| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dominique Trudel, Yves Fradet, François Meyer, François Harel, Bernard Têt. Membrane-type-1 matrix metalloproteinase, matrix metalloproteinase 2, and tissue inhibitor of matrix proteinase 2 in prostate cancer: identification of patients with poor prognosis by immunohistochemistry. Human pathology. vol 39. issue 5. 2008-06-16. PMID:18329693. |
membrane-type-1 mmp (mmp14) activates mmp2 using pro-mmp2 specific inhibitor, tissue inhibitor of matrix proteinase 2 (timp2), as a receptor. |
2008-06-16 |
2023-08-12 |
Not clear |
| Jun Wu, Jie Liu, Michael P Waalkes, Ming-Liang Cheng, Ling Li, Cheng-Xiu Li, Qing Yan. High dietary fat exacerbates arsenic-induced liver fibrosis in mice. Experimental biology and medicine (Maywood, N.J.). vol 233. issue 3. 2008-04-15. PMID:18296743. |
the expression of genes encoding matrix metalloproteinases (mmp2, mmp9) and tissue inhibitors of metalloproteinases (timp1, timp2) was also enhanced, suggestive of early oncogenic events. |
2008-04-15 |
2023-08-12 |
mouse |
| Monica Amati, Marco Tomasetti, Mario Scartozzi, Laura Mariotti, Renata Alleva, Elettra Pignotti, Battista Borghi, Matteo Valentino, Mario Governa, Jiri Neuzil, Lory Santarell. Profiling tumor-associated markers for early detection of malignant mesothelioma: an epidemiologic study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 17. issue 1. 2008-04-01. PMID:18199721. |
ninety-four asbestos-exposed subjects defined at high risk, 22 patients with mm, and 54 healthy subjects were recruited for evaluation of the clinical significance of 8-hydroxy-2'-deoxyguanosine (8ohdg) in wbcs and plasma concentrations of soluble mesothelin-related peptides (smrps), angiogenic factors [platelet-derived growth factor beta, hepatocyte growth factor, basic fibroblast growth factor, and vascular endothelial growth factor beta (vegfbeta)], and matrix proteases [matrix metalloproteinase (mmp) 2, mmp9, tissue inhibitor of metalloproteinase (timp) 1, and timp2] for potential early detection of mm. |
2008-04-01 |
2023-08-12 |
human |
| R G Newman, B E Kitchell, M A Wallig, B Pari. The cloning and expression of matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase 2 in normal canine lymph nodes and in canine lymphoma. Research in veterinary science. vol 84. issue 2. 2008-03-27. PMID:17604063. |
matrix metalloproteinase-2 (mmp-2) and its inhibitor, tissue inhibitor of matrix metalloproteinase 2 (timp2), are known to be important in cancer. |
2008-03-27 |
2023-08-12 |
Not clear |
| Shun-Chieh Young, Chau-Jong Wang, Jing-Jing Lin, Pei-Ling Peng, Jui-Ling Hsu, Fen-Pi Cho. Protection effect of piper betel leaf extract against carbon tetrachloride-induced liver fibrosis in rats. Archives of toxicology. vol 81. issue 1. 2007-10-24. PMID:16676162. |
the histological examination showed the pbl extract protected liver from the damage induced by ccl(4) by decreasing alpha-smooth muscle actin (alpha-sma) expression, inducing active matrix metalloproteinase-2 (mmp2) expression though ras/erk pathway, and inhibiting timp2 level that consequently attenuated the fibrosis of liver. |
2007-10-24 |
2023-08-12 |
rat |
| Andrew H Baker, Vincenzo Sica, Lorraine M Work, Sharon Williams-Ignarro, Filomena de Nigris, Lilach O Lerman, Amelia Casamassimi, Alessandro Lanza, Concetta Schiano, Monica Rienzo, Louis J Ignarro, Claudio Napol. Brain protection using autologous bone marrow cell, metalloproteinase inhibitors, and metabolic treatment in cerebral ischemia. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 9. 2007-06-13. PMID:17360688. |
in a rat model of transient cerebral ischemia (middle cerebral artery occlusion) gene delivery vectors were used to overexpress tissue inhibitor of matrix metalloproteinase 1 and 2 (timp1 and timp2) 3 days before ischemia. |
2007-06-13 |
2023-08-12 |
rat |
| Xia Wan, Hu-hui Huang, Jing-gao L. [Effects of losartan on MT3-MMP and TIMP2 mRNA expressions in diabetic rat kidney]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA. vol 24. issue 12. 2007-05-11. PMID:15604066. |
to investigate the changes of the mrna expressions of membrane type 3-matrix metalloproteinase (mt3-mmp) and tissue inhibitor of matrix metalloproteinase 2 (timp2) in diabetic rat kidneys and the effect of losartan on such changes. |
2007-05-11 |
2023-08-12 |
rat |
| Mayra Solis, Peter Wilkinson, Raphaelle Romieu, Eduardo Hernandez, Mark A Wainberg, John Hiscot. Gene expression profiling of the host response to HIV-1 B, C, or A/E infection in monocyte-derived dendritic cells. Virology. vol 352. issue 1. 2006-09-19. PMID:16730773. |
by 72 h postinfection, genes upregulated by subtype b included the inhibitor of the matrix metalloproteinase timp2 and the heat shock protein 40 homolog (hsp40) dnajb1, whereas the ifn inducible gene stat1, the mapk1/erk2 kinase regulator st5, and the chemokine cxcl3 and shc1 genes were induced by subtypes c and a/e. |
2006-09-19 |
2023-08-12 |
human |
| P Lund, K Weisshaupt, T Mikeska, D Jammas, X Chen, R-J Kuban, U Ungethüm, U Krapfenbauer, H-P Herzel, R Schäfer, J Walter, C Ser. Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation. Oncogene. vol 25. issue 35. 2006-09-13. PMID:16568090. |
analysis of gene expression by microarray and northern blot analysis revealed the mek/erk target genes clusterin, matrix metalloproteinase 2 (mmp2), peptidylpropyl isomerase c-associated protein, syndecan 4, timp2 and thbs1 to be repressed in the hras-transformed fe-8 cells in a mek/erk- and methylation-dependent manner. |
2006-09-13 |
2023-08-12 |
rat |
| Emmanouil D Karagiannis, Aleksander S Pope. Distinct modes of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell: insights from a computational model. Journal of theoretical biology. vol 238. issue 1. 2006-05-03. PMID:16005020. |
membrane type i matrix metalloproteinase (mt1-mmp) and the diffusible matrix metalloproteinase mmp2, in the presence of the tissue inhibitor of metalloproteinases timp2, constitute a system of proteins that play an important role during the proteolysis of collagen type i matrices. |
2006-05-03 |
2023-08-12 |
Not clear |
| Ray F Gariano, Diane Hu, Jill Helm. Expression of angiogenesis-related genes during retinal development. Gene expression patterns : GEP. vol 6. issue 2. 2006-04-17. PMID:16330258. |
expression of flk, flt1, the matrix metalloproteinase mt1-mmp, and the tissue inhibitor of metalloproteinase timp2, but not of mmp2, mmp9, timp1, or timp3, correlates with inner retinal vascularization. |
2006-04-17 |
2023-08-12 |
mouse |
| Monica Cattaneo, Enrico Fontanella, Cristina Canton, Domenico Delia, Ida Biunn. SEL1L affects human pancreatic cancer cell cycle and invasiveness through modulation of PTEN and genes related to cell-matrix interactions. Neoplasia (New York, N.Y.). vol 7. issue 11. 2006-01-26. PMID:16331889. |
superarray and real-time analysis revealed that sel1l modulates the expression of the matrix metalloproteinase inhibitors timp1 (p < .04-.03) and timp2 (p < .03-.05), and the pten gene (p < .03-.05). |
2006-01-26 |
2023-08-12 |
human |
| Shan Bai, Ryan Thummel, Alan R Godwin, Hideaki Nagase, Yoshifumi Itoh, Li Li, Richard Evans, Jeffrey McDermott, Motoharu Seiki, Michael P Sarra. Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2. Matrix biology : journal of the International Society for Matrix Biology. vol 24. issue 4. 2005-09-19. PMID:15935631. |
matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of mt1-mmp, mmp2 and timp2. |
2005-09-19 |
2023-08-12 |
zebrafish |
| Paul M Coussens, Chas B Pudrith, Kerstin Skovgaard, Xiaoning Ren, Steven P Suchyta, Judith R Stabel, Peter M H Heegaar. Johne's disease in cattle is associated with enhanced expression of genes encoding IL-5, GATA-3, tissue inhibitors of matrix metalloproteinases 1 and 2, and factors promoting apoptosis in peripheral blood mononuclear cells. Veterinary immunology and immunopathology. vol 105. issue 3-4. 2005-06-01. PMID:15808302. |
our results indicate that t cells within pbmcs from m. paratuberculosis-infected cows have adopted a predominant th 2-like phenotype (enhanced expression of il-5, gata 3, and possibly il-4 mrna), that cells within infected cow pbmcs may exhibit tissue remodeling deficiencies through higher expression of tissue inhibitor of matrix metalloproteinase (timp) 1 and timp2 rna and lower expression of matrix metalloproteinase (mmp) 14 rna than similar cells from healthy controls, and that cells within the pbmc population of m. paratuberculosis-infected cows are likely poised for rapid apoptosis (upregulation of cide-a, bad, tnfri, and fas). |
2005-06-01 |
2023-08-12 |
cattle |
| A E Hegab, T Sakamoto, Y Uchida, A Nomura, Y Ishii, Y Morishima, M Mochizuki, T Kimura, W Saitoh, T Kiwamoto, T Iizuka, H H Massoud, H M Massoud, K M Hassanein, K Sekizaw. Association analysis of tissue inhibitor of metalloproteinase2 gene polymorphisms with COPD in Egyptians. Respiratory medicine. vol 99. issue 1. 2005-05-12. PMID:15672858. |
a relative increase in the activities of matrix metalloproteinases might be caused by mutations of tissue inhibitor of metalloproteinase2 (timp2). |
2005-05-12 |
2023-08-12 |
Not clear |
| Emmanouil D Karagiannis, Aleksander S Pope. A theoretical model of type I collagen proteolysis by matrix metalloproteinase (MMP) 2 and membrane type 1 MMP in the presence of tissue inhibitor of metalloproteinase 2. The Journal of biological chemistry. vol 279. issue 37. 2004-10-19. PMID:15252025. |
here we present the first theoretical model of the biochemical network describing the proteolysis of collagen i by matrix metalloproteinases 2 (mmp2) and membrane type 1 matrix metalloproteinases (mt1-mmp) in the presence of the tissue inhibitor of metalloproteinases 2 (timp2) in a bulk, cell-free, well stirred environment. |
2004-10-19 |
2023-08-12 |
Not clear |
| T William Axelrad, Dayanand D Deo, Paulo Ottino, Jennefer Van Kirk, Nicolas G Bazan, Haydee E P Bazan, Jay D Hun. Platelet-activating factor (PAF) induces activation of matrix metalloproteinase 2 activity and vascular endothelial cell invasion and migration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 3. 2004-06-01. PMID:14715700. |
prommp2 is activated in part through its interactions with membrane type 1 mmp (mt1-mmp) and tissue inhibitor of matrix metalloproteinase 2 (timp2). |
2004-06-01 |
2023-08-12 |
human |
| F Gaultier, A Foucault-Bertaud, E Lamy, A L Ejeil, S M Dridi, N Piccardi, A Piccirilli, P Msika, G Godeau, B Gogl. Effects of a vegetable extract from Lupinus albus (LU105) on the production of matrix metalloproteinases (MMP1, MMP2, MMP9) and tissue inhibitor of metalloproteinases (TIMP1, TIMP2) by human gingival fibroblasts in culture. Clinical oral investigations. vol 7. issue 4. 2004-02-18. PMID:12802622. |
effects of a vegetable extract from lupinus albus (lu105) on the production of matrix metalloproteinases (mmp1, mmp2, mmp9) and tissue inhibitor of metalloproteinases (timp1, timp2) by human gingival fibroblasts in culture. |
2004-02-18 |
2023-08-12 |
human |
| Gilles L'Allemai. [An original mechanism of action for TIMP2, a tissue-inhibitor of matrix metalloproteinases]. Bulletin du cancer. vol 90. issue 11. 2004-02-05. PMID:14706893. |
[an original mechanism of action for timp2, a tissue-inhibitor of matrix metalloproteinases]. |
2004-02-05 |
2023-08-12 |
Not clear |
| Micha F Dorsch, Jenny A Barrett, Richard A Lawrance, Azhar Maqbool, Nigel P Durham, Stacey Ellis, Nilesh J Samani, Tim Bishop, Stephen G Ball, Anthony J Balmforth, Alistair S Hal. Premature coronary artery disease shows no evidence of linkage to loci encoding for tissue inhibitors of matrix metalloproteinases. Journal of human genetics. vol 48. issue 10. 2004-01-23. PMID:14505232. |
tissue inhibitors of metalloproteinases (timp1, timp2, timp3) are naturally occurring inhibitors of matrix metalloproteinases (mmps). |
2004-01-23 |
2023-08-12 |
Not clear |