular vascular formation 1 month post dmm, compared to wild-type mice, and did so without altering the expression pattern of matrix metalloproteinases and vascular endothelial growth factors. |
2012-09-17 |
2023-08-12 |
mouse |
| G F Korytina, O S Tselousova, L Z Akhmadishina, E V Victorova, Sh Z Zagidullin, T V Victorov. [Association of the MMP3, MMP9, ADAM33 and TIMP3 genes polymorphic markers with development and progression of chronic obstructive pulmonary disease]. Molekuliarnaia biologiia. vol 46. issue 3. 2012-08-29. PMID:22888638. |
the contribution of the polymorphic markers of the matrix metalloproteinases mmp1 (-1607g > gg, rs1799750; -519a > g, rs494379), mmp2 (-735c > t, rs2285053), mmp3 (-1171 5a > 6a, rs35068180), mmp9 (-1562c > t, rs3918242; 2660a > g, rs17576), mmp12 (-82a > g, rs2276109), the disintegrin and metalloprotease 33 adam33 (12418a > g, rs2280091; 13491c > g, rs2787094), the tissue inhibitors of metalloproteinases timp2 (-418g > c, rs8179090), timp3 (-1296t > c, rs9619311) genes to chronic obstructive pulmonary disease has been assessed. |
2012-08-29 |
2023-08-12 |
Not clear |